Patients Treated with Leksell Gamma Knife

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1 Patients Treated with Leksell Gamma Knife

2 TREATMENTS REPORTED 2016 BY REGION AND INDICATION INDICATION Asia excl. Europe Latin Middle East & Africa North Grand Total Benign Tumors Craniopharyngioma Diffuse Astrocytoma, Grade II Dysembryoplastic Neuroepithelial Tumor Ependymoma Ganglioglioma Glomus Tumor Hemangioblastoma Hemangioma Hemangiopericytoma, Grade II Jugular Foramen Schwannoma Juvenile Pilocytic Astrocytoma Meningioma Grade I (typical) Meningioma Grade II (atypical) Neurocytoma Oligodendroglioma, Grade II+A Other Benign Tumor Other Schwannoma Pineal Region Tumor Pituitary Adenoma Plexomorphic Xanthoastrocytoma (PXA) Trigeminal Schwannoma Vestibular Schwannoma Functional Disorders Cluster Headache Essential Tremor Hypothalamic Hamartoma Intractable Pain Mesial Temporal Lobe Epilepsy OCD Other Behavioral Disorders Other Epilepsy Other Movement Disorders Other Pain Disorders Parkinson's Disease Trigeminal Neuralgia Malignant Tumors Anaplastic Astrocytoma, Grade III Chondrosarcoma Chordoma Ependymoma (anaplastic), Grade II or III Esthesioneuroblastoma Glioblastoma Hemangiopericytoma, Grade III (anaplastic) Medulloblastoma/PNET Meningioma (anaplastic), Grade III Metastatic Tumor Nasopharyngeal Carcinoma

3 Oligodendroglioma (anaplastic), Grade II or III Other Malignant Tumor Solitary Fibrous Tumor Ocular Disorders Other Ocular Disorder Uveal Melanoma Vascular Disorders Aneurysm AVM Cavernous Malformation Dural Arteriovenous Fistula Other Vascular Disorder Grand Total % of all Leksell Gamma Knife centers submitted their 2016 treatment data

4 INDICATION ACCUMULATED TREATMENTS REPORTED BY REGION AND INDICATION Asia excl. Europe Latin Middle East & Africa North Grand Total Benign Tumors Benign Glial Tumors (Grade I and II) Craniopharyngioma Diffuse Astrocytoma, Grade II Dysembryoplastic Neuroepithelial Tumor Ependymoma Fibrillary Astrocytoma, Grade II Ganglioglioma Glomus Tumor Hemangioblastoma Hemangioma Hemangiopericytoma Hemangiopericytoma, Grade II Jugular Foramen Schwannoma Juvenile Pilocytic Astrocytoma Meningioma Meningioma Grade I (typical) Meningioma Grade II (atypical) Neurocytoma Oligodendroglioma, Grade II+A Other Benign Tumor Other Schwannoma Pineal Region Tumor Pituitary Adenoma Plexomorphic Xanthoastrocytoma (PXA) Trigeminal Schwannoma Vestibular Schwannoma Functional Disorders Cluster Headache Depression 3 3 Epilepsy Essential Tremor Hypothalamic Hamartoma Intractable Pain Mesial Temporal Lobe Epilepsy OCD Other Behavioral Disorders Other Epilepsy Other Functional Disorder Other Movement Disorders Other Pain Disorders Parkinson's Disease Trigeminal Neuralgia Malignant Tumors Anaplastic Astrocytoma, Grade III Chondrosarcoma Chordoma Ependymoma (anaplastic), Grade II or III

5 Esthesioneuroblastoma Glioblastoma Hemangiopericytoma, Grade III (anaplastic) Malignant Glial Tumor (grade III and IV) Medulloblastoma Medulloblastoma/PNET Meningioma (anaplastic), Grade III Metastatic Tumor Nasopharyngeal Carcinoma Oligodendroglioma (anaplastic), Grade II or III Other Malignant Tumor Solitary Fibrous Tumor Ocular Disorders Glaucoma Other Ocular Disorder Uveal Melanoma Vascular Disorders Aneurysm AVM Cavernous Malformation Dural Arteriovenous Fistula Other Vascular Disorder Grand Total The percentage of centers submitting their numbers each year has varied between % from 1968 to 2016 *Essential Tremor treatments reported as Other Functional Disorders prior to 2012 **Meningioma Grade I & II treatments reported as Meningioma prior to 2015 ***Glioblastoma reported as Malignant Glial Tumor (Grade III & IV) prior to 2015 ****Malignant Glial Tumor (Grade III & IV) treatments broken down by indication from 2015 ***** Epilepsy treatments broken down by indication from 2015

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