The following slides were presented at the TIGA Workshop, and are enclosed in the PP show format (*.pps) in order to include all presented details.
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1 Disclaimer: The following slides were presented at the TIGA Workshop, and are enclosed in the PP show format (*.pps) in order to include all presented details. These slides are proprietary and should not be copied or otherwise reproduced in part without the written permission from Visiopharm (contact Niels Foged,
2 1 st European Workshop on Tissue Imaging and Analysis Heidelberg Feb at Copenhagen University LIFE Quantitative Histomorphometry of Whole Slide Digital Images of Tumor Tissue Michael Grunkin & Niels T. Foged
3 Visiopharm A/S: A brief company introduction Founded in HQ in Copenhagen. Subsidiary in US Business focus: Automated quantitative microscopy Products: Advanced software for histomorphometry Customers: Scientists in universities/hospitals & biotech/pharma Increasing requests: Pathologists and teachers
4 Products: Software modules for automated: imaging, data base management, image analysis and stereology Software handles all types of image files. Visiopharm software users can easily switch between traditional microscopy and slide scanning. Visiopharm is expanding from life science to clinical applications
5 Collaboration projects in (breast) cancer pathology Malignancy grading H&E Primary Tumor IHC Proximity ligation IHC Tubularity Nucl. pleomorph. Mitotic grade ER/PR IHC HER-2 IHC TIMP-1 IHC
6 Proximity Ligation Assay (PLA) Dual antibody-based immunohistochemistry, e.g. HER-2/3 dimers Blob -signals by Rolling Circle Amplification Quantification of signals per cell by Visiomorph TM software module Assay kits by Olink AB; Uppsala, Sweden
7 Collaboration projects in (breast) cancer pathology Malignancy grading H&E Primary Tumor IHC Proximity ligation IHC Sentinel node IHC Chromosomal FISH/CISH Tubularity Nucl. Pleomorph. Mitotic grade HER2 FISH/CISH TOP2A FISH/CISH TIMP-1 FISH/CISH ER/PR IHC HER-2 IHC TIMP-1 IHC Individual grading and staging of cancer SLN metastasis: Presence Vol./stereology Today s focus: HER-2 Immunohistochemistry
8 HER-2 IHC Algorithm: Work in progress Clinical collaboration study with Mogens Vyberg, NordiQC (Aalborg Hospital) Tumor tissue from 75 breast cancer patients Three TMA s stained with the Herceptest TM (Dako) Adjudicated consensus scores by a panel of expert pathologists Scanned with x20 Visiopharm proprietary software used for feature extraction
9 ENHANCING STAINED NUCLEI (BLUE) USING A SPECIAL FILTER
10 ENHANCING STAINED MEMBRANES (BROWN) USING A SPECIAL FILTER
11 POST PROCESSING STEP1: Remove (too) small nuclei & membrane objects
12 POST PROCESSING STEP2: Remove nuclei without a membrane and membrane structures without a nucleus
13 FINAL SEGMENTATION
14 MEASURING STAINING INTENSITY Using a special algorithm quantifying brown
15 MEASURING STAINING INTENSITY Measuring average staining intensity (i.e. brown) below the identified membrane label
16 PLANIMETRIC FEATURES Measuring area of membrane, number of nuclei, and average amount of membrane per identified nucleus.
17 Preliminary results of comparison to consensus scores obtained by manual microscopy 7,5 HercepTest (Dako) 7 6,5 Score by Visiopharm image analysis algorithm 6 5,5 5 4,5 n=71 (work-inprogress) 4 3, Consensus score by Manual Microscopy
18 Please feel free to visit the Visiopharm booth for further discussions and a live demo by Jakob Raundahl, PhD
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