Prepared for your next patient. Autism Update 2011

Transcription

1 Prepared for your next patient. Autism Update 2011 Patricia Manning Courtney, MD, FAAP The Kelly O Leary Center for Autism Spectrum Disorders Division of Developmental and Behavioral Pediatrics Cincinnati Children s Hospital Medical Center

2 Disclaimers Statements and opinions expressed are those of the authors and not necessarily those of the American Academy of Pediatrics. Mead Johnson sponsors programs such as this to give healthcare professionals access to scientific and educational information provided by experts. The presenter has complete and independent control over the planning and content of the presentation, and is not receiving any compensation from Mead Johnson for this presentation. The presenter s comments and opinions are not necessarily those of Mead Johnson. In the event that the presentation contains statements about uses of drugs that are not within the drugs' approved indications, Mead Johnson does not promote the use of any drug for indications outside the FDA approved product label.

3 Learning Objectives Define and describe autism spectrum disorders (ASDs). Review epidemiology, demographics, and etiology. Review screening and diagnosis recommendations. Review treatment approaches. Discuss current controversies.

4 PERVASIVE DEVELOPMENTAL DISORDERS Autism Asperger Syndrome Rett Syndrome Childhood Disintegrative Disorder PDD-NOS Abbreviation: PDD NOS, pervasive developmental disorder not otherwise specified.

5

6 Changes in 2013 Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM 5) revisions Autism spectrum disorders Includes autism, Asperger syndrome, PDD NOS, and child disintegrative disorder (CDD) Concentrates on required features Social/communication deficits Restricted, repetitive patterns of behavior, interests, activities o Addition of sensory criteria Increases specificity while maintaining sensitivity Important to distinguish spectrum from non spectrum developmental disabilities Improves stability of diagnosis

7 DSM 5 Criteria: Social Communication Persistent deficits in social communication and social interaction across contexts, not accounted for by general developmental delays, manifested by all of the following: Deficits in social emotional reciprocity Deficits in nonverbal communicative behaviors Deficits in developing and maintaining relationships appropriate to the developmental level

8 DSM 5 Criteria: Restricted/Repetitive Behaviors Restricted, repetitive patterns of behavior, interests, or activities as manifested by at least 2 of the following: Stereotyped or repetitive speech, motor movements, or use of objects Excessive adherence to routines Highly restricted, fixated interests that are abnormal in intensity or focus Hyper or hypo reactivity to sensory input or unusual sensory interests

9 DSM 5 Criteria Symptoms must be present in early childhood. Symptoms together limit and impair everyday functioning.

10 What Else Can Look Like ASD? Attention deficit/hyperactivity disorder (ADHD) plus anxiety Nonverbal learning disability Obsessive compulsive disorder Anxiety plus language delay (with/without sensory issues) Cognitive delay plus anxiety

11 Diagnostic Stability Likelihood of stable diagnosis is high If diagnosed with autism at 2 years of age with standard tests by highly experienced clinicians If diagnosed with PDD NOS at 2 years of age, diagnostic shift is more likely, but still not common >10% shifted from PDD NOS to out of spectrum 30% maintained PDD NOS diagnosis at 9 years of age Most change occurred between 2 and 5 years of age We may see more shift than is reported in this study

12

13 Epidemiology Traditionally a rare disorder occurring in 4 5 per 10,000 Ratio of males to females unchanged (3 4:1) Recent studies show 1% of all 8 year olds with an ASD Kogan MD, Blumberg SJ, Schieve LA, et al. The prevalence of parent reported diagnosis of autism spectrum disorder among children in the US, Pediatrics. 2009;124(5): ; Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders autism and developmental disabilities monitoring network, United States, MMWR Surveill Summ. 2009;58(10):1 20.

14 Epidemiology Many studies rely either on parent report or school record review. Kogan study found that of people reporting their child had received a diagnosis of ASD, 40% reported their child no longer had ASD.

