Proceedings of the 36th World Small Animal Veterinary Congress WSAVA
|
|
- Stuart Carr
- 6 years ago
- Views:
Transcription
1 Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct , 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA
2 14(Fri) ~ 17(Mon) October 2011 ICC Jeju, Korea 2011 WSAVA FASAVA World Congress OC-I09 CANINE MAMMARY TUMORS: TREATMENT, PROGNOSTIC FACTORS AND OUTCOME Karin U. Sorenmo, DVM, Dipl ACVIM, ECVIM-CA (oncology) Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA, USA Abstract Surgery represents the most important treatment modality in canine mammary tumors. The goal of surgery is to remove all current tumors +/- prevent new tumors in the mammary glands. Dogs with negative clinical or histopathological prognostic factors are not treated effectively with surgery alone. Systemic therapy, including OHE and/or chemotherapy may be considered for these dogs. Surgical Treatment Surgery is the mainstay of treatment in canine mammary tumors and can be curative in patients with benign tumors, low grade histology or early stage disease (small tumors). According to a large prospective randomized trial, there is no benefit to performing radical mastectomy compared to simple mastectomy, i.e. removing only the affected gland(s) in dogs with mammary tumors¹. No difference was found between remission and survival in dogs treated with radical versus simple mastectomy. Based on these findings, a standard surgical approach to mammary tumors has been adapted by many: Depending on the size, location and numbers of tumors, the surgery may include simple mastectomy, regional mastectomy radical mastectomy or a combination of these procedures. The goal of the surgery is to remove all current tumors with complete surgical margins. Prophylactic mastectomy of normal mammary glands is not indicated according to these guidelines. However, other publications have reported a very high incidence (50-95%) of new mammary tumors in dogs with a prior history of malignant tumors 2,3,4. One of these studies included only dogs with one mammary tumor and concluded that an ipsilateral mastectomy should be performed in such patients based on the high incidence of new tumors in the same chain 4. Another study included dogs with multiple tumors (70%), both sides were equally affected and new tumors developed in 50 % of dogs with prior malignant tumors³. These observations may suggest that prophylactic mastectomies may indeed have a role in selected high risk patients. However, there are currently no studies or guidelines to appropriately identify the dogs in which prophylactic mastectomy should be performed. Alternatively, owners should be advised that new tumors are common, further surgeries may be needed and therefore continued monitoring is important. However, some owners may be reluctant to subject their dogs to a second surgery. Unfortunately, an untreated new primary tumor and subsequent metastasis is, according to the WSAVA FASAVA World Congress Proceedings
3 CANINE MAMMARY TUMORS: TREATMENT, PROGNOSTIC FACTORS AND OUTCOME author s experience, not an uncommon cause of death in some of these dogs. A simple mastectomy, i.e. removal of the entire affected gland rather than a smaller procedure such as a lumpectomy may also be considered in patients with small tumors; studies have found a high incidence of high grade pre-neoplastic lesions adjacent to malignant lesions 2,5. A simple mastectomy will prevent progression and subsequent new tumors developing from such lesions. Canine mammary tumors represent a wide range of clinical presentations and biological behaviors; it is therefore not likely that one standard surgical guideline is appropriate for all cases. Further research is needed to better identify cases that benefit from prophylactic mastectomy so that the recommendations can be tailored to a patient s specific risk profile. Prognostic Factors Several prognostic factors have been identified in dogs with mammary gland tumors. These factors help identify patients that are not treated effectively with surgery alone and require systemic therapy. The most important clinical prognostic factors include tumor size, lymph node status and WHO stage. The histological prognostic factors include tumor type, histological grade and vascular invasion. Clinical prognostic factors: Tumor size has been found to be prognostic according to many independent investigators. Three different size categories are described in both staging systems: T1: < 3 cm, T2: 3-5 cm, and T3: > 5 cm. There is general agreement that size have prognostic significance, and these size categories capture crucial changes in prognosis based on tumor size alone 1,6,7. In reality there is likely a gradual change in prognosis with increasing tumor size, but the current size categories provide provides reliable prognostic information. Lymph node status is also important for prognosis. Metastasis to the local lymph node confirms a metastatic phenotype and implies metastasis beyond the affected lymph node. Several studies have confirmed that dogs with positive regional lymph nodes have a significantly worse prognosis than dogs with negative lymph nodes 6. In fact, tumor size becomes irrelevant if the local lymph nodes are involved. A positive local lymph node constitutes stage IV disease as indicated by the revised staging system, and is a clear indication for systemic