Pleomorphic carcinoma is a rare epithelial malignant. Personal Experience in Surgical Management of Pulmonary Pleomorphic Carcinoma
|
|
- Adelia Preston
- 6 years ago
- Views:
Transcription
1 Personal Experience in Surgical Management of Pulmonary Pleomorphic Carcinoma Federico Raveglia, MD, Maurizio Mezzetti, MD, Tiziana Panigalli, MD, Simone Furia, MD, Luigi Giuliani, MD, Serena Conforti, MD, and Stefano Meda, MD University of Milan, Milan, Italy Background. Pleomorphic carcinoma is a rare epithelial malignant tumor. Pulmonary pleomorphic carcinoma was introduced by the 1999 World Health Organization classification as a new peculiar type of lung carcinoma showing concurrent malignant epithelial and sarcomatoid spindle cell elements. Few reports describe its clinical behavior. My colleagues and I report a series of patients surgically treated for pulmonary pleomorphic carcinoma to describe our experience with this malignant neoplasm. Methods. Twenty cases of pleomorphic pulmonary carcinoma were collected and studied clinicopathologically. All patients underwent surgical resection. The cases were as follows: 6 stage I, 12 stage II, and 2 stage IIIA. Histologic diagnosis was established by using light microscopic examination and immunohistochemistry. rates were calculated with the Kaplan-Meier method. Results. We postoperatively diagnosed 20 cases of pleomorphic carcinoma: 14 cases were exclusively spindle and giant-cell carcinomas, 2 cases were spindle and giant-cell carcinoma combined with adenocarcinoma, 2 were combined with squamous cell carcinoma, and 2 were combined with large cell carcinoma. At last followup, 4 patients were still alive; they were postoperative T1 N0 and T2 N0. The remaining 16 patients died from early distant metastases. The median duration of disease-free survival was 5 months. The median duration of overall survival was 8 months. Conclusions. The prognosis of patients with pleomorphic carcinoma was poor, despite surgery and adjuvant chemotherapy, because of early relapse of disease. Nodal involvement was a determinant prognostic variable, because advanced stages were related to worse prognosis. In case of preoperatively proven pulmonary pleomorphic carcinoma, surgery should be recommended to N0 patients. (Ann Thorac Surg 2004;78:1742 7) 2004 by The Society of Thoracic Surgeons Pleomorphic carcinoma is a rare epithelial malignant tumor [1]. It has been described in several human organs, including the lung parenchyma [2, 3]. The 1999 World Health Organization (WHO) classification identified pulmonary pleomorphic carcinoma as a specific type of lung cancer among neoplasms with pleomorphic, sarcomatoid, or sarcomatous elements [4]. This is a group of poorly differentiated non small-cell carcinomas that contain a component of sarcomatoid elements. According to the 1999 WHO definition, pleomorphic carcinoma is a pulmonary carcinoma consisting of spindle or giants cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma. Pure spindle and giant-cell carcinomas are rare. The spindle or giant-cell component should comprise at least 10% of the neoplasm for diagnosis. The adenocarcinoma, squamous cell carcinoma, or large-cell carcinoma components of the tumor should be always documented when present. The WHO considers pleomorphic carcinoma as an entity separate from squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma on the basis of the mutational spectrum seen in these tumor types [5, 6]. Accepted for publication April 27, Address reprint requests to Dr Raveglia, Piazza Leonardo da Vinci 7, Milan, Italy; ravegliafederico@tiscali.it. Before 1999 pleomorphic carcinoma was considered as a variant of other well-known lung carcinomas because of its biphasic appearance and its frequent association with the other histologic types [7]. Diagnosis of this histotype was problematic and confusing because of the lack of uniform diagnostic criteria. The lack of widely accepted criteria and the rarity of this pulmonary carcinoma made its behavior unclear and its appropriate treatment controversial. In 1999 the WHO reclassified spindle cell carcinoma combined with squamous cell carcinoma, adenocarcinoma, giant-cell carcinoma, or large-cell carcinoma as a new class of lung tumor named pleomorphic carcinoma [8]. Classification of these tumors is based on light microscopic criteria, sometimes supported by immunohistochemistry [4]. Few large series of patients with pulmonary pleomorphic carcinoma according to the 1999 WHO classification have been described in the international literature, and most of these articles focused on the histologic features. The pleomorphic carcinoma histopathologic classification is universally adopted, but its clinical relevance and the behavior of the tumor are still uncertain. My colleagues and I diagnosed pulmonary pleomorphic carcinoma in a small number of patients surgically treated for lung carcinoma. We collected all clinical data 2004 by The Society of Thoracic Surgeons /04/$30.00 Published by Elsevier Inc doi: /j.athoracsur
