Effects of nicotine on neuronal firing patterns in human subthalamic nucleus. Kim Scott Mentor: Henry Lester SURF seminar, January 15, 2009
|
|
- Herbert Carpenter
- 6 years ago
- Views:
Transcription
1 Effects of nicotine on neuronal firing patterns in human subthalamic nucleus Kim Scott Mentor: Henry Lester SURF seminar, January 15, 2009
2 Smoking tobacco protects against Parkinson s Disease (PD). Identical twins: 10 pack-years difference! (Tanner et al. 2002) Risk increases with years since quitting (Ritz et al. 2007) Nicotine has a protective effect in culture and animal models (Quik et al 2007) Conclusion: Chronic nicotine prevents the degeneration of dopaminergic neurons in the substantia nigra. 2
3 Deep brain stimulation in PD Electrical stimulation of the subthalamic nucleus (STN) at Hz immediately relieves motor symptoms of PD. 3
4 Deep brain stimulation in PD Bevan et al Garcia et al Why is this important to us? It s an ethical reason to put electrodes in human brains Suggests a focus on subthalamic nucleus (STN) 4
5 How does nicotine affect firing patterns in STN: What changes? Experimental protocol Spike detection and sorting 1-2 Hz oscillation Hope for the future 5
6 Recording procedure Baseline Nasal saline solution (placebo) Nasal nicotine solution 1.2 mm 1.2 mm Currently available STN recordings: 8 patients (2 smokers) Placebo recordings in all but first two patients. Active placebo in newest patient! Variable lengths of recording, ~5 minutes total. Protocol Spike detection Oscillation Hope and plans 6
7 S i g n a l 0 0 ( µ V ) S i g n a l 0 0 ( µ V ) Spike detection isn t automatic ms 20 μv T im e ( m s ) Protocol Spike detection Oscillation Hope 87820and plans T im e ( m s )
8 Osort: spike detection and sorting filtered trace power signal S detected spikes M Rutishauser et al Protocol Spike detection Oscillation Hope and plans 8
9 count Sample sorted cluster: LUD ch. 2 Interspike interval histogram Protocol Spike detection Oscillation Hope and plans 9
10 Nothing obvious changes. Peak amplitude, variation therein, variation in shape of waveform Firing rate, coefficient of variation Burst propensity Connections among these factors Protocol Spike detection Oscillation Hope and plans 10
11 1-2 Hz bursting oscillation is real. 25 s 10 μv 5 s Protocol Spike detection Oscillation Hope and plans 1 s 11
12 Firing of an STN neuron isn t a renewal process. Protocol Spike detection Oscillation Hope and plans 12
13 The autocorrelation function Patient LUD, channel 1 Lags (s) Protocol Spike detection Oscillation Hope and plans 13
14 Properties of 1-2 Hz oscillation Statistically significant oscillation detected in 30 of 47 clusters Tightly clustered frequencies across channels in the same patient: average variance Hz Consistent changes across channels with placebo and nicotine Units tend to synchronize in or out of phase Almost unique to our group Protocol Spike detection Oscillation Hope and plans 14
15 Brief contralateral stimulation abolishes 1-2 Hz oscillation Percent of units oscillating at 0-2 Hz (Data from Chibirova et al., 2005) Side I Side II Protocol Spike detection Oscillation Hope and plans 15
16 Possible sources of oscillation Plenz & Kital 1999: STN oscillates in culture! STN-GPe cut: abolishes synchronization and oscillation STN-cortex cut: centers frequency at 0.8 Hz Magill et al. 2001: ~ 1 Hz oscillation in STN phase-locked to slowwave activity in cortex Bursting is more intense in dopamine depletion Protocol Spike detection Oscillation Hope and plans 16
17 Nothing obvious changes. Peak amplitude, variation therein, variation in shape of waveform Firing rate, coefficient of variation Burst propensity Strength of oscillation (several measures) Variation in oscillation timing Frequency of oscillation Phase variance, strength, or frequency of synchronization Connections among these Protocol Spike detection Oscillation Hope and plans 17
18 Next steps in analysis Measures of synchrony across all clusters Higher-order features: clustering of bursts Connections between low-frequency components of raw trace and burst timing Future recordings ECG control Blood samples Drug comparison Protocol Spike detection Oscillation Hope and plans 18
19 Acknowledgments Henry Lester Johannes Schwarz (Universität Leipzig) Shawna Frazier Ueli Rutishauser Pam Fong Lester lab the Caltech SURF program and Richter Memorial Fund 19
