Brain Tumor Syllabus

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1 ASN Las Vegas 2013 Brain Tumor Syllabus Laszlo L. Mechtler, M.D. Chief of Neuro-Oncology Associate Professor of Neurology. Neuro-oncology and Neuroimaging Roswell Park Cancer Institute Dent Neurologic Institute ASTROCYTOMA Terminology Primary brain tumor of astrocytic origin with intrinsic tendency for malignant progression, degeneration into anaplastic astrocytoma (AA). Imaging Findings Best diagnostic clue: Focal or diffuse nonenhancing white matter (WM) mass Cerebral hemispheres, supratentorial 2/3 May appear circumscribed on imaging but isn t; tumor cells typically found beyond imaged signal abnormality! Top Differential Diagnoses Anaplastic astrocytoma (AA) Ischemia Cerebritis

2 Oligodendroglioma Herpes encephalitis Status epilepticus Pathology Represents 25-30% of gliomas in adults 10-15% of all astrocytomas Diffusely infiltrating mass with blurring of GM/WM interface WHO grade II Clinical Issues Majority occur between ages of years Inherent tendency for malignant progression of AA = major cause of mortality Median survival 6-10 years. Terminology Tectal glioma (tectal) PEDIATRIC BRAINSTEM GLIOMA

3 Focal tegmental mesencephalic (FTM) Diffuse (intrinsic) pontine glioma (DPG) Heterogeneous group of focal or diffuse gliomas involving mesencephalon, pons, or medulla Imaging Findings Classic imaging appearance varies with tumor type and location Tectal: Pilocytic, focal, variable enhancement/ca ++ FTM: Pilocytic, cyst plus nodule DPG: Fibrillary, diffuse, nonenhancing All BSG are not equal! Geography predict prognosis Borders/margins predictive of prognosis Top Differential Diagnoses Congenital aqueductal stenosis vs tectal glioma Alexander disease vs tectal glioma Neurofibromatosis type 1 vs DPG Other brainstem gliomas Pathology General path comments: No metastases outside CNS Epidemiology: 10-20% pediatric brain tumors Diagnostic Checklist Not all expansile brainstem lesions are neoplasms Geography predicts prognosis PEARLS IN THE DIAGNOSIS OF BRAIN STEM GLIOMAS Peak age: 6-8 years Signal: Hyperintense on T2 (95%), exophytic tumor produces brighter signal Growth patterns a. Cystic tectum (20%)

4 b. Infiltrative, pons (70%) Dedifferentiation of glioblastoma multiforme 5-7% of pediatric cases Location a. Pontomedullary (80%) b. Midbrain (60%) c. Cerebellum (40%) d. Cervical cord (35%) e. Posterior thalamus (30%) Enhancement: Variable and may not be present Calcification: Less than 4% Differential diagnosis a. Vascular malformation (flow void or hemorrhage signal, non-expansile) b. Metastases (adults with history of primary neoplasm, contrast enhancement) RANGE OF NORMAL ANTEROPOSTERIOR BRAIN STEM DIAMETERS Midbrain tegmentum: mm Pons: mm Pontomedullary junction: mm Cervicomedullary junction: 8-11 mm

5 ANAPLASTIC ASTROCYTOMA Terminology Diffusely infiltrating astrocytoma with focal or diffuse anaplasia and a marked proliferative potential Imaging Findings Infiltrating mass that predominately involves white matter (WM) Variable enhancement, typically none; may be focal or patchy Hemispheric WM, frontal & temporal lobes common Neoplastic cells almost always found beyond areas of abnormal signal intensity Top Differential Diagnoses Low grade glioma Glioblastoma multiforme (GBM) Cerebritis Ischemia Oligodendroglioma Status epilepticus Herpes encephalitis Pathology AA have histologic and imaging characteristics among spectrum between low grade astrocytoma and GMB 1/3 of astrocytomas May appear discrete but tumor always infiltrates adjacent brain WHO grade III Clinical Issues Median survival 2-3 years Commonly arise as recurrence after resection of a grade II tumor

6 GLIOBLASTOMA MULTIFORME Terminology Rapidly enlarging malignant astrocytic tumor characterized by necrosis and neovascularity Most common of all primary intracranial neoplasms Imaging Findings Best diagnostic clue: Thick, irregular-enhancing rind of neoplastic tissue surrounding necrotic core Top Differential Diagnoses Abscess Metastasis Primary CNS lymphoma Anaplastic astrocytoma (AA Tumefactive demyelination Subacute ischemia Status epilepticus Pathology Two types, primary (de novo) and secondary (degeneration from lower grade astrocytoma) 50-60% of astrocytomas WHO grade IV Clinical Issues(Filippi et al., 1996) Age: Peak years but may occur at any age Relentless progression Prognosis is dismal (death in 9-12 months) Diagnostic Checklist Viable tumor extends far beyond signal abnormalities!

7 Terminology Rare malignant neoplasm with both glial, mesenchymal elements GLIOSARCOMA Imaging Findings Heterogeneously enhancing mass with dural invasion, +/- skull involvement

8 May be indistinguishable from GBM Top Differential Diagnoses Glioblastoma multiforme (GBM) Metastasis Abscess Hemangiopericytoma Malignant meningioma Clinical Issues Poor prognosis, median survival of 6-12 months GLIOMATOSIS CEREBRI Terminology Diffusely infiltrating glial tumor involving two or more lobes, frequently bilateral Infiltrative extent of tumor is out of proportion to histologic and clinical features Imaging Findings Best diagnostic clue: T2 hyperintense infiltrating mass with enlargement of involved structures Typically hemispheric white matter involvement, may also involve cortex (19%) May cross corpus callosum or massa intermedia Morphology: Infiltrates, enlarges yet preserves underlying brain architecture Typically no or minimal enhancement Marked elevation of myo-inositol (mi) Top Differential Diagnoses Arteriolosclerosis Anaplastic astrocytoma (AA) Viral encephalitis

9 Lymphoma Pathology Underlying brain architecture preserved Usually WHO grade III Clinical Issues Peak incidence between years Poor prognosis Diagnostic Checklist Rare diffusely infiltrating glial tumor that can be mistaken for nonneoplastic WM disease Terminology Pilocytic astrocytoma (PA), juvenile pilocytic astrocytoma (JPA) PILOCYTIC ASTROCYTOMA Imaging Findings Cystic cerebella mass with enhancing mural nodule Enlarged optic nerve/chiasm/tract with variable enhancement Paradoxical findings: MRS does not accurately reflect historical behavior of tumor Multiplanar or 3D volume post contrast imaging key to showing point to origin and degree of extension

