Identifying Youth at Clinical High Risk for Psychosis
|
|
- Myra Watson
- 5 years ago
- Views:
Transcription
1 Identifying Youth at Clinical High Risk for Psychosis Jean Addington PhD University of Calgary Department of Psychiatry 1 Identifying Youth at Clinical High Risk for Psychosis Part 1: What do we know about risk for and the prodrome for psychosis 2 WHAT IS PSYCHOSIS? The word psychosis is used to describe conditions which affect the mind, where there has been some loss of contact with reality. When someone becomes ill in this way it is called a psychotic episode. 3 1
2 TYPES OF PSYCHOSIS Drug induced psychosis Organic psychosis Brief psychotic episode Schizophreniform disorder Schizophrenia Delusional disorder Bipolar disorder Schizoaffective disorder Psychotic depression 4 Symptoms of schizophrenia and other psychotic disorders POSITIVE SOCIAL DEFICITS hallucinations delusions COGNITIVE thought disorder PROBLEMS bizarre behavior NEGATIVE flat or blunted affect OTHER alogia depression anhedonia anxiety low energy somatic concerns Withdrawal 5 Genetic Risk General population 1% 2 nd degree relative 2-6% 1 st degree relative 6-13% Identical twin 48% 6 2
3 Clinical Course of Schizophrenia Premorbid Prodromal Progressive Residual Behavioral Functioning Onset of Psychosis Psychotic Symptoms B Early Intervention Is Key Premorbid Prodromal Progressive Residual Behavioral Adaptation?? First Episode Treatment Psychotic Symptoms B Early Interest in the Sz Prodrome The psychiatrist sees too many end states and deals professionally with too few of the pre-psychotic [states] With this in mind, it would seem as if we should lay great stress on the prompt investigation of failing adjustment, rather than, as is so often the case, wait and see what happens I feel certain that many incipient cases might be arrested before the efficient contact with reality is completely suspended, and a long stay in institutions made necessary. Sullivan, H.S., The onset of schizophrenia. Am. J. Psychiatry, 6, pp
4 Terminology Genetic high risk Prodromal Clinical high risk 10 Prodromal Syndromes Identified by a structured interview Attenuated positive symptom syndrome Unusual thought content, delusional ideas Suspiciousness/persecutory ideas Grandiose ideas Perceptual abnormalities, hallucinations Disorganized communication Genetic risk + deterioration syndrome Miller et al., 2003; Yung et al
5 Identifying Clinical High Risk Distressed Functioning poorly Have significant disability Help-seeking Willing to accept professional help Different from subgroup who report isolated psychotic symptoms in apparent absence of distress, disability or progressive change and who do not desire assistance 13 Variable Transition Rates Study N Rate Follow-up PACE (Aus) % 12-mo PRIME (Yale) 13 54% 12-mo PRIME (NA) 60 35% 12-mo RAP (NY) 34 27% 6-mo EDIE (UK) 23 22% 12-mo CARE (SD) 50 15% 12-mo Toronto 50 20% 12-mo 14 Survival Distribution Function in NAPLS Consortium % Non-Converted to Psychosis UHR Cases (N=291) Genetic HR Cases (N=43) Controls HSC & NPC (N=250) 0-mo 6-mo 12-mo 18-mo 24-mo 30-mo Follow-Up Epoch Cannon et al., 2008, Archives Gen. Psychiat. 15 5
6 From research what do we know about the Clinical High Risk Group? 16 Recruitment Difficulties CHR Conversion FE 0 Presentation in 1 year at the Toronto PRIME & FE Clinics 17 Symptomatic High level of depression and anxiety Many present with a range of comorbid diagnoses 18 6
7 Social Functioning Clinical High Risk subjects consistently demonstrate deficits equivalent to those seen in FE subjects in current social functioning premorbid social functioning social cognition facial affect recognition social judgments Addington et al Brit J Psych; Addington et al. in press Schiz Res 19 Cognitive Deficits Cognitive performance profiles intermediate to normal control and FE psychosis cohorts across domains of attention, memory and executive ability Preliminary but inconsistent results with respect to lower deficits in those who progress to psychosis (verbal memory and vigilance) Evidence of olfactory identification deficits that were specific to the CHR group that developed schizophrenia 20 Stress Hormones Association between stress and psychosis onset might be mediated by the effect of stress-induced cortisol secretion on neurotransmitter systems (dopaminergic and glutamatergic) Cortisol secretion is higher in prodromal cases who convert 21 7
8 Genomic Markers Existing studies support roles for candidate genes (eg Neuregulin 1, Dystrobrevin binding protein 1, DISC1) - suboptimal since they do not identify specific risk alleles Need large scale genomewide association studies to determine specific alleles associated with psychotic disorders Genetic susceptibility, endophentypes and gene environment interactions (DISC 1, COMT) 22 Genomic Markers Identify patterns of gene expression in peripheral white blood cells Test specific risk polymorphisms or other genetic variations NRG1 variant is associated with decreased activation of frontal & temporal regions, increased development of psychotic symptoms, decreased premorbid IQ (Nature Neuroscience, 2006) 23 Imaging Findings generally demonstrate changes post conversion but no differences to aid prediction Structural Reduction in grey matter and hippocampus after conversion Larger pituitary volume (due to activation of hormonal stress response) 24 8
