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1 XHANCE is a prescription medicine used to treat nasal polyps in adults. XHANCE uses an Optinose Exhalation Delivery System (EDS) that is designed to deliver medication 1,2 : High and deep in the nasal passages To regions where sinuses drain and nasal polyps often originate. TO DOWNLOAD YOUR XHANCE COPAY SAVINGS CARD PLEASE: 1. Visit XHANCE.com 2. Click on Learn how to save on XHANCE 3. Click on Download Copay Savings Card For assistance please call XHANCE1

2 NASAL POLYPS CAN BE HARD TO REACH Nasal polyposis is an inflammatory condition that can be difficult to treat and affects millions of people in the US. Nasal polyps originate on inflamed tissue, high and deep in the nasal passages where sinuses drain. This area is hard to reach with medication. SIGNS AND SYMPTOMS OF NASAL POLYPS AND ASSOCIATED INFLAMMATION: STUFFY NOSE RUNNY NOSE FACIAL PAIN AND PRESSURE REDUCED SENSE OF SMELL PRESENCE OF NASAL POLYPS The good news? There s XHANCE. References: 1. Full Prescribing Information for XHANCE ( uticasone propionate). OptiNose US, Inc.; Data on le. OptiNose US, Inc.

3 EXPERIENCE THE DIFFERENCE XHANCE is a different type of nasal spray. You blow, and don t sniff. With XHANCE, your breath helps deliver medicine high and deep into your nasal passages to areas of inflamed tissues where nasal polyps originate and sinuses drain. By blowing into XHANCE, your throat naturally seals off from the nose and helps block the medicine from going down. Instead, the medicine goes high and deep into the nasal passages. This may give you the relief you are seeking. XHANCE HAS BEEN SHOWN TO HELP* XHANCE is approved for the treatment of nasal polyps. XHANCE improved symptoms of nasal polyps, such as stuffy nose (nasal congestion), as early as 2 weeks, and symptoms continued to get better over time. In addition, XHANCE significantly reduced the size of nasal polyps over time. * During the 16-week clinical trials. XHANCE REDUCED STUFFY NOSE XHANCE REDUCED NASAL POLYPS

4 IMPORTANT SAFETY INFORMATION for XHANCE ( uticasone propionate) nasal spray, 93 mcg IMPORTANT SAFETY INFORMATION Do not use XHANCE if you are allergic to uticasone propionate or any of the ingredients in XHANCE. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. It is very important to tell your healthcare provider if you take antifungal or anti-hiv medicines. XHANCE can cause nasal problems such as nosebleeds, crusting in the nose, sores (ulcers) in the nose, hole in the cartilage of the nose (nasal septal perforation). XHANCE can cause eye problems including glaucoma and cataracts. You should have regular eye exams when using XHANCE. Call your healthcare provider right away or get emergency medical care if you get any of these signs of a serious allergic reaction: rash, hives, swelling of your face, mouth, and tongue, breathing problems, and low blood pressure. XHANCE can weaken your immune system, make you more likely to get infections, and can make certain infections worse. Avoid contact with people who have a contagious disease such as chickenpox or measles while using XHANCE. If you come in contact with someone who has chickenpox or measles, call your healthcare provider right away. XHANCE can cause reduced production of steroid hormones by your adrenal gland, resulting in tiredness, weakness, nausea and vomiting, and low blood pressure. XHANCE can weaken bones (osteoporosis). The most common side effects with XHANCE include nose bleeds, thrush (fungal infection in your nose and throat), sores (ulcers) in your nose, pain or swelling of your nose or throat (nasopharyngitis), redness in your nose, nasal congestion, sinus infection, slow wound healing and headache. Before using XHANCE, carefully read the FDA-approved Patient INDICATION XHANCE is a prescription medicine used to treat nasal polyps in adults. ADVERSE REACTIONS: The most common adverse reactions (incidence 3%) are epistaxis, nasal septal ulceration, nasopharyngitis, nasal mucosal erythema, nasal mucosal ulcerations, nasal congestion, acute sinusitis, nasal septal erythema, headache, and pharyngitis.

5 * ELIGIBILITY AND RESTRICTIONS Offer is valid for patients age 18 and older. Medicare, Medicaid, TRICARE, or other patients of other federal or state programs are not eligible. Optinose reserves the right to rescind, revoke, or amend this offer without notice. Offer good only in the USA, including Puerto Rico, at participating retail pharmacies. Void if prohibited by law, taxed, or restricted. This offer has no cash value and may not be used in combination with any other discount, coupon, rebate, free trial, or similar offer for the speci ed product. Please see copay savings card for eligibility and restrictions. For assistance please call XHANCE OptiNose, Inc.

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