308 nm excimer lamp in combination with topical tacrolimus: A retrospective study of its efficacy and safety in childhood vitiligo

Size: px
Start display at page:

Download "308 nm excimer lamp in combination with topical tacrolimus: A retrospective study of its efficacy and safety in childhood vitiligo"

Transcription

1 ORIGINAL ARTICLE 308 nm excimer lmp in comintion with topicl tcrolimus: A retrospective study of its efficcy nd sfety in childhood vitiligo BS Chndrshekr, N Shoh, P Deprtment of Dermtology, Cutis, Acdemy of Cutneous Sciences, Bnglore ABSTRACT Vitiligo is chronic, polygenic dyschromi tht presents with multiple depigmented mcules nd ptches. Among the vrious therpeutic modlities for tretment of vitiligo in children, phototherpy s one of the minsty tretments hs vrying therpeutic efficcy. There is limited dt regrding the use of comintion of tcrolimus nd 308 nm excimer lmp for tretment of vitiligo in children. The im of the present study is to retrospectively ssess the efficcy nd tolerility of 308 nm Excimer lmp in comintion with topicl tcrolimus to tret vitiligo in children elow 17 yers with skin type III, IV nd V. Methods: Cse sheets nd photogrphs of 47 vitiligo ptches from 24 children (mle = 9, femle = 15), <17 yers were evluted in this study. Dt of ptients with ctive disese nd stle vitiligo not treted previously were chosen for this study. The ptches were treted with topicl tcrolimus dily nd excimer lmp thrice weekly, for mximum of 20 sittings. Results: Of the 47 ptches, 35 ptches chieved repigmenttion ccounting to 74.4% of the totl ptches. The repigmenttion response ws good in ultrviolet (UV) sensitive res ut miniml in UV resistnt res. All the ptches retined pigmenttion during the follow-up period of months. Conclusion: The degree of repigmenttion chieved with topicl tcrolimus nd excimer lmp in period of 4-6 weeks is much higher thn other contemporry vitiligo therpies in children. This dul therpy of topicl tcrolimus nd 308 nm Excimer lmp is sfe nd effective therpy showing n erly response, for loclized vitiligo in children. Key words: 308 nm excimer lmp, childhood vitiligo, repigmenttion, topicl tcrolimus INTRODUCTION itiligo is chronic, idiopthic cquired disorder which is chrcterized y progressive loss of melnocytes from the epidermis nd the epiderml ppendges. However successful tretment of vitiligo in ll ptients is still mirge, lthough vrious comintion modlities like topicl steroids, immunomodultors, phototherpy nd surgicl therpies re commonly used. In the mjority of Quick Response Code Access this rticle online Wesite: DOI: / ptients, it ffects the psychosocil development nd prevlence of vitiligo is 1 3%. [1] In 50% of ffected ptients, the onset is elow 20 yers of ge, [2] further dding on to prentl pprehensions nd nxiety. Therefore, it is very importnt tht childhood vitiligo is dignosed nd treted t the pproprite time. normlities of oth humorl nd cell medited immunity. Tcrolimus, topicl immunomodultor, modultes the immune system y inhiiting T cell ctivtion through down regultion of the ADDRESS FOR CORRESPONDENCE Dr. BS Chndrshekr, #5/1, 4 th Min Rod, MRCR Lyout, Ner Veeresh Thetre Behind Godrej Interio, Vijyngr, Bengluru , Krntk, Indi. E-mil: cutisclinic@gmil.com 74

2 trnscription genes encoding proinflmmtory cytokines, nmely interleukin (IL) 2, IL 3, IL 4, γ α grnulocyte mcrophge colony stimulting fctor. pproved for topic dermtitis nd is used off lel for severl other dermtologic conditions, such of ction of tcrolimus hs een elucidted, dt descriing how tcrolimus modultes the cutneous milieu remin unknown. [3] The 308 nm excimer lmp genertes single spot size of 2 cm 2 cm nd pulse repetition rte up to 200 Hz. It hs n djustle exposure time. The 308 nm wvelength is prticulrly effective t inducing poptosis of T lymphocytes nd stimultion of melnocyte migrtion nd prolifertion from the niche locted in the hir follicles. [4] It stilizes the progression of the disese nd induces n erly repigmenttion with fce lesions responding the erliest nd est. [5] is chieved, depending on dosge nd loction of 308 nm excimer lmp therpy is the difficulty in cost of tretment nd equipment. [4] lmp is n effective modlity to tret vitiligo in dults. However its efficcy in children is less explored. AIM To retrospectively ssess the efficcy nd tolerility tcrolimus to tret vitiligo in children elow 17 yers METHODS Cse sheets nd photogrphs of 47 vitiligo ptches in 24 children (mle = 9, femle = 15), less thn 17 yers were included in the study. Dt of ptients with ctive disese nd stle vitiligo, previously not treted were chosen for this study. Tretment hd strted with one miniml erythem dose (equivlent to 150 mj/cm 2 ) nd ws incresed in stepwise pttern y 100 mj/cm 2 every sitting until redness hd developed, in which cse the dose ws kept constnt, reduced or skipped (if urning or listering developed). Tretment ws given thrice tcrolimus ws used for ll ptches on dily sis protective glsses. neck, lips nd sclp, trunk, lims nd extremities, which were tken t seline, 2 nd, 4 th nd 6 th week of tretment, were evluted for erythem nd otining repigmenttion scores. The repigmenttion ws grded on 5 point scle, (0 4) ssessed ccording to Tle 1. RESULTS 47 vitiligo ptches in 24 children were evluted for repigmenttion on 5 point scle (0 4) s shown in Tle 1. Of the 47 ptches 35 ptches hve shown repigmenttion, ccounting to 74.4% of the totl tht hve chieved 0 4 grdes of repigmenttion. Some of the ptches egn repigmenttion s erly s the 4 th ptches responded y the 12 th week of the tretment except for the ptches on plms, soles nd sclp. The vried response of ll vitiligo ptches from different Tle 2. Tle 1: The grding repigm enttion Grdes Repigmenttion ( % ) Tle 2: The repigmenttion grdes t different ody sites fter 20 sittings of excimer lmp therpy Grde of repigmenttion Totl ( 47) Fce nd neck Trunk Lims Lips Plms, soles, fingers nd toes Sclp Averge dose (mj/ cm 2 )

