Exhaled Nitric Oxide during Academic Examination Stress in Students with Asthma
|
|
- Gloria Walton
- 5 years ago
- Views:
Transcription
1 Online Data Supplement Exhaled Nitric Oxide during Academic Examination Stress in Students with Asthma Thomas Ritz 1, Ana F. Trueba 1,2, Jiayan Liu 3, Richard J. Auchus 3,4, and David Rosenfield 1 1 Department of Psychology, Southern Methodist University, Dallas, TX, USA 2 Department of Psychology, Universidad San Francisco de Quito, Quito, Ecuador 3 Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 4 Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA
2 Expanded Methods for Selected Sections Measures FeNO was measured using a hand-held electrochemical analyzer (NIOXmino, Aerocrine, Solna, Sweden; E1) following standard recommendations(e2,e3)3,26). Participants were instructed to avoid exercise or heavier physical activity in the two hours before the assessments and food or drinks except for water should be avoided for one hour before assessments. Temporal stability of exhaled nitric oxide measurements has been demonstrated in prior research (E4,E5). A handheld spirometer (CareFusion/JaegerAM2) was used to obtain forced expiratory flow in the 1 st second (FEV 1 ) and peak expiratory flow (PEF) as the best of three valid forced expiratory maneuvers. These assessments were scheduled at the end of the session to avoid influences on FeNO (E6). Percent of predicted FEV 1 and PEF were determined with reference to standard norm populations(e7). Saliva was collected with Salivettes (Sarstedt, Inc., Newton, NC) containing sterile cotton plugs, which participants were instructed to place in the mouth for two minutes. Samples were subsequently stored at 80 Celsius. Salivary cortisol was determined using a Coat-A-Count cortisol kit TKCO2 (Siemens Medical Solutions Diagnostics, Los Angeles, CA) with a detection limit of 0.03 pg/ml with serial dilution of the lowest calibrator standard. Participants filled in the 20-item Positive Affect Negative Affect Schedule (PANAS-NA; E8) for current mood. The 10 items of the negative affect scale were scored. The 14-item Hospital Anxiety and Depression Scale (HADS; E9) was used for measuring anxious and E2
3 depressive mood in the past week with 7 items each. The 10-item Perceived Stress Scale (PSS; E10) measured feelings of stress, lack of control, and being overwhelmed in the past 4 weeks. Additionally, the 44-item Wisconsin Upper Respiratory Symptom Survey 44 (WURSS; E11) was used to control for respiratory infection symptom, the 32-item symptom severity scale was analyzed. Participants with asthma also completed the 5-item Asthma Control Test (ACT; E12). Data Analysis Basic biometric and demographic variables were compared by t-test or 2 -test. Multilevel models (MLMs) were used to analyze the longitudinal data because MLM is an intent-to-treat analysis that retains all participants regardless of missing data or dropout, thereby maximizing power and generalizability (n=5 asthmatic, n=3 controls did not complete the second exam stress assessment, the small number precluded meaningful statistical comparison between completers and non-completers on early exam stress levels and negative affect). The growth curve of the outcomes over time were modeled as quadratic. However, quadratic effects were dropped from final models if they were nonsignificant to arrive at the most parsimonious model and to minimize Type II error(e13, E14). Gender, age, and cold symptoms were used as covariates in all initial models, but cold symptoms were not significant in any model, so they were dropped from all final analyses. Because the raw scores for FeNO and cortisol were skewed (skewness>2.0), log transformation was used to reduce skewness (post-transformed scores skewness<1.0). All references to FeNO and cortisol in the Results section refer to these log-transformed values. E3
4 After calculating the growth curves for each outcome measure over the three time points, we investigated whether the changes over time were moderated by baseline levels of stress (PSS) and/or depressive symptoms (HADS-D). To make sure that results for each were not due to their relation with the other, both were included as simultaneous moderators of the growth curve of each outcome. To assess moderation, interactions were formed between the moderators and all of the growth curve parameters (intercept, linear slope, quadratic slope). Again, nonsignificant interactions were dropped and final models were then calculated. We examined also whether within-subjects changes in cortisol were related to withinsubjects changes in FeNO and negative affect over time. Following a recommended procedure (E15) we converted the raw scores for each assessment of cortisol, FeNO, and negative affect into deviation scores. These deviation scores represent the difference between the score at each time point and the person s average score over all three time points, as shown in the following formula: Ydev ij = Y ij - Ymean i where Ydev ij is the deviation score on an outcome variable for individual i at assessment j, Y ij is the raw outcome score for individual i at assessment j, and Ymean i is the average score on outcome Y for individual i over the three assessments. These deviation scores were then used in the analyses examining the relations between within-subjects change in cortisol and withinsubjects change in FeNO and negative affect. In particular, we added the deviations scores for cortisol to the growth curve model for FeNO and for negative affect, to determine the relation between deviations in cortisol and deviations in outcome, over and above any relation that might be due to their coincident change over time. E4
