Ewing s sarcoma of the finger: Report of two cases and literature review

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1 Orthopaedics & Traumatology: Surgery & Research (2012) 98, Available online at CASE REPORT Ewing s sarcoma of the finger: Report of two cases and literature review S. Baccari a, M.F. Hamdi b,, Z. Mabrouki a, M. Daghfous a, L. Tarhouni a a Department of Hand and Reconstructive Surgery, Kassab Institute of Traumatic and orthopaedic surgery, Manouba 2010, Tunisia b Department of Trauma and Orthopaedic Surgery, Fattouma Bourguiba University hospital, Monastir 5000, Tunisia Accepted: 20 June 2011 KEYWORDS Chemotherapy; Ewing s sarcoma; Finger; Surgery Summary Ewing s sarcoma of the finger is extremely rare. Pain and swelling of the affected finger are the most frequent presenting features. We report two cases of Ewing s sarcoma located at ring finger and the thumb in two children aged 14 and 10 years. The first patient died of generalised metastases despite surgery, chemotherapy and radiation therapy. The second had no localised recurrence or metastases after surgery and chemotherapy at last follow-up of 4.5 years after tumour resection. The tumour s surgical accessibility, chemotherapy, and radiation therapy improve the prognosis of this tumour Elsevier Masson SAS. All rights reserved. Introduction Cases report Ewing s sarcoma was first described in 1921 [1,2]. It is the second most frequent primary bone cancer of childhood and adolescence, after osteosarcoma [3]. It usually affects the long bones, but in the hand this tumour is rare, and exceptional in the finger. Different treatments using surgery, chemotherapy, radiotherapy, and their combinations are described. The aim is to save the hand and the patient s life. We report two cases of Ewing s sarcoma, one in the thumb and the other in the ring finger. Corresponding author. Tel.: / ; fax: address: hamdi.medfaouzi@yahoo.fr (M.F. Hamdi). Case report 1 A 14-year-old, right hand dominant boy presented with 11 months history of a gradual pain and tumefaction involving the proximal part of the left ring finger (Fig. 1). There was no recent trauma or fever or loss of weight. Locally, the swelling was indurate; the range of motion of the metacarpophalangeal joint was restricted. The X-ray examination of the affected finger, revealed bone destruction with sclerosis and soft tissue component of the proximal phalanx (Fig. 2). The laboratory findings were within normal limits. At the Magnetic Resonance Imaging (MRI), the tumour was detected with more precision (Fig. 3); and the tumour appeared to be malignant on MRI. Open surgical biopsy was performed. The histology confirmed the diagnosis of Ewing s sarcoma. The preoperative /$ see front matter 2012 Elsevier Masson SAS. All rights reserved. doi: /j.otsr

2 234 S. Baccari et al. Figure 1 Clinical view of the left hand showing a proximal swelling of the ring finger. assessment including chest tomography, and whole-body bone scan showed no metastatic disease. Preoperative chemotherapy (VIDE protocol) was indicated and used for six courses using vincristine, ifosfamide, adriamycin, ectoposide. After the parent s consent, a wide excision of the tumour and the involved tissues (ray amputation) was carried out without local reconstruction (Fig. 4). The surgical margins were negative. The histological findings proved a poor response to chemotherapy. After surgery, a second treatment course of chemotherapy using vincristine, actinomycine D, ifosfamide, was administered for six courses. The radiotherapy was indicated because the histological study of the excised tumour revealed more than 10% of tumour cells; the area of the tumour was irradiated with 40 Gy. Six months later, the patient developed metastases in the lung and tibia. Unfortunately, the patient died of generalised Figure 3 Magnetic resonance imaging (T1 weighted coronal section) showing large cortical destruction of proximal phalanx of the left ring finger associated with soft tissue involvement. metastases 41 months after the diagnosis of the tumour was established. Case report 2 A 10-year-old, left hand dominant boy presented with a mass arising in the distal phalanx of the left thumb for 4 months. This isolated mass was fixed and painful (Fig. 5). The radiological examination revealed permeative bone destruction and perpendicular spicules of the distal phalanx of the left thumb (Fig. 6). A biopsy was performed. Figure 2 A lytic lesion of the proximal phalanx of the ring finger with no evidence of periosteal reaction. Figure 4 Postoperative radiograph of the left hand showing the ray resection without reconstruction.