20 References Benarroch, E.E. Subthalamic nucleus and its connections: anatomic substrate for the network effects of deep brain stimulation. Neurology 70, (2008). Bevan, M.D., Magill, P.J., Terman, D., Bolam, J.B. & Wilson, C.J. Move to the rhythm: oscillations in the subthalamic nucleus-external globus pallidus network. TRENDS in Neurosciences 25, (2002). Chibirova O.K., Aksenova T.I., Benabid A., Chabardes S., Larouche S., Rouat J., & Villa A.E.P. Unsupervised spike sorting of extracellular electrophysiological recording in subthalamic nucleus of Parkinsonian patients. BioSystems 79, (2005). Garcia, L., D'Alessandro, G., Bioulac, B. & Hammond, C. High-frequency stimulation in Parkinson's disease: more or less? TRENDS in Neurosciences 28, (2005). Hahnloser, R.H.R. Cross-intensity functions and the estimate of spike-time jitter. Biol Cybern 96, (2007). Levy, R., Hutchison, W.D., Lozano, A.M. & Dostrovsky, J.O. High-frequency synchronization of neuronal activity in the subthalamic nucleus of Parkinsonian patients with limb tremor. J Neurosci 20, (2000). Magill, P.J., Bolam, J.P. & Bevan, M.D. Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network. Neuroscience 106, (2001). Plentz, D. & Kital, S.T. A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus. Nature 400, (1999). Quik, M., Bordia, T. & O'Leary, K. Nicotinic receptors as CNS targets for Parkinson's disease. Biochem Pharmacol 74, (2007). Ritz, B., Ascherio, A., Checkoway, H., Marder, K.S., Nelson, L.M., Rocca, W.A., Ross, G.W., Strickland, D., Van Den Eeden, S.K., & Gorell, J. Pooled analysis of tobacco use and risk of Parkinson disease. Arch Neurol 64(7): (2007). Rutishauser, U., Schuman, E.M. & Mamelak, A.N. Online detection and sorting of extracellularly recorded action potentials in human medial temporal lobe recordings, in vivo. J Neurosci Methods 154, (2006). Tanner, C.M., Goldman, S.M./, Aston, D.A., Ottman, R., Ellenberg, J., Mayeux, R., Langston, J.W. Smoking and Parkinson s disease in twins. Neurology 58: (2002). 20
21 Signal 00 (µv) Signal 00 (µv) Signal 00 (µv) 800 Challenge: artifact ID & correction 100 HAE Time (ms) VOG Time (ms) WEN s 1.36 µv Time (s) Protocol Spike detection Oscillation What changes? Progress and plans 21
22 Gain changes during recording 22
23 are removable! 23
24 Power thresholding 24
25 We re not limited to studying pairs of clusters The cross-correlation is only defined for two signals, but: 1 Compute pairwise autocorrelations 2 Optimally align spike trains 3 Pool aligned spike trains 4 Compute the autocorrelation 5 Compare to control Protocol Spike detection Oscillation What changes? Progress and plans 25
26 26
27 Direct pathway: striatum inhibits Gpi/SNr inhibits thalamus Indirect pathway: striatum inhibits Gpe inhibits STN excites Gpi/SNr inhibits thalamus. STN is part of the indirect pathway Disfunction leads to impulsivity B.G. possibly participate in action selection. 27
Levodopa vs. deep brain stimulation: computational models of treatments for Parkinson's disease
Levodopa vs. deep brain stimulation: computational models of treatments for Parkinson's disease Abstract Parkinson's disease (PD) is a neurodegenerative disease affecting the dopaminergic neurons of the
More informationCOGNITIVE SCIENCE 107A. Motor Systems: Basal Ganglia. Jaime A. Pineda, Ph.D.
COGNITIVE SCIENCE 107A Motor Systems: Basal Ganglia Jaime A. Pineda, Ph.D. Two major descending s Pyramidal vs. extrapyramidal Motor cortex Pyramidal system Pathway for voluntary movement Most fibers originate
More informationDeep Brain Stimulation Surgery for Parkinson s Disease
Deep Brain Stimulation Surgery for Parkinson s Disease Demystifying Medicine 24 January 2012 Kareem A. Zaghloul, MD, PhD Staff Physician, Surgical Neurology Branch NINDS Surgery for Parkinson s Disease
More informationNEURAL CONTROL OF MOVEMENT: ENGINEERING THE RHYTHMS OF THE BRAIN
NEURAL CONTROL OF MOVEMENT: ENGINEERING THE RHYTHMS OF THE BRAIN Madeleine Lowery School of Electrical and Electronic Engineering Centre for Biomedical Engineering University College Dublin Parkinson s
More informationSYNCHRONIZATION OF PALLIDAL ACTIVITY IN THE MPTP PRIMATE MODEL OF PARKINSONISM IS NOT LIMITED TO OSCILLATORY ACTIVITY
SYNCHRONIZATION OF PALLIDAL ACTIVITY IN THE MPTP PRIMATE MODEL OF PARKINSONISM IS NOT LIMITED TO OSCILLATORY ACTIVITY Gali Heimer, Izhar Bar-Gad, Joshua A. Goldberg and Hagai Bergman * 1. INTRODUCTION
More informationAnatomy of the basal ganglia. Dana Cohen Gonda Brain Research Center, room 410
Anatomy of the basal ganglia Dana Cohen Gonda Brain Research Center, room 410 danacoh@gmail.com The basal ganglia The nuclei form a small minority of the brain s neuronal population. Little is known about
More informationDown regulation of the HCN2 channel in rat models of Parkinson s disease
Down regulation of the HCN2 channel in rat models of Parkinson s disease Abstract The basal ganglia is a key control centre involved with the regulation of movement. It is therefore a primary interest
