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1 Bridges Between Bipolar and Borderline Personality Disorders: Clarifying Comorbidity Through the Analysis of Complex Network of Connections Between s Daniel Castro 1, Filipa Ferreira 1, Ana Sofia Mendes 1, Tiago Bento Ferreira 1 1 University Institute of Maia (ISMAI), Maia, Portugal Corresponding author: Daniel Castro dcastro@ismai.pt Received: 12 December 217 Accepted: 19 July 218 Supplementary Material Epub ahead of printing. July, 218

2 Comorbidity network of bipolar disorder and borderline personality disorder Table S1. CIDI Questions and Corresponding s Labels, Numbers, and DSM-5 Criteria Disorder CIDI question Label Depressive Episode In your lifetime, have you ever had two weeks or more when nearly every day you felt sad, blue, or depressed? Has there ever been a period of 2 weeks or longer when you lost your appetite? Has there ever been at least 2 weeks when you had an increase in appetite, other than when you were growing (or pregnant)? Have you ever had 2 weeks or more when nearly every night you had trouble falling asleep? Have you ever had 2 weeks or longer when nearly every day you were sleeping too much? Has there ever been a period lasting 2 weeks or more when you lacked energy or felt tired out all the time even when you had not been working very hard? Has there ever been 2 weeks or more when nearly every day you talked or moved more slowly than is normal for you? Has there ever been 2 weeks or more when nearly every day you had to be moving all the time - that is, you could not sit still and paced up and down? Has there ever been two weeks or more when you lost interest in most things like work, hobbies, or things you usually liked to do for fun? Has there ever been 2 weeks or more when nearly every day you felt worthless? Has there ever been 2 weeks or more when nearly every day you felt guilty? Has there ever been 2 weeks or more when nearly every day you had a lot more trouble concentrating than is normal for you? Have you ever had 2 weeks or more when nearly every day your thoughts came much slower than usual or seemed mixed up? Have you ever had 2 weeks or more when nearly every day you were unable to make up your mind about things you ordinarily have no trouble deciding about? Has there ever been a period of 2 weeks or more when you thought a lot about death either your own, someone else's, or death in general? Have you ever felt so low you thought about committing suicide? Number DSM-5 Criteria Depressed mood 1 A1 Decreased appetite 2 A3 Increased appetite 3 A3 Insomnia 4 A4 Hypersomnia 5 A4 Fatigue 6 A6 Psychomotor retardation 7 A5 Psychomotor agitation 8 A5 Diminished interest 9 A2 Worthlessness 1 A7 Guilt 11 A7 Diminished concentration 12 A8 Slowing thoughts 13 A8 Indecision 14 A8 Thoughts of dead 15 A9 Suicidal ideation 16 A9 Have you ever attempted suicide? Suicidal attempt 17 A9 Epub ahead of printing. July, 218

