Masaya Iwamuro Æ Shinichiro Nakamura Æ Hidenori Shiraha Æ Yoshiyuki Kobayashi Æ Hirotoshi Fukatsu Æ Kazuhide Yamamoto
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1 Clin J Gastroenterol (2009) 2:30 35 DOI /s CASE REPORT A case of primary intracranial hemangiopericytoma with hepatic metastases: successful treatment with radiofrequency ablation and transcatheter arterial chemoembolization Masaya Iwamuro Æ Shinichiro Nakamura Æ Hidenori Shiraha Æ Yoshiyuki Kobayashi Æ Hirotoshi Fukatsu Æ Kazuhide Yamamoto Received: 11 July 2008 / Accepted: 17 August 2008 / Published online: 29 November 2008 Ó Springer 2008 Abstract Intracranial hemangiopericytoma is an uncommon soft tissue sarcoma. We report a case of a 54-year-old Japanese female with hepatic metastasis from primary intracranial hemangiopericytoma. At age 44 years the patient underwent primary resection of the intracranial tumor, followed by no adjuvant therapy. At age 53 years she underwent resection of bone metastases in her left upper arm and tenth right rib. The following year, three hepatic tumors with high vascularity were detected by ultrasonography, computed tomography scans, and magnetic resonance imaging. An ultrasound-guided liver biopsy specimen confirmed the diagnosis of hepatic metastases from the primary intracranial hemangiopericytoma. A combination therapy of transcatheter arterial chemoembolization and radiofrequency ablation was performed against the hepatic metastasis. After 5 years, there has been no local recurrence in the liver. Keywords Hemangiopericytoma Hepatic metastasis Transcatheter arterial chemoembolization Radiofrequency ablation Introduction Intracranial hemangiopericytoma is an uncommon central nervous system tumor originated from pericytes of blood M. Iwamuro (&) S. Nakamura H. Shiraha Y. Kobayashi H. Fukatsu K. Yamamoto Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Shikata, Okayama , Japan iwamuro@mc.neweb.ne.jp vessels [1, 2]. It is characterized clinically by delayed local recurrence and extracranial metastasis [2, 3]. Surgical resection of metastatic tumors is the only curative treatment for metastatic hemangiopericytoma; monotherapy consisting of chemotherapy, radiotherapy or transcatheter arterial chemoembolization (TACE) is not sufficient to control metastasis [4 6]. Herein, we report a case of hepatic metastases of primary intracranial hemangiopericytoma that was successfully treated with radiofrequency (RF) ablation after TACE. Case report A 54-year-old Japanese female was admitted to the Department of Gastroenterology and Hepatology in Okayama University Hospital in 2002 for further examination of hepatic tumors. Her history included a resection of intracranial hemangiopericytoma in 1992 (Fig. 1). She did not receive adjuvant radiotherapy after that initial resection. In 2001, she developed bone metastases in her left upper arm and right tenth rib. She was treated by surgical resection of the metastatic tumors. A physical examination on admission revealed no abnormalities. She was 155 cm tall and weighed 55 kg. Her blood pressure was 112/71 mmhg, and her pulse was 63 per min. Laboratory studies revealed a decreased white blood cell count with a normal differential count (Table 1). Red blood cell, hemoglobin, and hematocrit levels were also low, although she had no symptoms related to anemia. No elevation was found in serum tumor markers, including carcinoembryonic antigen, alpha-fetoprotein, carbohydrate antigen 19-9, and carbohydrate antigen 125. An ultrasound examination revealed three tumors in the liver. These liver tumors were identified as hypoechoic