9 Imaging Functional Activation of the parietal lobe, decreased activation of the anterior cingulate Small increases in activation with increasing task difficulty in the right lingual gyrus and bilateral temporal regions Significantly greater rate of change in the dorsolateral prefrontal cortical region 25 Clinical Trials 26 PACE Clinic, Melbourne Australia (Personal Assistance & Crisis Evaluation) Non-blind randomized trial Risperidone n=31; Supportive therapy n=28 At the end of treatment transition rates 9.7% and 36% Six months after the end of treatment transition rates 19% and 36% Those who were adherent in treatment phase less likely to relapse at follow-up McGorry et al., 2002, Arch Gen Psych 27 9
10 PRIME Trial Investigator (McGlashan, Yale) designed study with sites in Calgary, Toronto, & N Carolina Randomized double-blind parallel study of 60 prodromal comparing the efficacy of olanzapine, in preventing or delaying the onset of psychosis Medication versus placebo for 1 year, 1 year follow-up no medication 1 Year 16% of olanzapine treated patients & 35% of placebo treated patients converted to psychosis All those who converted in the treatment group did so in the 1 st month Olanzapine reduced conversion by 50% McGlashan et al., 2006 Am J Psych 28 Medication Concerns Concerns about drug side effects particularly if subjects are false positives Do not address potential environmental stressors psychosocial stress substances Clinical high risk individuals are help seeking but only 14-16% want medication (Addington & Addington, 2005) compared to 90-95% who consent to psychological treatments 29 The Early Detection and Intervention (EDIE ) (Manchester) Single blind randomized controlled trial of n=58 Psychological intervention Results at 12 months CBT 3 out of 35 converted Control 7 out of 23 converted from CBT group Morrison et al., 2004, Brit J Psych 30 10
11 Access, Detection & Psychological Treatments (ADAPT) RCT to evaluate the effectiveness of CBT compared to a supportive therapy (ST) in preventing or delaying the onset of a psychotic illness reducing the presenting concerns (depression, anxiety, functioning etc) of the clinical high risk group 31 Summary of ADAPT No change in negative symptoms No change in social functioning Improvement in anxiety, GAF, positive symptoms and depression Conversions only in ST group 32 Future Research Directions Can prediction algorithm with positive predictive power >80% be replicated/improved? Clinical risk factors, neurocognition, biomarkers Impacts risk/benefit calculus for prevention trials Which mechanisms account for psychosis onset? Neural, hormonal, and cognitive pathways Exogenous triggers (trauma, substance abuse, etc.) Are there alternatives to antipsychotic therapy? Lithium, Omega-3 fatty acids, Glycine? Cognitive and behavioral exercises to strengthen residual adaptive capacity? 33 11
12 North American Prodrome Longitudinal Study (NAPLS) NIMH program liaison: Robert Heinssen PhD Jean Addington PhD University of Calgary Kristin Cadenhead MD UCSD Tyrone Cannon PhD UCLA Barbara Cornblatt PhD Hillside Hospital Thomas McGlashan MD Yale University Diana Perkins MD University of North Carolina Larry Seidman PhD Harvard University Ming Tsuang MD Harvard University/UCSD Elaine Walker PhD Emory University Scott Woods MD Yale University Addington et al., (2007) Schiz. Bulletin 34 Aims for NAPLS Prospective Study To replicate clinical risk prediction algorithm in a new prospective sample and extend it by incorporating information on neurocognitive functioning 720 prodromal patients, 240 demographically matched controls Focus is on maximizing prediction (PPP and sensitivity) using measures easily implemented in community settings 35 Aims for NAPLS Prospective Study To investigate a model of neural dysconnectivity as the proximal mechanism underlying conversion to psychosis Gray matter density, functional connectivity/coherence 36 12
13 Aims for NAPLS Prospective Study To develop predictive biomarkers of risk for psychosis Mixture of hypothesis driven (MRI, EEG, Cortisol, candidate gene) and discovery-science (DNA, RNA, proteomics) methods Can be used to ascertain risk status of individuals before behavioral expression begins to escalate Can help identify novel targets for preventive interventions based on understanding of mechanisms underlying disease onset and course 37 Questions/Discussion 38 Thank you for your participation For information about Telemental Health education sessions: (403) Initiatives Telemental Health Current Telelearning Sessions 39 13
Dr. Jean Addington Annual Report
Alberta Centennial Mental Health Research Chairs Program Dr. Jean Addington Annual Report website version Dr. Jean Addington Alberta Centennial Mental Health Research Chair Inaugural Chair in Child and/or