3 Seven out of 19 ptches hd % repigmenttion the excimer lmp. Complete repigmenttion of the the ptches in the trunk region responded to the excimer lmp. Out of 4 ptches in the lims, 2 ptches showed Out of nine ptches in this region, only two ptches no repigmenttion t ll. The Lips nd Sclp Like the extremities, this re too showed comprtively poor response to excimer lmp tretment s shown in repigmenttion. Both the ptches in the sclp showed retined the pigmenttion during the months follow up period. DISCUSSION Of ll the modlities ville for treting vitiligo in children, phototherpy is the minsty nd is involvement. It requires regulr sessions severl times week for out yer to chieve expected therpeutic response. Trgeted 308 nm excimer monotherpy is n lterntive therpy which ctively controls the disese progression nd lso induces repigmention in short durtion. In study y Ostovri et l., the effectiveness of the 308 nm excimer lmp tretment ws not ffected y ptient ge, suggesting tht this modlity my e useful in the peditric popultion. [6] dvntge of delivering high intensity rdition to the disesed skin, thus reducing the exposure of norml skin to rdition side effects. [2] Ostovri et l. nd Tnej et l sensitive res chieved 75% repigmenttion versus [6,7] neck nd lims) showed repigmenttion, of which plms, soles, fingers nd toes) 4 ptches (=25%) ptients chieved more thn 75% repigmenttion on 3 months tretment. [8] Studies y Hofer et l. with excimer showed more thn 75% repigmenttion in 13% of ptients with 30 tretment sessions. [9] These dt indicte tht repigmenttion is chieved within 30 tretment sessions. This is comprle to our study where repigmenttion response ws noted s erly s the fourth sitting, with incresing pigmenttion on continuing tretment (74.4% repigmenttion of 35/47 ptches over 7 weeks tretment), with n verge dose of 500 mj/cm 2 in showed miniml response with n verge dose s high s 1400 mj/cm 2 repigmenttion did not egin y the 12 th sitting then proly further sittings with excimer or lternte phototherpy re not eneficil. topicl tcrolimus with excimer lmp cts synergisticlly reducing the durtion of clinicl response. [10,11] Figure 1: Pie chrt depicting the overll repigmenttion grdes chieved in 20 sittings of excimer lmp therpy Side effects were noted in 6 ptches (fce, neck nd lips) cutioning the slow increment in the dose of rdition 76

4 Figure 2 nd : Pictures efore the excimer tretment nd fter 4 th sitting depicting the strt of repigmenttion Figure 3: Br chrt showing grdes of repigmenttion t different sites following excimer lmp tretment Figure 4 nd : Grde 4 repigmenttion efore the excimer tretment in 4 nd fter 20 sittings of the excimer tretment in 4 Figure 5 nd : Grde 0 repigmenttion in the lips region efore the excimer lser tretment 5 nd fter 20 sittings of the excimer tretment 5 considered. Topicl tcrolimus nd excimer lmp ct synergisticlly, therey reducing the durtion of clinicl response. Figure 6-c: Pictures efore excimer therpy in 6, 6 showing of erythem nd urns following the 9 th sitting. Grde 4 improvements ws seen y the end of 15 th sitting depicted in 6c ws noted in some ptches which reduced following discontinution of therpy. However, further prospective studies with lrger study popultion nd control group cn e conducted to study the effect of excimer therpy in children. CONCLUSION repigmenttion, primrily children with vitiligo in children s it prevents clustrophoi, which is excimer lmp, n lternte therpy should e c 308 nm excimer lmps cn e sfely used, with n effective nd erly response in childhood vitiligo, minimizing the exposure to rdition thus resulting in cosmeticlly stisfying results. REFERENCES 1. Hdi SM, Spencer JM, Lewohl M. The use of the 308 nm excimer lser for the tretment of vitiligo. Dermtol Surg et l. Tretment of vitiligo y 308 nm excimer lser: 77

5 et l. Topicl tcrolimus nd the 308 nm excimer How to cite this rticle: Chndrshekr BS, Shoh N, Jgdish P, Vsnth V, Rjshekr ML, Sndeep MA. 308 nm excimer lmp in comintion with topicl tcrolimus: A retrospective study of its efficcy nd sfety in childhood vitiligo. Indin J Peditr Dermtol 2014;15:74-8. Source of Support: Nil, Conflict of Interest: None declred Announcement iphone App A free ppliction to rowse nd serch the journl s content is now ville for iphone/ipd. The ppliction provides Tle of Contents of the ltest issues, which re stored on the device for future offline rowsing. Internet connection is required to ccess the ck issues nd serch fcility. The ppliction is Comptile with iphone, ipod touch, nd ipd nd Requires ios 3.1 or lter. The ppliction cn e downloded from id ?ls=1&mt=8. For suggestions nd comments do write ck to us. 78

Punch Skin Graft in Stable Vitiligo: Donor and Recipient Site Changes - A Retrospective Study

Punch Skin Graft in Stable Vitiligo: Donor and Recipient Site Changes - A Retrospective Study Originl Article Print ISSN: 2321-6379 Online ISSN: 2321-595X DOI: 10.17354/ijss/2017/430 Punch Skin Grft in Stle Vitiligo: Donor nd Recipient Site Chnges - A Retrospective Study Muthukumrn Rjrm 1, Um Selvrj

More information

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer CheckMte 53: Rndomized Results of Continuous vs -Yer Fixed-Durtion Nivolumb in Ptients With Advnced Non-Smll Cell Lung Cncer Abstrct 297O Spigel DR, McCleod M, Hussein MA, Wterhouse DM, Einhorn L, Horn

More information

Evaluation of Microneedling Fractional Radiofrequency Device for Treatment of Acne Scars

Evaluation of Microneedling Fractional Radiofrequency Device for Treatment of Acne Scars Originl Article Evlution of Microneedling Frctionl Rdiofrequency Device for Tretment of Acne Scrs Bylekere Shivnn Chndrshekr, Rshmi Srirm, Rjdeep Mysore, Spnshree Bhskr, Ahishek Shetty Deprtment of Dermtology,

More information

Efficacy of Pembrolizumab in Patients With Advanced Melanoma With Stable Brain Metastases at Baseline: A Pooled Retrospective Analysis

Efficacy of Pembrolizumab in Patients With Advanced Melanoma With Stable Brain Metastases at Baseline: A Pooled Retrospective Analysis Efficcy of Pembrolizumb in Ptients With Advnced Melnom With Stble Brin Metstses t Bseline: A Pooled Retrospective Anlysis Abstrct 1248PD Hmid O, Ribs A, Dud A, Butler MO, Crlino MS, Hwu WJ, Long GV, Ancell