5 Expanded Results for Selected Sections Asthma-Specific Effects Individuals with asthma had higher initial levels of FeNO and tended to have greater reductions in FeNO (b=.12, t(110)=1.90, p=.061) over time than healthy controls. The average reduction of FeNO was ppb in asthma, compared to -1.2 ppb in controls. Because of the steeper FeNO decline in asthma, log-transformed values were not significantly different (b=-.22, t(105)=-1.78, p=.077) from healthy controls in late stress. Cortisol levels increased less from the low stress time point to late stress in asthma than in controls (b=.05, t(86)=2.26, p=.027). Negative affect increased more at the beginning of the high-stress period for controls than for asthmatics, leading to higher negative affect among controls at the early stress time point (b=3.32, t(103)=2.24,p=.017). But for both controls and asthmatics, negative affect was higher during both stress periods than during the low stress time (for controls: b=.7.57, t(106)=10.26, p<.001 for early stress vs. low stress and b=2.95, t(104)=4.04, p<.001 for late stress vs. low stress; for asthma: b=4.72, t(103)=4.71, p<.001 for early stress vs. low stress, and b=3.81, t(101)=3.82, p<.001 for late stress vs. low stress). For controls, momentary stress was higher at both early and late stress time points than at the low stress time point (b=1.08, t(100)=3.46, p=.001, and b=1.06, t(99)=3.15, p=.002), but did not differ between early stress and late stress. For asthmatics, momentary stress was not higher during the stress periods than during the low stress time point (b=.66, t(96)=1.54, p=.127, and b=.06, t(95)=0.13,p=.897 for the early and late stress time points). Neither FEV 1 nor PEF changes differed between groups, but individuals with asthma were marginally lower than controls on overall FEV 1 (b=3.87, t(107)=1.68, p=.097). E5
6 Dependency of Findings on Initial Depression and Perceived Stress Higher depressive symptoms at baseline led to a steeper decline in FeNO over time, regardless of group (b=.06, t(84)=-2.09,p=.039 for the depressive symptoms x Time interaction). Baseline PSS had no effect on controls (p=.872), but for asthmatics, higher PSS was associated with lower FeNO during non-stress times (b=-.25, t(92)=-2.49p=.015), while not being related to FeNO during the stressful exam period (ps>.374). Neither PSS nor depressive symptoms were significantly related to cortisol. Higher baseline PSS was associated with marginally faster rates of decline in FEV 1 over time, across groups (b=1.28,t(88)=1.94,p=.055), and higher baseline depressive symptoms were related to faster rates of decline in PEF over time, across groups (b=-1.99, t(64)=-2.27, p=.026).higher baseline PSS was associated with lower PEF across time and groups, b=4.85, t(83)=-2.26, p=.026, as well as higher average momentary stress levels across time for asthmatics (b=.78, t(86)=4.22,p<.001) but not for controls (b=.05, t(87)=0.35, p=.728). Finally, higher baseline depressive symptoms were related to higher reported negative affect across time and groups (b=1.98, t(88)=4.23,p<.001) and higher momentary stress level s across time and groups (b=.36, t(84)=3.15, p=.002). Effects of Seasons and Inhaled Corticosteroid Use in Asthma To examine the impact of seasons (spring versus fall), allergies, inhaled corticosteroids, or maintenance medication (including leukotriene modifiers) on FeNO, cortisol, negative affect, and spirometric lung function, we added these variables to the growth curve models. None of these variables affected any of the temporal trajectories. Inhaled corticosteroid use and allergies were related to overall higher FEV 1 (b=8.98, t(26)=2.67, p=.013, and b=5.51, E6
7 t(107)=2.49, p=.014, respectively) and marginally to lower cortisol (b=-.12, t(21)=-1.98,p=.061, and b=.06, t(102)=1.85, p=.067, respectively). Finally, allergies were also related to higher negative mood (b=3.07, t(106)=3.57, p=.001). None of the participants reported changes in medication between time points. E7
8 Online Data Supplement References E1. Alving K, Jansson C, Nordvall L. Performance of a new hand-held device for exhaled nitric oxide measurement in adults and children. Respiratory Research 2006;7:67. E2. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, American Thoracic Society; European Respiratory Society. Am J Respir Crit Care Med 2005;171: E3. Silkoff PE, Erzurum SC, Lundberg JO, et al. ATS workshop proceedings: exhaled nitric oxide and nitric oxide oxidative metabolism in exhaled breath condensate. Proc Am Thorac Soc 2006;3: E4. Kharitonov SA, Gonio F, Kelly C, Meah S, Barnes PJ. Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children. Eur Respir J. 2003; 21: E5. Khalili B1, Boggs PB, Bahna SL. Reliability of a new hand-held device for the measurement of exhaled nitric oxide. Allergy 2007;62: E6. Silkoff PE, Wakita S, Chatkin J, et al. Exhaled nitric oxide after beta2-agonist inhalation and spirometry in asthma. Am J Respir Crit Care Med 1999;159: E7. Quanier PH, Tammelig GJ, Cotes JE, Pedersen OF, Peslin R, Yernault J-C. Lung volumes and forced ventilatory flows. Eur Respir J 1993;6:Suppl 16, E8. Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: The PANAS scales. J Pers Soc Psychol 1988;54: E9. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983;24: E10. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983;67: E11. Barrett B, Brown R, Mundt M, Safdar N, Dye L, Maberry R, Alt J. The Wisconsin Upper Respiratory Symptom Survey is responsive, reliable, and valid. J Clin Epidemiol 2005;58: E12. Nathan RA, Sorkness CA, Kosinski M, et al. Development of the asthma control test: A survey for assessing asthma control. J Allergy Clin Immunol 2004;113: E13. Hox JJ. Multilevel analysis: techniques and applications New York, NY, Routledge,2010. E14. Heck RH, Thomas SL, Tabata LN. Multilevel and longitudinal modeling with IBM SPSS (2nd ed.). Routledge, New York, NY, E15. Hedeker D, Gibbons RD. Longitudinal data analysis. John Wiley, Hoboken NJ, E8
