Has little therapeutic value. Has multiple actions. Has short t ½ Activates muscarinic & nicotinic receptors. 10/17/2017 2
|
|
- Grant Taylor
- 5 years ago
- Views:
Transcription
1
2 Has little therapeutic value. Has multiple actions. Has short t ½ Activates muscarinic & nicotinic receptors. 10/17/2017 2
3 Muscarinic stimulation: On the CVS: -ve chronotropic & inotropic effects. Decrease stroke volume & cardiac output. Decrease ABP: Stimulation of vascular M 3 receptors Increase NO release from endothelium 10/17/2017 3
4 Eye: Miosis: Contraction of circular muscle of iris. Accommodation to near vision: Contraction of ciliary muscle of the eye Decrease IOP( intra-occular pressure) 10/17/2017 4
5 Exocrine glands & GI secretion: Increase secretion. Contraction of intestinal wall & relaxation of sphincters: Defecation Contraction of bladder wall & relaxation of sphincter: Urination 10/17/2017 5
6 Bronchi: Bronchoconstriction. Increase mucosal secretion. Penile erection: Increase release of nitric oxide. 10/17/2017 6
7 Nicotinic receptor stimulation: Autonomic ganglia: Stimulation Adrenal medulla: Increase noradrenaline & adrenaline secretion NM Junction transmission: Muscle contraction 10/17/2017 7
8 Mimic or simulate actions of Ach: Direct-acting. Indirect-acting. 10/17/2017 8
9
10 Activate directly cholinergic receptors: Choline esters: Bethanechol, Carbachol, Methacholine. Resist degradation by cholinesterases. Have longer duration of action than Ach. Natural alkaloid: Pilocarpine. Acts directly on end organs like the eye. 10/17/
11
12
13 Derivative of Ach Has: Little nicotinic effects Good muscarinic effects on bladder & GIT Leads to easy urination & defecation Used to treat post-operative or post-labour: Urinary retention or paralytic ileus: the weakness of intestine to push its content causing constipation because of weak peristaltic activity 10/17/
14 Derivative of Ach Has muscarinic & nicotinic actions Limited use: Because of nicotinic effects on ganglia & adrenal medulla Used mainly topically as miotic in glaucoma to decrease high intraocular pressure (IOP) 10/17/
15 Natural plant alkaloid Resistant to CE enzyme It produces: Miosis (contraction of circular muscle of iris) Contraction of ciliary muscle of the eye Reduction of IOP Used topically in glaucoma 10/17/
16 Lowers high IOP in close-angle & open angle chronic glaucoma Improves outflow of aqueous humour: Opens fluid pathway Increase aqueous flow through canal of Schlemm Secondary to contraction of circular muscle of the iris & ciliary muscle Stimulates sweating, lacrimation, salivation 10/17/
17 10/17/
18
19 Paralytic ileus (Bethanechol) Urinary retention (Bethanechol) Glaucoma (Pilocarpine & Carbachol topically Xerostomia (dry mouth) of Sjogren s syndrome (oral pilocarpine) 10/17/
20
21 Excessive sweating, salivation Flushing, hypotension Abdominal colic & diarrhoea Bronchospasm Pilocarpine: Impaired accommodation to far vision & darkness 10/17/
22 Bronchial asthma Peptic ulcer 10/17/
23 CE is a protein In cholinergic synapses & RBC Metabolizes Ach into choline & acetate Specific for Ach in cholinergic synapses Pseudocholinesterase in plasma & liver Not specific to Ach Metabolizes other drugs (suxamethonium, procaine) 23
24 Classified into: Reversible cholinesterase inhibitors Irreversible cholinesterase inhibitors 24
25 Diagnosis of MG (Edrophonium) Treatment of MG (Pyridostigmine) Reversible NMB intoxication (Neostigmine) Alzheimer s disease (Donepezil) Irreversible CEI: insecticides 25
26
27 Autoimmune (autoantibodies to N M in NMJ) Reduction in receptor number Muscle weakness, fatigability,, difficult speaking & swallowing Treatment: Reversible CEI Thymectomy Immunosuppressant 27
28 Inhibit reversibly CE enzyme Accumulation of Ach Electrostatic bonds Stimulate nicotinic & muscarinic receptors Useful in myasthenia gravis 28
29 Synthetic CEI, does not cross BBB Duration of action (4 hrs) Mainly in MG & also in: Antidote to competitive NM blocker tubocurarine poisoning Paralytic ileus, urinary retention Given orally, SC 29
30 Similar to neostigmine Has longer duration of action (6 hrs) Useful orally in myasthenia gravis 30
31 Over-stimulating of nicotinic receptors can cause muscle weakness and paralysis by the excessive intake of Anticholinesterases which are (indirect drugs) Over-stimulation of nicotinic receptors will lead to its blockage instead of further activation.