15 A More Recent Study Study in South Korea 1 in 38 children diagnosed with ASD (7 12 years of age) Collaboration with researchers at Yale Child Study Center Typical children and children in special education participated in a 2 level screening/evaluation process A large number identified in typical schools 16% with intellectual disability 12% with superior intelligence 2/3 with milder form Kim YS, Leventhal BL, Koh YJ, et al. Prevalence of autism spectrum disorders in a total population sample. Am J Psychiatry. 2011;168(9):

16 Epidemiology *Recent research has indicated that changes in diagnostic practices may account for at least 25% of the increase in prevalence over time, however much of the increase is still unaccounted for and may be influenced by environmental factors Autism Speaks Inc. Autism Speaks and Autism Speaks It s Time to Listen & Design are trademarks owned by Autism Speaks Inc. All rights reserved.

17 Changes in Prevalence of ASDs among Children 8 Years of Age, 2002 to 2006 Abbreviation: ADDM, Autism and Developmental Disabilities Monitoring.

18 Epidemiology True increase or epidemic? Increased awareness, broader diagnostic criteria, diagnostic substitution Probably a little of both

19 Etiology Unknown Initially described as a disorder of parenting/ refrigerator mothers Neurobiologic disorder Gene/environment interaction Role of other systems Immune Gastrointestinal (GI)

20 Genetics Complex, yet strong genetic factors influencing Strongest evidence from twin studies with 60% of monozygotic twins concordant for full syndrome; 90% for related social or cognitive abnormalities Risk of any form of PDD for sibling of proband with autism as high as 5% Relatives may be affected by difficulties that are conceptually related to autistic behaviors (broader autistic phenotype)

21

22 Recent Studies Suggest Larger Environmental Role Previous studies suggested strong genetic role Current study looked at 192 twin pairs 54 identical, 138 fraternal Identical twins with 60 70% chance of dual diagnoses Fraternal twins with 20 30% chance of dual diagnoses Two fold increase risk for ASD when mother on a selective serotonin reuptake inhibitor (SSRI) Hallmayer J, Cleveland B, Torres A, et al. Genetic heritability and shared environmental factors among twins with autism. Arch Gen Psychiatry. Online July 2011; Croen LA, Grether JK, Yoshida CK, et al. Antidepressant use during pregnancy and childhood autism spectrum disorders. Arch Gen Psychiatry. Online July 2011.

23 Screening for ASD AAP recommendations Developmental surveillance at all well child visits Elicit parent concerns Developmental screening at 9, 18, and 30 (or 24) month well child visits Use structured developmental assessment Screening for autism at 18 and 30 (or 24) month well child visits American Academy of Pediatrics Council on Children With Disabilities, Section on Developmental Behavioral Pediatrics, Bright Futures Steering Committee and Medical Home Initiatives for Children With Special Needs Project Advisory Committee. Identifying infants and young children with developmental disorders in the medical home: an algorithm for developmental surveillance and screening. Pediatrics. 2006;118(1): ; Johnson CP, Myers SM, and American Academy of Pediatrics Council on Children With Disabilities. Identification and evaluation of children with autism spectrum disorders. Pediatrics. 2007;120(7):

24 This Just In! Study in Pediatrics Recommended against routine screening due to lack of solid support for screening based on traditional rules for screening tools Excellent points made: Poor specificity of screening tools Lack of validated interventions Long wait lists Still supportive of surveillance Al Qabandi M, Gorter JW, Rosenbaum P. Early autism detection: are we ready for routine screening? Pediatrics. 2011;128(1):e211 e217.

25 Surveillance of ASDs Direct observation/interactions/ clinical probes Pointing and directing child to look (12 15 months) Calling child s name (12 months) Asking Where s mommy? Eye contact, gaze referencing, pointing evidence of joint attention Observe for unusual movements (looking at things closely, out of corner of eye, repetitive movements, sensitivities)

26 Surveillance of ASDs Probing questions for parents: What is your child s favorite toy/type of play? (12 to 18 months) Does your child babble? Wave bye bye? Raise arms to be lifted? Hear your voice as well as other things in the environment? (9 to 12 months) Does your child have echolalia, pop up words, exceptional labeling? (12, 15, and 24 months)

27 Surveillance of ASDs Development of social skills and language is more delayed and characteristically out of sync with motor, adaptive and cognitive functioning. Johnson CP. Recognition of autism before age 2 years. Pediatr Rev. 2008;29(3):86 96.

