Curriculum Vitae (Uptdated on )

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1 Curriculum Vitae (Uptdated on ) Personal information First name(s) / Surname(s) Address(es) 73, via Vespucci, 56125, Pisa, Italy Telephone(s) Mobile: Fax(es) a.guzzetta@inpe.unipi.it Nationality Italian Date of birth Titles MD, PhD, Child Neuropsychiatrist Work experience Dates Department 18/12/2013 Senior Researcher University of Pisa Department of Clinical and Experimental Medicine Dates Main activities and responsibilities 01/01/ /04/ /06/2009 Consultant Fondazione Stella Maris, Pisa, Italy Head of the Infant Neurology Section Head of the SMILE Lab Consultant neurologist at the NICU, Pisa University Hospital Responsible for the Follow-up program of the infant at neurodevelopmental risk Responsible for the Newborn Neurophysiology Service Member of the MRI Lab Main activities and responsibilities Dates 01/07/ /12/2010 Senior Research Fellow University of Queensland, Brisbane, Australia Research set-up and coordination Grant writing PhD and Honors students tutoring Education and training Dates 01/01/ /12/2004 PhD in Basic and Developmental Neuroscience Development of the human nervous system after early brain damage: maturation and integration of motor and visuo-perceptual functions University of Pisa Level of international classification ISCED 6 Page 1/5 - Curriculum vitae of

2 Dates 01/06/ /02/2005 Pediatric functional MRI Dept. of Child Neurology, University Hospital of Tuebingen, Germany Advisors: Prof. Ingeborg Krageloh-Mann; Prof. Martin Staudt Dates 01/01/ /10/2001 First Class Honours specialization in Child Neurology and Psychiatry General Movements as a prognostic tool for the early assessment of congenital arterial stroke University of Pisa Level of international classification ISCED 6 Dates 01/10/ /05/2000 Neonatal Neurology Paediatrics Hammersmith Hospital Imperial College, London, UK Advisors: Prof. Lilly Dubowitz; Prof. Eugenio Mercuri; Prof. Frances Cowan; Prof. Mary Rutherford Dates 01/10/ /02/2000 Pediatric Neuro-ophthalmology Visual Development Unit, London, Department of Psychology, University College, London, UK Advisors: Prof. Janette Atkinson; Prof. Oliver Braddick Dates 10/10/ /04/1996 Thesis title Level of international classification ISCED 5 First Class Honours degree in Medicine and Surgery Congenital hypothyroidism: correlation between hormonal indexes at birth and neurodevelopmental outcome University of Rome La Sapienza Funded Grants Fondation Jerome Lejeune Mapping cerebral circuits in Down syndrome Starting year (duration in months) 2011 (30) 21k CI Starting year (duration in months) 2011 (30) R-11-86_FONDAZIONE MARIANI (Italy) The effect of infant action observation training on the early development of hand reaching and grasping in healthy infants and in infants with asymmetrical brain damage. 150k Starting year (duration in months) 2011 (36) PI 1.06M GR Ministero della Salute (Italy) Non-invasive tools for early detection of Autism Spectrum Disorders Page 2/5 - Curriculum vitae of

3 Starting year (duration in months) 2011 (24) DP Australia Research Council (Australia) Effect of Infant Hand Observation Training on the Early Development of Hand Reaching and Grasping in Healthy Infants and those with Early Brain Damage 280K Starting year (duration in months) 2009 (24) CI RFEM 1/09 TELETHON (Italy) Identification of neuronal substrates of Rett syndrome and validation of therapies in prelinical models: a genomic, morphofunctional, and behavioural analysis in mouse models and patients 170K Starting year (duration in months) 2009 (12) RFEM 3/09 CARILI (Italy) Development of a biomechatronic gym as a clinical and research instrument for the assessment of hand function 7K PI RFEM 13/05 ALLERGAN (Italy) Use of botulinic toxin for the upper limb in children effected by hemiplegia Starting year (duration in months) 2006 (48) 150K Starting year (duration in months) 2006 (36) RFEM 9/05 MARIANI FOUNDATION (Italy) Disorders of visual perception in children born preterm 105K Starting year (duration in months) 2005 (48) RFEM 10/04 CRP (Italy) CHILD VISUAL BRN-D: integrated package for the assessment and treatment of neuro-visual disorders in children. 180K Starting year (duration in months) 2004 (24) RT 5/02 MARIANI FOUNDATION (Italy) Early visual and cognitive functions in the first year of life in infants with early onset epileptic sindrome 200K RT 8/01 MIUR RBNE01AZ FIRB (Italy) Sensori-motor and cognitive neural plasticity: integrated functional imaging. Starting year (duration in months) 2003 (48) 400K Page 3/5 - Curriculum vitae of