3 Ewing s sarcoma of the finger: Report of two cases and literature review 235 Figure 7 No local recurrence of the tumour after metacarpophalangeal disarticulation. Discussion Figure 5 Clinical picture of the multinodular tumour with necrotic area involving the distal part of the left thumb. The histopathological diagnosis was Ewing s sarcoma. The chest tomography showed no metastatic lesions. A technetium bone scan revealed increased uptake only in the distal area of the left thumb. Amputation at the metacarpophalangeal level was carried out (Fig. 7). The patient had postoperative adjuvant chemotherapy using vincristine, ifosfamide, adriamycin, ectoposide for six cycles. The patient did not develop metastasis or local recurrence; he was well and alive at 4.5 years after surgery. Figure 6 An X-ray film of the left thumb showing bone destruction with perpendicular spicules of the distal phalanx. Soft tissue mass visualized in the border of distal phalanx. Initially Ewing s sarcoma was described as a malignant tumour of bone origin, invading the soft tissue. The origin of Ewing s sarcoma is a subject of much debate. Once thought to be derived from primitive neuroectodermal cells [4], many now believe it to arise from a mesenchymal stem cell [5]. We must mention Ewing tumour and not Ewing sarcoma [4]. Genetic factors play a role in its pathogenesis. There is a form of anomaly chromosomal translocation of two chromosomes 22 and 15 [6]. Usually this tumour occurs during the first or second decade of life; it particularly affects long bones and pelvis [7]. In the hand Ewing sarcoma is very rare, Kissane JM series of 303 cases of Ewing sarcoma, identified one lesion in the hand [8]. The metacarpals are most commonly affected and occurrence at the phalanges is quite rare [9 11]. Regardless of the treatment modality, the location of the tumour in the hand is an important factor of prognosis [10]. Because the survival is highest in lesions of the distal bones of the extremities [8]. The review of literature found 15 cases of Ewing s sarcoma of the finger [1,3,9 17]. We report the summary of those cases (Table 1). According to literature review, males were more affected (69%); the average age of detection of the tumour was 18.5 years (5 month 51 years). The tumour was located at the proximal phalanx in 53% of cases. The thumb (28%) and the long finger (28%) were the most affected fingers. Pain and swelling of the affected fingers were the most frequent complaints at diagnosis [7], initially the patient had a general good health, and there were no fever and loss of weight [4]. Sometimes the tumour is clinically mistaken for a local infection because of pain and local inflammatory symptoms, X-ray findings can also be mistaken for osteomyelitis because of the bone destruction [1]. Several studies [4,7,9,10,17] have suggested wide radical resection of the tumour, combined with chemotherapy as the best therapy. This is easily accomplished in case of digital localisation. The surgical accessibility of Ewing s sarcoma of the phalanx makes them amenable to radical resection [1,11]. Two cases of Ewing s sarcoma of the thumb [11,14] were treated by primary amputation without radiation therapy or chemotherapy. There was no evidence of disease in 26 to 60 months following up.