therapy. WHO stage (both original and revised) has been shown to have prognostic significance. Information regarding tumor size and lymph node status are incorporated into the staging systems and since both of these factors carry prognostic significance by themselves, it is therefore not surprising that WHO stage also is prognostic. Several studies have shown that dogs with lower stage disease have a significantly better prognosis than dogs with advanced stage disease 7. Histopathological prognostic factors: Primary malignant mesenchymal mammary tumors (sarcomas) are associated with a guarded prognosis. Osteosarcomas are the most common primary mammary gland sarcomas and are characterized by aggressive biological behavior, similar osteosarcomas in other sites8. The WHO staging system used for epithelial tumors does not apply here; and it is important to note that sarcomas usually do not metastasis via the local lymph node but rather via the hematogenous route; therefore dogs with primary mammary gland osteosarcomas have a poor prognosis despite the absence of lymph node metastasis. Tumor grade is also predictive of outcome in dogs with epithelial tumors. The presence or absence of tubule formation, nuclear pleomorphism, and number of mitosis per 10HPF are evaluated and scored. Tumors are graded as grade I: well differentiated, grade II: intermediate, and grade III: undifferentiated. Despite subtle differences these grading systems are nevertheless useful in identifying dogs with aggressive tumors. Dogs with simple carcinomas have a worse prognosis than dogs with other carcinomas, and the presence of histological and 2011 WSAVA FASAVA World Congress Proceedings 761
4 vascular invasion is associated with a worse prognosis, and should therefore be considered when making decision regarding systemic therapy 8. Systemic Treatment and outcome Dogs with large tumors, lymph node metastasis or unfavorable histology are not treated effectively with local therapy alone. Dogs with distant metastasis are not likely to benefit from surgery, but may be palliated with chemotherapy. The options for systemic treatment in canine mammary tumors include hormonal therapy in the form of surgical ovarian hormonal ablation, i.e. ovariohysterectomy and/or chemotherapy. Hormonal therapy: The goal of hormonal therapy is to prevent carcinoma cells from receiving stimulation from hormones. This can be achieved through ovariohysterectomy (OHE) or medical means, such as specific estrogen receptor modulators (SERMS), suppression of estrogen synthesis by aromatase inhibitors or LHRH agonists. Tamoxifen, an estrogen receptor antagonist, commonly used in women with ER positive breast cancer, has also been evaluated in dogs, but due to the side effects, this is not a feasible option in dogs. OHE is a practical solution. The use of hormonal therapy in canine mammary tumors is based on the documentation of these tumors hormone dependence as well as the lessons learned from human breast cancer therapy where hormonal therapy has been found to significantly reduce recurrence and prolong survival in hormone receptor positive breast cancers. The results from the canine studies, all retrospective and non-randomized, however, are conflicting 9,10,11. Only a high powered prospective randomized trial where the effect of OHE stratified and analyzed in context of hormone receptor status can determine whether hormonal therapy has a role in dogs with mammary tumors. Chemotherapy: Similar to hormonal therapy, there are no prospective randomized trials on the effect of chemotherapy in dogs with high risk tumors. Nevertheless, chemotherapy is often used in dogs with negative prognostic factors. A prospective non-randomized study showed a significant survival benefit in dogs with high risk tumors (WHO stage III) treated with a combination of cyclophosphamide and 5-fluorouracil 12. Many oncologists also add doxorubicin to the above protocol. This is based on the fact that this is one of the most effective agents in high risk human breast cancer. No studies have confirmed its activity in dogs however. Primary mammary gland Osteosarcoma is highly aggressive and associated with a poor prognosis; similar protocols to those used for appendicular osteosarcomas may be useful in these cases. Case examples will be presented illustrating the use of systemic therapy and outcome in dogs with mammary tumors WSAVA FASAVA World Congress Proceedings
5 CANINE MAMMARY TUMORS: TREATMENT, PROGNOSTIC FACTORS AND OUTCOME References 1) MacEwen EG, Harvey HJ, Patnaik AK, et al Evaluation of the effect of levamizole and surgery on canine mammary cancer. J Biol Resp Mod 4, ) Gilbertson SR, Kurzman ID, Zachrau RE, et al Canine mammary epithelial neoplasms: Biologic implications of morphologic characteristics assessed in 232 dogs. Vet Pathol 20, ) Sorenmo KU, Kristiansen VM, Cofone MA, et al Canine mammary gland tumors; a histological continuum from benign to malignant; clinical and histopathological evidence. Vet Comp Oncol. 7, ) Stratmann N, Failing K, Richter A, et al Mammary tumor recurrence in bitches after regional mastectomy. Veterinary Surgery 37, ) Antuofermo E, Miller M, Pirino S, Xie J, Badve S, Mohammed SI Spontaneous Mammary Intraepithelial Lesions in Dogs-A model of Breast Cancer. Cancer Epidemiology, Biomarkers & Prevention 16, ) Kurzman ID, Gilbertson SR Prognostic factors in canine mammary tumors. Semin Vet Med Surg 1, ) Yamagami T, Kobayashi T, Takahashi K Prognosis for canine malignant mammary tumors based on the TNM and histologic classification. J Vet Med Sci 58, ) Goldschmidt M, Pena L, Rasotto R Classification and grading of canine mammary tumors. Vet Pathol. 