3 Castro et al Table S1 (Continued). CIDI Questions and Corresponding s Labels, Numbers, and DSM-5 Criteria Disorder CIDI question Label Number DSM-5 Criteria Manic Episode Has there ever been a period of at least two days when you were so happy or excited that you got into trouble, or your family or friends worried about it, or a doctor said you were manic? Has there ever been a period when you were so much more active than usual that you or your family or friends were concerned about it? Has there ever been a period when you went on spending sprees, spending so much money that it caused you or your family some financial trouble, or a period when you made foolish decisions about money? Have you ever had a period when your interest in sex was so much stronger than is typical for you that you wanted to have sex a lot more frequently than is normal for you or with people you normally would not be interested in? Was there ever a period when you were easily distracted so that any little interruption could get you off the track? Has there ever been a period when you hardly slept at all but still did not feel tired or sleepy? Has there ever been a period when you talked so fast that people said they could not understand you or you had to keep talking all of the time? Have you ever had a period when thoughts raced through your head so fast that you could not keep track of them? Has there ever been a period of several days when you could not sit still and paced up and down? Euphoria 18 A Increased activity 19 B6 Money spending 2 B7 Sexual indiscretions 21 B7 Distractibility 22 B5 Decreased sleep 23 B2 Talkative 24 B3 Thought acceleration 25 B4 Psychomotor agitation 8 B6 Epub ahead of printing. July, 218

4 Comorbidity network of bipolar disorder and borderline personality disorder Table S1 (Continued). CIDI Questions and Corresponding s Labels, Numbers, and DSM-5 Criteria Disorder CIDI question Label Number DSM-5 Criteria Borderline Personality Disorder Has there ever been a period of several days when you were so irritable that you threw or broke things, started arguments, shouted at people, or hit someone? Has there ever been a period when you went on spending sprees, spending so much money that it caused you or your family some financial trouble, or a period when you made foolish decisions about money? Have you ever had a period when your interest in sex was so much stronger than is typical for you that you wanted to have sex a lot more frequently than is normal for you or with people you normally would not be interested in? In any one year period of your entire life. did you have at least 12 drinks of any kind of alcoholic beverage? Unstable relationships 26 2 Money spending 2 4 Sexual indiscretions 21 4 Substance abuse 27 4 In general, how much are you unstable? Unstable affect 28 6 In general, how much are you irritable? Anger 29 8 Have you ever attempted suicide? Suicidal attempt 17 5 The idea of losing a close friend is terrifying to me. Fear of abandonment 3 1 I often find that I do not live up to my own standards or ideals. Identity disturbance 31 3 Many times I feel helpless. Emptiness 32 7 Epub ahead of printing. July, 218

5 Comorbidity network of bipolar disorder and borderline personality disorder Table S2.Connections Weights Matrix D1 D2 D3 D4 D5 D6 D7 D8 D9 D1 D11 D12 D13 D14 D15 D16 D17 M1 M2 M3 M4 M5 M6 M7 M8 B1 B2 B3 B4 B5 B6 B7 D D D D D D D D D D D D D D D D D M M M M M M M M B B B B B B B7 Epub ahead of printing. July, 218