28 Screening Tools No validated tools for use in children under 18 months Level 1 screening tools for at risk or no risk children Checklist for Autism in Toddlers (CHAT) Modified Checklist for Autism in Toddlers (M CHAT) Pervasive Developmental Disorders Screening Test II (PDDST II) No recommendation for screening school age children Consider Social Communication Questionnaire

29 M CHAT 23 yes no questions Measures social reciprocity, language, some motor 18 months to 4 years of age Detects ASD, language impairment, mental retardation Sensitivity/specificity

30 M CHAT and Autism Screening Failing score if 2 or more critical items or any 3 items are failed Free download at 2 page scoring guide Takes 5 minutes to complete and 5 minutes to score Autism screen recommended by AAP Autism Expert Panel for use at month well child visit

31 Diagnosis Comprehensive, multidisciplinary evaluation Autism Treatment Network Protocol Medical evaluation Psychological evaluation Autism Diagnostic Observation Schedule (ADOS), other autism specific diagnostic tools Screening for common, related medical issues Sleep problems, GI problems DSM IV criteria insufficient

32 Treatment: Getting Started Speech/Language Therapy Picture Exchange Communication System Auditory Integration Therapy Occupational Therapy Sensory Integration Behavior Management Early Intervention/Pre School/School Age

33

34

35 Treatment: More Intensive Approaches Applied Behavioral Analysis Only evidence based intensive intervention Son Rise Program Floor time Relationship Development Intervention (RDI) Rapid Prompting Method (RPM)

36

37 Treatment: Teach Treatment and Education of Autistic and Related Communication Handicapped Children (TEACHH) Statewide system of services for individuals with autism and their families Increase level of skill through adapting the environment to accommodate the characteristics of children with autism

38 Treatment: Medical Regular follow up recommended Monitoring, screening of common medical issues Sleep issues, GI issues, nutritional concerns Medication management Medications Alternative medical treatments

39 Medications Target symptoms Anxiety Aggression Obsessive/compulsive features ADHD features Sleep problems Seizures Mood lability Repetitive behaviors

40 Medications Stimulants SSRIs Atypical antipsychotics Risperdal Melatonin Seizure medication

41 Alternative Treatments Diet Gluten and casein free diet Vitamins B6, Mg, B12 Super Nu Thera Yeast treatments Manipulation Secretin, intravenous immune globulin (IVIG), steroids, antivirals, chelation

42 Autism and Vaccines Currently no evidence to support a relationship between vaccines and autism Theories continue to change Recent retraction of Lancet article Families still caught in the middle between research and media

43 Retraction Retraction Ileal-lymphoid-nodular hyperplasia, nonspecific colitis, and pervasive developmental disorder in children Following the judgment of the UK General Medical Council s Fitness to Practise Panel on Jan 28, 2010, it has become clear that several elements of the 1998 paper by Wakefield et al 1 are incorrect, contrary to the findings of an earlier investigation. 2 In particular, the claims in the original paper that children were consecutively referred and that investigations were approved by the local ethics committee have been proven to be false. Therefore we fully retract this paper from the published record. The Editors of The Lancet The Lancet, London NW1 7BY, UK 1 Wakefield AJ, Murch SH, Anthony A, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet. 1998;351: Hodgson H. A statement by The Royal Free and University College Medical School and The Royal Free Hampstead NHS Trust. Lancet. 2004;363:824.

44

45 Prognosis Previous studies summarized: 10 15% with good outcomes 15 25% with fair outcomes 15 25% with poor outcomes 30 50% with very poor outcomes Few current longitudinal studies exist Issues of diagnostic shift, diagnostic stability

46

47

48

49 Resources Autism Society of America society.org Autism Speaks 100 Day Kit Centers for Disease Control and Prevention American Academy of Pediatrics

50 For more information On this topic and a host of other topics, visit: Pediatric Care Online is a convenient electronic resource for immediate expert help with virtually every pediatric clinical information need. Must have resources are included in a comprehensive reference library and time saving clinical tools. Haven't activated your Pediatric Care Online trial subscription yet? It's quick and easy: simply follow the steps on the back of the card you received from your Mead Johnson representative. Haven't received your free trial card? Contact your Mead Johnson representative or call 888/ today.