More information

SYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT

SYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT Finl Arevited Clinicl Study Report Nme of Sponsor/Compny: Bristol-Myers Squi Ipilimum Individul Study Tle Referring to the Dossier (For Ntionl Authority Use Only) Nme of Finished Product: Yervoy Nme of

More information

PROVEN ANTICOCCIDIAL IN NEW FORMULATION

PROVEN ANTICOCCIDIAL IN NEW FORMULATION PROVEN ANTICOCCIDIAL IN NEW FORMULATION Coxidin 100 microgrnulte A coccidiosttic dditive for roilers, chickens rered for lying nd turkeys Contins 100 g of monensin sodium per kg Aville s homogenous grnules

More information

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 :

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 : PNEUMOVAX 23 is recommended y the CDC for ll your pproprite dult ptients t incresed risk for pneumococcl disese 1,2 : Adults ged

More information

Identical twins with borderline lepromatous leprosy mimicking extensive alopecia areata: A rare presentation

Identical twins with borderline lepromatous leprosy mimicking extensive alopecia areata: A rare presentation Lepr Rev (2018) 89, 301 305 CASE REPORT Identicl twins with orderline lepromtous leprosy mimicking extensive lopeci ret: A rre presenttion RUBINA JASSI*, KRISHNA DEB BURMAN**, BHAVYA SWARNKAR** & RADHIKA

More information

Using Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids

Using Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids Using Pcloutrzol to Suppress Inflorescence Height of Potted Phlenopsis Orchids A REPORT SUBMITTED TO FINE AMERICAS Linsey Newton nd Erik Runkle Deprtment of Horticulture Spring 28 Using Pcloutrzol to Suppress

More information

Invasive Pneumococcal Disease Quarterly Report July September 2018

Invasive Pneumococcal Disease Quarterly Report July September 2018 Invsive Pneumococcl Disese Qurterly Report July Septemer Introduction Since 17 Octoer 2008, invsive pneumococcl disese (IPD) hs een notifile to the locl Medicl Officer of Helth under the Helth Act 1956.

More information

WSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265;

WSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265; FINAL REPORT WTFRC Project # AH-1-5 WSU Project # 13C-355-3 Project title: PI: Orgniztion: Coopertors: of Sunburn in Apples with RAYNOX Lrry Schrder, Horticulturist WSU Tree Fruit Reserch nd Extension

More information

The Dynamics of Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus

The Dynamics of Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus Chpter 2 The Dynmics of Vricell-Zoster Virus Epithelil Kertitis in Herpes Zoster Ophthlmicus The morphology of n individul VZV lesion reflects sequence of events triggered y the virus impct on cornel epithelil

More information

Presented at the 75 th Annual Meeting of the American Academy of Dermatology, Orlando, FL, March 3-7, 2017 METHODS INTRODUCTION OBJECTIVE

Presented at the 75 th Annual Meeting of the American Academy of Dermatology, Orlando, FL, March 3-7, 2017 METHODS INTRODUCTION OBJECTIVE Seven-Yer Interim Results from the ESPRIT 10-Yer Postmrketing Surveillnce Registry of Adlimumb for Moderte to Severe Psorisis Frncisco Kerdel, 1 Aln Menter, 2 Jshin J. Wu, 3 Mreike Bereswill, 4 Dilek Arikn,

More information

Safety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA

Safety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA Sfety nd Tolerbility of Subcutneous Srilumb nd Intrvenous Tocilizumb in Ptients With RA Pul Emery, 1 Jun Rondon, 2 Anju Grg, 3 Hubert vn Hoogstrten, 3 Neil M.H. Grhm, 4 Ming Liu, 4 Nncy Liu, 3 Jnie Prrino,

More information

DR. MARC PAGÈS Project Manager R&D Biologicals - Coccidia Projects, HIPRA

DR. MARC PAGÈS Project Manager R&D Biologicals - Coccidia Projects, HIPRA DR. MARC PAGÈS Project Mnger R&D Biologicls - Coccidi Projects, HIPRA Dr. Mrc Pgès Bosch otined Microiology nd Genetics degree t the University of Brcelon in 1998. He otined his PhD working on the synptoneml

More information

Optimizing Metam Sodium Fumigation in Fine-Textured Soils

Optimizing Metam Sodium Fumigation in Fine-Textured Soils Optimizing Metm Sodium Fumigtion in Fine-Textured Soils Neil C Gudmestd University Distinguished Professor & Endowed Chir of Potto Pthology Deprtment of Plnt Pthology North Dkot Stte University Erly Dying

More information

Bioactive milk components to secure growth and gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM

Bioactive milk components to secure growth and gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM Bioctive milk components to secure growth nd gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM STSM Pigutnet FA1401 STSM 03/Septemer 30/Novemer/2017 (3 months) Host: Home: Thoms

More information

Effect of fungicide timing and wheat varietal resistance on Mycosphaerella graminicola and its sterol 14 α-demethylation-inhibitorresistant

Effect of fungicide timing and wheat varietal resistance on Mycosphaerella graminicola and its sterol 14 α-demethylation-inhibitorresistant Effect of fungicide timing nd whet vrietl resistnce on Mycospherell grminicol nd its sterol 14 α-demethyltion-inhiitorresistnt genotypes Didierlurent L., Roisin-Fichter C., Snssené J., Selim S. Pltform

More information

Optimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality

Optimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality Optimistion of diets for Atlntic cod (Gdus morhu) roodstock: effect of rchidonic cid on egg & lrvl qulity Dr Gordon Bell, Ms. An Blnco, Dr Bill Roy, Dr Derek Roertson, Dr Jim Henderson nd Mr Richrd Prickett,

More information

Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults Executive Summary

Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults Executive Summary Comprtive Effectiveness Review Numer 33 Effective Helth Cre Progrm Nonphrmcologic Interventions for Tretment-Resistnt Depression in Adults Executive Summry Bckground Mjor depressive disorder (MDD) is common

More information

A review of the patterns of docetaxel use for hormone-resistant prostate cancer at the Princess Margaret Hospital

A review of the patterns of docetaxel use for hormone-resistant prostate cancer at the Princess Margaret Hospital MEDICAL ONCOLOGY A review of the ptterns of docetxel use for hormone-resistnt prostte cncer t the Princess Mrgret Hospitl S.N. Chin MD,* L. Wng MSc, M. Moore MD,* nd S.S. Sridhr MD MSc* ABSTRACT Bckground

More information

Abstract. Background. Aim. Patients and Methods. Patients. Study Design

Abstract. Background. Aim. Patients and Methods. Patients. Study Design Impct of the Use of Drugs nd Substitution Tretments on the Antivirl Tretment of Chronic Heptitis C: Anlysis of Complince, Virologicl Response nd Qulity of Life (CHEOBS). Melin, 1 J.-. Lng, D. Ouzn, 3 M.