32 Similar to neostigmine IV, short duration of action (10-20 min) Useful in diagnosis of MG To differentiate between weakness due to myasthenic crisis or cholinergic crisis: Myasthenic crisis 32 improvement
33 Excessive salivation Flushing and hypotension Abdominal colic and diarrhoea Bronchospasm 3 3
34 Tacrine Reversible CEI used in treatment of Alzheimer s disease; hepatotoxic Donepezil New selective CEI Once daily Lacks hepatoxicity of tacrine Useful in Alzheimer s disease 34
35 Organophosphorous (OP) compounds. Irreversibly inhibit CE. Covalent bond in Enzyme-inhibitor complex. Used as insecticides: Parathion, malathion As nerve gases in chemical warfare: Tabun, Sarin, Soman 35
36 OP compound. Irreversibly inhibits CE. Insecticide. Toxicity: excessive cholinergic stimulation. May be used topically in glaucoma. Duration of action about a week. 36
37 New agent. Similar to isoflurophate. Long duration of action (week). 37
38 Actions on receptors: Direct Indirect Pharmacodynamic effects: Similar Central effects with indirect: Cross BBB 38
39 Agricultural or industrial accidents Excessive cholinergic manifestations GIT (diarrhoea, colic) Respiratory (dyspnoea, bronchospam) CV (bradycardia, hypotension) Micturition, excessive sweating, M. paralysis Miosis (pin-point pupil), convulsions & death 39
40 General measures. High doses atropine IV or IM. Mechanical ventilation. Diazepam for convulsions. Enzyme reactivation by pralidoxime IM. 40
#10 part 1+ mind maps. cholinomimetics. made by lama shatat corrected by laith sorour date 25/10
#10 part 1+ mind maps cholinomimetics made by lama shatat corrected by laith sorour date 25/10 Cholinergic Cholinergic agonists Direct (activates directly Cholinergic Receptor) ANS drugs Antagonists Adrenergic
More informationCholinergic receptors( cholinoceptors ) are two families muscarinic and nicotinic depending on their affinities to cholinomimetic agents(agents that
Cholinergic drugs Cholinergic drugs Are drugs act on receptors that are activated by acetylcholine(ach) which is the neurotransmitter of the parasympathetic nervous system. ACH is synthesized in the cholinergic
More informationDrugs Affecting the Autonomic Nervous System-2 Cholinergic agents
Drugs Affecting the Autonomic Nervous System-2 Cholinergic agents Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia Cholinergic agents, Cholinomimetic drugs,
More informationParasympathetic Nervous System Part I
Parasympathetic Nervous System Part I Edward JN Ishac, Ph.D. Professor Smith Building, Room 742 eishac@vcu.edu 828 2127 Department of Pharmacology and Toxicology Medical College of Virginia Campus of Virginia
More informationDr. Hesham Aly Salem Dept. of Pharmacology & Toxicology F O P C U 2016
Dr. Hesham Aly Salem Dept. of Pharmacology & Toxicology F O P C U 2016 Release Acetylcholine (Ach) 1. All motor nerves leaving CNS: 1. All preganglionic fibers (sympathetic & parasympathetic) 2. Somatic
More informationAutonomic Pharmacology: Cholinergic agonists
Autonomic Pharmacology: Cholinergic agonists Öner Süzer www.onersuzer.com osuzer@istanbul.edu.tr Last update: 23.01.2013 1 Acetylcholine Acetylcholine (ACh), the naturally occurring neurotransmitter for
More informationPharmacology Autonomic Nervous System Lecture10
Pharmacology Autonomic Nervous System Lecture10 Note : Most of the time in this lecture, the doctor was only reading from the slides, so I m going to write only the extra information he mentioned So Please
More informationBIMM118. Autonomic Nervous System
Autonomic Nervous System Autonomic Nervous System Autonomic Nervous System Ganglia close to the innervated organs Myelinated axons Ganglia close to the spinal column Preganglionic axons are myelinated;
More informationNervous System. Peripheral Nervous System ( PNS ) Central Nervous System ( CNS ) Somatic. Autonomic ( ANS ) Enteric.