10 Top differential Diagnoses Medulloblastoma (PNET-MB) Pilomyxoid astrocytoma Pathology 15% of NF1 patients develop PAs, most commonly in optic pathway Up to 1/3 of patients with optic pathway PAs have NF1 WHO grade 1 Clinical Issues Peak incidence: 5-15 years of age Older than children with medulloblastoma Diagnostic Checklist Generally not a reasonable diagnostic consideration in adults An enhancing intra-axial tumor with cystic change in a middle-age child is more likely to be PA than anything else

11 PLEOMoRPHIC XANTHOASTROCYTOMA Terminology Distinct type of (usually) benign supratentorial astrocytoma found almost exclusively in young adults Imaging Findings Supratentorial cortical mass with adjacent enhancing dural tail Temporal lobe most common Top Differential Diagnoses Ganglioglioma Pilocytic astrocytoma Dysembryoplastic neuroepithelial tumor (DNET)

12 Oligodendroglioma Meningioma Low grade astrocytoma (Grade II) Pathology Superficial, circumscribed astrocytic tumor noted for cellular pleomorphism and xanthomatous change < 1% of all astrocytomas Cystic mass with mural nodule abutting meninges Deep margin may show infiltration of parenchyma WHO grade II Clinical Issues Majority with long-standing epilepsy, often partial complex seizures (temporal lobe) Tumor of children/young adults Diagnostic Checklist Cortical mass & meningeal thickening in a young adult with long seizure history? Think PXA! SUBEPENDYMAL GIANT CELL ASTROCYTOMA Imaging Findings Enlarging, enhancing intraventricular mass in patient with tuberous sclerosis complex (TSC) Location: Almost always near foramen of Monro Well marginated, often lobulated Heterogeneous, strong enhancement Presence of interval growth suggests SGCT Enhancement alone does not allow discrimination from hamartoma FLAIR MR to detect subtle CNS features of TSC Recommend brain MR with contrast every 1-2 years for SGCT follow-up

13 Top Differential Diagnoses Choroid plexus tumors Astrocytoma Germinoma Subependymoma Pathology Most common CNS neoplasm in TSC Does not seed CSF pathways WHO grade I Clinical Issues Increased ICP secondary to tumor obstructing foramen of Monro Diagnostic Checklist SGCA in tuberous sclerosis patient with worsening seizures and/or symptoms of ventricular obstruction

14 OLIGODENDROGLIOMA Terminology Well-differentiated, slowly growing but diffusely infiltrating cortical/subcortical tumor Imaging Findings Best diagnostic clue: Partially Ca++ subcortical/cortical mass in middle-aged adult Typically involves subcortical white matter (WM) and cortex Majority supratentorial (85%), hemispheric WM Most common site is frontal lobe May involve temporal, parietal or occipital lobes Morphology: Infiltrative mass that appears well demarcated Majority calcify, nodular or clumped Ca++ (70-90%)

15 Top Differential Diagnoses Anaplastic oligodendroglioma (AO) Astrocytoma Ganglioglioma Dysembryoplastic neuroepithelial tumor (DNET) Pleomorphic xanthoastrocytoma (PXA) Cerebritis Ischemia Pathology WHO grade II Clinical Issues Seizures, headaches Peak incidence 4 th and 5 th decades Surgical resection in primary treatment Pearls in the Diagnosis of Oligodendroglioma Peak age: years Calcification: 80% Cyst formation: 10% Edema: 50% Location: frontotemporal centrum Hemorrhage: 80-90% Margins: poorly defined; therefore, all areas of T2 relaxation prolongation should be radiated Enhancement: moderate and inhomogeneous Differential Diagnosis: o Meningioma (pseudocapsule, extra-axial) o Ganglioglioma (males, temporal love and anterior third ventricle predilection) o Calcified glioma (less infiltrative, more mass effect, less calcification) o Arteriovenous malformation (hypointense flow void signal, T2 dependent hemosiderin)

16 ANAPLASTIC OLIGODENDROGLIOMA Terminology Oligodendroglioma with focal or diffuse histologic features of malignancy Imaging Findings Best diagnostic clue: Calcified frontal lob mass involving cortex/subcortical white matter (WM) May appear discrete, but always infiltrative Neoplastic cells almost always found beyond areas of abnormal signal intensity Top Differential Diagnoses Oligodendroglioma Anaplastic multiforme (GBM) Cerebritis Ischemia

17 Pathology Well-differentiated (grade II) and anaplastic (grade III) types of oligodendroglioma Oligoastrocytoma (mixed tumor with 2 distinct neoplastic cell types) are common (50%) Oligos have better prognosis that astrocytomas of same grade Average number of chromosomes involved is higher in grade III than grade II oligos 20-50% of oligodendrogliomas are anaplastic WHO grade III Clinical Issues Peak incidence fourth through sixth decade Median survival 4 years Local tumor recurrence common EPENDYMOMA Terminology Sloe-growing tumor of ependymal cells Imaging Findings Soft or plastic tumor: Squeezes out through 4 th ventricle foramina into cisterns 2/3 rd infratentorial, 4 th ventricle 1/3 rd supratentorial, majority periventricular WM Ca++ common (50%); +/- cysts, hemorrhage MR spectoroscopy alone does not reliably differentiate ependymoma from astrocytoma or PNET-MB High-quality sagittal imaging can distinguish point of origin as floor vs roof of 4 th ventricle Top Differential Diagnoses Medulloblastoma (PNET-MB)

18 Pathology Arise from ependymal cells or ependymal rests Third most common posterior fossa tumor in children (after PA and PNET-MB) WHO grade II (low grade, well-differentiated) WHO grade III (high grade, anaplastic) Clinical Issues Clinical profile: 1-5 yo with headache, vomiting Gross total resection + XRT correlates with improved survival Diagnostic Checklist Indistinct interface with floor of 4 th ventricle = ependymoma Pearls in the Diagnosis of Ependymoma Tendency to involve the filum Hemorrhagic in a significant percentage of the cases, especially the myxopaillary form of the filum Tendency to form cysts a. Marginal cysts located at the tumor edge and easily amenable to syringotomy decompression b. Central cysts which are located within the lesion and must be excised if they are to be treated Ependymomas tend to have hypointense T1 and hyperintense T2 signal and either show cyst formation or signal inhomogeneity Filum location is a strong tip-off to the diagnosis (these lesions tend to seed the CSF and may be a result of drop metastases) Enhancement is moderate to marked Indistinct interface with roof of 4 th ventricle = PNET-MB

19 MRI Scan (Transaxial View-same patient as Figures 1, 4 & 5) 4 th Ventricular Ependymoma. The tumor (centrally located lighter "grey" mass) fills the 4th Ventricle in these images (Arrows) Terminology Rare, benign well-differentiated intraventricular ependymal tumor SUBEPENDYMOMA Imaging Findings Best diagnostic clue: T2 hyperintense lobular, nonenhancing intraventricular mass Intraventricular, inferior 4 th ventricle typical (60%) Other: Lateral > 3 rd ventricle > spinal cord Well-defined solid lobular mass When large, may see cysts, hemorrhage, Ca++