More information

PULSED DYE LASER TREATMENT FOR RECALCITRANT VIRAL WARTS: AUTO-SIMULTANEOUS LASER TREATMENT

PULSED DYE LASER TREATMENT FOR RECALCITRANT VIRAL WARTS: AUTO-SIMULTANEOUS LASER TREATMENT PULSED DYE LASER TREATMENT FOR RECALCITRANT VIRAL WARTS: AUTO-SIMULTANEOUS LASER TREATMENT *Yuki Tniguchi 1, Toshio Ohshiro 2, Tkfumi Ohshiro 1, Ktsumi Sski 1 1: Ohshiro Clinic, Shinnomchi, Tokyo, Jpn

More information

Recall Bias in Childhood Atopic Diseases Among Adults in The Odense Adolescence Cohort Study

Recall Bias in Childhood Atopic Diseases Among Adults in The Odense Adolescence Cohort Study Syddnsk Universitet Recll Bis in Childhood Atopic Diseses Among Adults in The Odense Adolescence Cohort Study Mørtz, Chrlotte G; Andersen, Klus Ejner; Bindslev-Jensen, Crsten Published in: Act Dermto-Venereologic

More information

Thallium-201 chloride scintigraphy in soft tissue tumors

Thallium-201 chloride scintigraphy in soft tissue tumors 136 ORIGINAL Thllium-201 chloride scintigrphy in soft tissue tumors Hideki Otsuk, Kori Terzw, Nomi Morit, Yoichi Otomi, Shoichiro Tko, Seiji Iwmoto, Kyosuke Oski, Msfumi Hrd, nd Hiromu Nishitni Deprtment

More information

build Firm, sexy arms

build Firm, sexy arms w uild Firm, sexy rms Wnt toned, strong rms tht crown you pushup queen t oot cmp? Wnt to rock tnk top? These four moves re wht you need. Achieve Totl Arm Envy Mny women zero in on the show-off muscles,

More information

The effect of encapsulated butyric acid and zinc on performance, gut integrity and meat quality in male broiler chickens 1

The effect of encapsulated butyric acid and zinc on performance, gut integrity and meat quality in male broiler chickens 1 The effect of encpsulted utyric cid nd zinc on performnce, gut integrity nd met qulity in mle roiler chickens 1 Astrct This study evluted the impct of encpsulted utyric cid nd zinc (ButiPEARL Z) on performnce

More information

XII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV

XII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV XII. HIV/AIDS Knowledge bout HIV Trnsmission nd Misconceptions bout HIV One of the most importnt prerequisites for reducing the rte of HIV infection is ccurte knowledge of how HIV is trnsmitted nd strtegies

More information

Input from external experts and manufacturer on the 2 nd draft project plan Stool DNA testing for early detection of colorectal cancer

Input from external experts and manufacturer on the 2 nd draft project plan Stool DNA testing for early detection of colorectal cancer Input externl experts nd mnufcturer on the 2 nd drft project pln Stool DNA testing for erly detection of colorectl cncer (Project ID:OTJA10) All s nd uthor s replies on the 2nd drft project pln Stool DNA

More information

supplementary information

supplementary information DOI: 10.1038/nc2089 H3K4me1 H3K4me1 H3K4me1 H3K4me1 H3K4me1 H3K4me1 5 PN N1-2 PN H3K4me1 H3K4me1 H3K4me1 2-cell stge 2-c st cell ge Figure S1 Pttern of loclistion of H3K4me1 () nd () during zygotic development

More information

Bright Futures Medical Screening Reference Table 2 to 5 Day (First Week) Visit

Bright Futures Medical Screening Reference Table 2 to 5 Day (First Week) Visit Bright Futures Medicl Reference Tle 2 to 5 Dy (First Week) Visit Universl Action Metolic nd Verify documenttion of neworn metolic screening results, pproprite rescreening, nd needed follow-up. Document

More information

Efficacy of Sonidegib in Patients With Metastatic BCC (mbcc)

Efficacy of Sonidegib in Patients With Metastatic BCC (mbcc) AAD 216 eposter 3368 Efficcy of Sonidegib in Ptients With Metsttic BCC (mbcc) Colin Morton, 1 Michel Migden, 2 Tingting Yi, 3 Mnish Mone, 3 Dlil Sellmi, 3 Reinhrd Dummer 4 1 Stirling Community Hospitl,

More information

University of Texas Health Science Center, San Antonio, San Antonio, Texas, USA

University of Texas Health Science Center, San Antonio, San Antonio, Texas, USA Lung Cncer Chemotherpy Given Ner the End of Life by Community Oncologists for Advnced Non-Smll Cell Lung Cncer Jose R. Murillo, Jr., Jim Koeller b,c Methodist Hospitl, Houston, Texs, USA; b University

More information

Introduction. These patients benefit less from conventional chemotherapy than patients identified as MMR proficient or microsatellite stable 3-5

Introduction. These patients benefit less from conventional chemotherapy than patients identified as MMR proficient or microsatellite stable 3-5 Nivolumb + Ipilimumb Combintion in Ptients With DNA Mismtch Repir-Deficient/Microstellite Instbility-High Metsttic Colorectl Cncer: First Report of the Full Cohort From CheckMte-142 Abstrct 553 André T,

More information

P AND K IN POTATOES. Donald A Horneck Oregon State University Extension Service

P AND K IN POTATOES. Donald A Horneck Oregon State University Extension Service P AND K IN POTATOES Donld A Hornek Oregon Stte University Extension Servie INTRODUCTION Phosphorous nd potssium re importnt to grow high yielding nd qulity pottoes. Muh of the northwest hs hd trditionlly

More information

LATE RESULTS OF TRANSFER OF THE TIBIAL TUBERCLE FOR RECURRENT DISLOCATION OF THE PATELLA1

LATE RESULTS OF TRANSFER OF THE TIBIAL TUBERCLE FOR RECURRENT DISLOCATION OF THE PATELLA1 LATE RESULTS OF TRANSFER OF THE TIBIAL TUBERCLE FOR RECURRENT DISLOCATION OF THE PATELLA1 W. G. J. HAMPSON nd P. HILL, BRISTOL, ENGLAND The uthors wished to determine the lte results of the Huser opertion,

More information

THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS

THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS John F. Ptience nd Doug Gillis SUMMARY