NERVOUS SYSTEM Nervous System Peripheral Nervous System ( PNS ) Central Nervous System ( CNS ) Efferent (Motor) Afferent (Sensor) Autonomic ( ANS ) Somatic Parasympathetic Sympathetic Enteric Autonomic
More informationCholinoceptor - Activating &Cholinesterase-Inhibiting Drugs
Cholinoceptor - Activating &Cholinesterase-Inhibiting Drugs Choline Ester ACE Muscarinic Nicotinic Acetylcholine ++++ +++ +++ Methacholine + ++++ None Carbachol Negligible ++ +++ Bethanechol Negligible
More informationCholinergic Agonists & Antagonists
Cholinergic Agonists & Antagonists Course: Integrated Therapeutics I Professor: Judi Steinman, PhD Email: steinman@hawaii.edu Material covered on: Exam #1 Reading: Katzung 12 ed Chapter 7, 8, 9, 10 1 3
More informationnumber Done by Corrected by Doctor Malik
number 21 Done by Corrected by Dania Alkouz Doctor Malik Dr. Malik is going to repeat what Dr. Omar said about the cholinergic agonists and antagonists. The Autonomic Nervous system (ANS) (Just a quick
More informationPharmacology Second. - Contraction of detrusor muscle in the bladder.
Pharmacology Second 1) Which of the following is correct regarding the autonomic nervous system (ANS)? - Afferent neurons carry signals from the CNS to the effector organs. - The neurotransmitter at the
More informationCholinergic antagonists
Cholinergic antagonists Cholinergic antagonists: They are also called anticholinergic drugs or cholinergic blockers, this group include: 1.Antimuscarinic agents ( atropine, ipratropium, scopolamine) 2.
More informationNervous System Divisions
Nervous System Divisions AFFERENT EFFERENT Objectives: To discuss the physiology of parasympathetic system To discuss the parasympathomimetic drugs both synthetic & natural,direct and indirect. To discuss
More informationGanglion blocking agents
Ganglion blocking agents -out of date -Specifically act on the nicotinic receptors of both parasymphatetic and sympathetic ganglia - no selectivity toward PG or SG -These drugs are non-depolarizing, competitive
More informationPharmacology of the Parasympathetic Nervous System
Pharmacology of the Parasympathetic Nervous System Autonomic Nervous System Edward JN Ishac Smith Building, Room 742 eishac@hsc.vcu.edu 8-2127 8-2126 Department of Pharmacology and Toxicology Medical College
More informationBy Dr. Magdy M. Awny. (nerve agent)
By Dr. Magdy M. Awny (nerve agent) Pesticides Is any chemical substance or mixture of substances intended for preventing, destroying, repelling, or mitigating any pest are a group of insecticides or Organophosphorous
More informationAutonomic Nervous System (ANS):
Autonomic Nervous System (ANS): ANS is the major involuntary, unconscious, automatic portion of the nervous system. involuntary voluntary The motor (efferent)portion of the ANS is the major pathway for
More informationUSMLE Step 1 - Problem Drill 14: Pharmacology
USMLE Step 1 - Problem Drill 14: Pharmacology Question No. 1 of 10 1. shift dose response curves to the right, decrease potency and increase the EC50. Question #01 (A) Receptors (B) Non-competitive antagonists
More information(PP VIII) Dr. Samir Matloob
DRUGS ACTING ON THE CHOLINERGIC SYSTEM AND THE NEUROMUSCULAR BLOCKING DRUGS I (DIRECT ACTING CHOLINOMIMETIC AGONISTS) (PP VIII) Dr. Samir Matloob Dept. of Pharmacology Baghdad College of Medicine Drugs
More informationNEW ZEALAND DATA SHEET. Injection solution 2.5 mg/ml: a clear, colourless, particle-free solution containing 2.5 mg/ml Neostigmine methylsulphate.
NEW ZEALAND DATA SHEET NAME OF MEDICINE NEOSTIGMINE METHYLSULPHATE INJECTION B.P. Solution for injection 2.5 mg/ml. PRESENTATIONS Injection solution 2.5 mg/ml: a clear, colourless, particle-free solution
More informationAcetylcholine. Kevin K. Caldwell, Ph.D.
Acetylcholine Kevin K. Caldwell, Ph.D. Classification of Neurotransmitters Peptides Adenosine ATP Criteria for defining a neurotransmitter Purves, D. et al. Neuroscience, 4th edition, 2007 Synaptic vesicle
More informationPrinciples of Drug Action
Principles of Drug Action How Do Drugs Work? Drugs (usually small molecules) bind to proteins (large molecules) or nucleic acids (only a few) Drug target = binding site of drug (RICE) o Receptors o Ion
More informationLESSON ASSIGNMENT. LESSON OBJECTIVES 9-1. Given a group of statements, select the statement that best describes the term cholinergic agent.