2 Clin J Gastroenterol (2009) 2: Table 1 Laboratory findings on admission Fig. 1 Histological appearance of the intracranial hemangiopericytoma. High-power view of a resected specimen showing uniform neoplastic cells with scanty cytoplasm and indistinct cytoplasmic borders. These cells are arranged around thin-walled vascular spaces, with a staghorn appearance. Hematoxylin and eosin staining (H&E), normal magnification 9100 masses with halo. Mean tumor size was 25 mm in segment 4 (S4), 15 mm in S3, and 15 mm in S7. Color Doppler imaging of the ultrasound examination visualized blood flow from the tumor periphery to its center (Fig. 2). Dynamic computed tomography (CT) demonstrated strongly enhanced lesions with contrast material in the arterial phase, and the enhancement persisted during the portal venous and delayed phases (Fig. 3). Magnetic resonance (MR) imaging demonstrated low-signal-intensity liver tumors in T1-weighted images and high-signalintensity tumors in T2-weighted images (Fig. 4). Abdominal angiography demonstrated multiple hypervascular lesions in the early phase of arteriography for hepatic proper artery (Fig. 5). A chest CT revealed a nodule with a diameter of 5 mm in the right lung and an osteolytic lesion of 10 mm in the third lumbar vertebra. They were strongly suspected to be metastases of hemangiopericytoma. Hepatic resection is considered the treatment of choice for metastatic liver tumors. Since the patient refused hepatic resection, TACE and RF ablation therapy were combined as an alternative. TACE was performed with epirubicin hydrochloride (Farmorbicin TM ; Pharmacia, Tokyo, Japan) and iodized poppy seed oil (Lipiodol TM ; Andre Guerbet, Aulnaysous-Bois, France) followed by gelatin sponge particles (Gelfoam TM ; Upjohn, Kalamazoo, MI), and the arterial flow to each hepatic tumor was completely occluded. Ultrasound-guided liver biopsy, performed 1 week after TACE, revealed spindle-shaped neoplastic cells with pleomorphic oval to elongated nuclei and sporadic mitotic figures (Fig. 6). Pericellular reticulin fibers were sparsely seen in argyrophil-argentaffin staining. Blood count WBC 2,600 ll -1 RBC ll -1 Hemoglobin 10.3 g/dl Hematocrit 30.5% Platelet ll -1 Biochemistry Total bilirubin 0.55 mg/dl AST 23 IU/l ALT 14 IU/l ALP 341 IU/l c-gtp 47 IU/l Total protein 7.04 g/dl Albumin 3.79 g/dl c-globulin 1.34 g/dl Blood glucose 79 mg/dl Hemoglobin A1c 4.7% CRP 0.1 mg/dl Tumor marker CEA 0.6 ng/ml AFP 1 IU/ml CA IU/ml CA U/ml Virology HBs antigen Anti-HBc antibody Anti-HCV antibody WBC white blood cell, RBC red blood cell, CEA carcinoembryonic antigen, AFP alpha-fetoprotein, CA19-9 carbohydrate antigen 19-9, CA125 carbohydrate antigen 125, ALP alkaline phosphatase, CRP C- reactive protein, HB hepatitis B, HCV hepatitis C virus A histopathologic examination confirmed the diagnosis of hepatic metastases of the primary intracranial hemangiopericytoma. A total of eight sessions of RF ablation were performed after TACE. Thermal lesions were made using a 17-gauge internally cooled-tip electrode attached to a 480- khz monopolar RF generator (Radionics, Burlington, MA). Partial recanalization of the artery was observed in the dynamic CT evaluation of treatment after five sessions of RF ablation. Another three sessions of RF ablation were performed, after which a sufficient area of coagulation necrosis for each hepatic metastatic tumor was achieved (Fig. 7). Thereafter, the patient underwent laminectomy to treat her vertebral metastases. Five years after the combination therapy of TACE and RF ablation, an abdominal dynamic CT demonstrated no local recurrence of hemangiopericytoma in the liver. However, periodic chest CT revealed a slowly growing pulmonary tumor, most recently measured at 10 mm, in the
3 32 Clin J Gastroenterol (2009) 2:30 35 Fig. 2 Ultrasonography. A hypoechoic tumor in the liver is demonstrated (a). Color Doppler imaging reveals the blood flow, which has a basket pattern (b) Fig. 3 Computed tomography scan. Low-density lesions in both lobes of the liver (a). The three tumors are remarkably enhanced by contrast material during the hepatic arterial phase (b). The enhancing effect persists during the portal venous phase (c) middle lobe of the right lung. The patient is kept under observation, since the suspicious metastatic lung tumor is small and slow growing. Discussion Intracranial hemangiopericytoma is a rare mesenchymal tumor suggested to originate from Zimmerman s pericytes, which are leiomyoblastic cells spiraling around capillaries and postcapillary venules [1, 5]. Hemangiopericytoma is a highly vascularized neoplasm that displays a persistent vascular stain in contrast-enhanced CT and angiography [3]. As in former reports, the hepatic metastasis of hemangiopericytoma in the present case showed a strongly enhanced solid tumor in contrast-enhanced CT. Surgical excision and postoperative radiotherapy at a dose of 50 Gy or more are recommended as the initial