Comparison of exhaled nitric oxide measurements between NIOX MINO â electrochemical and Ecomedics chemiluminescence analyzer
Respiratory Medicine (2008) 102, 1667e1671 available at www.sciencedirect.com journal homepage: www.elsevier.com/locate/rmed SHORT COMMUNICATION Comparison of exhaled nitric oxide measurements between
More informationASTHMA TREATMENT EFFICACY ASSESSMENT BY FeNO MEASUREMENT
Bulletin of the Transilvania University of Braşov Series VI: Medical Sciences Vol. 5 (54) No. 2-2012 ASTHMA TREATMENT EFFICACY ASSESSMENT BY FeNO MEASUREMENT Dana ALEXANDRESCU 1 Abstract: The author of
More informationThis is a cross-sectional analysis of the National Health and Nutrition Examination
SUPPLEMENTAL METHODS Study Design and Setting This is a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) data 2007-2008, 2009-2010, and 2011-2012. The NHANES is
More informationNG80. Asthma: diagnosis, monitoring and chronic asthma management (NG80)
Asthma: diagnosis, monitoring and chronic asthma management (NG80) NG80 NICE has checked the use of its content in this product and the sponsor has had no influence on the content of this booklet. NICE
More informationImportance of fractional exhaled nitric oxide in diagnosis of bronchiectasis accompanied with bronchial asthma
Original Article Importance of fractional exhaled nitric oxide in diagnosis of bronchiectasis accompanied with bronchial asthma Feng-Jia Chen, Huai Liao, Xin-Yan Huang, Can-Mao Xie Department of Respiratory
More informationSpirometry and Flow Volume Measurements
Spirometry and Flow Volume Measurements Standards & Guidelines December 1998 To serve the public and guide the medical profession Revision Dates: December 1998 Approval Date: June 1998 Originating Committee:
More informationSPIROMETRY METHOD. COR-MAN IN / EN Issue A, Rev INNOVISION ApS Skovvænget 2 DK-5620 Glamsbjerg Denmark
SPIROMETRY METHOD COR-MAN-0000-006-IN / EN Issue A, Rev. 2 2013-07 INNOVISION ApS Skovvænget 2 DK-5620 Glamsbjerg Denmark Tel.: +45 65 95 91 00 Fax: +45 65 95 78 00 info@innovision.dk www.innovision.dk
More informationMeenu Singh, Joseph L. Mathew, Prabhjot Malhi, B.R. Srinivas and Lata Kumar
Comparison of Improvement in Quality of Life Score with Objective Parameters of Pulmonary Function in Indian Asthmatic Children Receiving Inhaled Corticosteroid Therapy Meenu Singh, Joseph L. Mathew, Prabhjot
More informationExhaled Nitric Oxide after 2 -agonist Inhalation and Spirometry in Asthma
Exhaled Nitric Oxide after 2 -agonist Inhalation and Spirometry in Asthma PHILIP E. SILKOFF, SUGURU WAKITA, JOSE CHATKIN, KHALIL ANSARIN, CARLOS GUTIERREZ, MARLOVA CARAMORI, PATRICIA MCCLEAN, ARTHUR S.
More informationExhaled Nitric Oxide among Bulgarian Children with Asthma Exacerbation
International Journal of Pharmaceutical Science Invention ISSN (Online): 2319 6718, ISSN (Print): 2319 670X Volume 6 Issue 4 April 2017 PP. 10-16 Exhaled Nitric Oxide among Bulgarian Children with Asthma
More informationOptimal Assessment of Asthma Control in Clinical Practice: Is there a role for biomarkers?
Disclosures: Optimal Assessment of Asthma Control in Clinical Practice: Is there a role for biomarkers? Stanley Fineman, MD Past-President, American College of Allergy, Asthma & Immunology Adjunct Associate
More informationNIOX VERO. For assessment and management of airway inflammation
NIOX VERO For assessment and management of airway inflammation NIOX VERO NIOX VERO is a point-of-care device for assessing airway inflammation in patients with respiratory problems such as asthma. NIOX
More informationcompare patients preferences and costs for asthma treatment regimens targeting three
APPENDIX I ADDITIONAL METHODS Trial design The Accurate trial lasted from September 2009 until January 2012 and was designed to compare patients preferences and costs for asthma treatment regimens targeting
More informationPeak Expiratory Flow Is Not a Quality Indicator for Spirometry*
Original Research PULMONARY FUNCTION TESTING Peak Expiratory Flow Is Not a Quality Indicator for Spirometry* Peak Expiratory Flow Variability and FEV 1 Are Poorly Correlated in an Elderly Population Matthew
More information2.6 MONITORING ASTHMA
2.6 MONITORING ASTHMA 2.6.1 MONITORING ASTHMA IN ADULTS In the majority of patients with asthma symptom-based monitoring is adequate. Patients achieving control of symptoms with treatment have a low risk
More informationUNIT TWO: OVERVIEW OF SPIROMETRY. A. Definition of Spirometry
UNIT TWO: OVERVIEW OF SPIROMETRY A. Definition of Spirometry Spirometry is a medical screening test that measures various aspects of breathing and lung function. It is performed by using a spirometer,
More informationOnline Data Supplement Effect of CPAP on Airways Reactivity in Asthma: A Randomized Sham-Controlled Clinical Trial
Online Data Supplement Effect of CPAP on Airways Reactivity in Asthma: A Randomized Sham-Controlled Clinical Trial Janet T. Holbrook, PhD, MPH, Elizabeth A. Sugar, PhD, Robert H. Brown, MD, MPH, Lea T.