More informationA. General features of the basal ganglia, one of our 3 major motor control centers:
Reading: Waxman pp. 141-146 are not very helpful! Computer Resources: HyperBrain, Chapter 12 Dental Neuroanatomy Suzanne S. Stensaas, Ph.D. March 1, 2012 THE BASAL GANGLIA Objectives: 1. What are the main
More informationA. General features of the basal ganglia, one of our 3 major motor control centers:
Reading: Waxman pp. 141-146 are not very helpful! Computer Resources: HyperBrain, Chapter 12 Dental Neuroanatomy Suzanne S. Stensaas, Ph.D. April 22, 2010 THE BASAL GANGLIA Objectives: 1. What are the
More informationNetwork Effects of Deep Brain Stimulation for Parkinson s Disease A Computational. Modeling Study. Karthik Kumaravelu
Network Effects of Deep Brain Stimulation for Parkinson s Disease A Computational Modeling Study by Karthik Kumaravelu Department of Biomedical Engineering Duke University Date: Approved: Warren M. Grill,
More informationBME 701 Examples of Biomedical Instrumentation. Hubert de Bruin Ph D, P Eng
BME 701 Examples of Biomedical Instrumentation Hubert de Bruin Ph D, P Eng 1 Instrumentation in Cardiology The major cellular components of the heart are: working muscle of the atria & ventricles specialized
More informationTeach-SHEET Basal Ganglia
Teach-SHEET Basal Ganglia Purves D, et al. Neuroscience, 5 th Ed., Sinauer Associates, 2012 Common organizational principles Basic Circuits or Loops: Motor loop concerned with learned movements (scaling
More informationSupplementary Information for Decreased activity of single subthalamic nucleus neurons in Parkinson patients responding to placebo
Supplementary Information for Decreased activity of single subthalamic nucleus neurons in Parkinson patients responding to placebo Fabrizio Benedetti, 1,2 Luana Colloca, 1,2 Elena Torre, 1 Michele Lanotte,
More informationElectrophysiology of Subthalamic Nucleus in Normal and Parkinson s Disease
Continuing Medical Education 206 Electrophysiology of Subthalamic Nucleus in Normal and Parkinson s Disease Chun-Hwei Tai and Chung-Chin Kuo Abstract- Subthalamic nucleus (STN) has been known to play an
More informationGBME graduate course. Chapter 43. The Basal Ganglia
GBME graduate course Chapter 43. The Basal Ganglia Basal ganglia in history Parkinson s disease Huntington s disease Parkinson s disease 1817 Parkinson's disease (PD) is a degenerative disorder of the
More informationBasal Ganglia. Steven McLoon Department of Neuroscience University of Minnesota
Basal Ganglia Steven McLoon Department of Neuroscience University of Minnesota 1 Course News Graduate School Discussion Wednesday, Nov 1, 11:00am MoosT 2-690 with Paul Mermelstein (invite your friends)
More informationBasal Ganglia. Introduction. Basal Ganglia at a Glance. Role of the BG
Basal Ganglia Shepherd (2004) Chapter 9 Charles J. Wilson Instructor: Yoonsuck Choe; CPSC 644 Cortical Networks Introduction A set of nuclei in the forebrain and midbrain area in mammals, birds, and reptiles.
More informationMaking Things Happen 2: Motor Disorders
Making Things Happen 2: Motor Disorders How Your Brain Works Prof. Jan Schnupp wschnupp@cityu.edu.hk HowYourBrainWorks.net On the Menu in This Lecture In the previous lecture we saw how motor cortex and
More informationTemporal patterning of neural synchrony in the basal ganglia in Parkinson s disease
Temporal patterning of neural synchrony in the basal ganglia in Parkinson s disease Shivakeshavan Ratnadurai-Giridharan 1, S. Elizabeth Zauber 2, Robert M. Worth 1,3, Thomas Witt 3, Sungwoo Ahn 1,5, Leonid
More informationSynchronization in Nonlinear Systems and Networks
Synchronization in Nonlinear Systems and Networks Yuri Maistrenko E-mail: y.maistrenko@biomed.kiev.ua you can find me in room EW 632 1 Lecture 2-09.11.2011 SYNCHRONIZATION At the heart of the Universe
More informationConnections of basal ganglia
Connections of basal ganglia Introduction The basal ganglia, or basal nuclei, are areas of subcortical grey matter that play a prominent role in modulating movement, as well as cognitive and emotional
More informationBasal ganglia Sujata Sofat, class of 2009
Basal ganglia Sujata Sofat, class of 2009 Basal ganglia Objectives Describe the function of the Basal Ganglia in movement Define the BG components and their locations Describe the motor loop of the BG
More informationBasal Ganglia General Info
Basal Ganglia General Info Neural clusters in peripheral nervous system are ganglia. In the central nervous system, they are called nuclei. Should be called Basal Nuclei but usually called Basal Ganglia.
