Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Review, H2 2015

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1 Published on Market Research Reports Inc. ( Home > Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Review, H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Review, H Publication ID: GMD Publication October 14, 2015 Date: Pages: 110 Publisher: Global Markets Direct Countries: Global [1] $2, Publication Type * - Select - Please choose the suitable license type from above. More details are at given under tab "Report License Types" below. Add to cart Diseases [2]

2 Pharma & Healthcare [3] Description: Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Review, H Summary Global Markets Direct s, Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Review, H2 2015, provides an overview of the Cognitive Impairment Associated With Schizophrenia (CIAS) s therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Cognitive Impairment Associated With Schizophrenia (CIAS), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Cognitive Impairment Associated With Schizophrenia (CIAS) and special features on late-stage and discontinued projects. Global Markets Direct s report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industryspecific third party sources, put together by Global Markets Direct s team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Cognitive Impairment Associated With Schizophrenia (CIAS) - The report reviews key pipeline products under drug profile section which includes, product

3 description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Cognitive Impairment Associated With Schizophrenia (CIAS) and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Cognitive Impairment Associated With Schizophrenia (CIAS) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Cognitive Impairment Associated With Schizophrenia (CIAS) pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counterstrategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Cognitive Impairment Associated With Schizophrenia (CIAS) - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Cognitive Impairment Associated With Schizophrenia (CIAS) pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline Table Of Contents: Table of Contents Table of Contents 2 List of Tables 7 List of Figures 8 Introduction 9 Global Markets Direct Report Coverage 9 Cognitive Impairment Associated With Schizophrenia (CIAS) Overview 10

4 Therapeutics Development 11 Pipeline Products for Cognitive Impairment Associated With Schizophrenia (CIAS) - Overview 11 Pipeline Products for Cognitive Impairment Associated With Schizophrenia (CIAS) - Comparative Analysis 12 Cognitive Impairment Associated With Schizophrenia (CIAS) - Therapeutics under Development by Companies 13 Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Products Glance 15 Late Stage Products 15 Clinical Stage Products 16 Early Stage Products 17 Cognitive Impairment Associated With Schizophrenia (CIAS) - Products under Development by Companies 18 Cognitive Impairment Associated With Schizophrenia (CIAS) - Companies Involved in Therapeutics Development 20 AbbVie Inc. 20 Amarantus Bioscience Holdings, Inc. 21 Astellas Pharma Inc. 22 Avineuro Pharmaceuticals, Inc. 23 Bristol-Myers Squibb Company 24 Eli Lilly and Company 25 FORUM Pharmaceuticals Inc. 26 H. Lundbeck A/S 27 Intra-Cellular Therapies, Inc. 28 Iproteos S.L. 29 Mnemosyne Pharmaceuticals, Inc. 30 Neuralstem, Inc. 31 Pfizer Inc. 32 Saniona AB 33 Siena Biotech S.p.A. 34 SK Biopharmaceuticals Co., Ltd. 35 Sunovion Pharmaceuticals Inc. 36 Takeda Pharmaceutical Company Limited 37 Upsher-Smith Laboratories, Inc. 38 Vanda Pharmaceuticals Inc. 39 Cognitive Impairment Associated With Schizophrenia (CIAS) - Therapeutics Assessment 40 Assessment by Monotherapy Products 40 Assessment by Target 41 Assessment by Mechanism of Action 43 Assessment by Route of Administration 45 Assessment by Molecule Type 47

5 Drug Profiles 49 A Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 AN Drug Profile 50 Product Description 50 Mechanism of Action 50 R&D Progress 50 AQW Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 ASP Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 ASP Drug Profile 53 Product Description 53 Mechanism of Action 53 R&D Progress 53 AUT-1 - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 AUT-6 - Drug Profile 55 Product Description 55 Mechanism of Action 55 R&D Progress 55 AUT-9 - Drug Profile 56 Product Description 56 Mechanism of Action 56 R&D Progress 56 AVL Drug Profile 57 Product Description 57 Mechanism of Action 57 R&D Progress 57 AVN Drug Profile 58 Product Description 58 Mechanism of Action 58

