Radiobiology & Radiobiological Modelling in Radiotherapy, March 2015, Port Sunlight UK. PROGRAMME (final)

Transcription

1 PROGRAMME (final) 1

2 FACULTY Dr. Colin Baker Professor Michael Brada Dr. Antony Carver Professor J. Don Chapman Professor Roger Dale Dr. Charles Deehan Dr. John Fenwick Dr. Tiziana Rancati (guest speaker) Dr. Andrzej Kacperek Dhvanil Karia Dr. Geoff Lawrence Professor Trevor McMillan Professor Alan E. Nahum Dr. Mike Partridge Dr. Marco Schwarz Dr. Navita Somaiah Dr. Isabel Syndikus Dr. Julien Uzan Professor Catharine West Physics dept., Clatterbridge Cancer Centre (CCC) and Dept. of Physics, Liverpool Univ. Radiotherapy dept. CCC, and Liverpool Univ. Research Physicist, CCC West Kelowna, BC (formerly Head of Radiobiology, Fox-Chase CC, Philadelphia) Imperial College, London King s College, London CRUK/MRC Oxford Inst. for Radiation Oncology Prostate Cancer Program Fondazione IRCCS Istituto Nazionale dei Tumori Milan Head of Cyclotron Unit CCC PhD student, Physics dept. CCC (formerly Head of Imaging Physics, CCC) Keele university Head of Physics Research CCC CRUK/MRC Oxford Inst. for Radiation Oncology Proton Therapy Centre, Trento, Italy Institute of Cancer Research and Royal Marsden Hospital, Sutton Consultant in Clinical Oncology CCC RaySearch AB, Stockholm Research physicist, Karolinska university hospital, Stockholm University of Manchester 2

3 (approx) Day Zero: Sunday 22 nd March Ice-Breaker, Leverhulme Hotel Drinks, nibbles, social interactions! Day ONE: Monday 23 rd March REGISTRATION (coffee) WELCOME to CLATTERBRIDGE Doug Errington COURSE INTRODUCTION (1- and 4-day versions) Alan Nahum INTRODUCTION to RADIOBIOLOGY Catharine West Why QUANTITATIVE RADIOBIOLOGY? Don Chapman Does the LINEAR-QUADRATIC (L-Q) MODEL satisfy our needs? Coffee IONISING RADIATION (IR)-INDUCED DNA DAMAGE and REPAIR Trevor McMillan ISO-EFFECT CALCULATIONS in RADIOTHERAPY Charles Deehan Lunch The BIOPHYSICAL BASIS of the L-Q MODEL Don Chapman TUMOUR CELL KINETICS; OPTIMUM FRACTIONATION Coffee RADIOBIOLOGICAL MODELLING of BRACHYTHERAPY and HIGH-LET THERAPY COMPENSATING for GAPS in RADIOTHERAPY TREATMENT SCHEDULES John Fenwick Roger Dale Charles Deehan END OF 1-DAY REFRESHER Computer Lab opens (4-day course) LQ-survivor Julien Uzan Dhvanil Karia 3

4 Day TWO: Tuesday 24 th March How can we QUANTIFY the CHEMOTHERAPY CONTRIBUTION to RADIO-CHEMOTHERAPY TREATMENT (RCT)? INDUCTION of (SECOND) CANCERS by RADIATION Coffee RADIOBIOLOGICAL ASPECTS of HEAVY-PARTICLE RADIOTHERAPY RADIOTHERAPY of NON-SMALL-CELL LUNG CANCER where next? RADIOBIOLOGICAL CONSIDERATIONS in BREAST RADIOTHERAPY Roger Dale Geoff Lawrence Andrzej Kacperek Michael Brada Navita Somaiah Lunch PROSTATE RADIOTHERAPY RADIOBIOLOGICAL CONSIDERATIONS Isabel Syndikus Visit to Lady Lever Gallery (optional) COMPUTER LAB LQ-survivor; RayStation; BioSuite ( advanced students) Julien Uzan, Dhvanil Karia, Coffee Course Dinner Sunlight Restaurant 2c Bromborough Road Bebington CH63 7RE 4

5 Day THREE: Wednesday 25 th March INTRODUCTION to (Radio)BIOLOGICAL MODELS in RADIOTHERAPY PREDICTING the INCIDENCE of NORMAL-TISSUE COMPLICATIONS: MATHEMATICAL MODELS for NTCP Alan Nahum Colin Baker TUMOUR CONTROL PROBABILITY (TCP) MODELS Alan Nahum Coffee From QUANTEC onwards: UPDATE on DOSE VOLUME PREDICTORS and NTCP MODEL PARAMETERS USING and INTERPRETING DOSE-VOLUME MODELS STATISTICAL CONSIDERATIONS Marco Schwarz John Fenwick Lunch APPLICATIONS of TCP MODELLING Alan Nahum PREDICTIVE MODELS of PATIENT-REPORTED TOXICITY after HIGH-DOSE RT for PROSTATE CANCER: the ITALIAN EXPERIENCE of MULTI- CENTRIC PROSPECTIVE TRIALS Coffee INTRODUCTION to BioSuite, BioFit, RayStation (approx.) COMPUTER LAB BioSuite, BioFit, RayStation Poster viewing Free Evening Computer Lab Open Tiziana Rancati (Guest speaker) Julien Uzan Anthony Carver Julien Uzan, Antony Carver, Dhvanil Karia 5

6 Day FOUR: Thursday 26 th March Use of EUD, TCP, NTCP for INDIVIDUALISING and OPTIMISING TREATMENT PLANS Marco Schwarz (approx) COMPUTER LAB RayStation; BioSuite; BioFit Coffee Julien Uzan, Dhvanil Karia, Anthony Carver FUNCTIONAL IMAGING in RADIOTHERAPY Mike Partridge The GENOMICS REVOLUTION and RADIOTHERAPY Catharine West Lunch Everybody! (return of evaluation forms thanks!) Close of the Course Thank you for coming have a safe journey home. 6