More informationParkinsonism or Parkinson s Disease I. Symptoms: Main disorder of movement. Named after, an English physician who described the then known, in 1817.
Parkinsonism or Parkinson s Disease I. Symptoms: Main disorder of movement. Named after, an English physician who described the then known, in 1817. Four (4) hallmark clinical signs: 1) Tremor: (Note -
More informationDBS efficacia, complicanze in cronico e nuovi orizzonti terapeutici
DBS efficacia, complicanze in cronico e nuovi orizzonti terapeutici TECNICHE DI NEUROMODULAZIONE Invasiva: odeep Brain Stimulation Non Invasiva: o Transcranial Magnetic Stimulation (TMS) o Transcranial
More informationVL VA BASAL GANGLIA. FUNCTIONAl COMPONENTS. Function Component Deficits Start/initiation Basal Ganglia Spontan movements
BASAL GANGLIA Chris Cohan, Ph.D. Dept. of Pathology/Anat Sci University at Buffalo I) Overview How do Basal Ganglia affect movement Basal ganglia enhance cortical motor activity and facilitate movement.
More informationTREATMENT-SPECIFIC ABNORMAL SYNAPTIC PLASTICITY IN EARLY PARKINSON S DISEASE
TREATMENT-SPECIFIC ABNORMAL SYNAPTIC PLASTICITY IN EARLY PARKINSON S DISEASE Angel Lago-Rodriguez 1, Binith Cheeran 2 and Miguel Fernández-Del-Olmo 3 1. Prism Lab, Behavioural Brain Sciences, School of
More informationMovement Disorders: A Brief Overview
Movement Disorders: A Brief Overview Albert Hung, MD, PhD Massachusetts General Hospital Harvard Medical School August 17, 2006 Cardinal Features of Parkinsonism Tremor Rigidity Bradykinesia Postural imbalance
More informationParkinson s Disease and Cortico-Basal Ganglia Circuits
Continuing Medical Education 213 Parkinson s Disease and Cortico-Basal Ganglia Circuits Ming-Kai Pan, Chun-Hwei Tai, Chung-Chin Kuo Abstract- Cortico-basal ganglia circuit model has been studied extensively
More informationModeling the interplay of short-term memory and the basal ganglia in sequence processing
Neurocomputing 26}27 (1999) 687}692 Modeling the interplay of short-term memory and the basal ganglia in sequence processing Tomoki Fukai* Department of Electronics, Tokai University, Hiratsuka, Kanagawa
More informationDamage on one side.. (Notes) Just remember: Unilateral damage to basal ganglia causes contralateral symptoms.
Lecture 20 - Basal Ganglia Basal Ganglia (Nolte 5 th Ed pp 464) Damage to the basal ganglia produces involuntary movements. Although the basal ganglia do not influence LMN directly (to cause this involuntary
More informationThe Effect of Weighted Compression Sleeves on Tremor Suppression in Individuals with Parkinson s Disease
The Effect of Weighted Compression Sleeves on Tremor Suppression in Individuals with Parkinson s Disease Jennifer Iannello, Garry Johnson, Lauren Pilla Parkinson s Disease Second most common chronic, progressive,
More informationExplorative Analysis and Data Mining in Big Neural Data
Explorative Analysis and Data Mining in Big Neural Data Jennifer Linge 2015 Master s Thesis Biomedical Engineering Faculty of Engineering LTH Department of Biomedical Engineering Supervisors: Frida Sandberg
More informationSimplified Model of Machado-Joseph Disease in Comparison to Parkinson s Disease and Normal Models
Simplified Model of Machado-Joseph Disease in Comparison to Parkinson s Disease and Normal Models 1 2 3 4 5 6 7 8 9 10 Anjulie Agrusa M.S. Student of Bioengineering UC San Diego San Diego CA Julia Hardy
More informationFunctional Distinctions
Functional Distinctions FUNCTION COMPONENT DEFICITS Start Basal Ganglia Spontaneous Movements Move UMN/LMN Cerebral Cortex Brainstem, Spinal cord Roots/peripheral nerves Plan Cerebellum Ataxia Adjust Cerebellum
More informationSaichiu Nelson Tong ALL RIGHTS RESERVED
2017 Saichiu Nelson Tong ALL RIGHTS RESERVED MODELING CLASSIFICATION NETWORK OF ELECTROENCEPHALOGRAPHIC ARTIFACTS AND SIGNALS ASSOCIATED WITH DEEP BRAIN STIMULATION By SAICHIU NELSON TONG A thesis submitted
More informationWhether deep brain stimulation can dramatically. Deep brain stimulation: How does it work?