6 Comorbidity network of bipolar disorder and borderline personality disorder Table S3. s Centrality, Impact, and Modular Roles Strength Structure Strength Betweenness Closeness Modular Modular Number Label Impact Impact Centrality Centrality Centrality Bridgeness Overlap 1 Depressed Mood Decreased Appetite Increased Appetite Insomnia Hypersomnia Fatigue Psychomotor Retardation Psychomotor Agitation Diminished Interest Worthlessness Guilt Diminished Concentration Slowing Thoughts Indecision Thoughts of Dead Suicidal Ideation Suicidal Attempt Euphoria Increased Activity Money Spending Sexual Indiscretions Distractibility Decreased Sleep Talkative Thought Acceleration Unstable Relationships Substance Abuse Unstable Affect Anger Fear of Abandonment Identity Disturbance Emptiness Epub ahead of printing. July, 218

7 Castro et al Table S4. s Modular Assignment Values Number Label Node Module Depressive Episode Manic Episode Borderline Personality Disorder 1 Depressed Mood Decreased Appetite Increased Appetite Insomnia Hypersomnia Fatigue Psychomotor Retardation Psychomotor Agitation Diminished Interest Worthlessness Guilt Diminished Concentration Slowing Thoughts Indecision Thoughts of Dead Suicidal Ideation Suicidal Attempt Euphoria Increased Activity Money Spending Sexual Indiscretions Distractibility Decreased Sleep Talkative Thought Acceleration Unstable Relationships Substance Abuse Unstable Affect Anger Fear of Abandonment Identity Disturbance Emptiness Epub ahead of printing. July, 218

8 Bridges Between Bipolar and Borderline Personality Disorders: Clarifying Comorbidity Through the Analysis of the Complex Network of Connections Between s Daniel Castro, Filipa Ferreira, Ana Sofia Mendes, Tiago Bento Supplementary materials Figure S1. 95% bootstrapped CIs of the weights of the estimated connections between the symptoms of BD and BPD edge V16 V17 V22 V26 V23 V26 V28 V29 V31 V32 V13 V14 V25 V26 V2 V26 V12 V13 V18 V19 V6 V7 V24 V25 V29 V3 V22 V25 V1 V15 V21 V26 V18 V25 V18 V23 V5 V6 V12 V14 V24 V26 V29 V31 V2 V21 V3 V31 V18 V22 V6 V9 V22 V23 V28 V32 V1 V11 V1 V16 V3 V6 V1 V6 V1 V4 V1 V16 V4 V6 V1 V2 V29 V32 V21 V22 V1 V1 V1 V12 V19 V23 V3 V32 V18 V2 V18 V21 V2 V4 V22 V24 V15 V16 V7 V13 V6 V12 V1 V9 V4 V8 V4 V12 V9 V15 V21 V27 V28 V31 V3 V9 V2 V9 V5 V9 V8 V24 V2 V22 V19 V24 V23 V25 V19 V25 V9 V12 V4 V9 V7 V14 V23 V24 V2 V25 V26 V29 V9 V1 V1 V13 V3 V5 V1 V32 V12 V15 V1 V14 V21 V23 V11 V16 V7 V12 V9 V16 V11 V12 V18 V24 V9 V13 V21 V25 V2 V23 V4 V7 V6 V14 V11 V15 V2 V8 V8 V13 V7 V8 V13 V25 V19 V22 V4 V23 V6 V1 V1 V26 V1 V11 V2 V12 V1 V17 V14 V32 V1 V8 V5 V2 V15 V25 V9 V14 V1 V13 V18 V28 V6 V11 V11 V14 V8 V25 V6 V15 V2 V6 V3 V12 V1 V3 V2 V13 V2 V7 V4 V1 V6 V16 V19 V2 V2 V24 V4 V15 V1 V5 V8 V19 V7 V1 V21 V28 V9 V11 V8 V23 V8 V12 V3 V7 V11 V31 V5 V1 V17 V25 V4 V13 V17 V2 V8 V14 V2 V17 V12 V22 V2 V15 V16 V28 V13 V19 V3 V2 V11 V13 V21 V24 V6 V22 V8 V9 V5 V12 V22 V32 V25 V32 V8 V11 V3 V8 V16 V31 V4 V5 V3 V4 V3 V15 V6 V29 V8 V15 V19 V21 V5 V21 V11 V21 V5 V28 V5 V14 V16 V21 V15 V17 V1 V12 V7 V15 V6 V8 V9 V29 V2 V1 V16 V32 V15 V3 V22 V29 V14 V15 V3 V11 V3 V31 V5 V16 V5 V31 V17 V19 V2 V11 V2 