20 Variable enhancement, typically none to mild Top Differential Diagnoses Ependymoma Central neurocytoma Subependymal giant cell astrocytoma Choroid plexus papilloma (CPP) Hemangioblastoma Metastases Pathology WHO grade I Clinical Issues Most asymptomatic Other signs/symptoms: Related to increased intracranial pressure, hydrocephalus Middle-aged/elderly adult, (typically 5 th -6 th decades) Surgical resection is curative in most cases

21 Diagnostic Checklist 4 th or lateral venricular hyperintense mass in an elderly male? Think sybependymoma! GANGLIOGLIOMA Terminology Well differentiated, slowly growing neuroepithelial tumor composed of neoplastic ganglion cells and neoplastic glial cells Imaging Findings Best diagnostic clue: Partially cystic, enhancing, cortically-based mass in child/young adult with TLE Can occur anywhere but most commonly superficial hemispheres, temporal lobe Top Differential Diagnoses Pleomorphic xanthoastrocytoma (PXA)

22 Dysembryoplastic neuroepithelial tumor (DNET) Pilocytic astrocytoma Low grade astrocytome (grade II) Oligodendroglioma Pathology Cortical dysplasia is commonly associated Most common mixed neuronal-glial tumor WHO grade I and II Clinical Issues Clinical profile: Most common neoplasm causing chronic temporal lobe epilepsy Excellent prognosis if surgical resection complete Malignant degeneration is rare, approximately 5-10% (glial component) Diagnostic Checklist In young patient with history of temporal lobe epilepsy, think ganglioglioma Cyst with an enhancing mural nodule is classic, but nonspecific for ganglioglioma Pearls in the Diagnosis of Ganglioglioma Age: years Gender: slight male predominance Location: temporal lobe or anterosuperior third ventricle Signal: nonspecific hypointense T1 and hyperintense T2 Enhancement: variable and nominal to moderate Cyst formation: 10% Hemorrhage: rare Calcification: 10-20% Insidious seizure history and lesion in the correct location are tipoffs to diagnosis Differential diagnosis: o Oligodendroglioma: more edema

23 o Vascular malformation: less mass effect, no edema, flow void, hemosiderin o Colloid cyst: smaller size, hyperintense T1 Terminology Best known as Lhermitte-Duclos disease (LDD) DYSPLASTIC CEREBELLAR GANGLIOCYTOMA Imaging Findings Best diagnostic clue: Widened cerebellar folia with striated appearance on MR Characteristics layered or striated pattern of alternating isointense and hyperintense signal Also called laminated, corduroy, lamellar, folial No diffusion disturbance on ADC maps T1 C+: Rare lesions enhance PET: Elevated 18-FDG uptake Elevated 201-thallium uptake on delayed imaging Top Differential Diagnoses Cerebellar infarction Acute cerebellitis Leptomeningeal Pathology Associated with Cowden syndrome Characterized by development of multiple hamartomas

24 Increased risk of thyroid and breast carcinoma Some evidence supports that all cases of LDD have Cowden syndrome Replacement and expansion of granular layer by large neurons Diagnostic Checklist Striated cerebellar hemisphere is Aunt Minnie for LDD DESMOPLASTIC INFANTILE GANGLIOGLIOMA Terminology Desmoplastic infantile (DIG, DIGG) or desmoplastic infantile astrocytoma (DIA) Imaging Findings Large cyst + cortical-based enhancing tumor nodule Location: frontal > parietal > temporal Solid tumor module(s) enhance markedly Enhancement of leptomeninges, dura adjacent to solid tumor is typical Top Differential Diagnosis Primitive neuroectodermal tumor (PNET) Supratentorial ependymoma Pleomorphic xanthoastrocytoma (PXA) Hemangioblastoma Ganglioglioma Pilocytic astrocytoma DNET

25 Terminology Dysembryoplastic neuroepithelial tumor (DNET) Benign, focal, intracortical mass superimposed on background of cortical dysplasia Imaging Findings Best diagnostic clue: Well-demarcated, wedge-shaped bubbly intracortical mass in young patient with longstanding partial seizures Temporal lobe (often amygdale/hippocampus) most common site Intracortical mass scallops inner table of skull and points towards ventricle Minimal or no mass effect Pathology Approximately 1-2% of primary brain tumors in patients < 20 years Reported in 5-80% of epilepsy specimens Clinical Issues Clinical profile: Longstanding (difficult to control) partial complex seizures in child or young adult NO or very slow increase in size over time Rare recurrence Beware of atypical features (enhancement) on pre-op imaging

26 CENTRAL NEUROCYTOMA Terminology Intraventricular neuroepithelial tumor with neuronal differentiation Imaging Findings Best diagnostic clue: Bubbly mass in frontal horn or body of lateral ventricle Intraventicular mass attached to septum pellucidum Circumscribed, lobulated mass with intratumoral cysts Ca++ common, 50-70% Top Differential Diagnosis Subependymoma Subependymal giant cell astrocytoma (SGCA) Metastasis Ependymoma Choroid plexus papilloma (CPP) Meningioma Cavernous malformation

27 Pathology < 1% of all primary intracranial neoplasms Represents 50% of intraventricular tumors on patients years Resembles oligodendroglioma WHO grade II Clinical Issues Most common signs/symptoms: Headaches, increased intracranial pressure, mental status changes, seizure Hydrocephalus secondary to forearm of Monro obstruction Complete surgical resection is treatment of choice Terminology Highly malignant, primitive embryonal tumor of pineal gland PINEOBLASTOMA Imaging Findings Large, heterogeneous pineal mass with exploded, peripheral Ca++ Nearly 100% with obstructive hydrocephalus

28 Top Differential Diagnoses Germ cell tumors (GCTs) Meningioma Pineocytoma (PC) Metastases Pathology PBs exhibit little to no differentiation, similar to other PNETs Clinical Issues Elevated ICP (hydrocephalus): Headache, nausea, vomiting, lethargy, papilledema, abducens nerve palsy Diagnostic Checklist Both PBs and germinomas frequently hyperdense on CT (hypointense T2WI) and prone to CSF dissemination Peripheral exploded Ca++ in PB and central engulfed Ca++ in germinoma classic but not always identified PINEOCYTOMAS Terminology Slow-growing pineal parenchymal tumor of young adults composed of small, uniform mature cells resembling pineocytes Imaging Findings Enhancing, circumscribed pineal mass which explodes pineal Ca++ May mimic pineal cyst or pineoblastoma Top Differential Diagnosis Pineoblastoma Nonneoplastic pineal cyst Astrocytoma Other germ cell tumors (GCT)