More informationWhat is psychosis? The Challenge 4/11/2011. Psychotic Spectrum Symptoms in Youth
What is psychosis? Psychotic Spectrum Symptoms in Youth Nick Weiss, MD PART Program Director, Child and Adolescent Psychiatry Clinics University of California, San Francisco Often thought of as catastrophically
More informationTracey G. Skale, MD Chief Medical Officer Greater Cincinnati Behavioral Health
Schizophrenia: What Do We Know? Where Do We Go From Here? Tracey G. Skale, MD Chief Medical Officer Greater Cincinnati Behavioral Health Objectives Participants will be able to: Understand the clinical
More informationUpdate on First Psychotic Episodes in Childhood and Adolescence. Cheryl Corcoran, MD Assistant Professor of Psychiatry Columbia University
Update on First Psychotic Episodes in Childhood and Adolescence Cheryl Corcoran, MD Assistant Professor of Psychiatry Columbia University Childhood-Onset Psychosis 8% of psychiatrically referred youth
More informationINSIGHTS INTO ADDRESSING EARLY SCHIZOPHRENIA: PRODROME AND FIRST EPISODE
INSIGHTS INTO ADDRESSING EARLY SCHIZOPHRENIA: PRODROME AND FIRST EPISODE S. Charles Schulz, MD Professor & Head Donald W. Hastings Endowed Chair Department of Psychiatry University of Minnesota Medical
More informationPreventing psychosis and targeting people at risk: From bright idea to NICE Guidelines. Paul French
Preventing psychosis and targeting people at risk: From bright idea to NICE Guidelines Paul French Psychosis: The Early Course Adapted from Larsen et al., 2001 Early Intervention in the atrisk phase ARMS
More informationSchizophrenia FAHAD ALOSAIMI
Schizophrenia FAHAD ALOSAIMI MBBS, SSC - PSYCH C ONSULTATION LIAISON PSYCHIATRIST K ING SAUD UNIVERSITY Schizophrenia - It is not a single disease but a group of disorders with heterogeneous etiologies.
More informationEarly Warning Signs of Psychotic Disorders and the Importance of Early Intervention
Early Warning Signs of Psychotic Disorders and the Importance of Early Intervention Margaret Migliorati, MA, LPCC The University of New Mexico mmigliorati@salud.unm.edu Mental Health As a Public Health
More informationCognitive enhancement therapy in schizophrenia. Matcheri S Keshavan MD
Cognitive enhancement therapy in schizophrenia Matcheri S Keshavan MD Harvard Medical School, Massachusetts Mental Health Center and Beth Israel Deaconess Medical Center NIMH MH 60902, 92440 and 105596;
More informationPsychosis. Paula Gibbs, MD Department of Psychiatry University of Utah
Psychosis Paula Gibbs, MD Department of Psychiatry University of Utah Psychotic Symptoms Psychosis in a broad sense, signifies impaired reality testing ability Symptoms include: hallucinations, delusions,
More informationPerceived discrimination in those at clinical high risk for psychosis
Journal Articles Donald and Barbara Zucker School of Medicine Academic Works 2014 Perceived discrimination in those at clinical high risk for psychosis M. M. Saleem J. Stowkowy K. S. Cadenhead T. D. Cannon
More informationAt Risk Mental State but at risk of what? An opportunity for discussion. Ray McEnhill EIS Wellington
At Risk Mental State but at risk of what? An opportunity for discussion Ray McEnhill EIS Wellington ARMS UHR subgroups & transition rates Diagnoses in those with ARMS Non-converters What we re doing in
More informationIndex. Note: Page numbers of article titles are in boldface type.
Index Note: Page numbers of article titles are in boldface type. A Abuse substance. See Substance abuse Acquired disorders presenting as psychosis in children and young adults, 581 608. See also specific
More informationPsychotic disorders Dr. Sarah DeLeon, MD PGYIV, Psychiatry ConceptsInPsychiatry.com
Psychotic disorders Dr. Sarah DeLeon, MD PGYIV, Psychiatry ConceptsInPsychiatry.com Introduction Psychotic spectrum disorders include schizotypal personality disorder, delusional disorder, brief psychotic
More information4. General overview Definition
4. General overview 4.1. Definition Schizophrenia is a severe psychotic mental disorder characterized by significant disturbances of mental functioning. It has also been called early dementia, intrapsychic
More informationDisease Modification in Schizophrenia: Overview of the Issues. ISCTM February 18 th 2014 Ravi Anand, MD Switzerland
Disease Modification in Schizophrenia: Overview of the Issues ISCTM February 18 th 2014 Ravi Anand, MD Switzerland Need for a New Treatment Paradigm in Schizophrenia Sixty years after approval for the
More informationContemporary Psychiatric-Mental Health Nursing. Features of Schizophrenia. Features of Schizophrenia - continued
Contemporary Psychiatric-Mental Health Nursing Chapter 16 Schizophrenia and Other Psychotic Disorders Features of Schizophrenia Prevalence in U.S. is 1.1%. Average onset is late teens to early twenties,
More informationEarly Stages of Psychosis. Learning Objectives
Early Stages of Psychosis Stephan Heckers, MD MSc Department of Psychiatry and Behavioral Sciences Vanderbilt University Learning Objectives Summarize the five domains of psychosis Describe how psychotic
More informationPsychotic prodrome: Are antipsychotics effective? Ethical?