V3 V3 V22 V17 V26 V4 V32 V2 V16 V3 V16 V4 V17 V8 V22 V2 V28 V3 V13 V28 V3 V5 V15 V12 V29 V13 V2 V18 V3 V14 V19 V5 V17 V6 V26 V11 V32 V4 V11 V5 V7 V9 V32 V13 V28 V1 V28 V14 V22 V4 V3 V4 V16 V4 V14 V3 V14 V5 V11 V25 V3 V2 V14 V8 V32 V6 V31 V11 V28 V6 V32 V3 V21 V13 V22 V16 V26 V25 V28 V12 V31 V15 V32 V1 V22 V9 V28 V19 V26 V7 V9 V7 V28 V2 V27 V2 V23 V7 V23 V9 V18 V9 V26 V25 V29 V11 V17 V11 V24 V24 V28 V3 V1 V1 V14 V7 V17 V8 V29 V8 V1 V24 V3 V7 V19 V3 V26 V1 V26 V17 V18 V7 V25 V4 V29 V11 V2 V1 V15 V12 V16 V22 V31 V8 V21 V16 V27 V26 V3 V7 V2 V11 V29 V22 V28 V6 V13 V5 V8 V14 V25 V16 V29 V1 V19 V1 V29 V16 V18 V3 V32 V5 V23 V9 V17 V22 V3 V18 V29 V11 V25 V11 V26 V13 V21 V21 V31 V8 V3 V5 V24 V13 V32 V19 V28 V7 V11 V6 V2 V5 V3 V17 V32 V3 V25 V3 V28 V14 V21 V3 V29 V15 V22 V5 V18 V12 V26 V1 V32 V12 V3 V15 V21 V16 V2 V12 V28 V15 V24 V3 V27 V16 V25 V13 V18 V1 V2 V17 V3 V19 V31 V2 V3 V21 V3 V23 V31 V5 V19 V7 V24 V23 V3 V14 V28 V9 V21 V15 V26 V1 V31 V27 V31 V5 V32 V14 V2 V14 V24 V17 V23 V13 V31 V14 V3 V5 V13 V11 V27 V15 V29 V4 V28 V3 V24 V2 V19 V3 V19 V4 V18 V19 V32 V11 V19 V8 V17 V13 V16 V4 V21 V17 V24 V1 V17 V7 V32 V8 V28 V6 V21 V2 V31 V6 V17 V15 V19 V23 V32 V1 V31 V1 V29 V13 V15 V1 V18 V3 V3 V6 V28 V23 V29 V13 V29 V1 V21 V4 V31 V4 V26 V17 V28 V9 V31 V13 V23 V16 V24 V14 V17 V17 V29 V2 V26 V15 V31 V15 V28 V2 V3 V2 V29 V16 V22 V16 V23 V13 V17 V22 V27 V15 V2 V17 V21 V5 V29 V5 V26 V12 V32 V2 V32 V9 V2 V16 V19 V19 V29 V6 V25 V18 V32 V2 V2 V2 V25 V4 V25 V17 V31 V12 V18 V25 V27 V24 V32 V9 V25 V24 V29 V3 V18 V9 V19 V15 V18 V2 V29 V17 V22 V2 V32 V14 V26 V8 V18 V2 V27 V13 V24 V7 V29 V12 V19 V6 V3 V9 V22 V26 V31 V7 V3 V5 V25 V14 V31 V18 V27 V2 V31 V14 V29 V25 V31 V17 V27 V19 V3 V13 V3 V23 V27 V4 V22 V11 V3 V1 V24 V7 V16 V1 V21 V7 V18 V2 V5 V27 V28 V12 V25 V1 V27 V14 V18 V6 V24 V5 V27 V1 V25 V3 V17 V21 V29 V4 V24 V24 V31 V9 V3 V27 V29 V1 V3 V12 V23 V4 V2 V18 V31 V12 V21 V14 V16 V6 V19 V7 V27 V7 V26 V12 V17 V1 V19 V4 V27 V8 V31 V11 V18 V2 V28 V13 V26 V14 V27 V1 V7 V8 V26 V15 V23 V12 V27 V7 V31 V6 V27 V23 V28 V1 V2 V19 V27 V12 V2 V11 V22 V2 V24 V9 V23 V5 V22 V4 V19 V12 V24 V15 V27 V1 V28 V8 V27 V16 V3 V21 V32 V13 V27 V1 V18 V14 V23 V1 V23 V1 V3 V1 V25 V1 V24 V7 V22 V2 V18 V2 V22 V26 V28 V9 V27 V3 V23 V26 V27 V11 V23 V1 V27 V8 V16 V8 V2 V26 V32 V9 V24 V1 V22 V7 V21 V2 V21 V6 V23 V1 V23 V6 V18 V24 V27 V27 V32 V27 V3 V18 V Note. V1 = Depressed Mood; V2 = Decreased Appetite; V3 = Increased Appetite; V4 = Insomnia; V5 = Hypersomnia; V6 = Fatigue; V7 = Psychomotor retardation; V8 = Psychomotor Agitation; V9 = Diminished Interest; V1 = Whorthlessness; V11 = Guilt; V12 = Diminished Concentration; V13 = Slowing Thoughts; V14 = Indecision; V15 = Thoughts of Dead; V16 = Suicidal Ideation; V17 = Suicide Attempt; V18 = Euphoria; V19 = Increased Activity; V2 = Money Spending; V21 = Sexual Indiscretions; V22 = Distractability; V23 = Decreased Sleep; V24 = Talkative; V25 = Thought Acceleration; V26 = Unstable Relationships; V27 = Substance Abuse; V28 = Unstable Affect; V29 = Anger; V3 = Fear of Abandonment; V31 = Identity Disturbance; V32 = Emptiness. The red dots indicate the weight of each of the estimated connections. The gray area indicates the corresponding 95% bootstrapped CI.

