While there is around a 3% increase shown in costs for Category M lines, I think this is due to the inclusion of more lines in Category M.

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1 April 2018 The usual quarterly of Category M prices Another set of similar comments as I made in January: significant increases in many lines which have been subject to price concessions but even more downward pressure on other Cat M lines resulting in some ridiculously cheap drugs e.g. 28 bendroflumethiazide 2.5mg tablets at 28p, 28 aspirin 75mg dispersible tablets at 33p and 28 warfarin 3mg tablets at 37p. While there is around a 3% increase shown in costs for Category M lines, I think this is due to the inclusion of more lines in Category M. Lines (included here) for which price concessions have been granted in March are highlighted orange (if not otherwise highlighted). concessions were eventually granted for 68 (11%) of Category M lines last month. Some significant s are highlighted yellow. Significant price increases: Glimepiride is the quarter's biggest Cat M riser, up 4-5 times. Perindopril is up about 3 fold. Other lines which were (and still will be?) the subject of price concessions make up the other siginicant Cat M increases; pregabalin being a good example. Significant price decreases: Rosuvastatin enters category M with prices falling by around 80% (phew; I planned for that!) With the exception of the 2.5mg strength, tadalafil has entered category M with drops of around 90% Further Cat M bonuses arise from etoricoxib capsules, travoprost eye drops and ibuprofen 5% gel. Paracetamol 500mg tablets are, at last, about 1p each. After price risies after concessions, sumatriptan tablets are substantially down. Remember that Category A s are compared with March, Category M s are compared with January. DT Description Category BNF 1.2 Mebeverine 135mg tablets (100) 435 M % 1.3 Esomeprazole 20mg gastro-resistant tablets (28) 232 M 3 1.3% Esomeprazole 40mg gastro-resistant tablets (28) 291 M % Lansoprazole 15mg gastro-resistant capsules (28) 57 M % Lansoprazole 15mg orodispersible tablets (28) 255 M % Lansoprazole 30mg gastro-resistant capsules (28) 89 M % Lansoprazole 30mg orodispersible tablets (28) 426 M % Omeprazole 10mg gastro-resistant capsules (28) 59 M % Omeprazole 10mg gastro-resistant tablets (28) 790 A und Omeprazole 20mg gastro-resistant capsules (28) 60 M % Omeprazole 20mg gastro-resistant tablets (28) 639 M % Omeprazole 40mg gastro-resistant capsules (7) 36 M % Omeprazole 40mg gastro-resistant tablets (7) 642 M % Pantoprazole 20mg gastro-resistant tablets (28) 62 M % Pantoprazole 40mg gastro-resistant tablets (28) 77 M % Rabeprazole 10mg gastro-resistant tablets (28) 99 M % Rabeprazole 20mg gastro-resistant tablets (28) 134 M % Ranitidine 150mg tablets (60) 76 M % Ranitidine 300mg tablets (30) 75 M % Ranitidine 75mg/5ml oral solution sugar free (300ml) 624 M % 1.6 Bisacodyl 5mg gastro-resistant tablets (60) 513 M % Macrogol compound oral powder sachets NPF sugar free (30) 427 C und Senna 7.5mg tablets (60) 161 M % Chapter Amiloride 5mg tablets (28) 324 M % Bendroflumethiazide 2.5mg tablets (28) 28 M % Bendroflumethiazide 5mg tablets (28) 34 M % Bumetanide 1mg tablets (28) 120 M % Bumetanide 5mg tablets (28) 698 A und Co-amilofruse 2.5mg/20mg tablets (28) 520 A % Co-amilofruse 5mg/40mg tablets (28) 667 A %