48, ) Schneider R, Dorn CR, Taylor DON: Factors influencing canine mammary cancer development and postsurgical survival. J Natl Cancer Inst. 43, ) Sorenmo, KU, Shofer FS, Goldschmidt MH 2000: Effect of spaying and timing of spaying on survival of dogs with mammary carcinoma. J Vet Intern Med 14, ) Chang SC, Chang CC, Chang TJ, Wong ML prognostic factors associated with survival two years after surgery in dogs with malignant mammary tumors: 79 cases ( ).J Am Vet Med Assoc 227(10): , ) Karayannopoulo M, Kaldrymidou E, Constantinidis TC, et al Adjuvant post-operative chemotherapy in bitches with mammary cancer. J Vet Med Series A 48, WSAVA FASAVA World Congress Proceedings 763
MAMMARY GLAND TUMORS General Information Pathology History & Clinical Signs
MAMMARY GLAND TUMORS Philip J. Bergman DVM, MS, PhD, DACVIM (Oncology) Chief Medical Officer, BrightHeart Veterinary Centers, Armonk, NY 10504 pbergman@brightheartvet.com (914) 219-5415 (office), 219-5417
More informationMammary Tumors. by Pamela A. Davol
Mammary Tumors by Pamela A. Davol Malignant tumors of the mammary glands occur with a higher incident than any other form of cancer in female dogs. Additionally, evidence suggests that females with benign
More informationHistological Grading and Prognosis in Dogs with Mammary Carcinomas: Application of a Human Grading Method
J. Comp. Path. 5, Vol. 133, 246 252 Histological Grading and Prognosis in Dogs with Mammary Carcinomas: Application of a Human Grading Method M. Karayannopoulou*, E. Kaldrymidou, T.C. Constantinidis and
More informationMammary tumours in dogs
continuing education Mammary tumours in dogs Gerry Polton North Downs Specialist Referrals, Brewerstreet Dairy Business Park, Brewerstreet, Bletchingley, Surrey RH1 4QP Introduction Mammary tumours arise
More informationA Canine Case of Complex Carcinoma of the Mammary Gland with Metastasis to the Axillary Lymph Node
A Canine Case of Complex Carcinoma of the Mammary Gland with Metastasis to the Axillary Lymph Node Kenjiro Hashimoto 1), Atsushi Kawabata 1), Tamio Ohmuro 2), Kinji Shirota 1, 3) * 1) Research Institute
More informationBreast Cancer. Dr. Andres Wiernik 2017
Breast Cancer Dr. Andres Wiernik 2017 Agenda: The Facts! (Epidemiology/Risk Factors) Biological Classification/Phenotypes of Breast Cancer Treatment approach Local Systemic Agenda: The Facts! (Epidemiology/Risk
More informationPost Neoadjuvant therapy: issues in interpretation
Post Neoadjuvant therapy: issues in interpretation Disclosure: Overview D Prognostic features in assessment of post treatment specimens: Tumor size Cellularity Grade Receptors LN Neoadjuvant chemotherapy:
More informationProceedings of the 36th World Small Animal Veterinary Congress WSAVA
www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: http://www.ivis.org October 14(Fri) ~ 17(Mon) 2011 ICC Jeju, Korea 2011 WSAVA
More informationIt is a malignancy originating from breast tissue
59 Breast cancer 1 It is a malignancy originating from breast tissue including both early stages which are potentially curable, and metastatic breast cancer (MBC) which is usually incurable. Most breast
More informationARTICLE IN PRESS. doi: /j.ijrobp METAPLASTIC CARCINOMA OF THE BREAST: A RETROSPECTIVE REVIEW
doi:10.1016/j.ijrobp.2005.08.024 Int. J. Radiation Oncology Biol. Phys., Vol. xx, No. x, pp. xxx, 2005 Copyright 2005 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/05/$ see front matter
More informationUniversity Journal of Pre and Para Clinical Sciences
ISSN 2455 2879 Volume 2 Issue 1 2016 Metaplastic carcinoma breast a rare case report Abstract : Metaplastic carcinoma of the breast is a rare malignancy with two distinct cell lines described as a breast
More informationImplications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers
日大医誌 75 (1): 10 15 (2016) 10 Original Article Implications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers Naotaka Uchida 1), Yasuki Matsui 1), Takeshi Notsu 1) and Manabu
More informationClinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05
Abstract No.: ABS-0075 Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer 2018/04/05 Cheol Min Kang Department of surgery, University of Ulsan
More informationCLASSIFICATION AND STAGING OF CANINE MAMMARY GLAND TUMOURS
Journal of Cell and Tissue Research Vol. 16() 5787-5792 (2016) (Available online at www. Tcrjournals.com) ISSN: 097-0028; E-ISSN: 0974-0910 Original Article CLASSIFICATION AND STAGING OF CANINE MAMMARY
More informationProceedings of the World Small Animal Veterinary Association Sydney, Australia 2007
Proceedings of the World Small Animal Sydney, Australia 2007 Hosted by: Next WSAVA Congress WHAT IS THE BEST PROTOCOL FOR CANINE LYMPHOMA? Antony S. Moore, M.V.Sc., Dipl. A.C.V.I.M. (Oncology) Veterinary
More informationRecurrence, new primary and bilateral breast cancer. José Palacios Calvo Servicio de Anatomía Patológica
Recurrence, new primary and bilateral breast cancer José Palacios Calvo Servicio de Anatomía Patológica Ipsilateral Breast Tumor Relapse (IBTR) IBTR can occur in approximately 5 20% of women after breast-conserving