More informationWhich asthma patient has allergic airway inflammation?
Which asthma patient has allergic airway inflammation? C o n t r o l l i n g A l l e r g i c A s t h m a Several underlying diseases can present symptoms similar to asthma. Therefore, a correct diagnos
More informationValidation of a New Portable Exhaled Nitric Oxide Analyzer, NIOX VERO : Randomized Studies in Asthma
DOI 10.1007/s41030-017-0032-8 ORIGINAL RESEARCH Validation of a New Portable Exhaled Nitric Oxide Analyzer, NIOX VERO : Randomized Studies in Asthma Kjell Alving. Robert Anolik. Glenn Crater. Craig F.
More informationKEY WORDS airflow limitation, airway hyperresponsiveness, airway inflammation, airway lability, peak expiratory flow rate
Allergology International. 2013;62:343-349 DOI: 10.2332 allergolint.13-oa-0543 ORIGINAL ARTICLE Stratifying a Risk for an Increased Variation of Airway Caliber among the Clinically Stable Asthma Atsushi
More informationExhaled Nitric Oxide: An Adjunctive Tool in the Diagnosis and Management of Asthma
Exhaled Nitric Oxide: An Adjunctive Tool in the Diagnosis and Management of Asthma Jason Debley, MD, MPH Assistant Professor, Pediatrics Division of Pulmonary Medicine University of Washington School of
More informationInhaled fluticasone decreases bronchial but not alveolar nitric oxide output in asthma
Eur Respir J 21; 18: 635 639 Printed in UK all rights reserved Copyright #ERS Journals Ltd 21 European Respiratory Journal ISSN 93-1936 Inhaled fluticasone decreases bronchial but not alveolar nitric oxide
More informationAssessment of accuracy and applicability of a new electronic peak flow meter and asthma monitor
Eur Respir J 18; 12: 45 42 DOI: 18/1.8.5 Printed in UK - all rights reserved Copyright ERS Journals Ltd 18 European Respiratory Journal ISSN - 1 Assessment of accuracy and applicability of a new electronic
More informationA diagnosis of asthma is made on the basis of compatible
383 ASTHMA Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests N Berkman, A Avital, R Breuer, E Bardach, C Springer, S Godfrey... See end of article for authors
More informationClinical Policy: Fractional Exhaled Nitric Oxide Reference Number: CP.MP.103
Clinical Policy: Reference Number: CP.MP.103 Effective Date: 01/16 Last Review Date: 01/17 Coding Implications Revision Log See Important Reminder at the end of this policy for important regulatory and
More informationB Y L E S L I E K U M P F, R R T, C P F T, A E - C
FeNO B Y L E S L I E K U M P F, R R T, C P F T, A E - C LESLIE KUMPF RRT, CPFT, AE-C Graduated from Henry Ford with a degree in Respiratory Therapy in 2006 Currently working on my BSRT Help start the RRT
More informationOutline FEF Reduced FEF25-75 in asthma. What does it mean and what are the clinical implications?
Reduced FEF25-75 in asthma. What does it mean and what are the clinical implications? Fernando Holguin MD MPH Director, Asthma Clinical & Research Program Center for lungs and Breathing University of Colorado
More informationDetermination of fractional exhaled nitric oxide (FENO) reference values in healthy Thai population
Asian Pacific Journal of Allergy and Immunology ORIGINAL ARTICLE Determination of fractional exhaled nitric oxide (FENO) reference values in healthy Thai population Yiwa Suksawat, Punchama Pacharn, Orathai
More informationOffice Based Spirometry
Osteopathic Family Physician (2014)1, 14-18 Scott Klosterman, DO; Woodson Crenshaw, OMS4 Spartanburg Regional Family Medicine Residency Program; Edward Via College of Osteopathic Medicine - Virginia Campus
More informationGlobal Initiative for Asthma (GINA) What s new in GINA 2017?
