6. SR, XR, CR, and TR are examples of formulations. A) oral B) modified release C) repeat action D) soft gels

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1 1. Which is a parenteral route of administration? A) oral B) vaginal C) sublingual D) rectal 2. A local effect occurs A) at the site of administration. B) throughout the body. C) only after intravenous administration. D) only within the alimentary tract. 3. Which is a mechanism of losing orally administered drug? A) degradation due to stomach acidity B) first pass metabolism C) retarded dissolution 4. A tablet that releases one dose immediately and then releases a second dose later is a tablet. A) enteric coated B) multiple compressed C) modified release D) repeat action 5. Which dosage form does not have disintegration and dissolution as part of their oral absorption process? A) tablets B) capsules C) bulk powders D) none of the above 6. SR, XR, CR, and TR are examples of formulations. A) oral B) modified release C) repeat action D) soft gels Page 1

2 7. Which oral liquid formulation is characterized by a high sucrose content? A) solution B) syrup C) elixir D) suspension 8. Which nonaqueous oral solution has 20 grams of drug per 100 ml of solution? A) non-potent tincture B) potent tincture C) spirit D) elixir 9. Which is an advantage of an oral solution formulation? A) It may require special additives to mask taste. B) The drug is less stable in solution than in a dry dosage form. C) The dosage can be easily adjusted. D) It will require a dosage measurement device. 10. Which is a disadvantage of an oral suspension formulation? A) It can be administered to patients who cannot swallow tablets. B) It settles over time. C) The drug is more stable than in solution formulations. D) It can mask objectionable tastes. 11. An oral liquid formulation which one liquid is dispersed throughout another liquid in the form of small droplets is called A) an emulsion. B) a suspension. C) a syrup. D) a solution. 12. Which oral liquid formulation is characterized by a three-dimensional network of particles? A) solution B) suspension C) emulsion D) gel Page 2

3 13. Which is a unique dosage form for sublingual administration? A) elixir B) lozenge C) insert D) colloid 14. The buccal route of administration is located A) under the tongue. B) inside the cheek of the mouth. C) in the sinus cavity. D) none of the above 15. When is rectal administration the preferred route of administration? A) When the patient is conscious. B) When oral administration is available. C) When the drug is degraded by gastric acidity. D) When a systemic effect is needed. 16. Which statement is false? A) Rectal administration can be used for systemic activity. B) Drug absorption from rectal administration is erratic and unpredictable. C) Rectal suppositories are intended to spread around the anal opening. D) Rectal enemas create an urge to defecate. 17. Which is not an injection dependent parenteral route? A) subcutaneous B) inhalation C) intramuscular D) epidural 18. Which is not a characteristic of an injection dependent parenteral route? A) Formulations administered are limited to solutions, suspensions, and emulsions. B) Formulations administered must be sterile. C) Formulations administered can be given in any volume. D) Formulations administered will have a carefully maintained ph. Page 3

4 19. Which listing of parenteral routes is the expected order of absorption rates from fastest to slowest? A) IV>IM>SC> B) IV>SC>IM> C) IM>IV>SC> D) all routes produce the same absorption rates 20. can occur if excess air is introduced into a vein. A) Phlebitis B) Air emboli C) Thrombus D) Necrosis 21. Injectability refers to the properties of a suspension while being. A) drawn into a vial B) injected through a needle C) mixed with fatty acids to make an emulsion D) dissolving a lyophilized powder with a diluent 22. Which intravenous (IV) administration device would be appropriate to inject a small volume of medication (e.g., 5 ml) over 1-2 minutes? A) syringe and needle B) piggyback minibag C) PCA pump D) elastomeric pump 23. PCA analgesia pumps have their flow rates controlled by the A) pain. B) pharmacist. C) patient. D) physician assistant. 24. Which is a site of intramuscular (IM) administration? A) vastus lateralis B) deltoid C) ventogluteal Page 4

5 25. To avoid, change or rotate the site of intramuscular (IM) administration. A) abscesses B) hematomas C) scar formation 26. Which ADME process does a drug have after intramuscular (IM) administration that is not present after intravenous (IV) administration? A) absorption B) distribution C) metabolism D) excretion 27. Subcutaneous injections are given in the A) upper part of the abdomen. B) front of the upper arm. C) upper back. D) back of the thigh. 28. When considering subcutaneous (SC) administration, which listing is the expected order of absorption rates from fastest to slowest? A) SC>IM>Oral B) IM>SC>Oral C) Oral>IM>SC D) Oral>SC>IM 29. Insulin, a very common subcutaneously administered drug, is formulated with different to produce different absorption rates. A) slowly soluble salt forms B) viscosity C) particle sizes 30. Co-administering epinephrine subcutaneously is expected to A) increase regional blood flow and decrease subcutaneous absorption. B) decrease systemic blood flow and decrease subcutaneous absorption. C) increase systemic blood flow and increase subcutaneous absorption. D) decrease systemic flood flow and increase subcutaneous absorption. Page 5