More informationProceedings of the 36th World Small Animal Veterinary Congress WSAVA
www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)
More informationProceedings of the 36th World Small Animal Veterinary Congress WSAVA
www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)
More informationProceedings of the 36th World Small Animal Veterinary Congress WSAVA
www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)
More informationProceedings of the 36th World Small Animal Veterinary Congress WSAVA
www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)
More informationIntro to Cancer Therapeutics
An Intro to Cancer Therapeutics Christopher R. Chitambar, MD Professor of Medicine Division of Hematology & Oncology Froedtert and Medical College of Wisconsin Clinical Cancer Center cchitamb@mcw.edu Intro
More informationOutcomes of Dogs with Grade 3 Mast Cell Tumors: 43 Cases ( )
RETROSPECTIVE STUDIES Outcomes of Dogs with Grade 3 Mast Cell Tumors: 43 Cases (1997 2007) Carrie Tupper Hume, VMD, Diplomate ACVIM*, Matti Kiupel, BS, MS, PhD, Diplomate ACVP, Lora Rigatti, VMD, Frances
More informationContents 1 The Windows of Susceptibility to Breast Cancer 2 The So Called Pre-Neoplastic Lesions and Carcinoma In Situ
Contents 1 The Windows of Susceptibility to Breast Cancer... 1 1.1 Introduction... 1 1.2 Risk Factor and Etiological Agents... 2 1.3 The Concept of the Windows of Susceptibility to Carcinogenesis... 5
More informationEvolving Practices in Breast Cancer Management
Evolving Practices in Breast Cancer Management The Georgia Tumor Registrars Association 2016 Priscilla R. Strom, MD, FACS Objectives 1. understand newer indications for neoadjuvant treatment 2. understand
More informationBreast Imaging: Multidisciplinary Approach. Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina
Breast Imaging: Multidisciplinary Approach Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina No Disclosures Objectives Discuss a multidisciplinary breast
More informationBreast Cancer. Most common cancer among women in the US. 2nd leading cause of death in women. Mortality rates though have declined
Breast Cancer Most common cancer among women in the US 2nd leading cause of death in women Mortality rates though have declined 1 in 8 women will develop breast cancer Breast Cancer Breast cancer increases
More informationCanine Cutaneous Melanoma
Canine Cutaneous Melanoma By Elizabeth Downing Clinical Advisor: Dr. Angharad Waite, VMD Basic Science Advisor: Dr. Cheryl Balkman, DVM, DACVIM Senior Seminar Paper Cornell University College of Veterinary
More informationBreast Cancer. Saima Saeed MD
Breast Cancer Saima Saeed MD Breast Cancer Most common cancer among women in the US 2nd leading cause of death in women 1 in 8 women will develop breast cancer Incidence/mortality rates have declined Breast
More informationUPDATE ON RADIOTHERAPY
1 Miriam Kleiter UPDATE ON RADIOTHERAPY Department for Companion Animals and Horses, Plattform Radiooncology and Nuclear Medicine, University of Veterinary Medicine Vienna Introduction Radiotherapy has
More informationAdjuvan Chemotherapy in Breast Cancer
Adjuvan Chemotherapy in Breast Cancer Prof Dr Adnan Aydıner Istanbul University, Oncology Institute aa1 Slide 1 aa1 adnan aydiner; 17.02.2008 15-Year Reductions in Recurrence and Disease-Specific Mortality
More informationCommon Canine Cancers Why do we care & what to look for at home
Common Canine Cancers Why do we care & what to look for at home BRIAN HUSBANDS, DVM, DIPLOMATE ACVIM ASSOCIATE CLINICAL PROFESSOR COLLEGE OF VET MED U OF MN DEVOTED AMERICAN WATER SPANIEL OWNER Why do
More informationRetrospective analysis to determine the use of tissue genomic analysis to predict the risk of recurrence in early stage invasive breast cancer.
Retrospective analysis to determine the use of tissue genomic analysis to predict the risk of recurrence in early stage invasive breast cancer. Goal of the study: 1.To assess whether patients at Truman
More informationCase # nd Annual SEVPAC May 17, Kathy-Anne Clarke
Case # 10 42 nd Annual SEVPAC May 17, 2014 Kathy-Anne Clarke Google images Babu Babu is 10 year old spayed female French Bulldog Chronic weight loss over 4 months Febrile and lethargic at the referring
More informationDuctal Carcinoma-in-Situ: New Concepts and Controversies
Ductal Carcinoma-in-Situ: New Concepts and Controversies James J. Stark, MD, FACP Medical Director, Cancer Program and Palliative Care Maryview Medical Center Professor of Medicine, EVMS Case Presentation
More informationIntroduction to Basic Oncology
Introduction to Basic Oncology Cancer Cell AHS 102 Med Term Dr. Susie Turner 1/3/13 General Oncology Study of Tumors Neoplasms/Tumors Abnormal growth of new tissue Are either; Benign or Malignant Onc/o
More informationPaget's Disease of the Breast: Clinical Analysis of 45 Patients
236 Paget's Disease of the Breast: Clinical Analysis of 45 Patients Mingfian Yang Hao Long Jiehua He Xi Wang Zeming Xie Department of Thoracic Oncology, Cancer Center of Sun Yat-sen University, Guangzhou
More informationDoes HER2/neu overexpression in breast cancer influence adjuvant chemotherapy and hormonal therapy choices by Ontario physicians? A physician survey
MYERS et al. ORIGINAL ARTICLE Does HER2/neu overexpression in breast cancer influence adjuvant chemotherapy and hormonal therapy choices by Ontario physicians? A physician survey J.A. Myers MD FRCPC, G.