LESSON ASSIGNMENT LESSON 9 Cholinergic Agents. TEXT ASSIGNMENT Paragraphs 9-1 through 9-6. LESSON OBJECTIVES 9-1. Given a group of statements, select the statement that best describes the term cholinergic
More informationParasympathetic Nervous System Part II
Parasympathetic Nervous System Part II Dr. Edward JN Ishac, Ph.D. Professor Smith Building, Room 742 eishac@vcu.edu 828-2127 Department of Pharmacology and Toxicology Medical College of Virginia Campus
More informationREFERENCES. Autonomic Nervous System DRUGS CANS) * Basic & clinical pharmacology-katzung * Examination It board
UNIVERSITY OF SULAIMANI COLLEGE OF PHARMACY DEPARTMENT OF PHARMACOLOGY Autonomic Nervous System DRUGS CANS) Dr.Zheen A. Mutabchi.,~ * Basic & clinical pharmacology-katzung * Examination It board review
More informationNERVOUS SYSTEM NERVOUS SYSTEM. Somatic nervous system. Brain Spinal Cord Autonomic nervous system. Sympathetic nervous system
SYNAPTIC NERVOUS SYSTEM NERVOUS SYSTEM CENTRAL NERVOUS SYSTEM PERIPHERAL NERVOUS SYSTEM Brain Spinal Cord Autonomic nervous system Somatic nervous system Sympathetic nervous system Parasympathetic nervous
More informationParasympathetic Nervous System Part II
Parasympathetic Nervous System Part II Neurons of the ANS Dr. Edward JN Ishac, Ph.D. Professor Smith Building, Room 742 eishac@vcu.edu 828-2127 Department of Pharmacology and Toxicology Medical College
More informationPharmacology med term exam
1-drug discovery & development usually starts with : -preclinical studies on tissues and animals - an idea or a hypothesis -phase 0 clinical drug trials - acute toxicity studies -bioavailability bioequivalence
More informationAnticholinesterases and anticholinergic drugs
Anticholinesterases and anticholinergic drugs V Priya Nair MB BS FRCA Jennifer M Hunter MB CHB PHD FRCA Key points There are two types of cholinesterase: acetylcholinesterase in the neuromuscular junction
More informationBIOP211 Pharmacology Tutorial Session 10 Drugs affecting the PNS
BIOP211 Pharmacology Tutorial Session 10 Drugs affecting the PNS Students problem-solve case studies of given drug scenarios affecting the peripheral nervous system Students continue to work on the Drug
More informationAutonomic Nervous System Fight Or Flight Vs. Rest And Digest
Autonomic Nervous System Fight Or Flight Vs. Rest And Digest Prof. Dr. Farooq Ahmed Director Medical Education Khyber Medical College Learning objectives At the end of these 2 presentations, the students
More informationCholinoceptor-Activating & Cholinesterase-Inhibiting Drugs INTRODUCTION
Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs INTRODUCTION Acetylcholine receptor stimulants and cholinesterase inhibitors together comprise a large group of drugs that mimic acetylcholine
More informationPHARMACOLOGY OF AUTONOMIC NERVOUS SYSTEM
PHARMACOLOGY OF AUTONOMIC NERVOUS SYSTEM Introduction The autonomic nervous system regulates functions which are not under voluntary control as the activity of cardiac muscle, smooth muscle and exocrine
More informationAutonomic nervous system
Lecture 3 Autonomic nervous system Sympathetic Parasympathetic Nerve impulses and synapses Axon terminal Synapse Receptors on the effector organ Basic arrangement of nerves: CNS nerve ganglion nerve effector
More informationLujain Hamdan. Ayman Musleh & Yahya Salem. Mohammed khatatbeh
12 Lujain Hamdan Ayman Musleh & Yahya Salem Mohammed khatatbeh the last lecture, we have studied the differences between the two divisions of the ANS: sympathetic and parasympathetic pathways which work
More informationPARASYMPATHOMIMETICS. Indirec t
PARASYMPATHOMIMETICS - These are drugs that stimulate the muscarinic receptors. - Classification: A. Direct Parasympathomimetics: They stimulate the Muscarinic Receptors directly: 1. Choline Esters: a.
More information2 QUALITATIVE AND QUANTITATIVE COMPOSITION
AUSTRALIAN PRODUCT INFORMATION NEOSTIGMINE INJECTION BP (NEOSTIGMINE METHYLSULFATE) 1 NAME OF THE MEDICINE Neostigmine methylsulfate. 2 QUALITATIVE AND QUANTITATIVE COMPOSITION 1 ml sterile solution of
More informationGanglionic Blockers. Ganglion- blocking agents competitively block the action of
Ganglionic Blockers Ganglion- blocking agents competitively block the action of acetylcholine and similar agonists at nicotinic (Nn) receptors of both parasympathetic and sympathetic autonomic ganglia.