More information

See 17 for PATIENT COUNSELING INFORMATION and FDAapproved patient labeling. Revised: 6/2016 FULL PRESCRIBING INFORMATION: CONTENTS*

See 17 for PATIENT COUNSELING INFORMATION and FDAapproved patient labeling. Revised: 6/2016 FULL PRESCRIBING INFORMATION: CONTENTS* 1 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use BASAGLAR sfely nd effectively. See full prescribing informtion for BASAGLAR BASAGLAR (insulin glrgine

More information

Meat and Food Safety. B.A. Crow, M.E. Dikeman, L.C. Hollis, R.A. Phebus, A.N. Ray, T.A. Houser, and J.P. Grobbel

Meat and Food Safety. B.A. Crow, M.E. Dikeman, L.C. Hollis, R.A. Phebus, A.N. Ray, T.A. Houser, and J.P. Grobbel Met nd Food Sfety Needle-Free Injection Enhncement of Beef Strip Loins with Phosphte nd Slt Hs Potentil to Improve Yield, Tenderness, nd Juiciness ut Hrm Texture nd Flvor B.A. Crow, M.E. Dikemn, L.C. Hollis,

More information

Vitamin D and Mushrooms: Enrichment With Pulsed UV Light. Michael Kalaras Department of Food Science The Pennsylvania State University

Vitamin D and Mushrooms: Enrichment With Pulsed UV Light. Michael Kalaras Department of Food Science The Pennsylvania State University Vitmin D nd Mushrooms: Enrichment With Pulsed UV Light Michel Klrs Deprtment of Food Science The Pennsylvni Stte University Vitmin D Synthesis Source: http://vitmind.ucr.edu/imges/chem1.gif Vitmin D In

More information

Original Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract:

Original Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract: Fridpur Med. Coll. J. 214;9(2):61-67 Originl Article Nebuliztion by Isotonic Mgnesium Sulphte Solution with Provide Erly nd Better Response s Compred to Conventionl Approch ( Plus Norml Sline) in Acute

More information

Debra A. Ignaut, R.N., B.S., C.D.E., and Haoda Fu, Ph.D.

Debra A. Ignaut, R.N., B.S., C.D.E., and Haoda Fu, Ph.D. Journl of Dietes Science nd Technology Volume 6, Issue 2, Mrch 2012 Dietes Technology Society TECHNOLOGY REPORT Comprison of Insulin Diluent Lekge Postinjection Using Two Different Needle Lengths nd Injection

More information

Supplementary Online Content

Supplementary Online Content Supplementry Online Content Rieckmnn N, Kronish IM, Shpiro PA, Whng W, Dvidson KW. Serotonin reuptke inhibitor use, depression, nd long-term outcomes fter n cute coronry : prospective cohort study. JAMA

More information

Agilent G6825AA MassHunter Pathways to PCDL Software Quick Start Guide

Agilent G6825AA MassHunter Pathways to PCDL Software Quick Start Guide Agilent G6825AA MssHunter Pthwys to PCDL Softwre Quick Strt Guide Wht is Agilent Pthwys to PCDL? Fetures of Pthwys to PCDL Agilent MssHunter Pthwys to PCDL converter is stnd-lone softwre designed to fcilitte

More information

Product Monograph. Published by

Product Monograph. Published by Product Monogrph Pulished y INDICATION AND LIMITATION OF USE JARDIANCE is indicted s n djunct to diet nd exercise to improve glycemic control in dults with type 2 dietes mellitus. JARDIANCE is not recommended

More information

Effectiveness of Infliximab in Treating Selected Cases of Sarcoidosis

Effectiveness of Infliximab in Treating Selected Cases of Sarcoidosis Specil Articles Efficcy of Inflixim in the Mngement of Srcoidosis Effectiveness of Inflixim in Treting Selected Cses of Srcoidosis Om P. Shrm, MD, FRCP, Professor of Medicine, Keck School of Medicine of

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION Prentl doi:.8/nture57 Figure S HPMECs LM Cells Cell lines VEGF (ng/ml) Prentl 7. +/-. LM 7. +/-.99 LM 7. +/-.99 Fold COX induction 5 VEGF: - + + + Bevcizum: - - 5 (µg/ml) Reltive MMP LM mock COX MMP LM+

More information

EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1

EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 Swine Dy 2001 Contents EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 C. W. Hstd, S. S. Dritz 2, J. L. Nelssen, M. D. Tokch, nd R. D. Goodbnd Summry Two trils were

More information

Antibiotic Cement Impregnated Nailing in Management of Infected Non-union of Femur and Tibia

Antibiotic Cement Impregnated Nailing in Management of Infected Non-union of Femur and Tibia Originl Article Print ISSN: 2321-6379 Online ISSN: 2321-595X DOI: 10.17354/ijss/2017/362 Antiiotic Cement Impregnted Niling in Mngement of Infected Non-union of Femur nd Tii A Srvnn 1, R Rj Gnesh 1, N

More information

EFFECT OF ATRIAL FIBRILLATION ON CARDIAC OUTPUT

EFFECT OF ATRIAL FIBRILLATION ON CARDIAC OUTPUT Brit. Hert J., 1965, 27, 719. EFFET OF TRIL FIBRILLTION ON RDI OUTPUT BY P. B. HLMOS* ND G.. PTTERSON From the Royl Victori Hospitl, Belfst Received Octoer 12, 1964 The introduction y Lown, mrsinghm, nd

More information

Start ORKAMBI today. INDICATIONS AND USAGE IMPORTANT SAFETY INFORMATION. Sydney Age 4

Start ORKAMBI today. INDICATIONS AND USAGE IMPORTANT SAFETY INFORMATION. Sydney Age 4 F O R H E A L T H C A R E P R O F E S S I O N A L S For ptients ge 2 yers nd older who re homozygous for the F508del muttion 1,2 Modify the course. Strt tody. Sydney Age 4 F508del/F508del INDICATIONS AND

More information

Exercise-induced bronchoconstriction, skin sensitivity,

Exercise-induced bronchoconstriction, skin sensitivity, rchives of Disese in Childhood, 1976, 51, 912. Exercise-induced bronchoconstriction, skin sensitivity, nd serum IgE in children with eczem J. F. PRICE, J. J. COGSWELL, M. C. JOSEPH, nd G. M. COCHRNE From

More information

EFFECT OF DIETARY ENZYME ON PERFORMANCE OF WEANLING PIGS

EFFECT OF DIETARY ENZYME ON PERFORMANCE OF WEANLING PIGS EFFECT OF DIETARY ENZYME ON PERFORMANCE OF WEANLING PIGS Finl report sumitted to Dniso Animl Nutrition E. vn Heugten nd B. Frederik North Crolin Stte University, Deprtment of Animl Siene Summry The urrent