More information4/13/2010. Silverman, Buchanan Breast, 2003
Tailoring Breast Cancer Treatment: Has Personalized Medicine Arrived? Judith Luce, M.D. San Francisco General Hospital Avon Comprehensive Breast Care Center Outline First, treatment of DCIS Sorting risk
More informationAdjuvant Systemic Therapy in Early Stage Breast Cancer
Adjuvant Systemic Therapy in Early Stage Breast Cancer Julie R. Gralow, M.D. Director, Breast Medical Oncology Jill Bennett Endowed Professor of Breast Cancer Professor, Global Health University of Washington
More informationInes Buccimazza 16 TH UP CONTROVERSIES AND PROBLEMS IN SURGERY SYMPOSIUM
BILATERAL MASTECTOMY IS NOT ROUTINELY JUSTIFIED IN PATIENTS WITH BILATERAL AXILLARY LYMPHADENOPATHY AND ONLY ONE DETECTABLE PRIMARY BREAST CANCER LESION SURGERY SYMPOSIUM Ines Buccimazza Breast Unit Department
More informationProceedings of the 36th World Small Animal Veterinary Congress WSAVA
www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)
More informationNeoplasms of the Canine, Feline and Lemur Liver:
Neoplasms of the Canine, Feline and Lemur Liver: Classification and Prognosis Annual Seminar of the French Society of Veterinary Pathology John M. Cullen VMD PhD DACVP North Carolina State University Primary
More informationProceeding of the NAVC North American Veterinary Conference Jan. 8-12, 2005, Orlando, Florida
Proceeding of the NAVC North American Veterinary Conference Jan. 8-12, 2005, Orlando, Florida Reprinted in the IVIS website with the permission of the NAVC http:/// The North American Veterinary Conference
More informationCancer Endorsement Maintenance 2011-Maintenance Measures
Measure Number Title Description Measure Steward 0210 Proportion receiving chemotherapy in the last 14 days of life 0211 Proportion with more than one emergency room visit in the last days of life 0212
More informationIMPROVING CHEMOTHERAPY AND ITS PROTOCOLS TUMOUR TYPES
Vet Times The website for the veterinary profession https://www.vettimes.co.uk IMPROVING CHEMOTHERAPY AND ITS PROTOCOLS TUMOUR TYPES Author : Frances Taylor Categories : Vets Date : August 29, 2011 Frances
More informationBreast Cancer. For breast cancer, the mortality risk varies with the stage of the cancer.
CREATED EXCLUSIVELY FOR FINANCIAL PROFESSIONALS Rx FOR SUCCESS Breast Cancer Breast cancer is the most common cancer in women in the United States and second only to lung cancer as a cause of cancer deaths.
More informationPrinciples of Surgical Oncology. Winnie Achilles Tierklinik Hollabrunn Lastenstrasse Hollabrunn
Principles of Surgical Oncology Winnie Achilles Tierklinik Hollabrunn Lastenstrasse 2 2020 Hollabrunn boexi@gmx.de The first surgery provides the best chance for a cure in an animal with a tumor Clinical
More informationCase Scenario 1: This case has been slightly modified from the case presented during the live session to add clarity.
Case Scenario 1: This case has been slightly modified from the case presented during the live session to add clarity. Background: 46 year old married premenopausal female with dense breasts has noticed
More informationBreast cancer in elderly patients (70 years and older): The University of Tennessee Medical Center at Knoxville 10 year experience
Breast cancer in elderly patients (70 years and older): The University of Tennessee Medical Center at Knoxville 10 year experience Curzon M, Curzon C, Heidel RE, Desai P, McLoughlin J, Panella T, Bell
More informationBreast Cancer. Excess Estrogen Exposure. Alcohol use + Pytoestrogens? Abortion. Infertility treatment?