JERROLD L. VITEK, MD, PhD Director, Neuromodulation Research Center, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH Deep brain stimulation: How does it work? ABSTRACT
More informationKinematic Modeling in Parkinson s Disease
Kinematic Modeling in Parkinson s Disease Alexander Hui Department of Bioengineering University of California, San Diego La Jolla, CA 92093 alexhui@ucsd.edu Abstract Parkinson s disease is a slowly progressing
More informationSUPPLEMENTAL DIGITAL CONTENT
SUPPLEMENTAL DIGITAL CONTENT FIGURE 1. Unilateral subthalamic nucleus (STN) deep brain stimulation (DBS) electrode and internal pulse generator. Copyright 2010 Oregon Health & Science University. Used
More informationFor more information about how to cite these materials visit
Author(s): Peter Hitchcock, PH.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Non-commercial Share Alike 3.0 License: http://creativecommons.org/licenses/by-nc-sa/3.0/
More informationKETAMINE S EFFECT ON SINGLE- UNIT ACTIVITY IN THE STRIATUM
KETAMINE S EFFECT ON SINGLE- UNIT ACTIVITY IN THE STRIATUM Item Type text; Electronic Thesis Authors SEGHEZZO, GIULIA FRANCESCA Publisher The University of Arizona. Rights Copyright is held by the author.
More informationTowards a Better Treatment of Parkinson's disease
Loma Linda University TheScholarsRepository@LLU: Digital Archive of Research, Scholarship & Creative Works Loma Linda University Electronic Theses, Dissertations & Projects 3-2014 Towards a Better Treatment
More informationNetwork effects of subthalamic deep brain stimulation drive a unique mixture of responses in basal ganglia output
Section: CECN Special Issue Proposed Associate Editor: Tomoki Fukai Network effects of subthalamic deep brain stimulation drive a unique mixture of responses in basal ganglia output Abbreviated title:
More informationEffects of Apomorphine on Subthalamic Nucleus and Globus Pallidus Internus Neurons in Patients With Parkinson s Disease
Effects of Apomorphine on Subthalamic Nucleus and Globus Pallidus Internus Neurons in Patients With Parkinson s Disease R. LEVY, 1 J. O. DOSTROVSKY, 1,3 A. E. LANG, 3,4 E. SIME, 3 W. D. HUTCHISON, 1 3
More informationDeep Brain Stimulation: Patient selection
Deep Brain Stimulation: Patient selection Halim Fadil, MD Movement Disorders Neurologist Kane Hall Barry Neurology Bedford/Keller, TX 1991: Thalamic (Vim) DBS for tremor Benabid AL, et al. Lancet. 1991;337(8738):403-406.
More informationLecture XIII. Brain Diseases I - Parkinsonism! Brain Diseases I!
Lecture XIII. Brain Diseases I - Parkinsonism! Bio 3411! Wednesday!! Lecture XIII. Brain Diseases - I.! 1! Brain Diseases I! NEUROSCIENCE 5 th ed! Page!!Figure!!Feature! 408 18.9 A!!Substantia Nigra in
More informationThe control of spiking by synaptic input in striatal and pallidal neurons
The control of spiking by synaptic input in striatal and pallidal neurons Dieter Jaeger Department of Biology, Emory University, Atlanta, GA 30322 Key words: Abstract: rat, slice, whole cell, dynamic current
More informationFunctional Neuroanatomy and Physiology for Movement Disorders
Functional Neuroanatomy and Physiology for Movement Disorders Chang, Won Seok Division of Stereotactic and Functional Neurosurgery, Department of Neurosurgery, Brain Research Institute, Yonsei University
More informationEmbryological origin of thalamus
diencephalon Embryological origin of thalamus The diencephalon gives rise to the: Thalamus Epithalamus (pineal gland, habenula, paraventricular n.) Hypothalamus Subthalamus (Subthalamic nuclei) The Thalamus:
More informationBASAL GANGLIA. Dr JAMILA EL MEDANY
BASAL GANGLIA Dr JAMILA EL MEDANY OBJECTIVES At the end of the lecture, the student should be able to: Define basal ganglia and enumerate its components. Enumerate parts of Corpus Striatum and their important
More informationBasal Ganglia George R. Leichnetz, Ph.D.