6 R&D Progress 58 DSP Drug Profile 59 Product Description 59 Mechanism of Action 59 R&D Progress 59 eltoprazine - Drug Profile 60 Product Description 60 Mechanism of Action 60 R&D Progress 60 encenicline hydrochloride - Drug Profile 62 Product Description 62 Mechanism of Action 62 R&D Progress 62 erteberel - Drug Profile 65 Product Description 65 Mechanism of Action 65 R&D Progress 65 IC Drug Profile 66 Product Description 66 Mechanism of Action 66 R&D Progress 66 IPR Drug Profile 67 Product Description 67 Mechanism of Action 67 R&D Progress 67 IPR Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 IPR-19 - Drug Profile 69 Product Description 69 Mechanism of Action 69 R&D Progress 69 ITI Drug Profile 70 Product Description 70 Mechanism of Action 70 R&D Progress 70 LUAF Drug Profile 71 Product Description 71 Mechanism of Action 71

7 R&D Progress 71 NSI Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 PF Drug Profile 74 Product Description 74 Mechanism of Action 74 R&D Progress 74 PNU Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 roflumilast - Drug Profile 76 Product Description 76 Mechanism of Action 76 R&D Progress 76 SEN Drug Profile 79 Product Description 79 Mechanism of Action 79 R&D Progress 79 SKL Drug Profile 80 Product Description 80 Mechanism of Action 80 R&D Progress 80 SKL-A4R - Drug Profile 81 Product Description 81 Mechanism of Action 81 R&D Progress 81 Small Molecule to Agonize Neuronal Acetylcholine Receptor Subunit Alpha-7 for Central Nervous System - Drug Profile 82 Product Description 82 Mechanism of Action 82 R&D Progress 82 Small Molecules for Cognitive Impairment Associated with Schizophrenia - Drug Profile 83 Product Description 83 Mechanism of Action 83 R&D Progress 83 Small Molecules to Agonize Dopamine D1 Receptor for Cognitive Impairment Associated with Schizophrenia - Drug Profile 84

8 Product Description 84 Mechanism of Action 84 R&D Progress 84 Small Molecules to Agonize NMDA2B for CIAS - Drug Profile 85 Product Description 85 Mechanism of Action 85 R&D Progress 85 TAK Drug Profile 87 Product Description 87 Mechanism of Action 87 R&D Progress 87 TAK Drug Profile 88 Product Description 88 Mechanism of Action 88 R&D Progress 88 Cognitive Impairment Associated With Schizophrenia (CIAS) - Recent Pipeline Updates 89 Cognitive Impairment Associated With Schizophrenia (CIAS) - Dormant Projects 101 Cognitive Impairment Associated With Schizophrenia (CIAS) - Discontinued Products 103 Cognitive Impairment Associated With Schizophrenia (CIAS) - Product Development Milestones 104 Featured News & Press Releases 104 Sep 14, 2015: FORUM Pharmaceuticals Updates Encenicline Phase 3 Clinical Trial Programs in Alzheimer s Disease and Cognitive Impairment in Schizophrenia 104 Jul 15, 2015: FORUM Pharmaceuticals Announces Publication of Encenicline Phase 2 Clinical Trial Results for Cognitive Impairment in Schizophrenia 104 Jun 22, 2015: FORUM Pharmaceuticals Receives FDA Fast Track Designation for Lead Compound Encenicline to Treat Cognitive Impairment in Schizophrenia 105 Jun 11, 2015: FORUM Pharmaceuticals Completes Patient Enrollment in Pivotal Phase 3 Clinical Trial Program of Encenicline for Cognitive Impairment in Schizophrenia 106 Apr 17, 2013: SK Biopharma Announces FDA's Authorization Of IND For SKL15508 For Treatment Of Cognitive Impairment Associated With Schizophrenia 107 Feb 19, 2013: Intra-Cellular Therapies Completes Phase I Single Rising Dose Trial Of Selective Phosphodiesterase 1 Inhibitor 108 Appendix 109 Methodology 109 Coverage 109 Secondary Research 109 Primary Research 109 Expert Panel Validation 109 Contact Us 109 Disclaimer 110