Breast Cancer Breast Cancer Excess Estrogen Exposure Nulliparity or late pregnancy + Early menarche + Late menopause + Cystic ovarian disease + External estrogens exposure + Breast Cancer Excess Estrogen
More informationSystemic Treatment of Breast Cancer. Hormone Therapy and Chemotherapy, Curative and Palliative
Systemic Treatment of Breast Cancer Hormone Therapy and Chemotherapy, Curative and Palliative Systemic Therapy Invasive breast cancers Two forms Curative Palliative Curative Systemic Therapy Adjuvant Therapy
More informationProceedings of the 36th World Small Animal Veterinary Congress WSAVA
www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)
More informationCarcinome du sein Biologie moléculaire. Thomas McKee Service de Pathologie Clinique Genève
Carcinome du sein Biologie moléculaire Thomas McKee Service de Pathologie Clinique Genève Pathology Diagnostic Prognostic information Predictive information The information provided depends on the available
More informationMAMMARY TUMOURS. Dr Gerard R Rutteman
MAMMARY TUMOURS Dr Gerard R Rutteman Parts in Italics are just for reading, not for studying I. MAMMARY TUMOURS IN THE DOG Mammary tumours are important in small animal veterinary practice. In the female
More informationCover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/55957 holds various files of this Leiden University dissertation Author: Dekker T.J.A. Title: Optimizing breast cancer survival models based on conventional
More informationDOCTORAL THESIS SUMMARY
UNIVERSITY OF MEDICINE AND PHARMACY CRAIOVA FACULTY OF MEDICINE DOCTORAL THESIS SUMMARY CLINICO-IMAGING STUDY OF INVASIVE DUCTAL BREAST CARCINOMAS CORRELATED TO HORMONAL RECEPTORS AND HER2/NEU ONCOPROTEIN
More informationThe efficacy of second-line hormone therapy for recurrence during adjuvant hormone therapy for breast cancer
517734TAM6210.1177/1758834013517734Therapeutic Advances in Medical OncologyR Mori and Y Nagao research-article2013 Therapeutic Advances in Medical Oncology Original Research The efficacy of second-line
More informationRare Breast Cancers and Male Breast Cancer
Johns Hopkins Hospital, Baltimore MD Rare Breast Cancers and Male Breast Cancer David Euhus, MD, FACS Professor of Surgery (PAR) Division of Surgical Oncology Breast Cancer Primary Cancers (97% of breast
More informationTreatment Results and Prognostic Factors of Early Breast Cancer Treated with a Breast Conserving Operation and Radiotherapy
Treatment Results and Prognostic Factors of Early Breast Cancer Treated with a Breast Conserving Operation and Radiotherapy Kyoung Ju Kim 1, Seung Jae Huh 1, Jung-Hyun Yang 2, Won Park 1, Seok Jin Nam
More informationPathology Report Patient Companion Guide
Pathology Report Patient Companion Guide Breast Cancer - Understanding Your Pathology Report Pathology Reports can be overwhelming. They contain scientific terms that are unfamiliar and might be a bit
More informationCase Scenario 1. 2/15/2011 The patient received IMRT 45 Gy at 1.8 Gy per fraction for 25 fractions.
Case Scenario 1 1/3/11 A 57 year old white female presents for her annual mammogram and is found to have a suspicious area of calcification, spread out over at least 4 centimeters. She is scheduled to
More informationFORELIMB SWEAT GLAND ADENOCARCINOMA IN A CAT
I: 2047-2051 ISSN: 2277 4998 FORELIMB SWEAT GLAND ADENOCARCINOMA IN A CAT ABEDI G 1, HESARAKI S 2, ASGHARI A 1* 1: Department of Clinical Science, Science and Research branch, Islamic Azad University,
More informationNEW PERSPECTIVES WITH CANINE MAST CELL TUMORS Brian Husbands, DVM, Diplomate ACVIM (oncology)
NEW PERSPECTIVES WITH CANINE MAST CELL TUMORS Brian Husbands, DVM, Diplomate ACVIM (oncology) Overview of Canine Mast Cell Tumors Mast cell tumors are the most common canine skin tumor in dogs accounting
More informationCase Scenario 1: This case has been slightly modified from the case presented during the live session to add clarity.
Case Scenario 1: This case has been slightly modified from the case presented during the live session to add clarity. Background: 46 year old married premenopausal female with dense breasts has noticed
More informationImmunohistochemical classification of breast tumours
Immunohistochemical classification of breast tumours Workshop in Diagnostic Immunohistochemistry September 19 th - 21 th 2018 Anne-Vibeke Lænkholm Department of Surgical Pathology, Zealand University Hospital,
More informationInternational Society of Gynecological Pathologists Symposium 2007
International Society of Gynecological Pathologists Symposium 2007 Anais Malpica, M.D. Department of Pathology The University of Texas M.D. Anderson Cancer Center Grading of Ovarian Cancer Histologic grade
More informationTitle: Spontaneous Feline Mammary Intraepithelial Lesions as a Model for Human Estrogen Receptor- and Progesterone Receptor-Negative Breast Lesions
Author's response to reviews Title: Spontaneous Feline Mammary Intraepithelial Lesions as a Model for Human Estrogen Receptor- and Progesterone Receptor-Negative Breast Lesions Authors: Giovanni P Burrai
More informationEvaluation of Pathologic Response in Breast Cancer Treated with Primary Systemic Therapy
Evaluation of Pathologic Response in Breast Cancer Treated with Primary Systemic Therapy Eun Yoon Cho, MD, PhD Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University
More informationIndex. Note: Page numbers of article titles are in boldface type.