9 Bridges Between Bipolar and Borderline Personality Disorders: Clarifying Comorbidity Through the Analysis of the Complex Network of Connections Between s Daniel Castro, Filipa Ferreira, Ana Sofia Mendes, Tiago Bento Supplementary materials Figure S2. Average correlations of the centrality measures between different sub samples of different sizes and the original complete sample 1. Average correlation with original sample.5..5 type betweenness closeness strength 1. 9% 8% 7% 6% 5% Sampled people Note. Means are indicated by the lines and the range of quantile is represented by the areas. 4% 3%

10 V16 V17 V22 V26 V23 V26 V28 V29 V31 V32 V13 V14 V25 V26 V2 V26 V12 V13 V18 V19 V6 V7 V24 V25 V29 V3 V22 V25 V1 V15 V21 V26 V18 V25 V18 V23 V5 V6 V12 V14 V24 V26 V29 V31 V2 V21 V3 V31 V18 V22 V6 V9 V22 V23 V28 V32 V1 V11 V1 V16 V3 V6 V1 V6 V1 V4 V1 V16 V4 V6 V1 V2 V29 V32 V21 V22 V1 V1 V1 V12 V19 V23 V3 V32 V18 V2 V18 V21 V2 V4 V22 V24 V15 V16 V7 V13 V6 V12 V1 V9 V4 V8 V4 V12 V9 V15 V21 V27 V28 V31 V3 V9 V2 V9 V5 V9 V8 V24 V2 V22 V19 V24 V23 V25 V19 V25 V9 V12 V4 V9 V7 V14 V23 V24 V2 V25 V26 V29 V9 V1 V1 V13 V3 V5 V1 V32 V12 V15 V1 V14 V21 V23 V11 V16 V7 V12 V9 V16 V11 V12 V18 V24 V9 V13 V21 V25 V2 V23 V4 V7 V6 V14 V11 V15 V2 V8 V8 V13 V7 V8 V13 V25 V19 V22 V4 V23 V6 V1 V1 V26 V1 V11 V2 V12 V1 V17 V14 V32 V1 V8 V5 V2 V15 V25 V9 V14 V1 V13 V18 V28 V6 V11 V11 V14 V8 V25 V6 V15 V2 V6 V3 V12 V1 V3 V2 V13 V2 V7 V4 V1 V6 V16 V19 V2 V2 V24 V4 V15 V1 V5 V8 V19 V7 V1 V21 V28 V9 V11 V8 V23 V8 V12 V3 V7 V11 V31 V5 V1 V17 V25 V4 V13 V17 V2 V8 V14 V2 V17 V12 V22 V2 V15 V16 V28 V13 V19 V3 V2 V11 V13 V21 V24 V6 V22 V8 V9 V5 V12 V22 V32 V25 V32 V8 V11 V3 V8 V16 V31 V4 V5 V3 V4 V3 V15 V6 V29 V8 V15 V19 V21 V5 V21 V11 V21 V5 V28 V5 V14 V16 V21 V15 V17 V1 V12 V7 V15 V6 V8 V9 V29 V2 V1 V16 V32 V15 V3 V22 V29 V14 V15 V3 V11 V3 V31 V5 V16 V5 V31 V17 V19 V2 V11 V2 V3 V3 V22 V17 V26 V4 V32 V2 V16 V3 V16 V4 V17 V8 V22 V2 V28 V3 V13 V28 V3 V5 V15 V12 V29 V13 V2 V18 V3 V14 V19 V5 V17 V6 V26 V11 V32 V4 V11 V5 V7 V9 V32 V13 V28 V1 V28 V14 V22 V4 V3 V4 V16 V4 V14 V3 V14 V5 V11 V25 V3 V2 V14 V8 V32 V6 V31 V11 V28 V6 V32 V3 V21 V13 V22 V16 V26 V25 V28 V12 V31 V15 V32 V1 V22 V9 V28 V24 V27 V27 V32 V27 V3 V18 V26 Bridges Between Bipolar and Borderline Personality Disorders: Clarifying Comorbidity Through the Analysis of the Complex Network of Connections Between s Daniel Castro, Filipa Ferreira, Ana Sofia Mendes, Tiago Bento Supplementary