Global Initiative for Asthma (GINA) GINA Global Strategy for Asthma Management and Prevention Asthma-COPD overlap The word syndrome has been removed from the previous term asthma-copd overlap syndrome
More informationA comparison of global questions versus health status questionnaires as measures of the severity and impact of asthma
Eur Respir J 1999; 1: 591±596 Printed in UK ± all rights reserved Copyright #ERS Journals Ltd 1999 European Respiratory Journal ISSN 93-1936 A comparison of global questions versus health status questionnaires
More informationSpirometry Training Courses. Spirometry for. Thoracic Society of Australia and New Zealand. June Developed in partnership with
Standards for Spirometry Training Courses Companion Document to Standards for the Delivery of Spirometry for Coal Mine Workers Thoracic Society of Australia and New Zealand June 2017 Developed in partnership
More informationPerforming a Methacholine Challenge Test
powder for solution, for inhalation Performing a Methacholine Challenge Test Provocholine is a registered trademark of Methapharm Inc. Copyright Methapharm Inc. 2016. All rights reserved. Healthcare professionals
More informationDomiciliary diurnal variation of exhaled nitric oxide fraction for asthma control
ORIGINAL ARTICLE ASTHMA Domiciliary diurnal variation of exhaled nitric oxide fraction for asthma control Junpei Saito, David Gibeon, Patricia Macedo, Andrew Menzies-Gow, Pankaj K. Bhavsar and Kian Fan
More informationYou Take My Breath Away. Student Information Page 5C Part 1
You Take My Breath Away Student Information Page 5C Part 1 Students with asthma or other respiratory problems should not participate in this activity because it involves repeated maximal inhalations and
More informationEvaluation of Exhaled Nitric Oxide in Schoolchildren at Different Exhalation Flow Rates
0031-3998/02/5203-0393 PEDIATRIC RESEARCH Vol. 52, No. 3, 2002 Copyright 2002 International Pediatric Research Foundation, Inc. Printed in U.S.A. Evaluation of Exhaled Nitric Oxide in Schoolchildren at
More informationExhaled Nitric Oxide Today s Asthma Biomarker. Richard F. Lavi, MD FAAAAI FAAP
Exhaled Nitric Oxide Today s Asthma Biomarker Richard F. Lavi, MD FAAAAI FAAP Objectives Describe exhaled nitric oxide physiology and pathophysiology Review the current literature regarding exhaled nitric
More informationDaily ambulatory exhaled nitric oxide measurements in asthma
Pediatr Allergy Immunol 2006: 17: 189 193 DOI: 10.1111/j.1399-3038.2006.00394.x Ó 2006 The Authors Journal compilation Ó 2006 Blackwell Munksgaard PEDIATRIC ALLERGY AND IMMUNOLOGY Daily ambulatory exhaled
More informationQuality Assurance Mapping Your QC Program Equipment and Test Quality. Susan Blonshine RRT, RPFT, FAARC, AE-C
Quality Assurance Mapping Your QC Program Equipment and Test Quality Susan Blonshine RRT, RPFT, FAARC, AE-C How to Begin Gather resources Define PF scope of service Procedures performed Equipment Describe
More informationKey words: asthma; dyspnea; exercise-induced bronchoconstriction; nitric oxide
Exhaled Nitric Oxide as a Predictor of Exercise-Induced Bronchoconstriction* Samy M. ElHalawani, DO; Nam T. Ly, MD; Richard T. Mahon, MD; and Dennis E. Amundson, DO Introduction: Exercise-induced bronchoconstriction
More informationPulmonary Function Tests. Mohammad Babai M.D Occupational Medicine Specialist
Pulmonary Function Tests Mohammad Babai M.D Occupational Medicine Specialist www.drbabai.com Pulmonary Function Tests Pulmonary Function Tests: Spirometry Peak-Flow metry Bronchoprovocation Tests Body
More informationComparative Repeatability of Two Handheld Fractional Exhaled Nitric Oxide Monitors
Comparative Repeatability of Two Handheld Fractional Exhaled Nitric Oxide Monitors Kirsty M. Kapande, MRes Med Sci, 1 Laura A. McConaghy, MBChB, 2 Isabella Douglas, RCNC, 3 Sonia McKenna, BSc, 3 Jenny
More informationChallenges in Meeting International Requirements for Clinical Bioequivalence of Inhaled Drug Products
Challenges in Meeting International Requirements for Clinical Bioequivalence of Inhaled Drug Products Tushar Shah, M.D. Sr. VP, Global Respiratory Research and Development TEVA Pharmaceuticals 1 Presentation
More informationMethacholine versus Mannitol Challenge in the Evaluation of Asthma Clinical applications of methacholine and mannitol challenges
Methacholine versus Mannitol Challenge in the Evaluation of Asthma Clinical applications of methacholine and mannitol challenges AAAAI San Antonio Tx February 2013 Catherine Lemière MD, MSc Hôpital du
More informationCover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/61041 holds various files of this Leiden University dissertation. Author: Thijs, W. Title: Obesity-related risk factors for impaired lung function Issue
More informationExhalation flow and pressure-controlled reservoir collection of exhaled nitric oxide for remote and delayed analysis
Thorax 998;5:775 779 775 Department of Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse Street, London SW 6LY, UK P Paredi S Loukides S A Kharitonov
More informationLabeling Summary/Package Insert NIOX VERO (According to 21CFR (b) Labeling for In Vitro Diagnostic Devices)
000249-10, December 2017 (EPS-000069) Labeling Summary/Package Insert NIOX VERO (According to 21CFR 809.10(b) Labeling for In Vitro Diagnostic Devices) Product Labeling Summary NIOX VERO 1. Proprietary
More informationLabeling Summary / Package Insert NIOX MINO
Labeling Summary / Package Insert NIOX MINO (According to 21CFR 809.10(b) Labeling for In Vitro Diagnostic Devices) For USA 1 Proprietary and Established Names NIOX MINO Airway Inflammation Monitor measures
More informationSpirometric protocol
Spirometric protocol Spirometry is the most common of the Pulmonary Function Test, that measures lung function, specifically the amount (volume) and/or speed (flow) of air that can be inhaled and exhaled.