2 DT Description Category Eplerenone 25mg tablets (28) 1452 M % Eplerenone 50mg tablets (28) 1152 M % Furosemide 40mg tablets (28) 33 M % Indapamide 2.5mg tablets (28) 70 M % 2.4 Atenolol 50mg tablets (28) 43 M % Atenolol 100mg tablets (28) 47 M % Bisoprolol 5mg tablets (28) 38 M % Bisoprolol 10mg tablets (28) 45 M % Carvedilol 12.5mg tablets (28) 57 M % Carvedilol 25mg tablets (28) 101 M 1 1.0% Nebivolol 2.5mg tablets (28) 1838 M % Nebivolol 5mg tablets (28) 89 M % Doxazosin 4mg tablets (28) 60 M % Enalapril 10mg tablets (28) 214 M % Enalapril 20mg tablets (28) 194 M % Lisinopril 10mg tablets (28) 61 M % Lisinopril 20mg tablets (28) 58 M % Perindopril erbumine 2mg tablets (30) 308 M % Perindopril erbumine 4mg tablets (30) 191 M % Perindopril erbumine 8mg tablets (30) 382 M % Ramipril 5mg capsules (28) 78 M % Ramipril 5mg tablets (28) 63 M % Ramipril 10mg capsules (28) 94 M % Ramipril 10mg tablets (28) 78 M % Candesartan 4mg tablets (7) 30 M % Candesartan 8mg tablets (28) 84 M 4 5.0% Candesartan 16mg tablets (28) 114 M 7 6.5% Candesartan 32mg tablets (28) 175 M % Irbesartan 75mg tablets (28) 80 M % Irbesartan 150mg tablets (28) 108 M % Irbesartan 300mg tablets (28) 177 M % Irbesartan 300mg / Hydrochlorothiazide 12.5mg tablets (28) 173 M % Irbesartan 300mg / Hydrochlorothiazide 25mg tablets (28) 646 A % Losartan 12.5mg tablets (28) 450 M % Losartan 25mg tablets (28) 55 M % Losartan 50mg tablets (28) 57 M % Losartan 100mg tablets (28) 116 M % Losartan 50mg / Hydrochlorothiazide 12.5mg tablets (28) 113 M % Losartan 100mg / Hydrochlorothiazide 25mg tablets (28) 143 M 5 3.5% Olmesartan medoxomil 10mg tablets (28) 124 M % Olmesartan medoxomil 20mg tablets (28) 151 M % Olmesartan medoxomil 40mg tablets (28) 226 M 8 3.7% Telmisartan 20mg tablets (28) 63 M % Telmisartan 40mg tablets (28) 105 M % Telmisartan 80mg tablets (28) 136 M % Valsartan 80mg capsules (28) 476 M % Valsartan 160mg capsules (28) 483 M % Valsartan 320mg tablets (28) 1857 A % Valsartan 160mg / Hydrochlorothiazide 12.5mg tablets (28) 185 M % Valsartan 160mg / Hydrochlorothiazide 25mg tablets (28) 1032 A und 2.6 Amlodipine 5mg tablets (28) 143 M % Amlodipine 10mg tablets (28) 158 M % Glyceryl trinitrate 400micrograms/dose aerosol sublingual spray (180dose) 304 A und Glyceryl trinitrate 400micrograms/dose pump sublingual spray (180dose) 146 M %