More information

Target: 10 mg/day within several days Schizophrenia in adolescents (2.1)

Target: 10 mg/day within several days Schizophrenia in adolescents (2.1) HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use ZYPREXA sfely nd effectively. See full prescribing informtion for ZYPREXA. ZYPREXA (olnzpine) Tblet

More information

The potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens

The potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens The potentil future of trgeted rdionuclide therpy: implictions for occuptionl exposure? Introduction: Trgeted Rdionuclide Therpy (TRT) Systemic tretment Molecule lbelled with rdionuclide delivers toxic

More information

Arthroscopic Anatomy of Shoulder

Arthroscopic Anatomy of Shoulder Arthroscopic Antomy of Shoulder Murt Bozkurt, Mehmet Emin Simsek, nd Hlil İrhim Açr 2 2.1 Introduction In the lst 30 yers, shoulder rthroscopy hs ecome of greter importnce in the dignosis nd tretment of

More information

Submitting a Statement of Medical Necessity (SMN) for Humatrope (somatropin for injection)

Submitting a Statement of Medical Necessity (SMN) for Humatrope (somatropin for injection) Sumitting Sttement of Medicl Necessity (SMN) for Humtrope (somtropin for injection) INFORMATION NEEDED FOR FULL SMN FORM SUBMISSION PATIENT INFORMATION: Plese provide Ptient Nme nd Dte of Birth. PRIMARY

More information

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE Swine Dy 22 Contents EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE B. J. Johnson, J. P. Kyser, J. D. Dunn, A. T. Wyln, S. S. Dritz 1, J.

More information

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess

More information

Case 18 A 63-year-old woman from Pathumthani. Chief complaint: Abnormal skin color on extremities for 20 years.

Case 18 A 63-year-old woman from Pathumthani. Chief complaint: Abnormal skin color on extremities for 20 years. Cse 18 A 63-yer-old womn from Pthumthni. Chief complint: Abnorml skin color extremities for 20 yers. F les Phs. res Sk top sm fee Hi leg Present illness: The ptient first noticed drkening of her skin the

More information

Levofloxacin in the Treatment of Pneumonia Caused by Streptococcus pneumoniae, Including Multidrug-Resistant Strains

Levofloxacin in the Treatment of Pneumonia Caused by Streptococcus pneumoniae, Including Multidrug-Resistant Strains Levofloxcin in the Tretment of Pneumoni Cused by Streptococcus pneumonie, Including Multidrug-Resistnt Strins Review Jnet Peterson, PhD Ortho-McNeil Jnssen Scientific Affirs, LLC; Rritn, New Jersey, USA

More information

Invasive Pneumococcal Disease Quarterly Report. July September 2017

Invasive Pneumococcal Disease Quarterly Report. July September 2017 Invsive Pneumococcl Disese Qurterly Report July September 2017 Prepred s prt of Ministry of Helth contrct for scientific services by Rebekh Roos Helen Heffernn October 2017 Acknowledgements This report

More information

Health-Related Quality of Life and Symptoms of Depression in Extremely Obese Persons Seeking Bariatric Surgery

Health-Related Quality of Life and Symptoms of Depression in Extremely Obese Persons Seeking Bariatric Surgery Oesity Surgery, 15, 3-39 Helth-Relted Qulity of Life nd Symptoms of Depression in Extremely Oese Persons Seeking Britric Surgery Anthony N. Frictore, PhD; Thoms A. Wdden, PhD; Dvid B. Srwer, PhD; Myles

More information

Severe Gummy Smile with Class II Malocclusion Treated with LeFort I Osteotomy Combined with Horseshoe Osteotomy and Intraoral Vertical Ramus

Severe Gummy Smile with Class II Malocclusion Treated with LeFort I Osteotomy Combined with Horseshoe Osteotomy and Intraoral Vertical Ramus 2013 67 1 5560 Severe Gummy Smile with Clss II Mlocclusion Treted with LeFort I Osteotomy Comined with Horseshoe Osteotomy nd Introrl Verticl Rmus Osteotomy * 56 Shimo et l. Act Med. Okym Vol. 67, No.

More information

Introduction. In developing countries, children s weight gain commonly falters in relation to reference data

Introduction. In developing countries, children s weight gain commonly falters in relation to reference data nd feeding of complementry foods ffects mel-specific food consumption nd mel durtion y helthy, rest fed Bngldeshi children M. Munirul Islm 1, Thmeed Ahmed 1, Jnet M. Peerson 2, M. Aid Hossin Mollh 3, Mkhdum

More information

Biliary tract cancer treatment: 5,584 results from the Biliary Tract Cancer Statistics Registry from 1998 to 2004 in Japan

Biliary tract cancer treatment: 5,584 results from the Biliary Tract Cancer Statistics Registry from 1998 to 2004 in Japan J Heptoiliry Pncret Surg (2009) 16:1 7 DOI 10.1007/s00534-008-0015-0 TOPICS Biliry trct cncer sttistics registry in Jpn Biliry trct cncer tretment: 5,584 results from the Biliry Trct Cncer Sttistics Registry

More information

ARTICLE. E. Pavlova 1, N. Atanassova 1, C. McKinnell 2, R.M. Sharpe 2 1 Institute of Experimental Morphology, Pathology and Anthropology with Museum,

ARTICLE. E. Pavlova 1, N. Atanassova 1, C. McKinnell 2, R.M. Sharpe 2 1 Institute of Experimental Morphology, Pathology and Anthropology with Museum, DOI:.554/5YRTIMB..3 OPPOSITE MODELS OF EXPRESSION OF ANDROGEN RECEPTOR (AR) AND RETINOIC ACID RECEPTOR-α (RAR-α) IN THE ONSET OF MALE GERM CELL DEVELOPMENT IN HORMONALLY MANIPULATED RATS E. Pvlov, N. Atnssov,

More information

Evaluation of Results of Locking Compression Plate in Distal Femur Fractures

Evaluation of Results of Locking Compression Plate in Distal Femur Fractures Originl Article Print ISSN: 2321-6379 Online ISSN: 2321-595X DOI: 10.17354/ijss/2018/110 Evlution of Results of Locking Compression Plte in Distl Femur Frctures Anuj Kumr Ll 1, S K Kushik 2, Utkl Gupt

More information

Products for weaners Benzoic acid or the combination of lactic acid and formic acid