29 Meningioma Pathology Pineocytoma and pineoblastomas account for 15% of pineal region neoplasms Pineocytomas represents approximately 45% of pineal parenchymal tumors Pineal parenchymal tumors << germinoma Cysts and small areas of hemorrhage may be seen May compress but do not invade adjacent structures WHO grade II Clinical Issues Overall 5 year survival 86% Diagnostic Checklist PCs explode gland Ca++ while germinomas engulf gland Ca++ Imaging of pineocytoma may be nonspecific MEDULLOBLASTOMA (PNET-MB)

30 Terminology Medulloblastoma (MB), posterior fossa PNET, PNET-MB Malignant, invasive, highly cellular embryonal tumor Imaging Findings Solid mass in 4 th ventricle Hydrocephalus common (95%) > 90% enhance Contrast essential to detect CSF dissemination Contrast-enhanced MR of spine (entire neuraxis) Top Differential Findings Cerebellar pilocytic astrocytoma (PA) Ependymoma Choroid plexus papilloma (CPP) Atypical teratoid/rhabdoid tumor (AT/RhT) Pathology 15-20% of all pediatric brain tumors WHO grade IV Clinical Issues Ataxia, signs of increased intracranial pressure Relatively short (< 1 month) of symptoms Rapid growth with early subarachnoid spread Standard risk clinical profile High risk clinical profile Diagnostic Checklist Remember AT/RhT in patients under 3 years

31 4 th V tumor arising from roof = PNET-MB 4 th V tumor arising from floor = ependymoma (Left): MRI Scan (Sagittal View-Gadolinium Enhanced) of a Young child with a large 4 th Ventricular Medulloblastoma (Vertical Arrow) with compression of the Cerebellum (Curved Arrow). Figure 1B (Center): MRI Scan (Coronal View-same patient). The tumor has considerable "enhancement" indicating a substantial blood supply. Figure 1C (Right): MRI Scan (Transaxial View-same patient). The tumor (Arrow) fills the 4 th Ventricle demonstrates extensive "enhancement". Distinctions among medulloblastoma, ependymoma, and astrocytoma in posterior fossa Feature Medulloblastoma Ependymoma Astrocytoma

32 Unenhanced CT Hyperdense Isodense Hypodense Enhancement Moderate Minimal Nodule enhances, cyst does not Calcification Uncommon (10%-21%) Common (40%-50%) Uncommon (< 10%) Origin Vermis 4 th ventricle ependyma Hemispheric T2WI Intermediate Intermediate Bright Site Midline Midline Eccentric Subarachnoid seeding 15%-50% Uncommon Rare Age (yr) Cyst formation 10-20% 15% 60-80% Foraminal spread No Yes (Luschka, Magendie) No Hemorrhage Rare 10% Rare MRS Metabolite NAA Low Intermediate Intermediate Lactate Absent Often present Often present Choline High Less elevated High SUPRATENTORIAL PNET Terminology Supratentorial primitive neuroectodermal tumor (S-PNET) Cerebral embryonal tumor composed of undifferentiated neuroepithelial cells Imaging Findings Best diagnostic clue: Large, complex hemispheric mass with minimal peritumoral edema Isoattenuating to hyperattenuating Calcification (50-70%) Hemorrhage and necrosis common Heterogeneous enhancement

33 DWI: Restricted diffusion common Best imaging tool: Enhanced MR of brain and spine Adding post-enhanced FLAIR aids in detecting leptomeningeal metastases Top Differential Diagnosis Astrocytoma Ependymoma Oligodendroglioma Atypical teratoid/rhabdoid tumor Top Differential Diagnosis Astrocytoma Ependymoma Oligodendroglioma Atypical teratoid/rhabdoid tumor Pathology WHO grade IV Clinical Issues Vary with site of origin and size of tumor Hemispheric seizures, disturbed consciousness, motor deficit, elevated ICP Suprasellar visual disturbance, endocrine problems Clinical profile: Infant presenting with microcephaly, seizures and large hemispheric mass S-PNET 30-35% 5 year survival

34 MENINGIOMA Imaging Findings Best diagnostic clue: Dural-based enhancing mass w/cortical buckling & trapped CSF clefts/cortical vessels Hyperostosis, irregular cortex, tumoral calcifications, increased vascular markings Brain cysts & trapped pools of CSF common Peritumoral hypodense vasogenic edema (60%) > 95% enhance homogeneously & intensely Elevated levels of Alanine at short TE DSA: Mother-in-law sign comes early, stays late Best imaging tool: MRI + contrast Top Differential Diagnoses Dural metastasis

35 Granuloma (sarcoid, TB) Idiopathic hypertrophic pachymeningitis Extramedullary hematopoiesis Pathology Loss of one copy of chromosome 22 is most prevalent chromosomal change in meningioma Arise from arachnoid meningothelial ( cap ) cells Most common adult intracranial tumor (13-20%) Clinical Issues < 10% of all meningiomas ever cause symptoms Age: Middle decade of life Gender: M:F ranges 1: 1.5 to 1:3 Ethnicity: More common in African-Americans Generally grow slowly, compress adjacent structures Asymptomatic followed with serial imaging Diagnostic Checklist Preoperatively define ENTIRE tumor extent Signs of Meningioma Iso- or Hypointensity on T2 images Inward white matter buckling Speckled T2 signal hyperintensity (microcyst formation) Focal T2 hypointensity (macrocalcifications) Prominent circumferential flow void (hypervascularity) Cisternal widening Calvarial hypointense T1 and T2 (sclerosis) or hyperintense T2 (edema or hyperemia) Pseudocapsule formation due to desmoplasia or fibrosis, displaced dura, CSF, and vessels Variable edema (edema can be pronounced) En plaque variant, ridge b. Wraps around structures especially basilar skull vessels

36 c. Aggressive d. Propensity for sphenoidal ridge e. Fibrovascular histology more common SCHWANNOMA Terminology Benign encapsulated nerve sheath tumor composed of differentiated neoplastic schwann cells Imaging Findings Best diagnostic clue: VS looks like ice cream on cone ; parenchymal looks like cyst with nodule All cranial nerves (exceptions: Olfactory, optic nerves) have myelinated schwann cell sheaths and are sites for intracranial schwannomas 1-2% intracerebral Top Differential Prognosis Pleomorphic xanthoastrocytoma (PXA) Pilocytic astrocytoma Ganglioglioma Metastasis Hemangioblastoma

37 Pathology Schwannomas = 5=8% of all intracranial neoplasms Two types of tissue (Antoni A, B) Clinical Issues Age: 70% of parenchymal schwannomas present before age of 30 Slowly growing: recurrence after surgery < 10% Malignant degeneration exceptionally rare Diagnostic Checklist Cystic, calcified, enhancing hemispheric parenchymal mass in a young patient isn t necessarily a glioma! Differential diagnosis of meningioma versus schwannoma Feature Meningioma Schwannoma Dural tail Frequent Extremely rare Boney reaction Osteolysis or hyperostosis Rare Angle made wit dura Obtuse Acute Calcification 20% Extremely rare Cyst/necrosis Rare Up to 10% Enhancement Uniform Inhomogeneous in 32% Extension into the internal auditory canal Rare 80% MRS Alanine Taurine, GABA Precontrast CT attenuation Hyperdense Isodense Hemorrhage Rar Somewhat more common