4 Clin J Gastroenterol (2009) 2: Fig. 4 Magnetic resonance imaging. Low-signal-intensity lesions are shown in the T1-weighted image (a) and high-signal-intensity lesions appear in the T2-weighted image (b) Fig. 5 An angiographic examination. Dense accumulation of contrast material in the arterial phase is shown treatment, as adjuvant radiotherapy resulted in significantly better local control than surgery alone [4]. Five-year local recurrence rates of 90% were reported with surgery alone, and 40% with adjuvant radiotherapy [3, 6, 7]. Primary intracranial hemangiopericytoma has a tendency toward delayed local recurrence and extracranial metastases. The recurrence rate increases year after year, and the rates at 5, 10, and 15 years were 65%, 76%, and 87%, respectively [3]. Extracranial metastases occur in 23% of cases and appear at a mean of 8 years after initial therapy [5]. Liver and bone are the most frequently involved sites of metastases [2, 4]. To the best of our knowledge, 32 cases of primary intracranial hemangiopericytoma with hepatic metastasis have been reported in the literature (10 males, 20 females, 2 unspecified). The patients ranged in age from 20 to 76 years, with a mean of 41 years, at initial diagnosis. Extracranial metastases occurred more than 5 years after craniotomy in most cases, and more than 10 years after in 10 of 31 patients. For the treatment of hepatic metastases, 13 patients underwent hepatectomy. Surgical resection of a metastatic tumor of the liver is sometimes impossible because of the anatomical location of the tumor or the poor general status of the patient. In these cases, radiotherapy, chemotherapy or TACE alone was performed. None of the reported cases underwent RF ablation. The role of radiotherapy or chemotherapy in the treatment of hepatic metastases of hemangiopericytoma has remained controversial. Doxorubicin-based chemotherapy might be effective [8]. TACE was performed for hepatic metastases in five cases, and partial reduction was reported in only one case [9]. In the treatment of intracranial hemangiopericytomas, preoperative embolization can reduce the risk of operative blood loss and its associated morbidity. However, sometimes it is hard to control the hemorrhage from such tumors because of their abundant blood supply [5, 10]. As in metastatic hemangiopericytoma, it is difficult to control blood flow with embolization. In the present case, gradual partial recanalization of blood flow was observed after TACE. Consequently, TACE is partially effective against hepatic metastasis of hemangiopericytoma, as no report has demonstrated successful control of hepatic metastasis of hemangiopericytoma with monotherapy of TACE. In the present case, a combination of TACE and RF ablation was efficient to eliminate the hepatic metastases of hemangiopericytoma. RF ablation has been widely used for the treatment of hepatocellular carcinoma (HCC) or metastatic liver tumor. Necrotic lesions are created by thermal coagulation [11]. Heat loss due to convection through blood flow may cause limited volume or irregular burn-in shape of necrosis during RF ablation. Reduction or elimination of the cooling effect in surrounding hepatic blood flow using occlusion of the hepatic artery during the RF ablation procedure increases the volume of thermal lesions [11, 12]. Since hemangiopericytoma is a highly vascular tumor, reducing the blood supply should be sufficient for coagulation by RF ablation. In the present case, epirubicin hydrochloride was administered in the TACE procedure, as