6 31. The maximum fluid volume that can be subcutaneously injected is ml. A) 0.1 B) 1 C) 2 D) Viadur Duros, Supprelin LA, and Implanon have which of the following in common? A) They are subcutaneous implants used to prevent pregnancy. B) They are subcutaneous implants. C) They are subcutaneous implants that operate on vapor pressure. D) They are intramuscular implants. 33. The usual site for an intradermal injection is the A) stomach. B) anterior surface of the forearm. C) buttocks. D) thigh. 34. An intradermal injection will produce a. A) Z-tract B) scar C) depot D) wheal 35. The tear volume in the eye turns over about every A) 2 minutes. B) 7 minutes. C) 20 minutes. D) 50 minutes. 36. The average drop size of an eyedropper is microliters. A) 50 B) 25 C) 10 D) 7 Page 6

7 37. Ophthalmic formulations must in their final container. A) be sterile B) be able to be shaken C) be liquid 38. Systemic absorption of a drug administered as an ophthalmic formulation can occur when A) too large of a dose is administered. B) the drug drains into the lacrimal canalicula. C) the drug is absorbed into the lacrimal gland. 39. Ophthalmic formulations should be administered A) directly on the eyeball. B) in the conjunctiva gutter. C) under the upper eyelid. D) in the corner of the eye next to the nose. 40. Most ophthalmic ointments are mixtures of A) lanolin and eucerin. B) polyethylene glycols. C) white petrolatum and mineral oil. D) hypomellose (hydroxypropyl methylcellulose) and glycerin. 41. How are drugs intranasally administered? A) inhaler for volatile drug B) liquid drops C) mist from plastic squeeze bottle 42. When intranasally administering a drug with an MDI aerosol, A) breathe in as the MDI is actuated. B) breathe in immediately after using the MDI. C) breathe out immediately after using the MDI. D) use in both nostrils. Page 7

8 43. It is recommended to use intranasal dosage forms for before discontinuing their use. A) 3-5 days B) days C) days D) days 44. What size particle is expected to reach the alveolar sacs after inhalation administration? A) 20 microns B) 10 microns C) 1 micron D) 0.6 micron 45. Which inhalation administration device will help patients coordinate inspiration and actuation? A) MDI aerosol B) dry powder inhaler C) spacer D) nebulizer 46. Which will not enhance dermal absorption? A) Apply to larger area. B) Apply to hydrated skin. C) Leave dosage form on the skin for a short period of time. D) Apply a larger quantity of formulation. 47. Which is the barrier to drug absorption after dermal administration? A) stratum corneum layer B) epidermis layer C) dermis layer D) subcutaneous tissue 48. A dermal collodion A) is used as an anti-infective. B) leaves a protective film after application. C) has a drug incorporated into a base. D) controls the rate of drug delivery to the skin. Page 8

9 49. Which dermal formulation is a suspension? A) gel B) lotion C) cream D) ointment 50. Which is a disadvantage of vaginal administration? A) avoids gastric degradation of the drug B) doses can be retrieved C) has variable absorption due to organ dynamics D) can provide extended drug absorption 51. Glycerinated gelatin is A) 50% glycerin, 30% gelatin, 20% water. B) 70% glycerin, 20% gelatin, 10% water. C) 60% glycerin, 30% gelatin, 10% propylene glycol. D) 40% glycerin 40% gelatin, 10% water, 10% propylene glycol. 52. Why is glycerinated gelatin the preferred vaginal suppository base? A) dissolves slowly in vaginal mucus secretion B) can be inserted with an applicator C) dissolves faster than polyethylene glycol suppositories in vaginal mucus secretions D) acts as a contraceptive 53. Intrauterine devices (IUDs) provide long term A) anti-infective therapy. B) contraception protection. C) slow dissolution of progesterone. Page 9

10 Answer Key 1. B 2. A 3. D 4. D 5. D 6. B 7. B 8. A 9. C 10. B 11. A 12. D 13. B 14. B 15. C 16. C 17. B 18. C 19. A 20. B 21. B 22. A 23. C 24. D 25. D 26. A 27. C 28. B 29. D 30. B 31. C 32. B 33. B 34. D 35. A 36. A 37. A 38. B 39. B 40. C 41. D 42. A 43. A 44. D Page 10

11 45. C 46. C 47. A 48. B 49. B 50. C 51. B 52. A 53. B Page 11

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