Basal Ganglia George R. Leichnetz, Ph.D. OBJECTIVES 1. To understand the brain structures which constitute the basal ganglia, and their interconnections 2. To understand the consequences (clinical manifestations)
More informationMulti-site Stimulation of Subthalamic Nucleus Diminishes Thalamocortical Relay Errors in a Biophysical Network Model
Multi-site Stimulation of Subthalamic Nucleus Diminishes Thalamocortical Relay Errors in a Biophysical Network Model Yixin Guo a,, Jonathan E. Rubin b a Department of Mathematics, Drexel University, Philadelphia,
More informationDeranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits
The Journal of Clinical Investigation Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits Ming-Kai Pan, 1,2,3 Chun-Hwei Tai, 2 Wen-Chuan Liu, 2 Ju-Chun Pei, 4 Wen-Sung
More informationMicroelectrode recording: lead point in STN-DBS surgery
Acta Neurochir Suppl (2006) 99: 37 42 # Springer-Verlag 2006 Printed in Austria Microelectrode recording: lead point in STN-DBS surgery M. S. Kim 1, Y. T. Jung 1, J. H. Sim 1,S.J.Kim 2, J. W. Kim 3, and
More informationnucleus accumbens septi hier-259 Nucleus+Accumbens birnlex_727
Nucleus accumbens From Wikipedia, the free encyclopedia Brain: Nucleus accumbens Nucleus accumbens visible in red. Latin NeuroNames MeSH NeuroLex ID nucleus accumbens septi hier-259 Nucleus+Accumbens birnlex_727
More informationComputational cognitive neuroscience: 8. Motor Control and Reinforcement Learning
1 Computational cognitive neuroscience: 8. Motor Control and Reinforcement Learning Lubica Beňušková Centre for Cognitive Science, FMFI Comenius University in Bratislava 2 Sensory-motor loop The essence
More informationSynchronous Oscillations in the Basal-Ganglia-Cortical Network: Do They Generate Tremor and Other Symptoms of Parkinson's Disease?
Synchronous Oscillations in the Basal-Ganglia-Cortical Network: Do They Generate Tremor and Other Symptoms of Parkinson's Disease? Thesis submitted for the degree of Doctor of Philosophy by Michal Rivlin-Etzion
More informationAuthor's personal copy
Neuroscience Letters 442 (2008) 195 199 Contents lists available at ScienceDirect Neuroscience Letters journal homepage: www. elsevier. com/ locate/ neulet Tremor-correlated neuronal activity in the subthalamic
More informationNeuroinformatics. (credits: Daniel Novák, Tomáš Sieger) 12th March Lecture 4: Case study - Deep brain stimulation for Parkinson s disease
Neuroinformatics Eduard Bakštein (credits: Daniel Novák, Tomáš Sieger) 12th March 2015 Lecture 4: Case study - Deep brain stimulation for Parkinson s disease Overview Why this lecture? Because... Parkinson
More informationThe motor regulator. 1) Basal ganglia/nucleus
The motor regulator 1) Basal ganglia/nucleus Neural structures involved in the control of movement Basal Ganglia - Components of the basal ganglia - Function of the basal ganglia - Connection and circuits
More informationAn Interactive Channel Model of the Basal Ganglia: Bifurcation Analysis Under Healthy and Parkinsonian Conditions
Journal of Mathematical Neuroscience (2013) 3:14 DOI 10.1186/2190-8567-3-14 RESEARCH OpenAccess An Interactive Channel Model of the Basal Ganglia: Bifurcation Analysis Under Healthy and Parkinsonian Conditions
More informationBasal nuclei, cerebellum and movement
Basal nuclei, cerebellum and movement MSTN121 - Neurophysiology Session 9 Department of Myotherapy Basal Nuclei (Ganglia) Basal Nuclei (Ganglia) Role: Predict the effects of various actions, then make
More informationMay 9, Q Financial Results
May 9, 2017 Q1 2017 Financial Results Agenda Today s Speakers Paul Cox, Senior Director, Investor Relations Jeff Jonas, M.D., Chief Executive Officer Steve Kanes, M.D., Ph.D., Chief Medical Officer Kimi
More informationGangli della Base: un network multifunzionale
Gangli della Base: un network multifunzionale Prof. Giovanni Abbruzzese Centro per la Malattia di Parkinson e i Disordini del Movimento DiNOGMI, Università di Genova IRCCS AOU San Martino IST Basal Ganglia
More informationDopamine replacement therapy reduces beta band burst duration in Parkinson s disease
DEGREE PROJECT IN MEDICAL ENGINEERING, SECOND CYCLE, 30 CREDITS STOCKHOLM, SWEDEN 2017 Dopamine replacement therapy reduces beta band burst duration in Parkinson s disease ALESSANDRO MECCONI KTH ROYAL
More informationIndications. DBS for Tremor. What is the PSA? 6/08/2014. Tremor. 1. Tremor. 2. Gait freezing/postural instability. 3. Motor fluctuations
Indications Deep brain stimulation for Parkinson s disease A Tailored Approach 1. Tremor 2. Gait freezing/postural instability Wesley Thevathasan FRACP DPhil.Oxf 3. Motor fluctuations Consultant Neurologist,
More informationMOVEMENT OUTLINE. The Control of Movement: Muscles! Motor Reflexes Brain Mechanisms of Movement Mirror Neurons Disorders of Movement
MOVEMENT 2 Dr. Steinmetz 3 OUTLINE The Control of Movement: Muscles! Motor Reflexes Brain Mechanisms of Movement Mirror Neurons Disorders of Movement Parkinson s Disease Huntington s Disease 1 4 TYPES
More informationBeta and Tremor-Related Oscillations in the Motor Thalamus of Essential Tremor Patients
IETF - WD Hutchison Feb 214 requesting $25, Beta and Tremor-Related Oscillations in the Motor Thalamus of Essential Tremor Patients 1. Specific aims of proposal The proposed study will examine beta oscillations
More informationNS219: Basal Ganglia Anatomy
NS219: Basal Ganglia Anatomy Human basal ganglia anatomy Analagous rodent basal ganglia nuclei Basal ganglia circuits: the classical model of direct and indirect pathways + Glutamate + - GABA - Gross anatomy
More informationParkinson disease: Parkinson Disease
Surgical Surgical treatment treatment for for Parkinson disease: Parkinson Disease the Present and the Future the Present and the Future Olga Klepitskaya, MD Associate Professor of Neurology Co-Director,
More information神經解剖學 NEUROANATOMY BASAL NUCLEI 盧家鋒助理教授臺北醫學大學醫學系解剖學暨細胞生物學科臺北醫學大學醫學院轉譯影像研究中心.