38 NEUROFIBROMA Terminology Plexiform NF (PNF) = infiltrative extrapeural tumor typically associated with neurofibromatosis 1 (NF1) Imaging Findings Best diagnostic clue: Worm-like soft tissue mass infiltrative scalp, orbit or parotid in patient with NF1 Top Differential Diagnoses Schwannoma Malignant peripheral nerve sheath tumor (MPNST) Vascular malformation of scalp Sarcoma or lymphoma of skull/scalp Metastasis Chronic interstitial demyelinating polyneuropathy (CIDP) Diagnostic Checklist Look for other stigmata of NF1 (café-au-lait spots, axillary freckling, Lisch nodules, etc) PEARLS IN THE DIAGNOSIS OF GLOMUS TUMOR Age: years Signal a. Intermediate T1, hyperintense T2 b. Punctuate speckled salt and pepper areas pinpoint flow void due to hypervascularity Location a. Jugular foramen (50-60%)= glomus jugulare b. Tympanic branch or Jacobson s nerve, glomus tympanicum (20-30%) c. Auricular branch or Arnold s nerve, glomus vagale (10%) d. Periganglia cells of the carotid bifurcation= glomus caroticum (less than 10%)Female predilection

39 Multiplicity (10%) particularly with multiple endocrine adenomatosis (3%) Eight percent harbor other neoplasms Most common primary middle ear neoplasm Second most common temporal bone neoplasm Enhancement: pronounced, early, mottled Associated thrombosis or flow phenomenon in the jugular vein Shape: Triangular shape in the coronal projection Differential diagnosis a. Neuroma: No punctate flow void, more rounded shape b. Meningioma: Flat dural margin, homogeneous enhancement, wraparound vessels with infiltrative growth pattern c. Normal slow flow in jugular vein HEMANGIOBLASTOMA Terminology HGBL currently classified as meningeal tumor of uncertain histogenesis (WHO, 2000) Imaging Findings Best diagnostic clue: Adult with intra-axial posterior fossa mass with cyst, enhancing mural nodule abutting pia 90-95% posterior fossa Size: Size varies from tiny to several cms 60% cyst + mural nodule 40% solid

40 Top Differential Diagnoses von Hippel-Lindau syndrome (VHL) Metastasis Astrocytoma Vascular neurocutaneous syndrome Cavernous malformation (CM) Clear cell ependymoma Pathology VHL phenotypes (based on presence, absence of pheochromocytoma and renal cell carcinoma) 1-2% of primary intracranial tumors 7-100% of posterior fossa tumors Secondary polycythemia (may elaborate erythropoietin) WHO grade I Diagnostic Checklist Screen entire neuraxis for other HGBLs Most common posterior fossa intra-axial mass in middle-aged/older adult = metastasis, not HGBL!

41 Pearls in the Diagnosis of Hemangioblastoma Sixty percent are intramedullary; 40% are extramedullary but intradural Thirty percent have Hippel-Lindau disease Thoracic location in 50% and cervical location in 40% Lesions are single in 80% and multiple in 20% Cyst formation in 40% MR findings a. Intermediate signal intensity nodule which enhances b. Speckled foci or flow void signal in and about the nodule c. Areas of marginal cyst formation above and below the lesion d. Round or ovoid shape MRI Scan (Gadolinium Enhanced Axial View) Left Cerebellar Hemisphere Cystic Tumor. The "Mural Nodule" (Curved Arrow) "enhances" due to its considerable blood supply and is responsible for the formation of the fluid of the cyst. The "Nodule" must be entirely removed in order to "cure" this lesion, particularly in "Sporadically" occurring cases.

42 Cysts of this size cause considerable pressure on the Brain Stem which can threaten the patient's life if left untreated. HEMANGIOPERICYTOMA Terminology Sarcoma related to neoplastic transformation of pericytes, contractile cells about capillaries Imaging Findings Lobular enhancing extra-axial mass with dural attachment, +/- skull erosion May mimic meningioma, but without Ca++ or hyperostosis Typically involve falx, tentorium, or dural sinuses Marked enhancement, often heterogeneous Top Differential Diagnoses Meningioma Dural metastases Lymphoma Neurosarcoidosis Gliosarcoma Solitary fibrous tumor

43 Pathology HPC is a distinctive mesenchymal neoplasm unrelated to meningioma Represents < 1% of primary CNS tumors Represents 2-4% of all meningeal tumors WHO grade II or III (anaplastic) Clinical Issues Most common 4 th -6 th decade, mean age 43 years Extracranial metastases common, up to 30% Diagnostic Checklist When a meningioma has atypical features (frank bone erosion, multiple flow voids) think HPC! PEARLS IN THE DIAGNOSIS OF CRANIOPHARYNGIOMA Peak age: Biphasic, 3-5 years and years Location a. Suprasellar (80%) b. Sellar/suprasellar (15%) c. Sellar (4%) d. Third ventricle (0.5%) e. Nasopharynx (0.5%) Signal a. Hyperintense T1 & T2: Hydrolyzed cholesterol and/or blood (65%) b. Intermediate T1, hyperintense T2: Keratin (20%) c. Hypointense T2: Calcification (75%) d. Hypointense T1, hyperintense T2: Cyst formation (40%) e. Intermediate T1 and T2: Solid tumor (15%) Calcification (75%): Twice as frequent in children as adults (Rathke s cyst do not calcify)

44 Origin: Rathke s cells or pouch having multilayered complex epithelium (Rathke s cysts have a simple single-layereed epithelium Enhancement: Variable, none to mild Hemorrhage: (10%) Differential diagnosis: Meningioma (homogenous, marked enhancement); aneurysm (flow void or clot); pituitary adenoma (more homogeneous signal, noncalcified, usually no hyperintense T1 signal) Terminology Malignant primary CNS neoplasm composed of B lymphocytes PRIMARY CNS LYMPHOMA Imaging Findings Best diagnostic clue: Enhancing lesion(s) within basal ganglia, periventricular WM 90% supratentorial Deep gray nuclei commonly affected Often involve, cross corpus callosum Frequently abut, extend along epenymal surfaces Top Differential Diagnoses Toxoplasmosis Glioblastoma multiforme (GBM) Abscess Progressive multifocal leukoencephalopathy (PML) Pathology 98% B cell, non-hodgkin lymphoma (NHL) Incidence increasing in immunocompetent, immunocompromised 1-7% of primary brain tumors, incidence rising Represents approximately 1% of lymphomas Clinical Issues Median survival months