3 DT Description Category Glyceryl trinitrate 400micrograms/dose pump sublingual spray (200dose) 149 M % Isosorbide mononitrate 10mg tablets (56) 97 M % Isosorbide mononitrate 20mg tablets (56) 95 M % Isosorbide mononitrate 40mg tablets (56) 128 M 3 2.4% Naftidrofuryl 100mg capsules (84) 617 M % 2.8 Warfarin 1mg tablets (28) 33 M % Warfarin 3mg tablets (28) 37 M % Warfarin 5mg tablets (28) 42 M % 2.9 Aspirin 75mg dispersible tablets (28) 33 M % Aspirin 75mg gastro-resistant tablets (28) 52 M % Clopidogrel 75mg tablets (28) 130 M % 2.12 Atorvastatin 10mg tablets (28) 57 M % Atorvastatin 20mg tablets (28) 70 M % Atorvastatin 40mg tablets (28) 98 M und Atorvastatin 80mg tablets (28) 206 M % Pravastatin 40mg tablets (28) 110 M % Rosuvastatin 5mg tablets (28) 292 C to M % Rosuvastatin 10mg tablets (28) 292 C to M % Rosuvastatin 20mg tablets (28) 448 C to M % Rosuvastatin 40mg tablets (28) 597 C to M % Simvastatin 10mg tablets (28) 35 M % Simvastatin 20mg tablets (28) 45 M % Simvastatin 40mg tablets (28) 65 M % Simvastatin 80mg tablets (28) 128 M % Chapter Montelukast 4mg chewable tablets sugar free (28) 89 M % Montelukast 4mg granules sachets sugar free (28) 485 M % Montelukast 5mg chewable tablets sugar free (28) 106 M % Montelukast 10mg tablets (28) 110 M 8 7.8% 3.4 Cetirizine 10mg tablets (30) 70 M % Desloratadine 5mg tablets (30) 86 M % Loratadine 10mg tablets (30) 45 M % Chapter Temazepam 10mg tablets (28) 136 M % Temazepam 10mg/5ml oral solution sugar free (300ml) A % Temazepam 20mg tablets (28) 143 M % 4.2 Aripiprazole 5mg tablets (28) 237 M % Aripiprazole 10mg tablets (28) 199 M % Aripiprazole 15mg tablets (28) 275 M % Aripiprazole 30mg tablets (28) 1144 A % Olanzapine 10mg orodispersible tablets sugar free (28) 3930 A % Olanzapine 10mg tablets (28) 1898 M % Olanzapine 15mg orodispersible tablets sugar free (28) 3700 A % Olanzapine 15mg tablets (28) 2458 M % Olanzapine 20mg orodispersible tablets sugar free (28) 7826 A % Olanzapine 20mg tablets (28) 3683 M % Quetiapine 100mg tablets (60) 4354 M % Quetiapine 150mg tablets (60) 5142 M % Quetiapine 200mg tablets (60) 4369 M % Quetiapine 300mg tablets (60) 7257 M % Risperidone 3mg orodispersible tablets sugar free (28) 4349 A und

4 DT Description Category Risperidone 3mg tablets (60) 157 M 2 1.3% Risperidone 4mg orodispersible tablets sugar free (28) 5006 A % Risperidone 4mg tablets (60) 183 M % Risperidone 6mg tablets (28) 266 A 1 0.4% 4.3 Citalopram 20mg tablets (28) 234 M % Citalopram 40mg tablets (28) 237 M % Duloxetine 30mg gastro-resistant capsules (28) 774 M % Duloxetine 60mg gastro-resistant capsules (28) 1157 M % Escitalopram 10mg tablets (28) 100 M % Escitalopram 20mg tablets (28) 143 M % Fluoxetine 20mg capsules (30) 58 M % Fluoxetine 20mg/5ml oral solution (70ml) 278 M 8 3.0% Fluoxetine 60mg capsules (30) 372 M % Mirtazapine 30mg orodispersible tablets (30) 117 M % Mirtazapine 30mg tablets (28) 104 M % Mirtazapine 45mg orodispersible tablets (30) 168 M % Mirtazapine 45mg tablets (28) 232 M 5 2.2% Nortriptyline 10mg tablets (100) 957 M % Nortriptyline 25mg tablets (100) 1157 M % Sertraline 50mg tablets (28) 67 M % Sertraline 100mg tablets (28) 91 M % 4.5 Orlistat 120mg capsules (84) 1590 M % 4.6 Betahistine 8mg tablets (84) 312 M % Betahistine 16mg tablets (84) 550 M % Ondansetron 4mg tablets (10) 