materials Figure S3. Bootstrap difference tests (alpha =.5) between the weights of the connections between the symptoms of BD and BPD that were non zero in the estimated comorbidity network edge V18 V26 V27 V3 V27 V32 V24 V27 V9 V28 V1 V22 V15 V32 V12 V31 V25 V28 V16 V26 V13 V22 V3 V21 V6 V32 V11 V28 V6 V31 V8 V32 V2 V14 V25 V3 V5 V11 V3 V14 V4 V14 V4 V16 V4 V3 V14 V22 V1 V28 V13 V28 V9 V32 V5 V7 V4 V11 V11 V32 V6 V26 V5 V17 V14 V19 V18 V3 V13 V2 V12 V29 V5 V15 V28 V3 V3 V13 V2 V28 V8 V22 V4 V17 V3 V16 V2 V16 V4 V32 V17 V26 V3 V22 V2 V3 V2 V11 V17 V19 V5 V31 V5 V16 V3 V31 V3 V11 V14 V15 V22 V29 V15 V3 V16 V32 V2 V1 V9 V29 V6 V8 V7 V15 V1 V12 V15 V17 V16 V21 V5 V14 V5 V28 V11 V21 V5 V21 V19 V21 V8 V15 V6 V29 V3 V15 V3 V4 V4 V5 V16 V31 V3 V8 V8 V11 V25 V32 V22 V32 V5 V12 V8 V9 V6 V22 V21 V24 V11 V13 V3 V2 V13 V19 V16 V28 V2 V15 V12 V22 V2 V17 V8 V14 V17 V2 V4 V13 V17 V25 V5 V1 V11 V31 V3 V7 V8 V12 V8 V23 V9 V11 V21 V28 V7 V1 V8 V19 V1 V5 V4 V15 V2 V24 V19 V2 V6 V16 V4 V1 V2 V7 V2 V13 V1 V3 V3 V12 V2 V6 V6 V15 V8 V25 V11 V14 V6 V11 V18 V28 V1 V13 V9 V14 V15 V25 V5 V2 V1 V8 V14 V32 V1 V17 V2 V12 V1 V11 V1 V26 V6 V1 V4 V23 V19 V22 V13 V25 V7 V8 V8 V13 V2 V8 V11 V15 V6 V14 V4 V7 V2 V23 V21 V25 V9 V13 V18 V24 V11 V12 V9 V16 V7 V12 V11 V16 V21 V23 V1 V14 V12 V15 V1 V32 V3 V5 V1 V13 V9 V1 V26 V29 V2 V25 V23 V24 V7 V14 V4 V9 V9 V12 V19 V25 V23 V25 V19 V24 V2 V22 V8 V24 V5 V9 V2 V9 V3 V9 V28 V31 V21 V27 V9 V15 V4 V12 V4 V8 V1 V9 V6 V12 V7 V13 V15 V16 V22 V24 V2 V4 V18 V21 V18 V2 V3 V32 V19 V23 V1 V12 V1 V1 V21 V22 V29 V32 V1 V2 V4 V6 V1 V16 V1 V4 V1 V6 V3 V6 V1 V16 V1 V11 V28 V32 V22 V23 V6 V9 V18 V22 V3 V31 V2 V21 V29 V31 V24 V26 V12 V14 V5 V6 V18 V23 V18 V25 V21 V26 V1 V15 V22 V25 V29 V3 V24 V25 V6 V7 V18 V19 V12 V13 V2 V26 V25 V26 V13 V14 V31 V32 V28 V29 V23 V26 V22 V26 V16 V17 Note. V1 = Depressed Mood; V2 = Decreased Appetite; V3 = Increased Appetite; V4 = Insomnia; V5 = Hypersomnia; V6 = Fatigue; V7 = Psychomotor retardation; V8 = Psychomotor Agitation; V9 = Diminished Interest; V1 = Whorthlessness; V11 = Guilt; V12 = Diminished Concentration; V13 = Slowing Thoughts; V14 = Indecision; V15 = Thoughts of Dead; V16 = Suicidal Ideation; V17 = Suicide Attempt; V18 = Euphoria; V19 = Increased Activity; V2 = Money Spending; V21 = Sexual Indiscretions; V22 = Distractability; V23 = Decreased Sleep; V24 = Talkative; V25 = Thought Acceleration; V26 = Unstable Relationships; V27 = Substance Abuse; V28 = Unstable Affect; V29 = Anger; V3 = Fear of Abandonment; V31 = Identity Disturbance; V32 = Emptiness. Connections between symptoms that do not differ significantly from one another are represented in gray boxes; the black boxes represent the connections between symptoms that do differ significantly. Colored boxes correspond to the color of the connections in Figure 1 of the paper and represent the weight of each connection. Red boxes represent negative connections weights, and blue boxes represent positive connections weights (the darker the blue tone, the stronger the connection weight).

11 Bridges Between Bipolar and Borderline Personality Disorders: Clarifying Comorbidity Through the Analysis of the Complex Network of Connections Between s Daniel Castro, Filipa Ferreira, Ana Sofia Mendes, Tiago Bento Supplementary materials Figure S4. Bootstrap difference tests (alpha =.5) between the strength centrality of each one of the 32 symptoms of BD and BPD strength 26: Unstable Relationships 6: Fatigue 22: Distractability 25: Thought Acceleration 1: Depressed Mood 18: Euphoria 12: Diminished Concentration 16: Suicidal Ideation 23: Decreased Sleep 9: Diminished Interest 13: Slowing Thoughts 4: Insomnia 21: Sexual Indiscretions 2: Money Spending 32: Emptiness 1: Whorthlessness 14: Indecision 29: Anger 24: Talkative 15: Thoughts of Dead 8: Psychomotor Agitation 31: Identity Disturbance 11: Guilt 7: Psychomotor retardation 19: Increased Activity 17: Suicide Attempt 28: Unstable Affect 2: Decreased Appetite 5: Hypersomnia 3: Increased Appetite 3: Fear of Abandonment 27: Substance Abuse : Substance Abuse 3: Fear of Abandonment 3: Increased Appetite 5: Hypersomnia 2: Decreased Appetite 28: Unstable Affect 17: Suicide Attempt 19: Increased Activity 7: Psychomotor retardation 11: Guilt 31: Identity Disturbance 8: Psychomotor Agitation 15: Thoughts of Dead 24: Talkative 29: Anger 14: Indecision 1: Whorthlessness 32: Emptiness 2: Money Spending 21: Sexual Indiscretions 4: Insomnia 13: Slowing Thoughts 9: Diminished Interest 23: Decreased Sleep 16: Suicidal Ideation 12: Diminished Concentration 18: Euphoria 1: Depressed Mood 25: Thought Acceleration 22: Distractability 6: Fatigue 26: Unstable Relationships Note. Gray boxes represent symptoms that do not differ significantly from one another and the black boxes represent symptoms that do differ significantly. The value of each symptom strength centrality is indicated in the white boxes.