More informationGanglionic Blocking Agents
Ganglionic Blocking Agents 1- Depolarizing Ganglionic Blocking Agents Depolarizing blocking agents are actually ganglionic stimulants. Thus, for nicotine, small doses give an action similar to that of
More informationThese drugs produce effects similar to the sympathetic nervous system
Terms adrenergic Drugs mydriasis sympathetic nervous system adrenergic drugs adrenergic mechanism of action positive inotropic effect positive chronotropic effect positive dromotropic effect adrenergic
More informationThe Autonomic Nervous System Outline of class lecture for Physiology
The Autonomic Nervous System Outline of class lecture for Physiology 1 After studying the endocrine system you should be able to: 1. Describe the organization of the nervous system. 2. Compare and contrast
More informationBenztropine and trihexyphenidyl: Centrally acting antimuscarinic agents used for treatment of Parkinson disease & extrapyramidal symptoms.
Scopolamine: Tertiary amine plant alkaloid. Produces peripheral effects similar to those of atropine. Unlike atropine, scopolamine has greater action on the CNS (observed at therapeutic doses). It has
More informationLESSON ASSIGNMENT. Cholinergic Blocking Agents (Anticholinergic Agents).
LESSON ASSIGNMENT LESSON 10 Cholinergic Blocking Agents (Anticholinergic Agents). TEXT ASSIGNMENT Paragraphs 10-1 through 10-4. LESSON OBJECTIVES 10-1. From a list of statements, select the statement that
More informationRMP section VI.2 Elements for Public Summary
RMP section VI.2 Elements for Public Summary Product: Atropin Stragen, 0,1 mg/ml solution for injection in pre-filled syringe Atropin Stragen, 0,2 mg/ml solution for injection in pre-filled syringe RMP:
More informationPRESCRIBING INFORMATION
PRESCRIBING INFORMATION Pr ATROPINE SULFATE INJECTION USP Anticholinergic (spasmolytic agent) Sandoz Canada Inc. Date of revision: March 4, 2011 145 Jules-Léger Boucherville, QC, Canada J4B 7K8 Control
More informationCan bind to several receptors in the body (nicotinic, muscarinic, everywhere)
Problems of acetylcholine: 1. Selectivity : Can bind to several receptors in the body (nicotinic, muscarinic, everywhere) 2. Absorption: because any drug that acts as a cholinergic agonist must have a
More informationA nerve cell fires an AP when it is depolarised. Module 1. Lecture 2- Principles of Drug Action
PCOL2012 Notes Module 1-Principles of Drug Action in the Nervous System... 2 Module 2-Drug Abuse, addiction and analgesia... 24 Module 3-Drug Treatment of Allergies and GI Disorders... 48 Module 4-Introduction
More informationAutonomic Targets. Review (again) Efferent Peripheral NS: The Autonomic & Somatic Motor Divisions
Review (again) Efferent Peripheral NS: The Autonomic & Somatic Motor Divisions Running Problem: Smoking Homeostasis and the Autonomic Division BP, HR, Resp., H 2 O balance, Temp... Mostly dual reciprocal
More information(PP XI) Dr. Samir Matloob
DRUGS ACTING ON THE CHOLINERGIC SYSTEM AND THE NEUROMUSCULAR BLOCKING DRUGS IV (NICOTINIC ANTAGONISTS) (PP XI) Dr. Samir Matloob Dept. of Pharmacology Baghdad College of Medicine Drugs acting on the cholinergic
More informationINTRODUTION. from atropos, one of the three fates, who according to Greek mythology,
Introduction INTRODUTION Atropine, a naturally occurring tertiary amine, derives its name from atropos, one of the three fates, who according to Greek mythology, chose how a person die. The atropine, a
More informationGlycopyrronium Bromide and Neostigmine Metilsulfate 0.5mg/2.5mg per ml
New Zealand Datasheet Glycopyrronium Bromide and Neostigmine Metilsulfate 0.5mg/2.5mg per ml Solution for injection Glycopyrronium bromide 0.5 mg/ml & Neostigmine metilsulfate 2.5 mg/ml Presentation is
More informationDrugs Affecting The Autonomic Nervous System(ANS)
Drugs Affecting The Autonomic Nervous System(ANS) ANS Pharmacology Lecture 1 Dr. Hiwa K. Saaed College of Pharmacy, University of Sulaimani 2018-2019 AUTOMATIC NERVOUS SYSTEM (ANS) The ANS is the major
More informationIntroduction to Autonomic
Part 2 Autonomic Pharmacology 3 Introduction to Autonomic Pharmacology FUNCTIONS OF THE AUTONOMIC NERVOUS SYSTEM The autonomic nervous system (Figure 3 1) is composed of the sympathetic and parasympathetic
More informationA Primer on Chemical Nerve Agents. Information for Public Health and EMS Workers
A Primer on Chemical Nerve Agents Information for Public Health and EMS Workers This information was adapted and developed from a presentation by: Area Health Education Center of Southern Nevada 2 Chemical
More informationOCULAR PHARMACOLOGY GLAUCOMA. increased intraocular pressure. normally mm Hg. when to Tx no fixed level.