4 236 S. Baccari et al. Table 1 Summary of published cases after literature review. Case Author Age Sex Finger Phalanx Treatment Alive Dead Follow-up (months) 1 Clifford RH [12] NP NP III Proximal S Ridings GR [13] 19 M II Proximal S Ch - R Dick MH [14] 12 M I Distal S Wilson KS, 1979 [15] 39 M II Distal S Ch - R Kinsella TJ [18] 18 M Proximal Ch - R Shirley SK [16] 11 M II Distal S - Ch Shirley SK [16] 21 M IV Proximal S Ch - R Lacey SH [9] 16 F III Proximal S - Ch Strege DW [17] 5 months M III Middle S - Ch Euler E [1] 22 III Proximal S Ch - R NP NP NP 11 Jones MW [10] 12 F I Distal S - Ch Yamaguchi T [11] 51 M I Distal S Seroussi D [4] 10 F I Proximal S - Ch Jerome TJ [7] 13 F V Distal S - Ch Anakwenze OA [3] 13 M II Proximal S - Ch F: female; M: male; S: surgery; Ch: chemotherapy; R: radiation; NP: no precision. Radiotherapy alone is not indicated because it cannot control the primary lesion, and induces major physical damage (soft tissue contracture, growth disturbances in young patient, secondary radiation-induced malignant tumour) [4,9]. The radiation is beneficial when wide margins cannot be surgically achieved or when the response to chemotherapy is incomplete [3]. In spite of the adjuvant therapy, most authors agree about the benefit from the tumour s resection, which remains the most important stage of the management of Ewing s sarcoma of the finger. Kinsella [18] suggested the combination of chemotherapy with radiotherapy without surgery, in controlling the primary lesion in the hand and to avoid a hand mutilating surgery, the long-term result remains uncertain. Ewing s tumours of the bones are more susceptible to chemotherapy [19]. This therapy is an integral part of the treatment in preoperative and postoperative surgery of the primary tumour, adjuvant chemotherapy adapted to the histological response to the neoadjuvant treatment. The treatment of Ewing s sarcoma is achieved through a Common European protocol called Euro Ewing 99 [20]. The prognosis depends on the tumour volume and histological response to initial chemotherapy type VIDES which associated vincristine, ifosfamide, adriamycin, and ectoposide. After surgery, the chemotherapy was administered. The tumours will be irradiated if the histological study revealed more than 10% of tumour cells after surgery and chemotherapy [4]. The final surgical management is to achieve an acceptable cosmetic appearance and excellent function of the hand. After the amputation of a finger, the reconstruction is possible for aesthetic and functional reasons. The reconstruction was achieved at the same time of tumour resection [9], or remotely after tumour excision [4]. Despite the extremely rarity of this tumour finger arising in the finger, the diagnosis should be considered in any lesion suspicious for malignancy. The treatment is urgent and specialized. Currently, the most favourable treatment of Ewing s sarcoma of the finger combines surgery and chemotherapy. The histological findings determine the usefulness of radiotherapy. Despite the small size of these tumours the preoperative chemotherapy is necessary. Disclosure of interest The authors declare that they have no conflicts of interest concerning this article. References [1] Euler E, Wilhelm K, Permanetter W, Kreusser T. Ewing s sarcoma of the hand: localization and treatment. J Hand Surg Am 1990;15(4): [2] Liu Y, Chen WY. Ewing s sarcoma of the metacarpal bone of the hand: a case report. J Hand Surg Am 1998;23(4): [3] Anakwenze OA, Parker WL, Wold LE, Amrami KK, Amadio PC. Ewing s sarcoma of the hand. J Hand Surg Eur Vol 2009;34(1):35 9. [4] Seroussi D, Renauld V, Hébrard W, Duport G, Cohrs D. Ewing sarcoma of thumb: report of a case and review of the literature. Ann Chir Plast Esthet 2004;49(4): [Review. French]. [5] Lin PP, Wang Y, Lozano G. Mesenchymal Stem Cells and the origin of Ewing s sarcoma. Sarcoma 2011: 2011 pii: Epub 2010 Oct 5. [6] Jinawath N, et al. Complex rearrangement of chromosomes 1, 7, 21, 22 in Ewing sarcoma. Cancer Genet Cytogenet 2010;201(1):42 7. [7] Jerome TJ, Varghese M, Sankaran B. Ewing s sarcoma of the distal phalanx of the little finger. J Hand Surg Eur Vol 2008;33(1):81 2. [8] Kissane JM, Askin FB, Foulkes M, Stratton LB, Shirley SF. Ewing s sarcoma of bone: clinicopathologic aspects of 303 cases from the Intergroup Ewing s Sarcoma Study. Hum Pathol 1983;14(9): [9] Lacey SH, Danish EH, Thompson GH, Joyce MJ. Ewing sarcoma of the proximal phalanx of a finger. A case report. J Bone Joint Surg Am 1987;69(6): [10] Jones MW. Ewing s sarcoma of the thumb. J Hand Surg Br 1993;18(3): [11] Yamaguchi T, Tamai K, Saotome K, Hoshino T, Masawa N. Ewing s sarcoma of the thumb. Skeletal Radiol 1997;26(12):725 8.

5 Ewing s sarcoma of the finger: Report of two cases and literature review 237 [12] Clifford RH, Kelly AP. Primary malignant tumors of the hand. Plast Reconst Surg 1955;15: [13] Ridings GR. Ewing s tumor. Radiol Clin North Am 1964;2: [14] Dick HM, Francis KC, Johnston AD. Ewing s sarcoma of the hand. J Bone Joint Surg Am 1971;53(2): [15] Wilson KS, Nyssen J, Alexander S. Ewing sarcoma: phalangeal primary with fatal cardiac metastases. Med Pediatr Oncol 1979;7: [16] Shirley SK, et al. Ewing s sarcoma in bones of the hands and feet: a clinic pathologic study and review of the literature. J Clin Oncol 1985;3: [17] Strege DW, Hanel DP, Vogler C, Schajowicz F. Ewing sarcoma in a phalanx of an infant s finger. A case report. J Bone Joint Surg Am 1989;71: [18] Kinsella TJ, Loeffler JS, Fraass BA, Tepper J. Extremity preservation by combined modality therapy in sarcomas of the hand and foot: an analysis of local control, disease free survival and functional result. Int J Radiat Oncol Biol Phys 1983;9: [19] Fayette J, Blay JY. Adjuvant chemotherapy in the treatment of sarcomas. Bull Cancer 2006;93(3): [Review French]. [20] Oberlin O, Harbrand JL. Ewing s sarcoma: towards a common protocol for adults and children. Cancer Radiother 2000;4(Suppl. 1):141 4.

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