Products for weaners Benzoic acid or the combination of lactic acid and formic acid Products for weners Benzoic cid or the comintion of lctic cid nd formic cid Tril report no.: 490 Novemer, 000 Hnne Mrio, Lrs Egelund Olsen, Bent Borg Jensen 1 nd Nuri Miquel 1 The Ntionl Committee for

More information

Intravitreal Triamcinolone Acetonide in Macular Edema due to Retinal Vein Occlusions: A Comparative Study of 1 mg and 4 mg Doses

Intravitreal Triamcinolone Acetonide in Macular Edema due to Retinal Vein Occlusions: A Comparative Study of 1 mg and 4 mg Doses Originl Article DOI: 10.17354/ijss/2015/548 Intrvitrel Trimcinolone Acetonide in Mculr Edem due to Retinl Vein Occlusions: A Comprtive Study of 1 mg nd 4 mg Doses Siknder A K Lodhi 1, Sntosh Devulplly

More information

Study of Stress Distribution in the Tibia During Stance Phase Running Using the Finite Element Method

Study of Stress Distribution in the Tibia During Stance Phase Running Using the Finite Element Method Ksetsrt J. (Nt. Sci.) 48 : 729-739 (2014) Study of Stress Distriution in the Tii During Stnce Phse Running Using the Finite Element Method Thepwchr Ruchirh 1, Tumrong Puttpitukporn 1, * nd Siriporn Ssimontonkul

More information

Global Intellectual Deficits in Cystinosis

Global Intellectual Deficits in Cystinosis Americn Journl of Medicl Genetics 49:83-87 (1994) Globl Intellectul Deficits in Cystinosis Brbr L.H. Willims, Jerry A. Schneider, nd Doris A. Truner Deprtments of Neurosciences (B.L.H.W.. D.A.T.) nd Peditrics

More information

Ultrasound-guided antegrade access during laparoscopic pyeloplasty in infants less than one year of age: A point of technique

Ultrasound-guided antegrade access during laparoscopic pyeloplasty in infants less than one year of age: A point of technique How I Do It Differently Ultrsound-guided ntegrde ccess during lproscopic pyeloplsty in infnts less thn one yer of ge: A point of technique Arvind Gnpule, Amit Bhttu, Shshiknt Mishr, Mhesh R Desi Deprtment

More information

Journal of Hainan Medical University.

Journal of Hainan Medical University. 132 Journl of Hinn Medicl University 2017; 23(11): 132-136 Journl of Hinn Medicl University http://www.hnykdxxb.com Assessment of the efficcy nd sfety of bronchil rtery perfusion chemotherpy combined with

More information

Analysis of alternatives for insulinizing patients to achieve glycemic control and avoid accompanying risks of hypoglycemia

Analysis of alternatives for insulinizing patients to achieve glycemic control and avoid accompanying risks of hypoglycemia 284 Anlysis of lterntives for izing ptients to chieve glycemic control nd void ccompnying risks of hypoglycemi JIALIN GAO 1,2*, QIANYIN XIONG 1,2*, JUN MIAO 1*, YAO ZHANG 2,3, LIBING XIA 1, MEIQIN LU 1,

More information

Addendum to the Evidence Review Group Report on Aripiprazole for the treatment of schizophrenia in adolescents (aged years)

Addendum to the Evidence Review Group Report on Aripiprazole for the treatment of schizophrenia in adolescents (aged years) Addendum to the Evidence Review Group Report on Aripiprzole for the tretment of schizophreni in dolescents (ged 15-17 yers) Produced by Authors Correspondence to Southmpton Helth Technology Assessments

More information

Chapter 5: The peripheral nervous system Learning activity suggested answers

Chapter 5: The peripheral nervous system Learning activity suggested answers Chpter 5: The peripherl nervous system Lerning ctivity suggested nswers Lerning Activity 5.1 (p. 222) 1 Briefly descrie the two min functions of the somtic nervous system. Description should refer to:

More information

Prevalence of Prehypertension in a Rural District of Southern India

Prevalence of Prehypertension in a Rural District of Southern India Interntionl Journl of Preventive Medicine Brief Communiction Open Access Prevlence of Prehypertension in Rurl District of Southern Indi Mrinyknkopplu R. Rvi, Ngrlu C. Ashok, M. Renuk Deprtment of Community

More information

A Study of Serological Markers of Hepatitis B and C Viruses in Istanbul, Turkey

A Study of Serological Markers of Hepatitis B and C Viruses in Istanbul, Turkey Originl Pper Med Princ Prct 2003;12:184 188 DOI: 10.1159/000070757 Received: Decemer 15, 2001 Revised: Decemer 21, 2002 A Study of Serologicl Mrkers of Heptitis B nd C Viruses in Istnul, Turkey S. Erden

More information

Paper-based skin patch for the diagnostic screening of cystic fibrosis

Paper-based skin patch for the diagnostic screening of cystic fibrosis Electronic Supplementry Mteril (ESI) for ChemComm. This journl is The Royl Society of Chemistry 2015 Supplementry informtion Pper-bsed skin ptch for the dignostic screening of cystic fibrosis Xun Mu,*

More information

YERVOY (ipilimumab) injection, for intravenous use Initial U.S. Approval: 2011

YERVOY (ipilimumab) injection, for intravenous use Initial U.S. Approval: 2011 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use sfely nd effectively. See full prescribing informtion for. (ipilimumb) injection, for intrvenous use

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION DOI: 1.138/nc286 Figure S1 e f Medium DMSO AktVIII PP242 Rp S6K1-I Gr1 + + + + + + Strvtion + + + + + IB: Akt-pT38 IB: Akt K-pT389 K IB: Rptor Gr1 shs6k1-a shs6k1-b shs6k1-c shrictor shrptor Gr1 c IB:

More information

See 17 for PATIENT COUNSELING INFORMATION. Revised: 01/2018 FULL PRESCRIBING INFORMATION: CONTENTS*

See 17 for PATIENT COUNSELING INFORMATION. Revised: 01/2018 FULL PRESCRIBING INFORMATION: CONTENTS* HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use sfely nd effectively. See full prescriing informtion for. (rifximin) tlets, for orl use Initil U.S.