OCULAR PHARMACOLOGY GLAUCOMA increased intraocular pressure normally 12 20 mm Hg. when to Tx no fixed level. literature sets ~21 mm Hg as upper limit of normal. some safe at 30 mm Hg some may have damage
More informationModule Objectives: Why to study Organic Pharmaceutical Chemistry? 24-Oct-17
1 2 Useful Info: Students are encouraged to visit the faculty website: http://pharmacy.uokerbala.edu.iq/ And most importantly the e-learning website: http://elearning.uokerbala.edu.iq Nevertheless, feel
More informationAutonomic Nervous System
Autonomic Nervous System Touqeer Ahmed PhD 3 rd March, 2017 Atta-ur-Rahman School of Applied Biosciences National University of Sciences and Technology Nervous System Divisions The peripheral nervous system
More informationAhmad Rabei & Hamad Mrayat. Ahmad Rabei & Hamad Mrayat. Mohd.Khatatbeh
10 Ahmad Rabei & Hamad Mrayat Ahmad Rabei & Hamad Mrayat Mohd.Khatatbeh Before you start: Important terminology: 1 Ganglion: Nerve cell cluster, where neurons are typically linked by synapses. Also, it`s
More informationAUTONOMIC NERVOUS SYSTEM PART I: SPINAL CORD
AUTONOMIC NERVOUS SYSTEM PART I: SPINAL CORD How is the organization of the autonomic nervous system different from that of the somatic nervous system? Peripheral Nervous System Divisions Somatic Nervous
More informationAutonomic Nervous System
Autonomic Nervous System Keri Muma Bio 6 Organization of the Nervous System Efferent Division Somatic Nervous System Voluntary control Effector = skeletal muscles Muscles must be excited by a motor neuron
More informationPharmacology of the Neuromuscular Junction (NMJ)
Pharmacology of the Neuromuscular Junction (NMJ) Edward JN Ishac, Ph.D. Professor Smith Building, Room 742 eishac@vcu.edu 828 2127 Department of Pharmacology and Toxicology Medical College of Virginia
More informationComposed by Natalia Leonidovna Svintsitskaya, Associate professor of the Chair of Human Anatomy, Candidate of Medicine
Theoretical background to the study of the autonomic nervous system. Sympathetic and parasympathetic divisions of the autonomic nervous system. Features of the structure, function Composed by Natalia Leonidovna
More informationAutonomic Nervous System
Autonomic Nervous System Autonomic Nervous System Ref: Textbook of Medical Physiology, Guyton, 12th ed: 729-738, 11th ed. P748-760, and 10th ed. p697-708. Fig.17.02 General functions Control and Adaptation
More informationORGANOPHOSPHORUS INSECTICIDE POISONING
Abstract ORGANOPHOSPHORUS INSECTICIDE POISONING Pages with reference to book, From 27 To 31 Hamida Jamil ( Department of Medicine Unit II, Jinnah Postgraduate Medical Centre, Karachi. ) A review of 755
More informationMUSCLE RELAXANTS. Mr. D.Raju, M.pharm, Lecturer
MUSCLE RELAXANTS Mr. D.Raju, M.pharm, Lecturer Muscle Relaxants are classified as: I)Peripherally acting A.Neuromuscular blocking agents:- 1) Depolarizing muscle relaxants. 2) Non-depolarizing muscle relaxants
More informationלמידע נוסף ניתן לעיין בעלון לרופא באתר משרד הבריאות או ליצור קשר טלפוני בטלפון
חברת פרמה מדיס שמחה לבשר על תחילת שיווקו של תכשיר חדש. שם התכשיר: NEOSTIGMINE - HAMELN 2.5 MG/ML INJECTION צורת מינון: SOLUTION FOR INJECTION דרך מתן: I.M, I.V, S.C הרכב )חומר פעיל(: NEOSTIGMINE METHYLSULFATE
More informationAutonomic Nervous System
Autonomic Nervous System 6 th March, 2015 & 19 th March, 2015 Touqeer Ahmed Ph.D. Atta-ur-Rahman School of Applied Biosciences National University of Sciences and Technology Autonomic Nervous System Role
More informationCALL US...TM. Anticholinesterase (Organic Phosphorus and Carbamate) Pesticide Poisoning
CALL US...TM The Official Newsletter of the California Poison Control System Volume 6, Number 2 Summer 2008 Anticholinesterase (Organic Phosphorus and Carbamate) Pesticide Poisoning Introduction Organic