62 M % Ondansetron 8mg tablets (10) 173 M % Co-codamol 8mg/500mg capsules (32) 455 A 5 1.1% Co-codamol 8mg/500mg effervescent tablets (100) 700 M % Co-codamol 8mg/500mg tablets (100) 197 M % Co-codamol 30mg/500mg capsules (100) 388 M % Co-codamol 30mg/500mg effervescent tablets (100) 716 M und Co-codamol 30mg/500mg tablets (100) 283 M % Paracetamol 500mg capsules (100) 188 M % Paracetamol 500mg soluble tablets (100) 729 M 8 1.1% Paracetamol 500mg tablets (100) 97 M % Frovatriptan 2.5mg tablets (6) 881 M % Naratriptan 2.5mg tablets (6) 1243 M % Rizatriptan 10mg orodispersible tablets sugar free (3) 1490 A % Rizatriptan 10mg tablets (3) 933 M % Sumatriptan 50mg tablets (6) 694 M % Sumatriptan 100mg tablets (6) 682 M % Zolmitriptan 2.5mg orodispersible tablets sugar free (6) 1484 M % Zolmitriptan 2.5mg tablets (6) 1578 M % Zolmitriptan 5mg orodispersible tablets sugar free (6) 1400 A 1 0.1% 4.8 Gabapentin 300mg capsules (100) 809 M % Gabapentin 400mg capsules (100) 594 M % Gabapentin 600mg tablets (100) 645 M % Gabapentin 800mg tablets (100) 2989 A 2 0.1% Lamotrigine 100mg dispersible tablets sugar free (56) 393 M % Lamotrigine 100mg tablets (56) 176 M % Lamotrigine 200mg tablets (56) 255 M % Levetiracetam 250mg tablets (60) 1931 M %

5 DT Description Category Levetiracetam 500mg tablets (60) 3073 M % Levetiracetam 750mg tablets (60) 4315 M % Levetiracetam 1g tablets (60) 5476 M % Pregabalin 50mg capsules (84) 872 M % Pregabalin 75mg capsules (56) 542 M % Pregabalin 100mg capsules (84) 775 M % Pregabalin 150mg capsules (56) 588 M % Pregabalin 200mg capsules (84) 789 M % Pregabalin 300mg capsules (56) 550 M % Topiramate 25mg capsules (60) 1702 M % Topiramate 25mg tablets (60) 101 M % Topiramate 50mg capsules (60) 5632 A und Topiramate 50mg tablets (60) 140 M % Topiramate 100mg tablets (60) 229 M 4 1.8% Topiramate 200mg tablets (60) 3302 A % 4.9 Entacapone 200mg tablets (30) 413 M % Ropinirole 500microgram tablets (28) 870 M % Ropinirole 1mg tablets (84) 5671 C und Ropinirole 2mg tablets (28) 2018 M % Ropinirole 5mg tablets (84) A und Rasagiline 1mg tablets (28) 529 M % Riluzole 50mg tablets (56) 1589 M % 4.11 Donepezil 5mg tablets (28) 52 M % Donepezil 10mg tablets (28) 76 M % Memantine 10mg tablets (28) 137 M % Memantine 20mg tablets (28) 160 M % Rivastigmine 3mg capsules (28) 260 M % Rivastigmine 4.5mg capsules (28) 2353 A 1 0.0% Rivastigmine 6mg capsules (28) 2928 A % Rivastigmine 9.5mg/24hours transdermal patches (30) 3002 A und Chapter Amoxicillin 250mg capsules (21) 60 M % Amoxicillin 500mg capsules (21) 78 M % Clarithromycin 250mg tablets (14) 107 M % Clarithromycin 500mg tablets (14) 195 M % Co-amoxiclav 250mg/125mg tablets (21) 167 M 2 1.2% Co-amoxiclav 500mg/125mg tablets (21) 184 M % Erythromycin 250mg gastro-resistant tablets (28) 128 M % Flucloxacillin 125mg/5ml oral solution (100ml) 693 M % Flucloxacillin 125mg/5ml oral solution sugar free (100ml) 2326 M % Flucloxacillin 250mg capsules (28) 111 M % Flucloxacillin 250mg/5ml oral solution sugar free (100ml) 2788 M % Flucloxacillin 500mg capsules (28) 194 M % Metronidazole 200mg tablets (21) 403 M % Metronidazole 400mg tablets (21) 430 M % Nitrofurantoin 50mg tablets (28) 1136 M % Nitrofurantoin 100mg tablets (28) 813 M % Oxytetracycline 250mg tablets (28) 47 M % Phenoxymethylpenicillin 250mg tablets (28) 71 M % Tetracycline 250mg tablets (28) 127 M % Trimethoprim 200mg tablets (14) 73 M % 5.2 Fluconazole 150mg capsules (1) 39 M % Terbinafine 250mg tablets (14) 846 M %

6 DT Description Category 5.3 Aciclovir 400mg tablets (56) 239 M 4 1.7% Aciclovir 800mg dispersible tablets (35) 1098 A und Aciclovir 800mg tablets (35) 288 M % Famciclovir 250mg tablets (21) A 8 0.1% Famciclovir 500mg tablets (14) A % Valaciclovir 500mg tablets (10) 292 M 8 2.8% Chapter Metformin 500mg tablets (28) 90 M % Metformin 500mg/5ml oral solution sugar free (150ml) 878 M % Metformin 850mg tablets (56) 117 M 1 0.9% Gliclazide 80mg tablets (28) 92 M % Glimepiride 2mg tablets (30) 254 M % Glimepiride 3mg tablets (30) 365 M % Glimepiride 4mg tablets (30) 474 M % Pioglitazone 15mg tablets (28) 50 M % Pioglitazone 30mg tablets (28) 92 M % Pioglitazone 45mg tablets (28) 66 M % 6.2 Carbimazole 5mg tablets (100) 4374 M % Carbimazole 20mg tablets (100) M % Levothyroxine sodium 25microgram tablets (28) 187 M % Levothyroxine sodium 50microgram tablets (28) 97 M % Levothyroxine sodium 100microgram tablets (28) 96 M % 6.3 Hydrocortisone 10mg tablets (30) 3279 M % Hydrocortisone 20mg tablets (30) 8355 A % Prednisolone 2.5mg gastro-resistant tablets (28) 74 M % Prednisolone 5mg gastro-resistant tablets (28) 76 M % Prednisolone 5mg soluble tablets (30) 2147 M % Prednisolone 5mg tablets (28) 47 M % 6.4 Finasteride 5mg tablets (28) 89 M % Raloxifene 60mg tablets (28) 342 M % 6.5 Desmopressin 100microgram tablets (90) 6307 A und Desmopressin 10micrograms/dose nasal spray (60dose) 2806 M % Desmopressin 200microgram tablets (30) 909 M % 6.6 Alendronic acid 10mg tablets (28) 147 M und Alendronic acid 70mg tablets (4) 60 M und Ibandronic acid 50mg tablets (28) 625 M % Ibandronic acid 150mg tablets (1) 83 M % Risedronate sodium 35mg tablets (4) 58 M % Chapter 7 Desogestrel 75microgram tablets (84) 295 M % Duloxetine 20mg gastro-resistant capsules (28) 646 M % Duloxetine 40mg gastro-resistant capsules (56) 1339 M % Oxybutynin 2.5mg tablets (56) 84 M % Oxybutynin 5mg tablets (56) 119 M % Sildenafil 25mg tablets (4) 37 M % Sildenafil 50mg tablets (4) 42 M % Sildenafil 100mg tablets (4) 59 M % Tadalafil 5mg tablets (28) 855 C to M % Tadalafil 10mg tablets (4) 213 C to M % Tadalafil 20mg tablets (4) 317 C to M % Tolterodine 1mg tablets (56) 179 M % Tolterodine 2mg tablets (56) 209 M %