12 1: Depressed Mood 26: Unstable Relationships 25: Thought Acceleration 13: Slowing Thoughts 23: Decreased Sleep 4: Insomnia 22: Distractability 12: Diminished Concentration 1: Whorthlessness 2: Money Spending 15: Thoughts of Dead 14: Indecision 6: Fatigue 24: Talkative 18: Euphoria 16: Suicidal Ideation 21: Sexual Indiscretions 9: Diminished Interest 8: Psychomotor Agitation 5: Hypersomnia 32: Emptiness 17: Suicide Attempt 7: Psychomotor retardation 2: Decreased Appetite 29: Anger 31: Identity Disturbance 19: Increased Activity 28: Unstable Affect 11: Guilt 3: Fear of Abandonment 3: Increased Appetite 27: Substance Abuse Bridges Between Bipolar and Borderline Personality Disorders: Clarifying Comorbidity Through the Analysis of the Complex Network of Connections Between s Daniel Castro, Filipa Ferreira, Ana Sofia Mendes, Tiago Bento Supplementary materials Figure S5. Bootstrap difference tests (alpha =.5) between the closeness centrality of the 32 symptoms of BD and BPD closeness : Substance Abuse 3: Increased Appetite 3: Fear of Abandonment 11: Guilt 28: Unstable Affect 19: Increased Activity 31: Identity Disturbance 29: Anger 2: Decreased Appetite 7: Psychomotor retardation 17: Suicide Attempt 32: Emptiness 5: Hypersomnia 8: Psychomotor Agitation 9: Diminished Interest 21: Sexual Indiscretions 16: Suicidal Ideation 18: Euphoria 24: Talkative 6: Fatigue 14: Indecision 15: Thoughts of Dead 2: Money Spending 1: Whorthlessness 12: Diminished Concentration 22: Distractability 4: Insomnia 23: Decreased Sleep 13: Slowing Thoughts 25: Thought Acceleration 26: Unstable Relationships 1: Depressed Mood Note. Gray boxes represent symptoms that do not differ significantly from one another and the black boxes represent symptoms that do differ significantly. The value of each symptom closeness centrality is indicated in the white boxes.

13 Bridges Between Bipolar and Borderline Personality Disorders: Clarifying Comorbidity Through the Analysis of the Complex Network of Connections Between s Daniel Castro, Filipa Ferreira, Ana Sofia Mendes, Tiago Bento Supplementary materials Figure S6. Bootstrap difference tests (alpha =.5) between the betweenness centrality of the 32 symptoms of BD and BPD betweenness 26: Unstable Relationships 3 1: Depressed Mood 26 32: Emptiness 11 1: Whorthlessness 11 6: Fatigue 11 29: Anger 8 25: Thought Acceleration 74 13: Slowing Thoughts 54 16: Suicidal Ideation 5 18: Euphoria 46 21: Sexual Indiscretions 4 4: Insomnia 4 12: Diminished Concentration 34 23: Decreased Sleep 32 14: Indecision 3 2: Money Spending 26 24: Talkative 24 5: Hypersomnia 6 8: Psychomotor Agitation 6 28: Unstable Affect 4 15: Thoughts of Dead 4 9: Diminished Interest 2 3: Fear of Abandonment 2 22: Distractability 17: Suicide Attempt 31: Identity Disturbance 7: Psychomotor retardation 19: Increased Activity 11: Guilt 3: Increased Appetite 2: Decreased Appetite 27: Substance Abuse 27: Substance Abuse 2: Decreased Appetite 3: Increased Appetite 11: Guilt 19: Increased Activity 7: Psychomotor retardation 31: Identity Disturbance 17: Suicide Attempt 22: Distractability 3: Fear of Abandonment 9: Diminished Interest 15: Thoughts of Dead 28: Unstable Affect 8: Psychomotor Agitation 5: Hypersomnia 24: Talkative 2: Money Spending 14: Indecision 23: Decreased Sleep 12: Diminished Concentration 4: Insomnia 21: Sexual Indiscretions 18: Euphoria 16: Suicidal Ideation 13: Slowing Thoughts 25: Thought Acceleration 29: Anger 6: Fatigue 1: Whorthlessness 32: Emptiness 1: Depressed Mood 26: Unstable Relationships Note. Gray boxes represent symptoms that do not differ significantly from one another and the black boxes represent symptoms that do differ significantly. The value of each symptom betweenness centrality is indicated in the white boxes.