Note: Page numbers of article titles are in boldface type. A Adjuvant therapy, for early-stage triple-negative breast cancer, 740 742 in older early-stage breast cancer patients, 790 795 anti-her2-directed
More informationNUCLEAR MORPHOMETRY IN RELATION TO METASTASES IN CANINE SPONTANEOUS CUTANEOUS SQUAMOUS CELL CARCINOMAS
Trakia Journal of Sciences, Vol. 8, No. 1, pp 74-78, 2010 Copyright 2009 Trakia University Available online at: http://www.uni-sz.bg ISSN 1313-7050 (print) ISSN 1313-3551 (online) Original Contribution
More informationNeoplasia 2018 Lecture 2. Dr Heyam Awad MD, FRCPath
Neoplasia 2018 Lecture 2 Dr Heyam Awad MD, FRCPath ILOS 1. List the differences between benign and malignant tumors. 2. Recognize the histological features of malignancy. 3. Define dysplasia and understand
More informationClinical and pathological portraits of axillary presentation breast cancer and effects of preoperative systemic therapy
Case Series Clinical and pathological portraits of axillary presentation breast cancer and effects of preoperative systemic therapy Ling Xu 1*, Fang Li 1,2*, Yinhua Liu 1, Xuening Duan 1, Jingming Ye 1,
More informationMEDICAL POLICY. SUBJECT: GENETIC ASSAY OF TUMOR TISSUE TO DETERMINE PROGNOSIS OF BREAST CANCER (OncotypeDX TM, MammaPrint )
MEDICAL POLICY PAGE: 1 OF: 8 If the member's subscriber contract excludes coverage for a specific service it is not covered under that contract. In such cases, medical policy criteria are not applied.
More informationEndocrine Therapy in Premenopausal Breast Cancer. Joyce O Shaughnessy, MD Baylor Sammons Cancer Center Texas Oncology, PA US Oncology
Endocrine Therapy in Premenopausal Breast Cancer Joyce O Shaughnessy, MD Baylor Sammons Cancer Center Texas Oncology, PA US Oncology Ovarian Ablation or Suppression vs. Not in ER + or ER UK Breast Cancer
More informationIntroduction ORIGINAL RESEARCH. Daniela Simon 1, Dorina Schoenrock 1, Ingo Nolte 1, Wolfgang Baumgärtner 2, Ronnie Barron 3, Reinhard Mischke 1
Veterinary Clinical Pathology ISSN 0275-6382 ORIGINAL RESEARCH Cytologic examination of fine-needle aspirates from mammary gland tumors in the dog: diagnostic accuracy with comparison to histopathology
More informationTriple Negative Breast Cancer
Triple Negative Breast Cancer Prof. Dr. Pornchai O-charoenrat Division of Head-Neck & Breast Surgery Department of Surgery Faculty of Medicine Siriraj Hospital Breast Cancer Classification Traditional
More informationMdi Medical Management of Breast Cancer Morbidity and Mortality Aug 13, 2009 Irina Kovatch, PGY3 Introduction Metastatic disease is the principal cause of death from breast cancer Metastatic events often
More informationAre there the specific prognostic factors for triplenegative subtype of early breast cancers (pt1-2n0m0)?
Are there the specific prognostic factors for triplenegative subtype of early breast cancers (pt1-2n0m0)? Department of General Surgery, Anam Hospital, Korea University, College of Medicine, 126-, Anam-dong
More informationPromise of a beautiful day
Promise of a beautiful day Ductal carcinoma in Situ Lobular Carcinoma in Situ Natural History Manosmed Tartous Oct 2009 Gérard ABADJIAN MD Pathology Department Hôtel-Dieu de France. Associate Professor
More informationGene Expression Profiling for Managing Breast Cancer Treatment. Policy Specific Section: Medical Necessity and Investigational / Experimental
Medical Policy Gene Expression Profiling for Managing Breast Cancer Treatment Type: Medical Necessity and Investigational / Experimental Policy Specific Section: Laboratory/Pathology Original Policy Date:
More informationACRIN 6666 Therapeutic Surgery Form
S1 ACRIN 6666 Therapeutic Surgery Form 6666 Instructions: Complete a separate S1 form for each separate area of each breast excised with the intent to treat a cancer (e.g. each lumpectomy or mastectomy).
More informationHave you been newly diagnosed with early-stage breast cancer? Have you discussed whether chemotherapy will be part of your treatment plan?
