Circle Yes or No Y N. [If no, skip to question 8.] 2. Has the patient been compliant with therapy as verified by the prescriber?
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1 06/01/2016 Prior Authorization AETA BETTER HEALTH OF MICHIGA (MEDICAID) Tecfidera (MI88) This fax machine is located in a secure location as required by HIPAA regulations. Complete/review information, sign and date. Fax signed forms to Aetna Better Health of Michigan at Please contact Aetna Better Health of Michigan at with questions regarding the Prior Authorization process. When conditions are met, we will authorize the coverage of Tecfidera (MI88). Please note that all authorization requests will be reviewed as the AB rated generic (when available) unless states otherwise. Drug ame (select from list of drugs shown) Tecfidera 120mg (dimethyl fumarate) Tecfidera 240mg (dimethyl fumarate) Tecfidera Starter Pack (dimethyl fumarate) Other, Please specify Quantity Frequency Strength Route of Administration Expected Length of therapy Patient Information Patient ame: Patient ID: Patient Group o.: Patient DOB: Patient Phone: Prescribing Physician Physician ame: Specialty: PI umber: Physician Fax: Physician Phone: Physician Address: City, State, Zip: Diagnosis: ICD Code: Please circle the appropriate answer for each question. Question 1. Has this plan authorized this medication in the past for this patient (i.e., previous authorization is on file under this plan)? Circle es or o [If no, skip to question 8.] 2. Has the patient been compliant with therapy as verified by the prescriber?
2 3. Has the patient demonstrated a positive response to Tecfidera (dimethyl fumarate) and stabilization of MS disease as evidenced by ALL of the following: A) Decrease in frequency and/or severity of relapses, B) Improvement in MRI measures of disease severity (decrease in number or volume of gadolinium-enhancing lesions, T2 hyperintense lesions and/or T1 hypointense lesions)? Circle es or o 4. Is the patient s Expanded Disability Status Scale (EDSS) score less than or equal to 5.5 OR has the patient demonstrated stabilization/improvement in routine neurological observation, mobility, or ability to perform activities of daily living since starting Tecfidera? 5. Has a validated patient reported outcome measure (i.e. Fatigue Impact Scale [FIS], Medical Outcome Study SF- 36, etc) been completed and reviewed by the prescriber? If yes, provide scale used and score or submit documentation with request. 6. Has documentation of a complete blood count (CBC) been submitted with request: If yes, provide lab result and date or submit documentation with request? 7. Does the patient have any of the following exclusions to therapy: A) History of significant gastrointestinal (GI) disease or chronic use of GI medications, B) Active malignancies, C) Steady progression of disability, D) Toxicity or serious adverse reaction to Tecfidera? [o further questions.]
3 8. Does the patient have a definitive diagnosis of a relapsing form of multiple sclerosis, including relapsingremitting multiple sclerosis (RRMS), secondaryprogressive multiple sclerosis (SPMS) with relapses, or progressive-relapsing multiple sclerosis (PRMS), as defined by the McDonald criteria? Circle es or o 9. Does the patient have an Expanded Disability Status Scale (EDSS) score of 5 or less (disability severe enough to impair full daily activities) OR is there documentation supporting the disability within this range? 10. Has the patient had a documented inadequate response (to at least 6 months of therapy) to an interferon beta product (Avonex, Rebif, Betaseron, or Extavia) as defined as meeting TWO of the following: A) Increase in frequency (at least two clinical relapses within the past 12 months), severity and/or sequelae of relapses, B) CS lesion progression as measured by MRI (increased number or volume of gadolinium-enhancing lesions, T2 hyperintense lesions and/or T1 hypointense lesions), C) Sustained worsening of EDSS score, routine neurological observation, mobility, or ability to perform activities of daily living? [If yes, then skip to question 12.] 11. Has the patient had a documented intolerance or hypersensitivity to an interferon beta product (Avonex, Rebif, Betaseron, or Extavia) or contraindication(s) to ALL interferon beta products? ote: eedle phobia or needle fatigue is not considered an intolerance or contraindication.
4 12. Has the patient had a documented inadequate response (to at least 6 months of therapy) to glatiramer acetate (Copaxone) as defined as meeting TWO of the following: A) Increase in frequency (at least two clinical relapses within the past 12 months), severity and/or sequelae of relapses, B) CS lesion progression as measured by MRI (increased number or volume of gadoliniumenhancing lesions, T2 hyperintense lesions and/or T1 hypointense lesions), C) Sustained worsening of EDSS score, routine neurological observation, mobility, or ability to perform activities of daily living? Circle es or o [If yes, then skip to question 14.] 13. Has the patient had a documented intolerance, FDA labeled contraindication, or hypersensitivity to glatiramer acetate (Copaxone)? ote: eedle phobia or needle fatigue is not considered an intolerance or contraindication. 14. Is Tecfidera being prescribed by a board-certified neurologist, board-certified multiple sclerosis physician specialist, or in consultation with one of these specialists? (Please submit consultation notes.) 15. Is the patient currently being treated with another disease-modifying agent for MS that will OT be discontinued when Tecfidera is initiated (i.e., patient will remain on the other agent after Tecfidera is initiated)? [If yes, then no further questions.] 16. Has documentation of a baseline MRI been submitted with the request? 17. Has documentation of a complete blood count (CBC) within 6 months prior to initiating therapy been submitted with the request which confirms that the patient does not have a low lymphocyte count? ote: Further CBC monitoring is recommended at least annually during therapy or as clinically necessary (based on signs and symptoms of infection).
5 Circle es or o 18. Is the patient 18 years of age or older? 19. Does the patient have any of the following exclusions to therapy: A) History of significant gastrointestinal (GI) disease or chronic use of GI medications, B) Active malignancies, C) Steady progression of disability? Comments: I affirm that the information given on this form is true and accurate as of this date. Prescriber (Or Authorized) Signature Prescriber (Or Authorized) Signature Date Date
Prior Authorization. Drug Name (select from list of drugs shown) Gilenya (fingolomid) Quantity Frequency Strength. Physician Name:
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More information3. Did the patient show evidence of remission by week 8 of Humira Y N therapy?
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More information2. Is this request for a preferred medication? Y N
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More information2. Is the patient responding to Remicade therapy? Y N
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More information3. Does the patient continue to receive nutritional or psychological counseling? Y N
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More information[If no, skip to question 10.] Y N. 2. Does the member have a diagnosis of Paget s disease of bone? Y N. [If no, skip to question 4.
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More information3. Has the patient had a sustained improvement in Pain or Function (e.g. PEG scale with a 30 percent response from baseline)?
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More information3. Has bone specific alkaline phosphatase level increased OR does the member have symptoms related to active Paget s?
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More information3. Have baseline A1c or fasting glucose, thyroid-stimulating hormone (TSH), and electrocardiography (EKG) been checked?
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More informationCircle Yes or No Y N. [If no, skip to question 7.] 2. Does the patient have a diagnosis of ulcerative colitis? Y N. [If no, skip to question 4.
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More information2. Does the patient have a diagnosis of Crohn s disease? Y N
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