APPENDIX 27: INTERVENTIONS FOR CHILDREN AND YOUNG PEOPLE STUDY CHARACTERISTICS

Transcription

1 APPEDIX 27: ITERVETIOS FOR CHILDRE AD YOUG PEOPLE STUDY CHARACTERISTICS 1.1 Pharmacological interventions Psychological interventions utritional interventions... 6 Abbreviations BRA ChIPS COL DSM(-IV, -TR) Dur Freq ID IRI (-PL) MEX /A R P-ChIPS PUR RUS TW WASH-U-KSADS XR ZAF attention deficit hyperactivity disorder Brazil Children's Interview for Psychiatric Syndromes Colombia Diagnostic and Statistical Manual of Mental Disorders ( fourth edition, - Text Revision) duration frequency India Iran Kiddie- Schedule for Affective Disorders and Schizophrenia (-Present and Lifetime Version) Mexico not applicable number of participants at post-treatment not reported number of participants randomised parent version Children's Interview for Psychiatric Syndromes Puerto Rico Russian Federation Taiwan United States of America Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia extended release South Africa 1

2 1.1 PHARMACOLOGICAL ITERVETIOS Medication for acute mania Aripiprazole compared with pill placebo Aripiprazole 10 mg 7 4 FIDLIG Aripiprazole 30 mg Placebo /A 7 4 TRAMOTIA2009 BRA 18 Aripiprazole 13 mg Placebo /A 7 6 Olanzapine compared with pill placebo TOHE2007, PUR Olanzapine 8.9 mg (DSM-IV-TR) Placebo /A 7 3 Quetiapine compared with pill placebo DELBELLO Quetiapine 432 mg Placebo /A 7 6 PATHAK Quetiapine 400 mg Quetiapine 600 mg 7 3 2

3 Risperidone compared with pill placebo Placebo /A Risperidone mg 7 3 HAAS2009 R Risperidone 3-6 mg Placebo /A 7 3 Topiramate compared with pill placebo DELBELLO Topiramate 278 mg Placebo /A 7 4 ELILILLY Topiramate 400 mg R (DSM-IV-TR) Placebo /A 7 12 Valproate compared with pill placebo WAGER Valproate 24.3 mg/kg Placebo /A 7 4 3

4 Ziprasidone compared with pill placebo PFIZER R R Ziprasidone R Placebo /A 7 4 Quetiapine compared with valproate DELBELLO Quetiapine 412 mg (DSM-IV-TR) Valproate 101 µg/ml 7 4 Risperidone compared with valproate PAVULURI2012 WASH-U- KSADS Risperidone 144 mg Valproate 856 mg 7 6 PAVULURI Risperidone mg Valproate R 7 6 Topiramate compared with valproate HEBRAI2009 IRI (DSM-IV-TR) R 71 R Topiramate R R Valproate R 7 8 4

5 Medication for Acute Depression Quetiapine compared with placebo ASTRAZEECA2011B, ID, COL, RUS, MEX, ZAF, TW R Quetiapine XR 300 mg Placebo /A 7 8 DELBELLO2009 (DSM-IV-TR) Quetiapine 400 mg Placebo /A 7 8 Fluoxetine and olanzapine compared with placebo ELILILLY2013 Long term management, RUS, MEX -PL R Fluoxetine and olanzapine 12 mg/50 mg 7 8 (DSM-IV-TR) Placebo /A Lithium 30 mg/kg 7 20 FIDLIG Valproate (divalproex sodium) 20 mg/kg 7 20 FIDLIG Aripiprazole 0.26 mg/kg

6 30 30 Placebo /A PSYCHOLOGICAL ITERVETIOS CUMMIGS2007 ChIPS and P-ChIPS Family psychoeducation Waitlist Family therapy 39 MIKLOWITZ Enhanced clinical intervention UTRITIOAL ITERVETIOS GRACIOUS Flax oil 3,300 mg Placebo /A