45 AIDS median survival 2-6 months Stereotactic biopsy, followed by radiation therapy and chemotherapy Diagnostic Checklist Imaging and prognosis varies with immune status Periventricular location and Subependymal involvement is characteristic of PCNSL PEARLS IN THE DIAGNOSIS OF PRIMARY & SECONDARY BRAIN LYMPHOMA Location a. Deep white gray matter (70%) b. Leptomeningeal signal: Intermediate T1 and isointense to hyperintense T2 (30%) Enhancement: Marked Margin: Sharply marginated intra-axial lesions which may be large, and round or oval in shape Edema: Mild to moderate Cyst formation: Extremely rare Hemorrhage Calcification: Rare Multiplicity: Extremely common Tipoff: Clinical history of immunosuppression or AIDS

46 CHORDOMA Terminology Malignant tumor arising from notochord remnants Imaging Findings Mass is hyperintense to discs on T2WI, with multiple septa Histologic identification of physaliphorous cell confirms diagnosis Location: Sacrococcygeal > spheno-occipital >> vertebral body Size: Several cm at presentation Morphology: Midline lobular soft tissue mass with osseous destruction May extend into disc, involve 2 or more adjacent vertebrae May extend into epidural/perivertebral space, compress cord May extend along nerve roots, enlarge neural foramina Amorphous intratumoral Ca++

47 Pathology 3 types described Typical: Lobules, sheets, and cords of clear cells with intracytoplasmic vacuoles (physaliphorous cells); abundant mucin Chondroid: Hyaline cartilage (usually spheno-occipital region) Dedifferentiated: Sarcomatous elements (rare, highly malignant) Pearls in the Diagnosis of Chordoma Age: years Location: o Sacrum 50% o Clivus 30% o Cervical (C2) 20% Intermediate T1 signal, mottles hyperintense T2 signal Calcification 30-50% Enhancement: none to mild Shape: cauliflower-like shape in the C2 and clival regions Tipoffs: cauliflower-shaped or exophytic mass involving intervertebral disc (sacrum) or straddling the clivus or C2 anteriorly and posteriorly in the sagittal projection PARENCHYMAL METASTASES

48 Terminology Parenchymal tumors that originate from, but are discontinuous with, other CNS primary or extracranial systemic neoplasms Imaging Findings Best diagnostic clue: Discrete parenchymal mass(es) at gray-white interface Best imaging tool: Contrast-enhanced MRI >> CECT Protocol advice: Double or triple-contrast dose increases sensitivity but questionable value on routine basis Top Differential Diagnoses Abscess Malignant glioma Thromboembolic stroke(s) Demyelinating disease Pathology Prevalence of metastases vs primary CNS neoplasms increasing Now account for up to 50% of all brain tumors Seen in 25% of cancer patients at autopsy Metastases usually displace rather than infiltrate tissue Clinical Issues Median survival with whole brain XRT = 3-6 months Diagnostic Checklist White matter disease ( UBOs ) in elderly patient can be caused by multifocal metastases Use contrast-enhanced scans Hemorrhagic Metastases Choriocarcinoma: 90-95% Melanoma: 85% PEARLS IN THE DIAGNOSIS OF METASTATIC DISEASE

49 Hypernephroma: 65% Thyroid carcinoma: 55% Lung carcinoma: 15% Breast carcinoma: 10% Alimentary tract carcinoma: 5-10% Other: Less than 5% Subtypes with a Lower Propensity toward Brain Metastases Squamous cell carcinoma Sarcoma Primary Brain Tumors Which May Metastasize Peripherally Medulloblastoma Cerebellar sarcoma Glioblastoma multiforme Subependymal or Intraventricular Tumor Spread Melanoma Lymphoma Breast carcinoma Lung carcinoma Leptomeningeal or Dural Carcinomatosis Breast carcinoma Lung carcinoma (adenocarcinoma) Melanoma Lymphoma Brain Metastases without Edema Squamous cell carcinoma

50 Cystic Metastases Lung carcinoma (oat cell) Radiated metastases Isointense Metastases Metastatic colon carcinoma (70%) Prostate carcinoma (60%) Osteogenic sarcoma Melanoma (30%) Pure Cortical Metastases Melanoma Chroiocarcinoma Lung carcinoma Intraventricular Choroidal Metastases Lung carcinoma Colon carcinoma Breast carcinoma Arachnoid cyst: Extra-axial, no edema, non-enhancing Cystic neoplasm (low tumor density): Edema, enhances Chronic subdural hematomoa or hygroma: Extra-axial Suprasellar cyst from dilated third ventricle Interhemispheric cyst from porencephaly Posterior fossa cyst form of Dandy-Walker malformation Enlarged cisterna magna Post-infarct cystic encephalomalacia INTRACRANIAL CYSTS ON MR

51 Cysts associated with isodense tumors a. Ganglioma: May calcify b. Cerebellar hemangioblastoma c. Cystic astrocytoma: Enhancing nodule Cysticerosis: Calcification ARACHNOID CYST Terminology Arachnoid cyst (AC), subarachnoid cyst Intra-arachnoid CSF-filled sac that does not communicate with ventricular system Imaging Findings Best diagnostic rule: Sharply demarcated round/ovoid extra-axial cyst that follows CSF attenuation/signal 50-60% middle cranial fossa (MCF) Sharply-marginated extra-axial fluid collection isointense with CSF FLAIR: Suppresses completely with FLAIR DWI: No restriction Top Differential Diagnoses Epidermoid cyst Chronic subdural hematoma Subdural hygroma Other nonneoplastic cysts Pathology 1% of all intracranial masses If in middle fossa, temporal lobe may appear (or be) hypoplastic Subdural hematoma (increased prevalence, especially MCF) Acs displace but don t engulf vessels, cranial nerves

52 Clinical Issues Often asymptomatic, found incidentally Diagnostic Checklist FLAIR, DWI best sequences for distinguishing etiology of cystic-appearing intracranial Pearls in the Diagnosis of Arachnoid Cyst Location: extra-axial a. Middle cranial fossa, peritemporal b. Cerebral convexity c. Posterior fossa, retrocerebellar d. Suprasellar quadrigeminal plate cisterm Homogeneous water-like signal, hypointense on T1 and very hyperintense on T2 (Remember that pulsation in the cyst may create the false impression of a nodule inside) There should be no evidence of intra-axial edema The margins of the lesion are smooth, sharp and straight, particularly in the middle fossa cysts along the posterior margin Suprasellar cysts are oval or square in shape, splay the cerebral peduncels and carotid termini, and push the mamillary body upward and posterior Differential Diagnosis Epidermoid: Hypintense T1, mixed hyperintense T2, does not match CSF fluid Ependymal- or nonependymal-lined cyst: Intra-axial Craniopharyngioma: Mixed T1 and T2 signal, variable hyperintense fat Dermoid tumor: Hyperintense T1 & T2 Cystic glioma: Hypointense T1, hyperintense T2, intra-axial with surrounding edema Masses