神經解剖學 NEUROANATOMY BASAL NUCLEI 盧家鋒助理教授臺北醫學大學醫學系解剖學暨細胞生物學科臺北醫學大學醫學院轉譯影像研究中心 http://www.ym.edu.tw/~cflu OUTLINE Components and Pathways of the Basal Nuclei Functions and Related Disorders of the Basal Nuclei
More informationStimulation of the Subthalamic Nucleus Changes the Firing Pattern of Pallidal Neurons
1916 The Journal of Neuroscience, March 1, 2003 23(5):1916 1923 Stimulation of the Subthalamic Nucleus Changes the Firing Pattern of Pallidal Neurons Takao Hashimoto, 1,2 Christopher M. Elder, 1 Michael
More information10/3/2016. T1 Anatomical structures are clearly identified, white matter (which has a high fat content) appears bright.
H2O -2 atoms of Hydrogen, 1 of Oxygen Hydrogen just has one single proton and orbited by one single electron Proton has a magnetic moment similar to the earths magnetic pole Also similar to earth in that
More informationModeling facilitation and inhibition of competing motor programs in basal ganglia subthalamic nucleus pallidal circuits
Modeling facilitation and inhibition of competing motor programs in basal ganglia subthalamic nucleus pallidal circuits Leonid L. Rubchinsky*, Nancy Kopell, and Karen A. Sigvardt* *Center for Neuroscience
More informationNeurodegenerative Disease. April 12, Cunningham. Department of Neurosciences
Neurodegenerative Disease April 12, 2017 Cunningham Department of Neurosciences NEURODEGENERATIVE DISEASE Any of a group of hereditary and sporadic conditions characterized by progressive dysfunction,
More informationThalamocortical relay reliability varies across subthalamic nucleus deep brain stimulation protocols in a data driven computational model
Thalamocortical relay reliability varies across subthalamic nucleus deep brain stimulation protocols in a data driven computational model Yixin Guo * Jonathan E. Rubin # Department of Mathematics Department
More informationData Mining Tools used in Deep Brain Stimulation Analysis Results
Data Mining Tools used in Deep Brain Stimulation Analysis Results Oana Geman PhD, Faculty of Electrical Engineering and Computer Science, Stefan cel Mare University, Suceava, Romania geman@eed.usv.ro Abstract.
More informationHigh Frequency Stimulation of the Subthalamic Nucleus Eliminates Pathological Thalamic Rhythmicity in a Computational Model
Journal of Computational Neuroscience 16, 211 235, 2004 c 2004 Kluwer Academic Publishers. Manufactured in The Netherlands. High Frequency Stimulation of the Subthalamic Nucleus Eliminates Pathological
More informationChapter 8. Parkinsonism. M.G.Rajanandh, Dept. of Pharmacy Practice, SRM College of Pharmacy, SRM University.
Chapter 8 Parkinsonism M.G.Rajanandh, Dept. of Pharmacy Practice, SRM College of Pharmacy, SRM University. Definition of Parkinson s Disease Parkinson's disease is a progressive, neurodegenerative disease
More informationNature Methods: doi: /nmeth Supplementary Figure 1. Activity in turtle dorsal cortex is sparse.
Supplementary Figure 1 Activity in turtle dorsal cortex is sparse. a. Probability distribution of firing rates across the population (notice log scale) in our data. The range of firing rates is wide but
More informationCourse Calendar
Clinical Neuroscience BMS 6706C Charles, Ph.D., Course Director charles.ouimet@med.fsu.edu (850) 644-2271 2004 2005 Course Calendar Click here to return to the syllabus Meeting Hours for entire semester:
More informationProperties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson s disease
Du et al. Translational Neurodegeneration (2018) 7:17 https://doi.org/10.1186/s40035-018-0123-y RESEARCH Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson
More informationChapter 8. Control of movement
Chapter 8 Control of movement 1st Type: Skeletal Muscle Skeletal Muscle: Ones that moves us Muscles contract, limb flex Flexion: a movement of a limb that tends to bend its joints, contraction of a flexor
More informationmodulation of multiple brain networks.