7 DT Description Category Trospium chloride 20mg tablets (60) 826 M % Chapter 8 Anastrozole 1mg tablets (28) 634 M % Azathioprine 25mg tablets (28) 130 M % Azathioprine 50mg tablets (56) 220 M 4 1.9% Bicalutamide 50mg tablets (28) 220 M % Bicalutamide 150mg tablets (28) 572 M % Exemestane 25mg tablets (30) 1725 M % Letrozole 2.5mg tablets (14) 79 M % Mycophenolate mofetil 500mg tablets (50) 566 M % Tamoxifen 20mg tablets (30) 248 M % Tamoxifen 40mg tablets (30) 4872 A und Chapter 9 Alfacalcidol 250nanogram capsules (30) 480 A 3 0.6% Alfacalcidol 500nanogram capsules (30) 965 A 5 0.5% Alfacalcidol 1microgram capsules (30) 1345 A 9 0.7% Hydroxocobalamin 1mg/1ml solution for injection ampoules (5) 670 M % Sevelamer 800mg tablets (180) 3052 M % Sodium bicarbonate 500mg capsules (56) 155 M 1 0.6% Chapter 10 Celecoxib 100mg capsules (60) 195 M % Celecoxib 200mg capsules (30) 169 M 1 0.6% Diclofenac sodium 25mg gastro-resistant tablets (28) 202 M % Diclofenac sodium 50mg gastro-resistant tablets (28) 225 M % Diclofenac sodium 75mg modified-release tablets (56) 1131 C und Diclofenac sodium 100mg modified-release tablets (28) 810 C und Etoricoxib 60mg tablets (28) 301 C to M % Etoricoxib 90mg tablets (28) 364 C to M % Ibuprofen 400mg tablets (84) 354 M % Ibuprofen 600mg tablets (84) 369 M und Ibuprofen 5% gel (100g) 174 A to M % Ketoprofen 2.5% gel (100g) 238 M % Leflunomide 10mg tablets (30) 708 M 9 1.3% Leflunomide 20mg tablets (30) 743 M % Naproxen 500mg gastro-resistant tablets (56) 489 M % Naproxen 500mg tablets (28) 113 M % Piroxicam 0.5% gel (112g) 474 M % Chapter Chloramphenicol 0.5% eye drops (10ml) 114 M % Chloramphenicol 1% eye ointment (4g) 189 M % Fusidic acid 1% modified-release eye drops (5g) 2906 C und 11.4 Sodium cromoglicate 2% eye drops (13.5ml) 987 M % 11.6 Brimonidine 0.2% eye drops (5ml) 113 M % Brinzolamide 10mg/ml eye drops (5ml) 189 M 1 0.5% Dorzolamide 2% / Timolol 0.5% eye drops (5ml) 150 M % Dorzolamide 2% eye drops (5ml) 155 M % Latanoprost 50micrograms/ml / Timolol 5mg/ml eye drops (2.5ml) 244 M % Latanoprost 50micrograms/ml eye drops (2.5ml) 153 M % Timolol 0.25% eye drops (5ml) 78 M % Timolol 0.5% eye drops (5ml) 80 M % Travoprost 40micrograms/ml eye drops (2.5ml) 727 M % 11.8 Hypromellose 0.3% eye drops (10ml) 106 M % Chapter 12 Beclometasone 50micrograms/dose nasal spray (200dose) 255 M 4 1.6%

8 DT Description Category Budesonide 64micrograms/dose nasal spray (120dose) 477 A und Ipratropium bromide 21micrograms/dose nasal spray (180dose) 654 C und Mometasone 50micrograms/dose nasal spray (140dose) 170 M 5 3.0% Nystatin 100,000units/ml oral suspension (30ml) 222 M % Chapter Betamethasone valerate 0.1% cream (30g) 257 M % Betamethasone valerate 0.1% ointment (30g) 161 M 5 3.2% Hydrocortisone 1% cream (30g) 142 M % Hydrocortisone 1% ointment (30g) 140 M % Hydrocortisone 2.5% cream (15g) 498 M % Hydrocortisone 2.5% ointment (15g) 2506 A % Mometasone 0.1% cream (30g) 153 M % Mometasone 0.1% ointment (30g) 157 M % 13.6 Co-cyprindiol 2000microgram/35microgram tablets (63) 570 A und Aciclovir 5% cream (2g) 110 A und Amorolfine 5% medicated nail lacquer (5ml) 614 M % Aqueous cream (500g) 280 M % Terbinafine 1% cream (30g) 196 M % Other pack sizes may be available; prices in direct proportion to those listed above.

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