53 This is a series of MRI Scans of a 54 year old Male who complained about recent hearing impairment and ringing ("Tinnitus") in his Right ear. The scans show a large Arachnoid Cyst in the Right Cerebellar Pontine Angle of the Posterior Cranial Fossa. DERMOID CYST Imaging Findings Best diagnostic clue: Fat appearance + droplets in cisterns, sulci, ventricles if ruptured T1 C+: With rupture: Extensive MR enhancement possible from chemical meningitis Use fat-suppression sequence to confirm diagnosis Top Differential Diagnoses Epidermoid cyst Craniopharyngioma Teratoma Pathology Rare: < 0.5% of primary intracranial tumors Unilocular cyst with thick wall of connective tissue

54 Clinical Issues Uncomplicated dermoid: Headache (32%), seizure (30%) are most common symptoms y Gender: Slight male predilection Larger lesions associated with higher rupture rate Rupture can cause significant morbidity/mortality Rare malignant transformation into SCCa Treatment: Complete microsurgical excision Diagnostic Checklist Follows fat characteristics on NECT and T1WI fat-suppressed MRI Terminology Intracranial epidermoids are congenital inclusion cysts EPIDERMOID CYST Imaging Findings Best diagnostic clue: CSF-like mass insinuates cisterns, encases nerves/vessels

55 Morphology: Lobulated, irregular, cauliflower-like mass with fronds FLAIR: Usually doesn t completely null Restricted diffusion yields high signal Top Differential Diagnoses Arachnoid cyst Inflammatory cyst (i.e., neurocysticercosis) Cystic neoplasm Dermoid cyst Pathology % of all primary intracranial tumors Clinical Issues Most common symptom: Headache Cranial nerve 5,7,8 neuropathy common Age: Presents at y with peak at 40 Grows slowly: Epithelial component growth rate commensurate to that of normal epithelium Rare malignant degeneration into squamous cell carcinoma (SCCa) reported Treatment: Microsurgical resection Diagnostic Checklist Resembles CSF on imaging studies, except usually incomplete nulling on FLAIR COLLOID CYST

56 Imaging Findings Best diagnostic clue: Hyperdense foramen of Monro mass on NECT Most anterosuperior ventricle location Size < 1.5 centimeters No or nominal contrast enhancement Density correlates inversely with hydration state 2/3 hyperintense on T1WI Majority isointense to brain on T2WI (small cysts may be difficult to see!) 25% mixed hypo/hyper ( black hole effect) Rare: May show peripheral (rim) enhancement Indirect Signs Intermittent hydrocephalus Paramagnetic

57 Appearance of Colloid Cysts by Signal Intensity Paramagnetic type, most common (60%): Hyperintense T1, hypointense T2, peripheral hyperintense T2 rim* Cystic type, uncommon (20%): Hypointense T1, hyperintense T2 Isointense type, rare (10%): Isointense T1 and isointense or minimally hyperintense T2 Mixed type, rare (less than 105): Hyperintense T1, isointense T2 *Fluid levels with T2 hypointensity layering dependently are seen in 30-40% of cases. Top Differential Diagnoses Neurocysticercosis CSF flow artifact (MR pseudocyst ) Neoplasm Choroid plexus mass Pathology From embryonic endoderm, not neuroectoderm! % primary brain tumors 15-20% intraventricular masses Clinical Issues Headache (50-60%) 3 rd -4 th decade 90% stable or stop enlarging 10 % enlarge May enlarge rapidly, cause coma/death! Diagnostic Checklist Notify referring MD immediately if CC identified (especially if hydrocephalus is present) Pearls in the Diagnosis of Colloid Cysts Signal intensity similar to hemorrhagic cysts or cystic craniopharyngioma Paramagnetic type, most frequent

58 Most anterosuperior third ventricle location Intermittent hydrocephalus Minimal enhancement on CEMR Internal constituents include calcium, magnesium, copper, iron, manganese, and sodium Rare in the pediatric population May simulate melanoma metastases RADIATION NECROSIS & RECURRENT NEOPLASM

59 Radiation Necrosis Hypointense T1, iso- to hyperintense T2, variable central HypointensityEnhancement is corrugalated, wavy & irregular (wrinkled configuration) Recurrent Neoplasm Variable T1 and T2 Masslike & Nodular Edema has no respect for the forceps major or corpus callosum Metabolism on Pet usually equals or exceeds that of white matter May recur early or late SIGNS OF INTRACRANIAL NEOPLASTIC HEMORRHAGE Intermediate signal intensity on T1 and T2 Signal alteration which does not correspond to any known pattern of blood evolution over an appropriate period of time Delayed temporal resolution of hemorrhage Bizarre or complex signal intensities Irregular, absent or complex hemosiderin rings Persistent or exaggerated edema Lesion multiplicity Absence of hypointense calcification Disproportionate mass effect for lesion size Nodular enhancement FREQUENCY OF HEMORRHAGE IN INTRACRANIAL NEOPLASMS Pineal choriocarcinoma or teratocarcinoma (90%) Primary intracranial neuroblastoma (85%) Oligodendroglioma (80%)

60 Melanoma (70%) Ependymoma (55%) Glioblastoma multiforme or high-grade astrocytic neoplasm (35%) Metastasis (especially renal cell, thyroid, bronchogenic, melanoma and choriocarcinoma) The frequency of intracranial neoplastic hemorrhage increases dramatically after cranial irradiation CYSTIC PITUITARY MASSES Empty Sella Homogeneous T1 hypointensity, T2 hyperintensity: Pure water signal Midline pituitary stalk Paucity of solid pituitary tissue No evidence of chiasmatic or suprasellar mass effect Enhancement of normal pituitary tissue only Arachnoid Cyst Homogenous T1 hypointensity, T2 hyperintensity: Pure water signal Sellar, suprasellar, retrosellar, and perisellar mass effect are common Effaced and displaced pituitary stalk, multidirectional Enhancement of normal pituitary tissue Cystic Craniopharyngioma May have foci of T1 hyperintensity May have hypointense T2 calcification Suprasellar +/- intrasellar extension Mixed enhancement Cystic Pituitary Adenoma or Neuroectodermal Tumor Moderate T1 hypointensity, T2 hyperintensity: Proteinaceous water signal (therefore no exact CSF match) Displaced pituitary stalk Hormonal abnormalities frequently present Intra- and suprasellar mass effect and/or extension