Psychotic prodrome: Are antipsychotics effective? Ethical? Evidence is mixed but risk is high when abnormal cognition falls short of schizophrenia Meera Narasimhan, MD Director, psychopharmacology division
More informationCondensed Clinical Practice Guideline Treatment Of Patients With Schizophrenia
Condensed Clinical Practice Guideline Treatment Of Patients With Schizophrenia I. Key Points a. Schizophrenia is a chronic illness affecting all aspects of person s life i. Treatment Planning Goals 1.
More information8/22/2016. Contemporary Psychiatric-Mental Health Nursing Third Edition. Features of Schizophrenia. Features of Schizophrenia (cont'd)
Contemporary Psychiatric-Mental Health Nursing Third Edition CHAPTER 16 Schizophrenia Features of Schizophrenia Prevalence in U.S. is 1.1%. Average onset is late teens to early twenties, but can be as
More informationNIH Public Access Author Manuscript Expert Rev Neurother. Author manuscript; available in PMC 2011 June 1.
NIH Public Access Author Manuscript Published in final edited form as: Expert Rev Neurother. 2010 August ; 10(8): 1347 1359. doi:10.1586/ern.10.93. Early signs, diagnosis and therapeutics of the prodromal
More informationEVIDENCE AND PERSPECTIVES IN EARLY RECOGNITION AND INTERVENTION FOR PSYCHOSIS and BEYOND. Patrick McGorry
EVIDENCE AND PERSPECTIVES IN EARLY RECOGNITION AND INTERVENTION FOR PSYCHOSIS and BEYOND Patrick McGorry TOTAL IEPA MEMBERS PER YEAR 3000 2900 2500 2000 1500 1000 1127 1328 1540 1828 1856 2090 2133 2489
More informationSchizophrenia and Other Psychotic Disorders
Schizophrenia and Other Psychotic Disorders Chapter 14 This multimedia product and its contents are protected under copyright law. The following are prohibited by law: any public performance or display,
More informationIdentifying Schizophrenia: Paradigm Shift The UHR Research
Western University Scholarship@Western Psychiatry Presentations Psychiatry 1-12-2009 Identifying Schizophrenia: Paradigm Shift The UHR Research Amresh Srivastava University of Western Ontario, Amresh.Srivastava@sjhc.london.on.ca
More informationInitial Prodrome Description in Recent Onset Schizophrenia
Amr El-Shribiny et al. Initial Prodrome Description in Recent Onset Schizophrenia Amr M M El-Shribiny, Salwa M. Rabie, Hanaa S. Soliman, Refaat Mahfouz Department of Neurology and Psychiatry, El-Minia
More informationPsychosis, Mood, and Personality: A Clinical Perspective
Psychosis, Mood, and Personality: A Clinical Perspective John R. Chamberlain, M.D. Assistant Director, Psychiatry and the Law Program Assistant Clinical Professor University of California San Francisco
More information4/29/2016. Psychosis A final common pathway. Early Intervention in Psychotic Disorders: Necessary, Effective, and Overdue
Early Intervention in Psychotic Disorders: Necessary, Effective, and Overdue Disclosures Financial relationships with commercial interests Douglas R. Robbins, M.D. Maine Medical Center Tufts University
More informationPsychotic Disorders. Schizophrenia. Age Distribution of Onset 2/24/2009. Schizophrenia. Hallmark trait is psychosis
Psychotic Disorders Schizophrenia Schizophrenia Affects people from all walks of life Is about as prevalent as epilepsy Usually begins in late adolescence or early adulthood Hallmark trait is psychosis
More informationEarly detection and intervention of psychosis
Early detection and intervention of psychosis New Data Benno G. Schimmelmann University Hospital of Child and Adolescent Psychiatry Bern, Bern, Switzerland Early detection of psychosis Early Detection
More informationChapter 12. Schizophrenia and Other Psychotic Disorders. PSY 440: Abnormal Psychology. Rick Grieve Western Kentucky University
Chapter 12 Schizophrenia and Other Psychotic Disorders PSY 440: Abnormal Psychology Rick Grieve Western Kentucky University psychotic disorders disorders so severe that the person has essentially lost
More informationSchizophrenia and Related Psychotic Disorders
and Related Psychotic Disorders Anand K. Pandurangi, MD Professor & Chair, Div. of Inpatient Psychiatry Director, Program VCU Medical Center 1 Kraeplin 1896 Dementia Praecox. Single, Homogenous Disorder
More informationSchizophrenia: New Concepts for Therapeutic Discovery
Schizophrenia: New Concepts for Therapeutic Discovery William T. Carpenter, M.D. Professor of Psychiatry and Pharmacology University of Maryland School of Medicine Department of Psychiatry Maryland Psychiatric
More informationDistress in relation to attenuated psychotic symptoms in the ultra-high-risk population is not associated with increased risk of psychotic disorder.
Royal College of Surgeons in Ireland e-publications@rcsi Psychiatry Articles Department of Psychiatry 15-3-2015 Distress in relation to attenuated psychotic symptoms in the ultra-high-risk population is
More informationProgram Outline. DSM-5 Schizophrenia Spectrum and Psychotic Disorders: Knowing it Better and Improving Clinical Practice.