More informationMSRC AIR Course Karla Stoermer Grossman, MSA, BSN, RN, AE-C
MSRC AIR Course Karla Stoermer Grossman, MSA, BSN, RN, AE-C Explain the importance of objective measures in the management of asthma Explain the different types of objective measures used in the management
More informationPulmonary Function Testing
In the Clinic Pulmonary Function Testing Hawa Edriss MD, Gilbert Berdine MD The term PFT encompasses three different measures of lung function: spirometry, lung volumes, and diffusion capacity. In this
More informationSPIROMETRY. Marijke Currie (CRFS) Care Medical Ltd Phone: Copyright CARE Medical ltd
SPIROMETRY Marijke Currie (CRFS) Care Medical Ltd Phone: 0800 333 808 Email: sales@caremed.co.nz What is spirometry Spirometry is a physiological test that measures the volume of air an individual can
More informationCIRCULAR INSTRUCTION REGARDING ESTABLISHMENT OF IMPAIRMENT DUE TO OCCUPATIONAL LUNG DISEASE FOR THE PURPOSES OF AWARDING PERMANENT DISABLEMENT
Circular Instruction 195 CIRCULAR INSTRUCTION REGARDING ESTABLISHMENT OF IMPAIRMENT DUE TO OCCUPATIONAL LUNG DISEASE FOR THE PURPOSES OF AWARDING PERMANENT DISABLEMENT COMPENSATION FOR OCCUPATIONAL INJURIES
More informationWhat do pulmonary function tests tell you?
Pulmonary Function Testing Michael Wert, MD Assistant Professor Clinical Department of Internal Medicine Division of Pulmonary, Critical Care, and Sleep Medicine The Ohio State University Wexner Medical
More informationMEDICAL POLICY. Proprietary Information of YourCare Health Plan
MEDICAL POLICY PAGE: 1 OF: 6 If the member's subscriber contract excludes coverage for a specific service it is not covered under that contract. In such cases, medical policy criteria are not applied.
More informationBeta 2 adrenoceptor agonists and the Olympic Games in Athens
Beta 2 adrenoceptor agonists and the Olympic Games in Athens 1 Appendix A of the Olympic Movement Anti-Doping Code, the List of Prohibited Substances and Prohibited Methods dated 1 st January 2003 states
More informationCorporate Medical Policy
Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: exhaled_nitric_oxide_measurement 2/2009 3/2018 3/2019 3/2018 Description of Procedure or Service Asthma is
More informationSpirometry is the most frequently performed. Obstructive and restrictive spirometric patterns: fixed cut-offs for FEV1/FEV6 and FEV6
Eur Respir J 2006; 27: 378 383 DOI: 10.1183/09031936.06.00036005 CopyrightßERS Journals Ltd 2006 Obstructive and restrictive spirometric patterns: fixed cut-offs for FEV1/ and J. Vandevoorde*, S. Verbanck
More informationExhaled nitric oxide levels in asthma: Personal best versus reference values
Exhaled nitric oxide levels in asthma: Personal best versus reference values Andrew D. Smith, MRCP(UK), Jan O. Cowan, and D. Robin Taylor, MD Dunedin, New Zealand Background: Factors affecting the fraction
More informationBudesonide treatment of moderate and severe asthma in children: A doseresponse
Budesonide treatment of moderate and severe asthma in children: A doseresponse study Soren Pedersen, MD, PhD, and Ove Ramsgaard Hansen, MD Kolding, Denmark Objective: The purpose of the study was to evaluate
More informationCase-Compare Impact Report
Case-Compare Impact Report October 8, 20 For CME Activity: Developed through an independent educational grant from Genentech: Moderate to Severe Persistent Asthma: A Case-Based Panel Discussion (March
More informationIndividual Study Table Referring to Part of the Dossier. Volume:
Final Report M/100977/21Final Version () 2. SYNOPSIS A Title of Study: A PHASE IIa, RANDOMISED, DOUBLE-BLIND, MULTIPLE DOSE, PLACEBO CONTROLLED, 3 PERIOD CROSS-OVER, ASCENDING DOSE CLINICAL TRIAL TO ASSESS
More informationAssessment of Bronchodilator Response in Various Spirometric Patterns
Original Article 2013 NRITLD, National Research Institute of Tuberculosis and Lung Disease, Iran ISSN: 1735-0344 TANAFFOS Assessment of Bronchodilator Response in Various Spirometric Patterns Amir Houshang
More informationCombined use of exhaled nitric oxide and airway hyperresponsiveness in characterizing asthma in a large population survey
Eur Respir J 2000; 15: 849±855 Printed in UK ± all rights reserved Copyright #ERS Journals Ltd 2000 European Respiratory Journal ISSN 0903-1936 Combined use of exhaled nitric oxide and airway hyperresponsiveness
More informationPulmonary Function Laboratory ATS Accreditation Are you prepared? Susan Blonshine RRT, RPFT, FAARC, AE-C
Pulmonary Function Laboratory ATS Accreditation Are you prepared? Susan Blonshine RRT, RPFT, FAARC, AE-C Why Quality Consistent, accurate, reliable results Cost-effective Diagnosis Misclassification Reduce
More informationGetting Spirometry Right It Matters! Performance, Quality Assessment, and Interpretation. Susan Blonshine RRT, RPFT, AE-C, FAARC
Getting Spirometry Right It Matters! Performance, Quality Assessment, and Interpretation Susan Blonshine RRT, RPFT, AE-C, FAARC Objectives Sample Title Recognize acceptable spirometry that meets the start
More informationMEDICAL POLICY. Proprietary Information of Excellus Health Plan, Inc. A nonprofit independent licensee of the BlueCross BlueShield Association
MEDICAL POLICY SUBJECT: MEASUREMENT OF EXHALED MARKERS OF AIRWAY INFLAMMATION IN PATIENTS WITH ASTHMA POLICY NUMBER: 2.01.41 CATEGORY: Technology Assessment EFFECTIVE DATE: 04/15/04 REVISED DATE: 02/17/05,
More informationValidity of Spirometry for Diagnosis of Cough Variant Asthma
http:// ijp.mums.ac.ir Original Article (Pages: 6431-6438) Validity of Spirometry for Diagnosis of Cough Variant Asthma Iman Vafaei 1, *Nemat Bilan 2,3, Masoumeh Ghasempour 41 1 Resident of Pediatrics,
More informationImpact of the new ATS/ERS pulmonary function test interpretation guidelines
Respiratory Medicine (2007) 101, 2336 2342 Impact of the new ATS/ERS pulmonary function test interpretation guidelines Mary Elizabeth Kreider a,, Michael A. Grippi a,b a Division of Pulmonary, Allergy,
More informationSpirometry Training Courses
Spirometry Training Courses A Position Paper of The Australian and New Zealand Society of Respiratory Science & The Thoracic Society of Australia and New Zealand At the time of the preparation of this
More informationAlveolar nitric oxide and asthma control in mild untreated asthma
Alveolar nitric oxide and asthma control in mild untreated asthma Nicola Scichilone, MD, Salvatore Battaglia, MD, Salvatore Taormina, PhD, Viviana Modica, PhD, Elena Pozzecco, PhD, and Vincenzo Bellia,
More informationDo current treatment protocols adequately prevent airway remodeling in children with mild intermittent asthma?