9 List of Tables Number of Products under Development for Cognitive Impairment Associated With Schizophrenia (CIAS), H Number of Products under Development for Cognitive Impairment Associated With Schizophrenia (CIAS) - Comparative Analysis, H Number of Products under Development by Companies, H Comparative Analysis by Late Stage Development, H Comparative Analysis by Clinical Stage Development, H Comparative Analysis by Early Stage Development, H Products under Development by Companies, H Products under Development by Companies, H (Contd..1) 19 Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by AbbVie Inc., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Amarantus Bioscience Holdings, Inc., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Astellas Pharma Inc., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Avineuro Pharmaceuticals, Inc., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Bristol-Myers Squibb Company, H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Eli Lilly and Company, H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by FORUM Pharmaceuticals Inc., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by H. Lundbeck A/S, H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Intra-Cellular Therapies, Inc., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Iproteos S.L., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Mnemosyne Pharmaceuticals, Inc., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Neuralstem, Inc., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Pfizer Inc., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Saniona AB, H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Siena Biotech S.p.A., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by SK Biopharmaceuticals Co., Ltd., H

10 Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Sunovion Pharmaceuticals Inc., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Takeda Pharmaceutical Company Limited, H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Upsher-Smith Laboratories, Inc., H Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Vanda Pharmaceuticals Inc., H Assessment by Monotherapy Products, H Number of Products by Stage and Target, H Number of Products by Stage and Mechanism of Action, H Number of Products by Stage and Route of Administration, H Number of Products by Stage and Molecule Type, H Cognitive Impairment Associated With Schizophrenia (CIAS) Therapeutics - Recent Pipeline Updates, H Cognitive Impairment Associated With Schizophrenia (CIAS) - Dormant Projects, H Cognitive Impairment Associated With Schizophrenia (CIAS) - Dormant Projects (Contd..1), H Cognitive Impairment Associated With Schizophrenia (CIAS) - Discontinued Products, H List of Figures Number of Products under Development for Cognitive Impairment Associated With Schizophrenia (CIAS), H Number of Products under Development for Cognitive Impairment Associated With Schizophrenia (CIAS) - Comparative Analysis, H Number of Products under Development by Companies, H Comparative Analysis by Clinical Stage Development, H Comparative Analysis by Early Stage Products, H Assessment by Monotherapy Products, H Number of Products by Top 10 Targets, H Number of Products by Stage and Top 10 Targets, H Number of Products by Top 10 Mechanism of Actions, H Number of Products by Stage and Top 10 Mechanism of Actions, H Number of Products by Top 10 Routes of Administration, H Number of Products by Stage and Top 10 Routes of Administration, H Number of Products by Top 10 Molecule Types, H Number of Products by Stage and Top 10 Molecule Types, H Companies Mentioned:

11 AbbVie Inc. Amarantus Bioscience Holdings, Inc. Astellas Pharma Inc. Avineuro Pharmaceuticals, Inc. Bristol-Myers Squibb Company Eli Lilly and Company FORUM Pharmaceuticals Inc. H. Lundbeck A/S Intra-Cellular Therapies, Inc. Iproteos S.L. Mnemosyne Pharmaceuticals, Inc. Neuralstem, Inc. Pfizer Inc. Saniona AB Siena Biotech S.p.A. SK Biopharmaceuticals Co., Ltd. Sunovion Pharmaceuticals Inc. Takeda Pharmaceutical Company Limited Upsher-Smith Laboratories, Inc. Vanda Pharmaceuticals Inc. License Types: Single User License (PDF) This license allows for use of a publication by one person. This person may print out a single copy of the publication. This person can include information given in the publication in presentations and internal reports by providing full copyright credit to the publisher. This person cannot share the publication (or any information contained therein) with any other person or persons. Unless a Enterprise License is purchased, a Single User License must be purchased for every person that wishes to use the publication within the same organization. Customers who infringe these license terms are liable for a Global license fee. Site License (PDF)* This license allows for use of a publication by all users within one corporate location, e.g. a regional office. These users may print out a single copy of the publication.

12 These users can include information given in the publication in presentations and internal reports by providing full copyright credit to the publisher. These users cannot share the publication (or any information contained therein) with any other person or persons outside the corporate location for which the publication is purchased. Unless a Enterprise License is purchased, a Site User License must be purchased for every corporate location by an organization that wishes to use the publication within the same organization. Customers who infringe these license terms are liable for a Global license fee. Global License (PDF)* This license allows for use of a publication by unlimited users within the purchasing organization e.g. all employees of a single company. Each of these people may use the publication on any computer, and may print out the report, but may not share the publication (or any information contained therein) with any other person or persons outside of the organization. These employees of purchasing organization can include information given in the publication in presentations and internal reports by providing full copyright credit to the publisher. *If Applicable. Source URL: Links [1] [2] [3]

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