DSM-5 Spectrum and Disorders: Knowing it Better and Improving Clinical Practice Rajiv Tandon, MD Professor of Psychiatry University of Florida College of Medicine Gainesville, Florida Program Outline Changes
More information9/3/2014. Contemporary Psychiatric-Mental Health Nursing Third Edition. Features of Schizophrenia. Features of Schizophrenia (cont'd)
Contemporary Psychiatric-Mental Health Nursing Third Edition CHAPTER 16 Schizophrenia Features of Schizophrenia Prevalence in U.S. is 1.1%. Average onset is late teens to early twenties, but can be as
More informationAccurate Diagnosis of Primary Psychotic Disorders
Accurate Diagnosis of Primary Psychotic Disorders The Care Transitions Network National Council for Behavioral Health Montefiore Medical Center Northwell Health New York State Office of Mental Health Netsmart
More informationYouth Mental Health and 22q11
Youth Mental Health and 22q11 Cameron S. Carter M.D. Director Center for Neuroscience U.C. Davis Early Diagnosis & Preventative Treatment Clinic (EDAPT) UC Davis Department of Psychiatry of Mental Health
More informationHandout 2: Understanding Psychotic Illness
Handout 2: Understanding Psychotic Illness A Psychosis refers to a state where a person loses contact with reality. The word is derived from the Latin words "psyche" meaning mind and "osis" meaning illness.
More informationMental Health Disorders Civil Commitment UNC School of Government
Mental Health Disorders 2017 Civil Commitment UNC School of Government Edward Poa, MD, FAPA Chief of Inpatient Services, The Menninger Clinic Associate Professor, Baylor College of Medicine NC statutes
More information4/7/2016. Auditory Hallucinations in Youth: The Good, the Bad, and the Reassuring. Objectives. Disclosures
Auditory Hallucinations in Youth: The Good, the Bad, and the Reassuring Nick Weiss, MD April 30, 2016 Objectives Participants will learn about the prevalence and patterns of auditory hallucinations in
More informationStress exposure and sensitivity in the clinical high-risk syndrome: Initial findings from the North American Prodrome Longitudinal Study (NAPLS)
Stress exposure and sensitivity in the clinical high-risk syndrome: Initial findings from the North American Prodrome Longitudinal Study (NAPLS) Hanan Trotman, Emory University Carrie W. Holtzman, Emory
More informationClinical Staging and the At-Risk Phase of Psychotic Disorder
Clinical Staging and the At-Risk Phase of Psychotic Disorder Sabina Abidi MD FRCPC IWK Youth Psychosis Program Capital Health Nova ScoCa Early Psychosis Program Key Findings in Early Psychosis Knowledge
More informationESSENTIAL PSYCHOPHARMACOLOGY, Neurobiology of Schizophrenia Carl Salzman MD Montreal
ESSENTIAL PSYCHOPHARMACOLOGY, 2011 Neurobiology of Schizophrenia Carl Salzman MD Montreal EVOLVING CONCEPTS OF SCHIZOPHRENIA Psychotic illness with delusions, hallucinations, thought disorder and deterioration;
More informationOpen Translational Science in Schizophrenia. Harvard Catalyst Workshop March 24, 2015
Open Translational Science in Schizophrenia Harvard Catalyst Workshop March 24, 2015 1 Fostering Use of the Janssen Clinical Trial Data The goal of this project is to foster collaborations around Janssen
More information#CHAIR2016. September 15 17, 2016 The Biltmore Hotel Miami, FL. Sponsored by
#CHAIR2016 September 15 17, 2016 The Biltmore Hotel Miami, FL Sponsored by Bending the Illness Curve: A New Treatment Model for Early Stage Psychoses Jeffrey A. Lieberman, M.D. Columbia University College
More informationLessons learned and future perspectives. Pia Jeppesen Marianne Melau Merete Nordentoft
Lessons learned and future perspectives Pia Jeppesen Marianne Melau Merete Nordentoft www.opus-kbh.dk Lessons learned from: OPUS trial I Future perspectives - studied in RCTs: OPUS trial II Neurocom CapOpus
More informationEarly Psychosis: A Bridge to Future
Western University Scholarship@Western Psychiatry Presentations Psychiatry 6-19-2007 Early Psychosis: A Bridge to Future Amresh Srivastava University of Western Ontario, Amresh.Srivastava@sjhc.london.on.ca
More informationDurham Research Online
Durham Research Online Deposited in DRO: 14 May 2013 Version of attached file: Peer-review status of attached file: Peer-reviewed Citation for published item: Welsh, P. (2009) Psychology and the At risk
More informationA Counselor s Role in Diagnosing the Proposed DSM-5 Attenuated Psychosis Syndrome: A Pathway to Early Intervention or Iatrogenic Consequences?