Respiratory Medicine (2006) 100, 458 462 Do current treatment protocols adequately prevent airway remodeling in children with mild intermittent asthma? Haim S. Bibi a,, David Feigenbaum a, Mariana Hessen
More informationStudy No.: Title: Rationale: Phase: Study Period: Study Design: Centres: Indication: Treatment: Objectives: Primary Outcome/Efficacy Variable:
The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.
More informationDiagnosis and Management of Asthma in Children based on the British Thoracic Society and Scottish Intercollegiate Guidelines Network September 2016
Diagnosis and Management of Asthma in Children based on the British Thoracic Society and Scottish Intercollegiate Guidelines Network September 2016 Diagnosis: There is no lower limit to the age at which
More information10801 Sixth St, Rancho Cucamonga, CA Tel (909) Fax (909) Visit our web site at:
for the Diagnosis and Management of Asthma and Other Pulmonary Disorders IEHP Policy: Based on a review of the currently available literature, there is insufficient evidence to support the use of FE NO
More informationAsthma Management for the Athlete
Asthma Management for the Athlete Khanh Lai, MD Assistant Professor Division of Pediatric Pulmonary and Sleep Medicine University of Utah School of Medicine 2 nd Annual Sports Medicine Symposium: The Pediatric
More information2.0 Scope: This document is to be used by the DCS staff when collecting participants spirometry measurements using the TruFlow Easy-On Spirometer.
Title: Spirometry Version Date: 2017-MAR-21 Document Effective Date: 2017-MAY-15 Number: Data Collection Site (DCS) Version: 2.3 Number of Pages: SOP_DCS_0012 6 1.0 Purpose: The purpose of this document
More informationDIAGNOSTIC ACCREDITATION PROGRAM. Spirometry Quality Control Plan
DIAGNOSTIC ACCREDITATION PROGRAM Spirometry Quality Control Plan Table of Contents Introduction...1 Spirometry Definitions and Requirements...2 Spirometry Requirements... 2...4 Daily Quality Control (see
More informationAsthma is among the most common chronic childhood diseases affecting 6 million children in the United States.
MEDICAL PROGRESS OFFICE-BASED OBJECTIVE MEASURES IN CHILDHOOD ASTHMA JOSEPH D. SPAHN, MD, AND BRADLEY E. CHIPPS, MD Asthma is among the most common chronic childhood diseases affecting 6 million children
More informationSUMMARY THIS IS A PRINTED COPY OF AN ELECTRONIC DOCUMENT. PLEASE CHECK ITS VALIDITY BEFORE USE.