More informationThe Autonomic Nervous System
The Autonomic Nervous System Responsible for control of visceral effectors and visceral reflexes: smooth muscle, glands, the heart. e.g. blood pressure, cardiac output, plasma glucose The autonomic system
More informationPharmacology of the Neuromuscular Junction (NMJ)
Pharmacology of the Neuromuscular Junction (NMJ) Edward JN Ishac, Ph.D. Professor Smith Building, Room 742 eishac@vcu.edu 828 2127 Department of Pharmacology and Toxicology Medical College of Virginia
More informationNERVE AGENTS & PRETREAMENT
MEDICAL MANAGEMENT OF CHEMICAL CASUALTIES MEDICAL MANAGEMENT OF CHEMICAL CASUALTIES NERVE AGENTS & PRETREAMENT U.S. ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE PROTECT, PROJECT, SUSTAIN DEFINITION
More informationCholinoceptor Blocking Drugs. Drugs that block muscarinic cholinoceptors.
Cholinoceptor Blocking Drugs Drugs that block muscarinic cholinoceptors. Absorption Natural alkaloids and most tertiary antimuscarinic drugs are well absorbed scopolamine is absorbed across the skin (transdermal
More informationPROSTIGMIN (neostigmine bromide)
PROSTIGMIN (neostigmine bromide) TABLETS DESCRIPTION: Prostigmin (neostigmine bromide), an anticholinesterase agent, is available for oral administration in 15 mg tablets. Each tablet also contains gelatin,
More informationDESCRIPTION Bethanechol chloride, USP, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related to acetylcholine.
BETHANECHOL CHLORIDE TABLETS, USP 5 mg, 10 mg, 25 mg and 50 mg Rx only DESCRIPTION Bethanechol chloride, USP, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related
More informationThe Autonomic Nervous System
UNIT II Drugs Affecting the Autonomic Nervous System The Autonomic Nervous System Rajan Radhakrishnan 3 I. OVERVIEW The autonomic nervous system (ANS), along with the endocrine system, coordinates the
More informationAutonomic Pharmacology: Cholinergic Antagonists
Autonomic Pharmacology: Cholinergic Antagonists Öner Süzer www.onersuzer.com osuzer@istanbul.edu.tr Last update: 23.01.2013 1 Classification of Anticholinergics Antimuscarinics Tertiary amines: e.g. atropine
More informationMESTINON NAME OF THE MEDICINE. Description: Pharmacology: Pyridostigmine Bromide. CAS number:
MESTINON NAME OF THE MEDICINE Pyridostigmine Bromide. C9H13BrN2O2 CAS number: 101-26-8 Description: Mestinon contains, as active substance, pyridostigmine bromide, chemically described as the dimethylcarbamic
More informationWhen motor nervous severed (cut, damaged), SK. Ms enter state of paralysis & atrophy
11/25/2012 1 Somatic NS have their cell bodies within CNS Conduct impulses along single axon from spinal cord to neuromuscular junction Send axon to SK.M Muscles consciously induced to contract or relax
More informationDrugs Used In Management Of Pain. Dr. Aliah Alshanwani
Drugs Used In Management Of Pain Dr. Aliah Alshanwani 1 Drugs Used In Management Of Pain A CASE OF OVERDOSE Sigmund Freud, the father of psychoanalysis His cancer of the jaw was causing him increasingly
More informationAutonomic Nervous System. Part of the nervous system that controls most of the visceral functions of the body ( Automatically?
Autonomic Response? Autonomic Nervous System Part of the nervous system that controls most of the visceral functions of the body ------ ( Automatically?) Classification Of CNS Autonomic Nervous System
More informationNEUROSCIENCE REVIEW DRUGS FOR HEADACHES, ANTICHOLINESTERASES, OPIOID ANALGESICS. Harvey Berman, PhD, MPH
NEUROSCIENCE REVIEW DRUGS FOR HEADACHES, ANTICHOLINESTERASES, OPIOID ANALGESICS Harvey Berman, PhD, MPH ERGOT ALKALOIDS Claviceps purpurea fungal sclerotia growing on barley Ergot in barley WHAT IS THIS?