Have you been newly diagnosed with early-stage breast cancer? Have you discussed whether chemotherapy will be part of your treatment plan? This guide is designed to educate newly diagnosed women with early-stage
More informationProperties of Synchronous Versus Metachronous Bilateral Breast Carcinoma with Long Time Follow Up
DOI:http://dx.doi.org/10.7314/APJCP.2015.16.12.4921 Properties of Synchronous Versus Metachronous Bilateral Breast Carcinoma with Long Time Follow Up RESEARCH ARTICLE Properties of Synchronous Versus Metachronous
More informationNEUROENDOCRINE DIFFERENTIATED BREAST CARCINOMA
+ NEUROENDOCRINE DIFFERENTIATED BREAST CARCINOMA + INTRODUCTION + NEUROENDOCRINE FEATURES IN BREAST CARCINOMA Incidence of 2-5% Seen in various histopathological types of breast carcinoma Seen in both
More informationNeoplasia literally means "new growth.
NEOPLASIA Neoplasia literally means "new growth. A neoplasm, defined as "an abnormal mass of tissue the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the
More informationEmbolotherapy for Cholangiocarcinoma: 2016 Update
Embolotherapy for Cholangiocarcinoma: 2016 Update Igor Lobko,MD Chief, Division Vascular and Interventional Radiology Long Island Jewish Medical Center GEST 2016 Igor Lobko, M.D. No relevant financial
More informationBreast Cancer Treatment
Breast Cancer Treatment Treatment 2 aspects 1. Treatment of the breast itself: Local Treatment 2. Treatment of the whole body = Systemic treatment Local Treatment Surgery +/- Radiation Usually: a. Breast
More informationClaudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression
Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression Mona A. Abd-Elazeem, Marwa A. Abd- Elazeem Pathology department, Faculty of Medicine, Tanta
More informationBreast Cancer Basics. Clinical Oncology for Public Health Professionals. Ben Ho Park, MD, PhD
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this
More informationManagement guideline for patients with differentiated thyroid cancer. Teeraporn Ratanaanekchai ENT, KKU 17 October 2007
Management guideline for patients with differentiated thyroid Teeraporn Ratanaanekchai ENT, KKU 17 October 2007 Incidence (Srinagarind Hospital, 2005, both sex) Site (all) cases % 1. Liver 1178 27 2. Lung
More informationOutcomes Following Negative Prostate Biopsy for Patients with Persistent Disease after Radiotherapy for Prostate Cancer
Clinical Urology Post-radiotherapy Prostate Biopsy for Recurrent Disease International Braz J Urol Vol. 36 (1): 44-48, January - February, 2010 doi: 10.1590/S1677-55382010000100007 Outcomes Following Negative
More informationLow-Grade Periductal Stromal of Breast: a case report
Low-Grade Periductal Stromal of Breast: a case report Rosanna Nenna 1 Cosimo Damiano Inchingolo 1 Domenico Palmieri 2 Annalisa De Lucia 1 Giusy Elicio 1 Pina Miscioscia 1 ( 1 ) U.O.C. di Anatomia Patologica,
More informationRadiation Therapy for the Oncologist in Breast Cancer
REVIEW ARTICLE Chonnam National University Medical School Sung-Ja Ahn, M.D. Adjuvant Tamoxifen with or without in Patients 70 Years of Age with Stage I ER-Positive Breast Cancer: Efficacy Outcomes (10
More informationSYSTEMIC THERAPY OPTIONS FOR BREAST CANCER IN 2014
SYSTEMIC THERAPY OPTIONS FOR BREAST Oncology Day 2014 CANCER IN 2014 Dr. Katherine Enright, M.D., M.P.H., F.R.C.P.(C) Katherine.enright@Trilliumhealthpartners.ca OBJECTIVES 1. Outline an approach to the
More informationKey Words. Adjuvant therapy Breast cancer Taxanes Anthracyclines
The Oncologist Mayo Clinic Hematology/Oncology Reviews Adjuvant Therapy for Breast Cancer: Recommendations for Management Based on Consensus Review and Recent Clinical Trials BETTY A. MINCEY, a,b FRANCES
More informationSee the latest estimates for new cases of salivary gland cancers in the US and what research is currently being done.
About Salivary Gland Cancer Overview and Types If you have been diagnosed with salivary gland cancer or are worried about it, you likely have a lot of questions. Learning some basics is a good place to
More informationMy Personalized Breast Cancer Worksheet
My Personalized Breast Cancer Worksheet KNOW For Early-Stage Breast Cancer. No Questions. Only Results. No two tumors are alike. What are the characteristics of your breast cancer and how will that effect
More informationCarcinoma mammario: le istologie non frequenti. Valentina Guarneri Università di Padova IOV-IRCCS
Carcinoma mammario: le istologie non frequenti Valentina Guarneri Università di Padova IOV-IRCCS Histological diversity of breast adenocarcinomas Different histological types are defined according to specific
More informationWhat s new for Mast Cell Tumors in Dogs?
What s new for Mast Cell Tumors in Dogs? Pascale C Salah, Dr. vet. med., DACVIM (oncology) Michael Mison, DVM, DACVS Lili Duda, VMD, MBE, DACVR(RO) Amy Durham, MS, VMD, DACVP (Anatomic Pathology) University
More informationOncotype DX tools User Guide
Oncotype DX tools User Guide This guide provides an overview of the data and quick access to the Oncotype DX tools Oncotype DX tools offers two quantitative calculator tools that may be used together with
More information