i SUMMARY ZENECA PHARMACEUTICALS FINISHED PRODUCT: ACTIVE INGREDIENT: ACCOLATE zafirlukast (ZD9188) Trial title (number): A Dose-ranging, Safety and Efficacy Trial with Zafirlukast (ACCOLATE ) in the Treatment
More informationDifference Between The Slow Vital Capacity And Forced Vital Capacity: Predictor Of Hyperinflation In Patients With Airflow Obstruction
ISPUB.COM The Internet Journal of Pulmonary Medicine Volume 4 Number 2 Difference Between The Slow Vital Capacity And Forced Vital Capacity: Predictor Of Hyperinflation In Patients With Airflow Obstruction
More informationExhaled carbon monoxide levels after a course of oral prednisone in children
Exhaled carbon monoxide levels after a course of oral prednisone in children with asthma exacerbation Background: Fractional exhaled nitric oxide (FE NO ) and exhaled carbon monoxide (ECO) have been proposed
More informationONLINE DATA SUPPLEMENT - ASTHMA INTERVENTION PROGRAM PREVENTS READMISSIONS IN HIGH HEALTHCARE UTILIZERS
R2 (REVISED MANUSCRIPT BLUE 200208-877OC) ONLINE DATA SUPPLEMENT - ASTHMA INTERVENTION PROGRAM PREVENTS READMISSIONS IN HIGH HEALTHCARE UTILIZERS Mario Castro, M.D., M.P.H. Nina A. Zimmermann R.N. Sue
More informationSYNOPSIS. First subject enrolled 15 August 2003 Therapeutic confirmatory (III) Last subject completed 03 February 2005
Drug product: SYMBICORT pmdi 160/4.5 μg Drug substance(s): Budesonide/formoterol Study code: SD-039-0728 Edition No.: FINAL Date: 27 February 2006 SYNOPSIS A 52-week, randomized, double-blind, single-dummy,
More informationPREDICTION EQUATIONS FOR LUNG FUNCTION IN HEALTHY, LIFE TIME NEVER-SMOKING MALAYSIAN POPULATION
Prediction Equations for Lung Function in Healthy, Non-smoking Malaysian Population PREDICTION EQUATIONS FOR LUNG FUNCTION IN HEALTHY, LIFE TIME NEVER-SMOKING MALAYSIAN POPULATION Justin Gnanou, Brinnell
More informationDual-Controller Asthma Therapy: Rationale and Clinical Benefits
B/1 Dual-Controller Asthma Therapy: Rationale and Clinical Benefits MODULE B The 1997 National Heart, Lung, and Blood Institute (NHLBI) Expert Panel guidelines on asthma management recommend a 4-step approach
More informationAnalysis of Lung Function
Computer 21 Spirometry is a valuable tool for analyzing the flow rate of air passing into and out of the lungs. Flow rates vary over the course of a respiratory cycle (a single inspiration followed by
More informationDiagnosing Asthma Comparisons between Exhaled Nitric Oxide Measurements and Conventional Tests
Diagnosing Asthma Comparisons between Exhaled Nitric Oxide Measurements and Conventional Tests Andrew D. Smith, Jan O. Cowan, Sue Filsell, Chris McLachlan, Gabrielle Monti-Sheehan, Pamela Jackson, and
More informationViral-Induced Asthma:
Viral-Induced : Sorting through the Studies Malcolm R. Sears, MB, FRACP, FRCPC Presented at the Respirology Update Continuing Education Program, January 2005 Viral-associated wheezing is common and not
More informationAvailable from Deakin Research Online:
This is the published version: Richardson, Ben and Fuller Tyszkiewicz, Matthew 2014, The application of non linear multilevel models to experience sampling data, European health psychologist, vol. 16,
More informationBETTER SPIROMETRY. Marijke Currie (CRFS) Care Medical Ltd Phone: Copyright CARE Medical ltd
BETTER SPIROMETRY Marijke Currie (CRFS) Care Medical Ltd Phone: 0800 333 808 Email: sales@caremed.co.nz What is spirometry Spirometry is a physiological test that measures the volume of air an individual
More informationAnnual lung function changes in young patients with chronic lung disease
Eur Respir J 22; 19: 886 891 DOI:.1183/931936.2.2492 Printed in UK all rights reserved Copyright #ERS Journals Ltd 22 European Respiratory Journal ISSN 93-1936 Annual lung function changes in young patients
More informationThe FDA Critical Path Initiative
The FDA Critical Path Initiative Clinical Considerations for Demonstration of Dose-response for Inhaled Corticosteroids - Exhaled Nitric Oxide Model Badrul A. Chowdhury, MD, PhD Director Division of Pulmonary
More informationExhaled nitric oxide and asthma control: a longitudinal study in unselected patients
ERJ Express. Published on December 5, 2007 as doi: 10.1183/09031936.00020407 Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients Alain Michils * PhD, Sandra Baldassarre
More informationComparison of the Effect of Short Course of Oral Prednisone in Patients with Acute Asthma
ISPUB.COM The Internet Journal of Pulmonary Medicine Volume 7 Number 1 Comparison of the Effect of Short Course of Oral Prednisone in Patients with Acute Asthma E Razi, G Moosavi Citation E Razi, G Moosavi.
More informationNitric oxide (NO) was first measured in exhaled
R E S E A R C H P A P E R Fractional Exhaled Nitric Oxide in Children with Acute Exacerbation of Asthma DINESH RAJ, RAKESH LODHA, APARNA MUKHERJEE, TAVPRITESH SETHI, *ANURAG AGRAWAL AND SUSHIL KUMAR KABRA
More informationCharacterization of exhaled nitric oxide: introducing a new reproducible method for nasal nitric oxide measurements
Eur Respir J ; 16: 236±241 Printed in UK ± all rights reserved Copyright #ERS Journals Ltd European Respiratory Journal ISSN 93-1936 Characterization of exhaled nitric oxide: introducing a new reproducible
More informationContent Indica c tion Lung v olumes e & Lung Indica c tions i n c paci c ties
Spirometry Content Indication Indications in occupational medicine Contraindications Confounding factors Complications Type of spirometer Lung volumes & Lung capacities Spirometric values Hygiene &
More informationExpired Nitric Oxide and Airway Obstruction in Asthma Patients with an Acute Exacerbation
Expired Nitric Oxide and Airway Obstruction in Asthma Patients with an Acute Exacerbation SCOTT E. CRATER, EDWARD J. PETERS, MARCUS L. MARTIN, ANDREW W. MURPHY, and THOMAS A. E. PLATTS-MILLS Asthma and
More informationMeasurement of Exhaled Nitric Oxide and Exhaled Breath Condensate in the Diagnosis and Management of Respiratory Disorders
Measurement of Exhaled Nitric Oxide and Exhaled Breath Condensate in the Diagnosis and Management of Respiratory Disorders Policy Number: 2.01.61 Last Review: 9/2018 Origination: 2/2007 Next Review: 3/2019
More information