More information2401 : Anatomy/Physiology
Dr. Chris Doumen Week 11 2401 : Anatomy/Physiology Autonomic Nervous System TextBook Readings Pages 533 through 552 Make use of the figures in your textbook ; a picture is worth a thousand words! Work
More informationChapter 14 The Autonomic Nervous System Chapter Outline
Chapter 14 The Autonomic Nervous System Chapter Outline Module 14.1 Overview of the Autonomic Nervous System (Figures 14.1 14.3) A. The autonomic nervous system (ANS) is the involuntary arm of the peripheral
More informationNew Zealand Data Sheet
New Zealand Data Sheet ATROPT EYE DROPS Atropine Sulfate Presentation ATROPT EYE DROPS contains atropine Sulfate (1%) in a sterile aqueous base. A clear, or almost clear, slightly viscous, colourless liquid
More informationNerve Agent/Organophosphate Pesticide Exposure Treatment
Nerve Agent/Organophosphate Pesticide Exposure Treatment Purpose: This Protocol is intended for EMS personnel at all levels to assess and treat patients exposed to nerve agents and organophosphate pesticides.
More informationAUTONOMIC NERVOUS SYSTEM (ANS):
University of Jordan Faculty of Medicine Department of Physiology & Biochemistry Medical 1 st year students, 2017/2018. ++++++++++++++++++++++++++++++++++++++++++++++++++ Textbook of Medical Physiology,
More informationDefinition of synapse:
Definition of synapse: A junctional connection between two neurons, across which a signal can pass Pre-synaptic neuron: Where a neurotransmitter is synthesized, stored and released upon cell activation.
More informationNEUROMUSCULAR BLOCKING AGENTS
NEUROMUSCULAR BLOCKING AGENTS Edward JN Ishac, Ph.D. Associate Professor, Pharmacology and Toxicology Smith 742, 828-2127, Email: eishac@vcu.edu Learning Objectives: 1. Understand the physiology of the
More informationTHE AUTONOMIC NERVOUS SYSTEM
1 THE AUTONOMIC NERVOUS SYSTEM The autonomic nervous system (ANS) is the portion of the nervous system which innervates smooth muscle, cardiac muscle & glands, & controls the visceral functions of the
More informationLearning Objectives. How do drugs work? Mechanisms of Drug Action. Liam Anderson Dept Pharmacology & Clinical Pharmacology
How do drugs work? Mechanisms of Drug Action Liam Anderson Dept Pharmacology & Clinical Pharmacology Learning Objectives Describe the potential drug targets within a human body. Describe the role of receptors,
More informationSummary of Product Characteristics
Translation from Latvian Summary of Product Characteristics 1. NAME OF THE MEDICINAL PRODUCT Neiromidin 20 mg tablets Neiromidin 5 mg/ml solution for injection Neiromidin 15 mg/ml solution for injection
More informationAutonomic Nervous System Dr. Ali Ebneshahidi
Autonomic Nervous System Dr. Ali Ebneshahidi Nervous System Divisions of the nervous system The human nervous system consists of the central nervous System (CNS) and the Peripheral Nervous System (PNS).
More informationI. Neural Control of Involuntary Effectors. Chapter 9. Autonomic Motor Nerves. Autonomic Neurons. Autonomic Ganglia. Autonomic Neurons 9/19/11
Chapter 9 I. Neural Control of Involuntary Effectors The Autonomic Nervous System Lecture PowerPoint Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Autonomic
More informationAutonomic Division of NS
Autonomic Division of NS Compare and contrast the structures of the sympathetic and the parasympathetic divisions, including functions and neurotransmitters. Show the levels of integration in the ANS,
More informationAutonomic Nervous System
Autonomic Nervous System Autonomic nervous system organization Sympathetic Nervous System division of the autonomic nervous system that arouses the body, mobilizing its energy in stressful situations
More informationNATO UNCLASSIFIED NATO UNCLASSIFIED 2-1 ORIGINAL CHAPTER 2 NERVE AGENTS SECTION I - GENERAL
NATO UNCLASSIFIED AMedP-6(B), Part III CHAPTER 2 NERVE AGENTS SECTION I - GENERAL 201. Introduction. The nerve agents (NA) are a group of particularly toxic chemical warfare agents. They were developed
More informationAutonomic Nervous System
Autonomic Nervous System Objectives 1. Describe the CNS components of the ANS 2. Understand the peripheral pathways that connect the ANS with targets in the body. 3. Understand the classes of disorders
More information