Portland State University PDXScholar Regional Research Institute Regional Research Institute 2012 A Counselor s Role in Diagnosing the Proposed DSM-5 Attenuated Psychosis Syndrome: A Pathway to Early Intervention
More informationPredictors for Future Episodes of Psychosis in the adolescent Population: A Systematic Review
Abstract Background: Studies have shown that shorter durations of untreated psychosis are associated with improved responses to antipsychotic treatment and decreased severity of negative symptoms. Therefore
More informationNovember 2014 MRC2.CORP.X.00004
This program is paid for by Otsuka America Pharmaceutical, Inc. and Lundbeck, LLC. The speaker is a paid consultant of Otsuka America Pharmaceutical, Inc. advice or professional diagnosis. Users seeking
More informationMending the Mind: treatment of the severely mentally ill
Mending the Mind: treatment of the severely mentally ill First, the bad news Mental Illness Prevalence: putting things in perspective --More than 54 million Americans have a mental disorder in any given
More informationNIH Public Access Author Manuscript Schizophr Res. Author manuscript; available in PMC 2012 June 1.
NIH Public Access Author Manuscript Published in final edited form as: Schizophr Res. 2011 June ; 129(1): 42 46. doi:10.1016/j.schres.2011.03.029. Psychosis Risk Screening with the Prodromal Questionnaire
More information10. Psychological Disorders & Health
10. Psychological Disorders & Health We will now study different psychological disorders and theories for treating psychopathology. We will also cover health, stress and how to cope with them. The sections
More informationCognitive remediation in Recent Onset Schizophrenia: Results of an effectiveness trial
The Brain Dynamics Centre www.brain-dynamics.net Westmead Hospital & University of Sydney Cognitive remediation in Recent Onset Schizophrenia: Results of an effectiveness trial Dr Anthony Harris University
More informationSevere Mental Disorders. Etheldreda Nakimuli-Mpungu, MMed (Psych), MBChB Johns Hopkins University
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this
More informationSchizophrenia and the Psychoses
Schizophrenia and the Psychoses Taking leave of one s senses Students of schizophrenia need to study and understand: Clinical presentation via case studies Terms and Definitions Biological features Prognosis
More informationSchizophrenia. Psychotic Disorders. Schizophrenia. Chapter 13
Schizophrenia Chapter 13 Psychotic Disorders Symptoms Alternations in perceptions, thoughts, or consciousness (delusions and hallucination) DSM-IV categories Schizophrenia Schizophreniform disorder Schizoaffective
More informationAT RISK MENTAL STATES FOR PSYCHOSIS AND SCHIZOPHRENIA IN CHILDREN AND YOUNG PEOPLE: RECOGNITION AND MANAGEMENT
APPENDIX 13A: CLINICAL EVIDENCE STUDY CHARACTERISTICS TABLES: AT RISK MENTAL STATES FOR PSYCHOSIS AND SCHIZOPHRENIA IN CHILDREN AND YOUNG PEOPLE: RECOGNITION AND MANAGEMENT Abbreviations... 2 Included
More informationSchizophrenia. Psychology 372 Physiological Psychology. Overview. Characterized by. Disorganized Thoughts Hallucinations Delusions Bizarre behaviors
Overview Schizophrenia Psychology 372 Physiological Psychology Steven E. Meier, Ph.D. Listen to the audio lecture while viewing these slides Probably consists of more than one disorder Is the most devastating
More informationSchizophrenia: an inside view. Nepean High School, November 2016 Introduction to Psychology class.
Schizophrenia: an inside view Nepean High School, November 2016 Introduction to Psychology class. Schizophrenia: basic definition Schizophrenia is a chronic and severe mental disorder that affects how
More informationschizophrenia :The latest news By Dr. Gamal Suliman Elgorashi MB BS,DPM, MRCpsych Consultant psychiatrist Kent & Medway NHS Trust UK
schizophrenia :The latest news By Dr. Gamal Suliman Elgorashi MB BS,DPM, MRCpsych Consultant psychiatrist Kent & Medway NHS Trust UK The argument Schizophrenia has for too long been known as a single
More informationPsychotic Disorders and their Treatment
Psychotic Disorders and their Treatment Bruce M. Cohen, M.D., Ph.D. Director, Stanley Research Center, McLean Hospital Professor of Psychiatry, Harvard Medical School MIT 69 Psychotic disorders are characterized
More informationEarly Psychosis Services: Philadelphia PEACE Program
Early Psychosis Services: Philadelphia PEACE Program Irene Hurford, M.D. Clinical Director, PEACE Program, Horizon House Assistant Professor, Department of Psychiatry, University of Pennsylvania 1 John
More informationAnxiety in youth at clinical high risk for psychosis