More information

Silicone Foley s catheter as an effective alternative to Hunter s rod in staged flexor tendon reconstruction of the hand

Silicone Foley s catheter as an effective alternative to Hunter s rod in staged flexor tendon reconstruction of the hand Originl Article Silicone Foley s ctheter s n effective lterntive to Hunter s rod in stged flexor tendon reconstruction of the hnd Twheed Ahmd, Sheikh Adil Bshir, Mohmmd Inm Zroo, Adil Hfeez Wni, Sim Rshid,

More information

Prime Enrollees Consumer Watch NHC Patuxent River FY 2016 Defense Health Cost Assessment & Program Evaluation

Prime Enrollees Consumer Watch NHC Patuxent River FY 2016 Defense Health Cost Assessment & Program Evaluation Prime Enrollees Consumer Wtch NHC Ptuxent River 16 Defense Helth Cost Assessment & Progrm Evlution NHC Ptuxent River: Smple size-1,457 Response rte-1.2% Source: Helth Cre Survey of DoD Beneficiries Inside

More information

US Food and Drug Administration-Mandated Trials of Long-Acting b -Agonists Safety in Asthma. Samy Suissa, PhD ; and Amnon Ariel, MD, FCCP

US Food and Drug Administration-Mandated Trials of Long-Acting b -Agonists Safety in Asthma. Samy Suissa, PhD ; and Amnon Ariel, MD, FCCP CHEST Commentry US Food nd Drug Administrtion-Mndted Trils of Long-Acting b -Agonists Sfety in Asthm Will We Know the Answer? Smy Suiss, PhD ; nd Amnon Ariel, MD, FCCP For 2 decdes, long-cting b -gonists

More information

Y. Yazici 1, D. Moniz Reed 2, C. Klem 2, L. Rosenblatt 2, G. Wu 2, J.M. Kremer 3

Y. Yazici 1, D. Moniz Reed 2, C. Klem 2, L. Rosenblatt 2, G. Wu 2, J.M. Kremer 3 Greter remission rtes in ptients with erly versus long-stnding disese in biologic-nive rheumtoid rthritis ptients treted with btcept: post hoc nlysis of rndomised clinicl tril dt Y. Yzici 1, D. Moniz Reed

More information

Regression of electrocardiographic left ventricular hypertrophy predicts regression of echocardiographic left ventricular mass: the LIFE study

Regression of electrocardiographic left ventricular hypertrophy predicts regression of echocardiographic left ventricular mass: the LIFE study (2004) 18, 403 409 & 2004 Nture Pulishing Group All rights reserved 0950-9240/04 $30.00 www.nture.com/jhh ORIGINAL ARTICLE Regression of electrocrdiogrphic left ventriculr hypertrophy predicts regression

More information

Original Research. Oral mucocutaneous lesions - Histopathological and immunofluorescence study Rameshkumar A et al

Original Research. Oral mucocutaneous lesions - Histopathological and immunofluorescence study Rameshkumar A et al Received: 18 th Septemer 2014 Accepted: 20 th Decemer 2014 Conflicts of Interest: None Source of Support: Nil Originl Reserch Orl Mucocutneous Lesions A Comprtive Clinicopthologicl nd Immunofluorescence

More information

1 Indications and Usage

1 Indications and Usage HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use ERBITUX sfely nd effectively. See full prescriing informtion for ERBITUX. ERBITUX (cetuxim) injection,

More information

Supplementary Information Titles

Supplementary Information Titles Supplementry Informtion Titles Journl: Nture Medicine Article Title: Corresponding Author: Modelling colorectl cncer using CRISPR-Cs9-medited engineering of humn intestinl orgnoids Toshiro Sto Supplementry

More information

EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE

EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE Swine Dy 21 EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE J. M. DeRouchey, M. D. Tokch, J. L. Nelssen, R. D. Goodbnd, S. S. Dritz 1, J. C. Woodworth, M. J. Webster, B. W.

More information

Review article. Key words non specific low back pain, exercise therapy, stretching, motor control. Grade D

Review article. Key words non specific low back pain, exercise therapy, stretching, motor control. Grade D Spinl Surgery 31 2 140 144 2017 総説 Review rticle Astrct Exercise therpy is useful for low ck pin. Exercise therpy ims to improve posturl lignment, muscle strength, nd endurnce, nd lso contriutes to pin

More information

Computed Tomography for Localization of Intra- Abdominally Dislocated Intrauterine Devices

Computed Tomography for Localization of Intra- Abdominally Dislocated Intrauterine Devices Act Rdiologic ISSN: 0284-1851 (Print) 1600-0455 (Online) Journl homepge: https://www.tndfonline.com/loi/ird20 Computed Tomogrphy for Locliztion of Intr- Adominlly Dislocted Intruterine Devices Esjörn Hederström,

More information

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients Effects of physicl exercise on working memory nd prefrontl cortex function in post-stroke ptients M Moriy, C Aoki, K Sktni Grdute School of Helth Sciences Reserch, Mjor of Physicl Therpy, TeikyoHeisei

More information

Patients with cancer are at an increased

Patients with cancer are at an increased Risk of Cncer-Associted Thrombosis nd Bleeding in Veterns With Mlignncy Who Are Receiving Direct Orl Anticogulnts Mtthew Stnkowicz, PhrmD; Megn Bnszynski, PhrmD, BCOP; nd Russell Crwford, BPhrm, BCOP The

More information

The Ever Changing World of Feed Additives in The Poultry Industry

The Ever Changing World of Feed Additives in The Poultry Industry The Ever Chnging World of Feed Additives in The Poultry Industry B. S. Lumpkins nd G.F. Mthis Southern Poultry Reserch Inc. Athens, GA, USA Outline Southern Poultry Reserch Impct of ethnol production of

More information

Adenosine A1 receptor antagonist improves intradialytic hypotension

Adenosine A1 receptor antagonist improves intradialytic hypotension http://www.kidney-interntionl.org & 26 Interntionl Society of Nephrology originl rticle see commentry on pge 789 Adenosine A1 receptor ntgonist improves intrdilytic hypotension E Imi 1, M Fujii 2, Y Kohno

More information

Heather M. Kelly Field Crops Plant Pathologist UT-WTREC, Jackson, TN

Heather M. Kelly Field Crops Plant Pathologist UT-WTREC, Jackson, TN Trget Spot: Potentil Impcts on Tennessee Cotton Hether M. Kelly Field Crops Plnt Pthologist UT-WTREC, Jckson, TN Trget Spot/ Corynespor lef spot First ppers on lower leves fter cnopy closure Defolites

More information

The RUTHERFORD-2 trial in heterozygous FH: Results and implications

The RUTHERFORD-2 trial in heterozygous FH: Results and implications The RUTHERFORD-2 tril in heterozygous FH: Results nd implictions Slide deck kindly supplied s n eductionl resource by Professor Derick Rl MD PhD Crbohydrte & Lipid Metbolism Reserch Unit University of

More information