Neuroanatomy of Deep Brain Stimulation: modulation of multiple brain networks. Dr. med. Ettore A. Accolla Maladie de Parkinson: un diagnostic clinique 1. Bradykinésie 2. Tremblement de repos (4-6 Hz) 3.
More informationEMERGING TREATMENTS FOR PARKINSON S DISEASE
EMERGING TREATMENTS FOR PARKINSON S DISEASE Katerina Markopoulou, MD, PhD Director Neurodegenerative Diseases Program Department of Neurology NorthShore University HealthSystem Clinical Assistant Professor
More informationBrain State Dependency of Coherent Oscillatory Activity in the Cerebral Cortex and Basal Ganglia of the Rat
J Neurophysiol 92: 2122 2136, 2004. First published June 2, 2004; 10.1152/jn.00333.2004. Brain State Dependency of Coherent Oscillatory Activity in the Cerebral Cortex and Basal Ganglia of the Rat Peter
More informationNeurobiology of Disease. Bertrand Degos, 1 Jean-Michel Deniau, 1 Anne-Marie Thierry, 2 Jacques Glowinski, 2 Laurent Pezard, 3 and Nicolas Maurice 1 1
The Journal of Neuroscience, August 17, 2005 25(33):7687 7696 7687 Neurobiology of Disease Neuroleptic-Induced Catalepsy: Electrophysiological Mechanisms of Functional Recovery Induced by High- Frequency
More informationIntracranial Studies Of Human Epilepsy In A Surgical Setting
Intracranial Studies Of Human Epilepsy In A Surgical Setting Department of Neurology David Geffen School of Medicine at UCLA Presentation Goals Epilepsy and seizures Basics of the electroencephalogram
More informationDeep Brain Stimulation: Surgical Process
Deep Brain Stimulation: Surgical Process Kia Shahlaie, MD, PhD Assistant Professor Bronte Endowed Chair in Epilepsy Research Director of Functional Neurosurgery Minimally Invasive Neurosurgery Department
More informationOrganization of the nervous system 2
Organization of the nervous system 2 Raghav Rajan Bio 334 Neurobiology I August 22nd 2013 1 Orienting within the brain absolute axes and relative axes SUPERIOR (above) ANTERIOR (in front) Anterior/Posterior,
More informationCourse Calendar - Neuroscience
2006-2007 Course Calendar - Neuroscience Meeting Hours for entire semester: Monday - Friday 1:00-2:20 p.m. Room 1200, COM August 28 August 29 August 30 August 31 September 1 Course introduction, Neurocytology:
More informationVisualization and simulated animations of pathology and symptoms of Parkinson s disease
Visualization and simulated animations of pathology and symptoms of Parkinson s disease Prof. Yifan HAN Email: bctycan@ust.hk 1. Introduction 2. Biochemistry of Parkinson s disease 3. Course Design 4.
More informationBasal Ganglia Anatomy, Physiology, and Function. NS201c
Basal Ganglia Anatomy, Physiology, and Function NS201c Human Basal Ganglia Anatomy Basal Ganglia Circuits: The Classical Model of Direct and Indirect Pathway Function Motor Cortex Premotor Cortex + Glutamate
More informationImplications of a Dynamic Causal Modeling Analysis of fmri Data. Andrea Stocco University of Washington, Seattle
Implications of a Dynamic Causal Modeling Analysis of fmri Data Andrea Stocco University of Washington, Seattle Production Rules and Basal Ganglia Buffer Buffer Buffer Thalamus Striatum Matching Striatum
More informationMechanisms of Deep Brain Stimulation in Movement Disorders as Revealed by Changes in Stimulus Frequency
Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics Mechanisms of Deep Brain Stimulation in Movement Disorders as Revealed by Changes in Stimulus Frequency Merrill
More informationMovement Disorders. Psychology 372 Physiological Psychology. Background. Myasthenia Gravis. Many Types
Background Movement Disorders Psychology 372 Physiological Psychology Steven E. Meier, Ph.D. Listen to the audio lecture while viewing these slides Early Studies Found some patients with progressive weakness
More informationBiological Bases of Behavior. 8: Control of Movement
Biological Bases of Behavior 8: Control of Movement m d Skeletal Muscle Movements of our body are accomplished by contraction of the skeletal muscles Flexion: contraction of a flexor muscle draws in a
More informationThe Nervous System. Neuron 01/12/2011. The Synapse: The Processor
The Nervous System Neuron Nucleus Cell body Dendrites they are part of the cell body of a neuron that collect chemical and electrical signals from other neurons at synapses and convert them into electrical
More informationCNS MCQ 2 nd term. Select the best answer:
Select the best answer: CNS MCQ 2 nd term 1) Vestibular apparatus: a) Represent the auditory part of the labyrinth. b) May help in initiating the voluntary movements. c) Contains receptors concerned with
More information