Anxiety in youth at clinical high risk for psychosis Laina McAusland, University of Calgary Lisa Buchy, University of Calgary Kristin S. Cadenhead, University of California San Diego Tyrone D. Cannon,
More informationPosi%ve Psychotherapy for Youth at Clinical High- Risk for Psychosis
Posi%ve Psychotherapy for Youth at Clinical High- Risk for Psychosis Lauren Drvaric, MSc. Psych., PhD. Candidate (co- inves%gator) Doctoral Research Trainee, Complex Mental Illness, Centre for Addic%on
More informationSchizophrenia. Introduction. Overview and Facts
Introduction is a chronic, severe and disabling brain disease that typically shows its first clear symptoms in late adolescence or early adulthood. It is one of several types of Psychotic Disorders. It
More informationReview Article The promise of early intervention
Early Intervention in Psychiatry 2007; 1: 294 307 doi:10.1111/j.1751-7893.2007.00043.x Review Article The promise of early intervention Jean Addington 1,2,3 1 Department of Psychiatry, University of Toronto,
More informationHope FIRST: An Innovative Treatment for First Episode Psychosis PRESENTATION BY REBECCA FLATTERY, LCSW AND BRIAN ROHLOFF, LPC
Hope FIRST: An Innovative Treatment for First Episode Psychosis PRESENTATION BY REBECCA FLATTERY, LCSW AND BRIAN ROHLOFF, LPC What is a first episode of psychosis? The word psychosis is used to describe
More informationThe use of CBT to prevent transition to psychosis in patients at ultra-high risk. a Journal Club presentation brought to you by Lisa Valentine
The use of CBT to prevent transition to psychosis in patients at ultra-high risk a Journal Club presentation brought to you by Lisa Valentine The Background Recent interest in early detection and intervention
More informationΝευροφυσιολογία και Αισθήσεις
Biomedical Imaging & Applied Optics University of Cyprus Νευροφυσιολογία και Αισθήσεις Διάλεξη 19 Ψυχασθένειες (Mental Illness) Introduction Neurology Branch of medicine concerned with the diagnosis and
More informationPsychopathology Psychopathy (con t) Psychopathy Characteristics High impulsivity Thrill seeking Low empathy Low anxiety What is the common factor? Callous Self-Centeredness N M P Dr. Robert Hare
More informationSocial-Emotional Development in 22q11.2 Deletion Syndrome: Psychiatric Risk Factors
Social-Emotional Development in 22q11.2 Deletion Syndrome: Psychiatric Risk Factors Presentation Outline Behavioral, temperament and psychiatric features Autistic Spectrum Disorders in 22qDS? Cognitive
More informationAbnormal Psychology Exam Notes
Abnormal Psychology Exam Notes Psychotic Disorders- Week 7- Chapter 4 Narrow definitions of psychosis only require the presence of hallucinations and delusions, whereas broad definitions of psychosis incorporate
More informationSchizophrenia. Severe and disabling pattern of disturbed thinking, emotion, perception and behavior.
Schizophrenia Severe and disabling pattern of disturbed thinking, emotion, perception and behavior. Nearly 1 in a 100 suffer from schizophrenia. World- 24 million people suffer from the disorder Strikes
More informationPreventing Psychotic Disorders by Early Detection and Intervention
Preventing Psychotic Disorders by Early Detection and Intervention William R. McFarlane, M.D., Director Early Detection, Intervention for the Prevention of Psychosis National Program Office Robert Wood
More informationFoster sustained recovery. from early psychosis. disorders. Conduct research to. o investigate the etiology of psychosis.
Outreach an nd Support Interventio on Services (OAS SIS) Diana O. Perkins, MD MPH Medical Director, OASIS Professor, Department of Psychiatry University of North Ca arolina at Chapel Hill OASIS Mission
More informationSchizophrenia. Can someone be psychotic without having schizophrenia? 11/30/2008. Name that Psychotic Disorder! Other psychotic disorders and causes
Schizophrenia Other psychotic disorders and causes Name that Psychotic Disorder! Chris has started spending large amounts of time guarding his home. They have bugged his phone and are sending cars past
More informationSchizophrenia. Positive Symptoms. Course of Schizophrenia. Psychotic Disorder
Schizophrenia Kimberley Clow kclow2@uwo.ca http://instruct.uwo.ca/psychology/155b/ Outline What is Schizophrenia? Positive Symptoms Negative Symptoms Subtypes Phases Development Causes Treatment What Is
More informationIs it real or not real? Do I have psychosis?
Is it real or not real? Do I have psychosis? Understanding Psychosis Getting Screened Getting Help Understanding Psychosis Rachel Loewy, Ph.D University of California, San Francisco What is Psychosis?
More informationDr. Fred Rose. Schizophrenia. Nature of Schizophrenia and Psychosis: An Overview. Prevalence of Schizophrenia 10/20/10. Schizophrenia vs.
