SUMITOMO Particle Therapy Technologies

Transcription

1 55 th AAPM annual meeting Particle Beam Therapy Symposium SUMITOMO Particle Therapy Technologies August 3, 2013 Yukio Kumata

2 Experience accelerators for science Current Status proton and carbon Future Technologies particle therapy 2

3 Experience accelerators for science 3

4 Accelerator business since 1971 Medical accelerators since 1980 Particle therapy system since 1998 over 14 years (R&D started in 1989) 4

5 R&D Accelerators since 1970s CYCLOTRON Osaka Univ K=150MeV Tohoku Univ K=50MeV RIKEN 1986 Heavy Ions K=540MeV Japan Atomic Energy Agency 1989 K=110MeV 5

6 R&D Accelerators since 1970s Ritsumeikan Univ Electron 700MeV Superconducting SYNCHROTRON Hiroshima Univ Electron 700MeV Normal conducting Injector (Racetrack Microtron) Electron 150MeV 6

7 R&D Accelerators since 1970s Heavy Ion Linac RIKEN 1978 C MeV/n NIRS 1989 C 4+ 7MeV/n HIMAC (RFQ+Alvarez) 7

8 Medical Accelerators Proton Therapy System Boron Neutron Capture Therapy System Injector for Carbon Therapy PET cyclotron 8

9 Components for Particle Therapy Proton therapy cyclotron (IBA) Carbon therapy injector (Mitsubishi etc.) Cryocooler for superconducting cyclotron (Varian, MEVION) for MRI SC magnet, too (GE, Siemens, Philips) 9

10 Current Status Proton and carbon 10

11 Proton Reference Sites Samsung Medical Center Korea Chang Gung Memorial Hospital Taiwan National Cancer Center Japan Aizawa Hospital Japan Starting

12 Carbon Injector Reference Sites Gunma University Heavy-Ion Medical Center [GHMC] operational:2010 National Institute of Radiological Sciences [NIRS HIMAT] operational:1994 Hyogo Ion Beam Medical Center operational: 2001 Ion-beam Radiation Oncology Center In Kanagawa [i-rock] start: 2015 SAGA Heavy Ion Medical Accelerator in Tosu [SAGA HIMAT] start:

13 14-Years Operation at NCC 1998 Upgraded in Gantry #1: MLC, Pencil beam scanning Gantry #2: Robotic couch, Orthogonal DR, CT on rail G#1 G#2 13

14 Double Decker Compact Solution: Aizawa Treatment room with CT on rail Single Gantry Double Decker Small vault footprint: 53 x 66 (16m x 20m) Performance achieved!! Treatment starts in Gantry Matsumoto city Cyclotron Sectional View 14

15 Taiwan First Proton: CGMH Proton Center Linkou Chang Gung Memorial Hosp., Taiwan 4 Gantries + 1 Fixed beam port First beam delivered to the treatment room!! Treatment will start in

16 Korean Second Proton: Samsung One of the top hospitals in Korea 2 Gantries, 3 vaults for future expansion Major components have been installed!! Treatment will start in 2015 Samsung Medical Center, Korea Cyclotron Beamline Hospital Building 16

17 Small vault footprint Conventional Gantry Short-length Gantry 50% DOWN in length 33 (10 m) 30% DOWN in vault area 15 (4.6 m) 360 deg. rotation 360 deg. rotation 17

18 Broad Beam & Pencil Beam MLC Broad beam Pencil beam Broad beam with an MLC & Pencil beam scanning capabilities in a single nozzle (multi-purpose nozzle) 18

19 Performance of Multi-Purpose Nozzle Broad beam (wobbling) Scanning beam Relative dose MeV Lateral Dose Profile L1.X L1.Y L2.X L2.Y L3.X L3.Y X/Y [mm] Gantry angle 270 deg 0 deg 230 MeV 70 MeV Beam size: 3 9 mm (1 sigma) PDD MeV PDD by Ridge Filters SOBP10cm SOBP5cm SOBP3cm Dose [Gy/MU] MeV+SD 70 MeV Scanning, mono-energy beam 230 MeV Depth [mm] Depth [mm] 19

20 Image-Guided Proton Therapy Orthogonal Digital Radiograph x-ray Tube Fluoroscopy CBCT CT on rail Positron Emission Detection FPD CBCT PET CT on rail 20

21 Respiratory Gating for Moving Target Laser sensor Respiratory signal Without Gating Gating signal With Gating 21

22 Future Technologies Particle Therapy 22

23 Ultrafast Layer Change for Moving Target Scanning + Layer change Proton Tumor Time structure of 20-layers scanning for 1 liter volume Scanning Layer change Current Line Scanning 4 s 40 s Total 44 s Ultrafast Layer Change Total 4 s 6 s 2 s Layer change: 2 sec/layer 0.1 sec/layer 6 sec for 1 liter volume Breath-hold No interplay effect 23

24 Superconducting AVF cyclotron Normal Conducting AVF cyclotron Downsizing Light weight Less expensive Quick delivery No trade off! Superconducting AVF cyclotron Coil structure Beam orbit 24

25 SC AVF cyclotron + Half-turn gantry SC AVF cyclotron Energy Selection System Half-turn Gantry 25

26 Light Ion Therapy System 300 MeV/u AVF superconducting cyclotron H 2+,, Li 3+, B 5+,C deg. Proton gantry 0/45/90 deg. Light-ion nozzle 26

27 Boron Neutron Capture Therapy (BNCT) System Proton Accelerator Beam Transport Target and Irradiation Moderator Target Collimator Laser Marker (Positioning) Boron Compound Magnets Cyclotron (30MeV) Proton beam Scanning Magnet Fast Neutron Epithermal Neutron Thermal Neutron Patient Clinical Trial is under way at Kyoto University in Japan. 27

28 Thank you! 28