Invited Journal: Nature Medicine. Sponsors: Thermo Fisher Novocure Merck. Venue: Spanish National Cancer Research Centre CNIO Auditorium Madrid, Spain

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1 CNIO Frontiers Meetings Primary and Secondary Brain Tumors 19th-22nd February 2017 Organisers: Richard Gilbertson CRUK Cambridge Institute, UK Michael Weller University Hospital Zurich, Switzerland Massimo Squatrito Spanish National Cancer Research Centre (CNIO), Madrid, Spain Manuel Valiente Spanish National Cancer Research Centre (CNIO), Madrid, Spain Invited Journal: Nature Medicine Sponsors: Thermo Fisher Novocure Merck Venue: Spanish National Cancer Research Centre CNIO Auditorium Madrid, Spain PRELIMINARY PROGRAM: 19th February, Sunday 20:00-21:30 Welcome Cocktail for all participants Venue: Hotel Don Pío (Avenida Pío XII, 25, 28016, Madrid) Sponsored by:

2 20th February, Monday 09:30-09:45 Opening Remarks Michael Weller 09:45-10:45 Keynote lecture Chairperson: Michael Weller Sponsored by: 10:45-11:00 Coffee break Mapping cancer origins - beyond the brain Richard Gilbertson, Cambridge Cancer Center, University of Cambridge, UK 11:00-12:10 Session#1 PRIMARY ADULT BRAIN TUMORS (I) Chairperson: Massimo Squatrito 11:00-11:30 Modeling the landscape of human gliomas in the mouse Eric Holland, Fred Hutchinson Cancer Research Center, US 11.:30-12:00 Microenvironmental conditioning in glioma Gabriele Bergers, Vesalius Research Center, Belgium 12:00-12:20 Short Talk 12:20-12:50 Mouse Models of Neural Cancer: Cancer Stem Cells & Therapeutic Insights Luis Parada, Memorial Sloan Kettering Cancer Center, US 12:50-14:00 Lunch break 14:00-17:40 Session#2 PRIMARY ADULT BRAIN TUMORS (II) Chairperson: Eric Holland 14:00-14:30 Signaling pathways in glioma tumor formation and therapy resistance Massimo Squatrito, Spanish National Cancer Research Center, CNIO, Spain 14:30-15:00 Next-generation brain tumor classification Stefan Pfister, DKFZ, Germany 15:00-15:20 Short Talk 15:20-15:40 Short Talk 15:40-16:10 Molecular dissection of disease evolution in glioma Roel Verhaak, The Jackson Laboratory, US

3 16:10-16:40 Coffee break 16:40-17:10 Immunotherapy for Glioblastoma Michael Weller, University Hospital Zurich & University of Zurich, Switzerland 17:10-17:40 Next Generation Immune Therapeutics for GBM Amy Heimberger, MD Anderson Cancer Center, US 17:40-19:30 Poster Session & Wine and cheese 21st February, Tuesday 09:30-09:55 'Nature Medicine, meet the editor' Javier Carmona, Assistant Editor 09:55-12:50 Session#3 SECONDARY ADULT BRAIN TUMORS (I) Chairperson: Manuel Valiente 09:55-10:25 Cellular Networks: Implications for Brain Tumor Biology and Therapy Frank Winkler, DKFZ, Germany 10:25-10:55 Genomic Evolution of Brain Metastases Priscilla Brastianos, Massachusetts General Hospital, US 10:55-11:15 Short Talk 11:15-11:45 Group Picture & coffee break 11:45-12:15 How to best design future clinical trials in brain metastasis Riccardo Soffietti, University and City of Health and Science University Hospital of Turin, Italy 12:15-12:35 Short Talk 12:35-13:05 Evolving intratumor heterogeneity in primary and secondary brain tumor Joan Seoane, Vall d Hebron Institute of Oncology, VHIO, Spain 13:05-14:00 Lunch break

4 14:00-17:30 Session#4 SECONDARY ADULT BRAIN TUMORS (II) Chairperson: Riccardo Soffietti 14:00-14:30 The inflammatory microenvironment of brain metastases and its potential role as therapy target Matthias Preusser, Comprehensive Cancer Center Vienna, Austria 14:30-15:00 On-site evolution of metastatic cells and their surrounding environment during brain colonization Manuel Valiente, Spanish National Cancer Research Center, CNIO, Spain 15:00-15:20 Short Talk 15:20-15:40 Short Talk 16:10-16:40 Coffee break 16:40-17:10 Targeting the inflammatory response for diagnosis and treatment of brain metastasis Nicola Sibson, CR-UK/MRC Oxford Institute for Radiation Oncology, UK 17:10-17:40 Clinical trials using molecular precision concepts Wolfgang Wick, DKFZ, Germany 17:40-19:30 Posters Session & Wine and cheese

5 22nd February, 2017 Wednesday 09:45-13:10 Session#5 PRIMARY AND METASTATIC PEDIATRIC TUMORS Chairperson: Richard Gilbertson 09:45-10:15 Biology and therapy for pediatric brain tumors Will A. Weiss, UCSF Helen Diller Family Comprehensive Cancer Center, US 10:15-10:35 Short Talk 10:35-10:55 Short Talk 10:55-11:30 Coffee break 11:30-12:00 The biology of medulloblastoma metastases Michael Taylor, The Hospital for Sick Children, Canada 12:00-12:20 Short Talk 12:20-12:40 Short Talk 12:40-13:10 Oncohistones: epigenetic drivers of pediatric high-grade glioma Suzanne Baker, St. Jude Children s Research Hospital, US 13:10-13:25 Poster Award Sponsored by: Thermo Fisher 13:25 Closing remarks Manuel Valiente and Massimo Squatrito

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