Schizophrenia Dr. Fred Rose Nature of Schizophrenia and Psychosis: An Overview Schizophrenia vs. Psychosis Psychosis Cluster of disorders; hallucinations and/or loss of contact with reality Schizophrenia
More informationStudy Guide Unit 3 Psych 2022, Fall 2003
Psychological Disorders: General Study Guide Unit 3 Psych 2022, Fall 2003 1. What are psychological disorders? 2. What was the main treatment for some psychological disorders prior to the 1950 s? 3. What
More informationSupplementary Online Content
Supplementary Online Content Subotnik KL, Casaus LR, Ventura J, et al. Long-acting injectable risperidone for relapse prevention and control of breakthrough symptoms after a recent first episode of schizophrenia:
More informationRECEPTOR TARGETS IN SCHIZOPHRENIA: LINKING RECEPTORS TO SYMPTOMS. Jeffrey A. Lieberman, MD Columbia University
RECEPTOR TARGETS IN SCHIZOPHRENIA: LINKING RECEPTORS TO SYMPTOMS Jeffrey A. Lieberman, MD Columbia University JEFFREY A. LIEBERMAN, MD Disclosures Research/Grants: Allon Therapeutics; Forest Laboratories,
More informationCHAPTER 6: ANXIETY AND STRESSOR-RELATED PROBLEMS KEY TERMS
CHAPTER 6: ANXIETY AND STRESSOR-RELATED PROBLEMS KEY TERMS Affectionless Control A type of parenting characterized by high levels of overprotection combined with a lack of warmth and care. Amygdala The
More informationPsychotic Disorders in Children and Adolescents
Psychotic Disorders in Children and Adolescents Dr. Marcelo Rodriguez-Chevres, M.D. Emergence Health Network Learning Objectives Audience will be able to: 1. Distinguish developmentally normal experiences
More informationWeek #1 Classification & Diagnosis
Week #1 Classification & Diagnosis 3 Categories in the Conceptualisation of Abnormality Psychological Dysfunction: Refers to a breakdown in cognitive, emotional or behavioural functioning. Knowing where
More informationPSYCH 335 Psychological Disorders
PSYCH 335 Psychological Disorders Chapter 10 Schizophrenia and Psychotic Disorders Outline/Overview Schizophrenia Statistics/Impact/History Criteria Prognostic indicators/ suicide Epidemiology/correlates
More informationPOSTER PRESENTATIONS FOOTHILLS II
Title: Youth At-Risk of Serious Mental Illness Author(s): Kyle Judd, Catherine Marshall, Glenda MacQueen, Jian Li Wang, Signe Bray, Catherine Lebel, Jean Addington The majority of serious mental illnesses
More informationBREWER, WOOD, MCGORRY, ET AL. (N=81) (56.7% male) were consecutively admitted to a personal assessment and crisis evaluation clinic. Detailed criteria
Article Impairment of Olfactory Identification Ability in Individuals at Ultra-High Risk for Psychosis Who Later Develop Schizophrenia Warrick J. Brewer, Ph.D. Stephen J. Wood, Ph.D. Patrick D. McGorry,
More informationEARLY ONSET SCHIZOPHRENIA
Psychiatry and Addictions Case Conference UW Medicine Psychiatry and Behavioral Sciences EARLY ONSET SCHIZOPHRENIA JON MCCLELLAN CHILD STUDY AND TREATMENT CENTER GENERAL DISCLOSURES The University of Washington
More informationSchizophrenia: Early Intervention
Focus on CME at The University of Western Ontario Schizophrenia: Early Intervention Rahul Manchanda, MD, MRCPsych, FRCP(C); and Ross M.G. Norman, PhD, CPsych Presented at A Psychiatric Update 2003, Regional
More information3/9/2017. A module within the 8 hour Responding to Crisis Course. Our purpose
A module within the 8 hour Responding to Crisis Course Our purpose 1 What is mental Illness Definition of Mental Illness A syndrome characterized by clinically significant disturbance in an individual
More informationGoal: To recognize and differentiate different forms of psychopathology that involve disordered thinking and reasoning and distorted perception
Goal: To recognize and differentiate different forms of psychopathology that involve disordered thinking and reasoning and distorted perception Psychotic disorders, or psychoses, are among the most serious
More informationACOEM Commercial Driver Medical Examiner Training Program
ACOEM Commercial Driver Medical Examiner Training Program Module 7: Psychological Psychological 49 CFR 391.41(b)(9) "A person is physically qualified to drive a commercial motor vehicle if that person
More informationRESEARCH UPDATES: Improving Functioning In Schizophrenia?
RESEARCH UPDATES: Improving Functioning In Schizophrenia? Stephen R. Marder, MD Professor and Director, Section on Psychosis Semel Institute for Neuroscience and Human Behavior at UCLA Director, Mental
More informationOF THE ILLNESS. Manote Lotrakul. Aug 2015
SCHIZOPHRENIA: ALL PHASES OF THE ILLNESS Manote Lotrakul Aug 2015 Outline Diagnostic criteria Clinical features Treatments DSM-5 : Schizophrenia A. Two (or more) of the following, each present for a significant
More informationREVIEW. In our opinion, prevention of psychosis in the prepsychotic precursor stages is possible. GERD HUBER,
REVIEW The Psychosis High-Risk State A Comprehensive State-of-the-Art Review Paolo Fusar-Poli, MD, PhD; Stefan Borgwardt, MD, PhD; Andreas Bechdolf, MD; Jean Addington, PhD; Anita Riecher-Rössler, MD,
More informationCIMR. What is the CIMR? May In this issue. Quarterly Newsletter. Volume 1, Issue 2
What is Department of : What is the? The has recently been established at University Health Network to promote the understanding of depression and mood disorders; to develop innovative evidence-based therapeutic
More information