5 34 Clin J Gastroenterol (2009) 2:30 35 Fig. 6 Microscopic appearance of a biopsy specimen of the hepatic tumor. Spindle-shaped neoplastic cells are shown. This specimen shows degenerative change due to TACE. The histological features are compatible with the hepatic metastasis of hemangiopericytoma. H&E, normal magnification 9400 (a). Pericellular reticulin fibers are demonstrated by argyrophil-argentaffin staining, normal magnification 9400 (b) In conclusion, combination therapy of TACE and RF ablation could benefit patients with hepatic metastasis of hemangiopericytoma. This therapy can be an alternative to surgery, especially when surgical excision is difficult due to the anatomical location of the tumor or the poor general condition of the patient. References Fig. 7 Contrast-enhanced computed tomographic image three days after the eight sessions of RF ablation. The nonenhanced areas at the sites of the treated metastatic nodules are confirmed anthracyclines were reported to be effective for hemangiopericytomas [8]. High accumulation of Lipiodol was achieved for each tumor by TACE, although gradual reduction of Lipiodol retention was observed. After TACE, RF ablation was performed without any technical difficulties due to TACE-related artifacts. The course of the present case suggests that RF ablation should be carried out immediately after TACE, since recanalization of blood flow was observed a few weeks after TACE. There has been one report of hepatic metastasis of hemangiopericytoma from the retroperitoneum, which was treated with a combination of RF ablation and TACE [13]. However, the follow-up period described in that report was only 1.8 years, which is too short to assess the long-term prognosis. In the present case, no local recurrence of the liver tumor has been observed for 5 years. To the best of our knowledge, this is the first report of success in controlling a hepatic tumor of hemangiopericytoma after the combination therapy of TACE and RF ablation for as long as 5 years. 1. Stout AP, Murray MR. Hemangiopericytoma: a vascular tumor featuring Zimmermann s pericytes. Ann Surg. 1942;116: Mena H, Ribas JL, Pezeshkpour GH, Cowan DN, Parisi JE. Hemangiopericytoma of the central nervous system: a review of 94 cases. Hum Pathol. 1991;22: Guthrie BL, Ebersold MJ, Scheithauer BW, Shaw EG. Meningeal hemangiopericytoma: histopathological features, treatment, and long-term follow-up of 44 cases. Neurosurgery. 1989;25: Spatola C, Privitera G. Recurrent intracranial hemangiopericytoma with extracranial and unusual multiple metastases: case report and review of the literature. Tumori. 2004;90: Fountas KN, Kapsalaki E, Kassam M, Feltes CH, Dimopoulos VG, Robinson JS, et al. Management of intracranial meningeal hemangiopericytomas: outcome and experience. Neurosurg Rev. 2006;29: Borg MF, Benjamin CS. Haemangiopericytoma of the central nervous system. Australas Radiol. 1995;39: Mira JG, Chu FC, Fortner JG. The role of radiotherapy in the management of malignant hemangiopericytoma: report of eleven new cases and review of the literature. Cancer. 1977;39: Bastin KT, Mehta MP. Meningeal hemangiopericytoma: defining the role for radiation therapy. J Neurooncol. 1992;14: Kishino M, Umehara I, Suzuki Y, Shimura H, Itobayashi E, Shibuya H. A case of multiple liver metastases from intracranial hemangiopericytoma treated by transcatheter chemoembolization (in Japanese with English abstract). Rinshohoushasen. 2002;47: Birzgalis AR, Ramsden RT, Lye RH, Richardson PL. Haemangiopericytoma of the temporal bone. J Laryngol Otol. 1990;104: Rossi S, Garbagnati F, Lencioni R, Allgaier HP, Marchiano A, Fornari F, et al. Percutaneous radio-frequency thermal ablation of
6 Clin J Gastroenterol (2009) 2: nonresectable hepatocellular carcinoma after occlusion of tumor blood supply. Radiology. 2000;217: Yamasaki T, Kurokawa F, Shirahashi H, Kusano N, Hironaka K, Okita K. Percutaneous radiofrequency ablation therapy for patients with hepatocellular carcinoma during occlusion of hepatic blood flow. Comparison with standard percutaneous radiofrequency ablation therapy. Cancer. 2002;95: Kondo S, Onodera H, Kaido T, Yamasaki S, Imamura M. Combined therapy with TAE and radiofrequency ablation is effective for multiple liver metastases of malignant hemangiopericytoma: a case report and review of the literature (in Japanese with English abstract). Jpn J Gastroenterol Surg. 2002;35:292 6.
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