4 RF 5/00 (Italy) Alzheimer Disease and Down Syndrome, neurobiological, neuropsychological and clinical correlations Starting year (duration in months) 2002 (36) 450K Track record in summary Total publications H index i10-index Total citations Best Scientific Publications IF=8.813 IF=7.49 IF=4.997 IF=4.495 IF=3.636 IF=3.264 Eyre JA, Smith, Dabydeen L; Clowry GJ; Petacchi E; Battini R; Guzzetta A; Cioni G. Is hemiplegic cerebral palsy equivalent to amblyopia of the corticospinal system? Ann Neurol 2007;62(5): This pioneering paper proposed strong evidence for the theory of activity dependent competition in the reorganization of motor function following early brain damage in humans. Guzzetta A, Baldini S, Bancale A, et al. Massage accelerates brain development and the maturation of visual function. J Neurosci May 6;29(18): This parallel murine and human model study demonstrates for the first time the effects of an environmental enrichment model in preterm infants as to brain development and visual function maturation. Morrone MC, Guzzetta A, Tinelli F, et al. Inversion of perceived direction of motion caused by spatial undersampling in two children with periventricular leukomalacia. J Cogn Neurosci. 2008;20(6): This psychophysics and fmri study described a new, previously unknown, type of visual disorder associated to bilateral spastic cerebral palsy, consisting in the inverted perception of translational motion stimuli. Tinelli F, Guzzetta A, Bertini C, Ricci D, Mercuri E, Ladavas E, Cioni G. Greater sparing of visual search abilities in children after congenital rather than acquired focal brain damage. Neurorehabil Neural Repair. 2011;25(8): This paper shows that children with very early brain lesions to the visual system have different (and more efficient) mechanisms of functional reorganization, as opposed to those with later damage. Frassinetti F, Fiori S, D'Angelo V, Magnani B, Guzzetta A, Brizzolara D, Cioni G. Body knowledge in brain-damaged children: a double-dissociation in self and other's body processing. Neuropsychologia. 2012;50(1): This paper shows that corporeal self recognition is present since at least 4 years of age and that self and others body parts processing are different and sustained by separate cerebral substrates. Guzzetta A, D Acunto MG, Carotenuto M, Berardi N, Bancale A, Biagioni E, Boldrini A, Ghirri P, Maffei L, Cioni G. The effects of preterm infant massage on brain electrical activity. Dev Med Child Neurol. 2011;53 Suppl 4: This paper demonstrates for the first time the effects of infant massage in preterm infants as to the maturation of brain electrical activity. IF=3.264 Guzzetta A, Pizzardi A, Belmonti V, Boldrini A, Carotenuto M, D Acunto MG, Ferrari F, Fiori S, Gallo C, Ghirri P, Mercuri E, Romeo DMM, Roversi MF, Cioni G. Hand movements at 3 months predict later hemiplegia in term infants with neonatal cerebral infaction. Dev Med Child Neurol Aug;52(8): This is the first paper to suggest that early spontaneous movements of the upper limb have different neurophysiological bases and therefore, when found abnormal, have different predictive value. Page 4/5 - Curriculum vitae of

5 IF=3.264 IF=3.04 IF=2.972 Guzzetta A, D'Acunto G, Rose S, Tinelli F, Boyd R, Cioni G. Plasticity of the visual system after early brain damage. Dev Med Child Neurol. 2010;52(10): This paper reviews the extensive and complex literature on the neuroplasticity of the visual system outlining the main specificities of the reorganization of a damaged young brain. Cioni G, D'Acunto G, Guzzetta A. Perinatal brain damage in children. Neuroplasticity, early intervention, and molecular mechanisms of recovery. Prog Brain Res. 2011;189: This paper reviews the literature and authors experience on the specific mechanisms of brain plasticity following brain damage of the young brain. Guzzetta A, Bonanni P, Biagi L, et al. Reorganisation of the somatosensory system after early brain damage. Clin Neurophysiol. 2007; 118(5): This paper defines the characteristics and the limits of neuroplasticity of the somatosensory system in children with congenital brain damage, with the integrated use of electrophysiological and neuroimaging techniques. Personal skills and competences Mother tongue(s) Italian Other language(s) Self-assessment Understanding Speaking Writing European level (*) Listening Reading Spoken interaction Spoken production English C2 Proficient user C2 Proficient user C2 Proficient user C2 Proficient user C2 Proficient user French B2 Independent user B2 Independent user A2 Basic user A2 Basic user A1 Basic user Page 5/5 - Curriculum vitae of