61 Foci of nodular enhancement from solid components Dermoid Hyperintense T1, hyperintense T2 Predominantly suprasellar Nonenhancing Epidermoid Hypointense T1, hyperintense T2 Inhomogeneous Minimal peripheral enhancement Irregular shape Cystic Optic Chiasmatic/Hypothalamic Glioma Neurofibromatosis frequently associated Origin in, or involvement of, the optic chiasm or hypothalamus Mild enhancement CRITERIA FOR SELLAR MICROADENOMA Direct Criteria T1 hypointensity < 1 cm in size Hypointense on CEMR < 8 minutes, can be isointense 8-40 minutes and hyperintense on CEMR > 40 minutes Indirect Criteria Stalk deviation Abnormal gland height (greater than) a. 6-7 mm male or prepubescent b. b mm gravid female postpuberty c. c mm female, peripartum Floor deviation Gland size asymmetry

62 PEARLS IN THE DIAGNOSIS OF PITUITARY MACROADENOMA Greater than 1 cm Isointense on T1 Iso- or hyperintense on T2 with mild to moderate enhancement Diaphragma sellar notching helps differentiate extrasellar mass growing down from pituitary mass growing up Complications of macroadenoma a. Chiasmatic compression b. Cavernous sinus invasion c. Prolactin levels > 2,000 picograms/dl implies cavernous invasion Cont. of Complications of macroadenoma ii. Abuts the lateral dural sinus walls iii. Loss of speckled signal in the cavernous sinus distribution c. Pituitary hemorrhage or apoplexy d. Pituitary adenoma recurrence e. Differential diagnosis of macroadenoma i. Craniopharyngioma ii. Meningioma (dark-isointense) iii. Aneurysm (lamellated) iv. Metastases (isointense-bright) INTRASELLAR PITUITARY SIGNAL VOIC OR HYPOINTENSITY Common Volume averaging of the parasellar carotid artery dura and CSF

63 Uncommon Aneurysm of the paracavernous carotid artery Rare Vascular malformation of the paracavernous carotid artery Primitive trigeminal artery aneurysm Pituilith Intrasellar calcified meningioma Pituitary gas associated with abscess formation or prior surgery Intrasellar calcified craniopharyngioma Postsurgical intrasellar susceptibility effect (clip, metal, etc.) INTRACRANIAL SIGNAL: HYPERINTENSE T1, HYPOINTENSE T2 Common Subacute hematoma or clot (mid or high field) Flow (first echo slice entry phenomenon) Melanoma metastases Hemorrhagic metastases (choriocarcinoma, neuroblastoma, embryonal cell carcinoma, thyroid carcinoma, renal cell carcinoma, malignant melanoma) Lipoma Pantopaque UncommonColloid cyst Calcified xanthogranuloma Aneurysm (with clot or slice entry)

64 Craniopharyngioma INTRACRANIAL SIGNAL: HYPO-TO ISOINTENSE T1, HYPOINTENSE T2 (1.5T) Common Acute hematoma Flow (first echo flow void, second echo rephasing) Aneurysm with flow phenomenon or acute clot Calcification (nontraumatic, nonhemorrhagic) Brain iron Neoplasm with acute hemorrhage or extensive calcification Meningioma Metastases (colon, prostate, osteogenic sarcoma, breast Uncommon Colloid cyst Melanoma Rare Chloroma INTRACRANIAL SIGNAL: ISOINTENSE-T1 & T2 Common Hyperacute hematoma (transition to acute hematoma [1.5 T]) Acute hematoma (mid field [0.5 T]) Subacute hematoma (high field)

65 Flow (combinations of flow void adding to flow-related hyperintensity) Aneurysm with flow phenomenon Meningioma Brain iron (low field) Isointense metastases (colon, prostate, osteogenic, sarcoma, breast) Hamartoma Uncommon Colloid cyst Rare Medulloblastoma or adult cerebellar sarcoma Lymphoma Tuberculoma Chloroma BLACK SIGNAL Flow Air or gas Hemosiderin (T2 dependent) Iron, copper or metal Bone Calcium Superparamagnetic contrast agents Ligaments, tendons, fascia Magnetic susceptibility

66 HYPOINTENSE RINGS Hemosiderin ring: Chronic hematoma Susceptibility rim artifact: Glial or astrocytic neoplasm Pseudocapsule of dura, cerebrospinal fluid, cleft, desmoplasia, vessels: Meningioma Fibrous rim: Abscess, neurocysticerosis, meningioma INTRAVENTRICULAR MASSES Hypointense T1, Hyperintense T2, Nonenhancing Arachnoid cyst Cysticerosis Colloid cyst (3 rd ventricle) Cystic craniopharyngioma Cystic meningioma Dandy-Walker cyst (4 th ventricle) Epidermoid (4 th ventricle) Neuroepithelial cyst, intraventricular type Neuroepithelial cyst (xanthogranuloma of the choroid plexus) CSF Signal Mass Arachnoid cyst Cysticerosis Dandy-Walker cyst or variant (4 th ventricle) Mega cisterna magna (pseudocyst) Trapped ventricle (pseudomass)hypointense T1 & T2, Enhancing Acute hematoma Calcified giant cell astrocytoma Calcified flomus of choroid plexus

67 Dense or calcified metastases (prostate, colon, osteogenic sarcoma) Heavily calcified meningioma Hemorrhagic ventricular metastases Hyperintense T1, Hypointense T2 Colloid cyst CSF flow Dermoid Early subacute hemorrhage Intraventricular craniopharyngioma (heavily calcified) Lipoma Pantopaque Xanthogranuloma of the choroid plexus Hyperintense T1 & T2 Dermoid Flow Intraventricular craniopharyngioma (3rd ventricle) Late subacute hemorrhage Intraventricular Masses by Site Lateral Third Fourth NEOPLASMS Choroid plexus pspilloma/ca Common, pediatric Common from Common, adult

68 Craniopharngioma suprasellar growth Ependymoma Medulloblastoma Meningioma Common, glomus, Along choroid plexus atrium Metastases Yes Yes Yes Choroid Rare Typical Not reported Differential of temporal lobe lesions Tumor Age Demarcation Edema? Percent of Tumors Causing Temporal Lobe Seizures Hemorrhage Cyst Formation Enhancement Cortical Involvement Calcification Ganglioglioma 0-30 Well Very little 40% Rare Common Uncommon Common Variable Low grade astrocytoma 0-30 Well Yes 26% Rare Common Uncommon Uncommon Variable to uncommon DNET Well None 18% Common Common, Uncommon to Always Common dominant multiple variable Oligodendrogli Less well Yes 6% Variable Variable Common Variable Common -oma PXA Well, but malignant Uncommo n 4% Rare Common Common in mural nodule Common, meningeal attachment Rare Desmoplastic infantile ganglioglioma change in 20% 0-1 Well Occasiona -lly < 3% No Common Common in nodule demoplasia Dural attachment None

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