2 Ann Thorac Surg RAVEGLIA ET AL 2004;78: PLEOMORPHIC CARCINOMA SURGICAL OUTCOMES 1743 about these patients from 1999 to obtain more information about this low-frequency tumor. This article describes our clinical experience with pulmonary pleomorphic carcinoma and reports histologic records, preoperative and postoperative staging, and the correlated outcomes. The purpose of the study was to better understand the clinical relevance in terms of the survival of this histotype by using information from the literature and our personal experience. With this article, focused on the outcomes in patients surgically treated for pulmonary pleomorphic carcinoma, we broached the role of surgery in this subgroup of non small-cell lung cancer. and Methods From the beginning of 1999 to the end of 2002, 513 patients underwent surgical resection for primary lung carcinoma at the Department of Thoracic Surgery, University of Milan. Of these, 20 cases were primary pleomorphic carcinoma. The 20 patients with pleomorphic carcinoma were registered for age, sex, presenting symptoms, smoking habits, and stage. There were 14 men and 6 women. The mean age at diagnosis was 60.3 years (range, 43 to 76 years); 80% of patients smoked. Eighteen patients presented with symptoms such as coughing, dyspnea, fever, hemoptysis, or obstructive pneumonia in case of endobronchial involvement. Two patients had an incidental roentgenogram finding of a pulmonary lesion. All patients were studied with contrast-enhanced chest computed tomography (CT) that demonstrated 8 leftlung and 12 right-lung single lesions with radiologic signs of malignancy. Overall, 12 lesions were in the right upper lobe, 6 in the left upper lobe, and 2 in the left lower lobe. We used contrast-enhanced CT for noninvasive intrathoracic staging. In addition, cervical mediastinoscopy was performed before operation to analyze superior mediastinal lymph nodes in 7 patients. One patient presented with a lesion in the right lung and dubious mediastinal lymphadenopathy at CT scan. The other 6 cases had a left upper lobe single lesion, and mediastinoscopy was performed to exclude right mediastinal nodal involvement because contralateral lymphatic spread is more likely for left upper lobe tumors. None of these patients presented with N3 disease. Two patients were positive for N2 nodal malignancy, which is compatible with non small-cell lung cancer. Metastatic disease was routinely detected by brain CT, abdominal CT, and bone scan. None of these patients presented with metastatic disease. All of the lesions were described as solitary masses. Twelve were centrally situated, and 8 were peripherally situated. Bronchoscopy was always performed to define the airway involvement and the extent of the pathologic tissue in the bronchus. Eight cases were described as endobronchial neoplasms, and endoscopic biopsy resulted in the diagnosis of 4 squamous cell carcinomas and 4 non small-cell carcinomas. In case of a preoperative established diagnosis, we elected surgery because of the malignancy. In 12 patients no proven pathologic preoperative diagnosis was achieved; we elected surgery on the basis of radiologic findings. In these 12 patients intraoperative histologic examination of the lung tumor was performed and was positive for malignant disease. On the basis of the frozen section examination results, we proceeded with surgical resection. The 2 patients preoperatively staged as N2 with mediastinoscopy underwent surgical resection because they were classified as having non small-cell lung cancer stage IIIA. All patients had pulmonary function tests and cardiac evaluation. Two patients with compromised pulmonary function underwent parenchyma-sparing resection (typical segmentectomy). None had preoperative chemotherapy. Anesthesiologic procedures were typical for major thoracic surgery. Ventilation was always by double-lumen tube. The incision was always a standard posterolateral thoracotomy. This allowed thorough evaluation of the anterior and posterior hilar structures and permitted complete ipsilateral mediastinal node dissection (nodal stations 2, 4, 5, 6, 7, 8, and 9). Operations included 2 left pneumonectomies, 2 right pneumonectomies, 8 right upper lobectomies, 4 left upper lobectomies, 2 left lower lobectomies, and 2 right upper lobe segmentectomies. Expert pathologists at the University of Milan examined all the pathologic material. Diagnosis was obtained by light microscopic findings and was completed with immunohistochemical examinations. Each case met the WHO criteria. Cases were classified as spindle cell carcinoma if at least 10% of the tumor was composed of fusiform malignant cells. Histologic components were classified as follows: spindle cell carcinoma, giant-cell carcinoma, squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma. Immunohistochemical procedures were performed by using antibodies against cytokeratin and vimentin [9 11]. A positive reaction to 1 epithelial marker was useful to confirm epithelial differentiation in the sarcomatoid component in case of poor carcinomatous differentiation at the light microscopic examination. All patients received adjuvant chemotherapy except in cases with N0 disease. They received a combination of chemotherapy agents. Chemotherapy cycles were repeated every 28 days according to the following pattern: cisplatin on the 1st day and gemcitabine on the 2nd, 8th, and 15th days. Follow-up was obtained for all patients with periodic clinical and radiographic controls (including standard chest radiographs and CT scanning) at our outpatient clinic until the patient s death. Flexible bronchoscopy was performed in patients who presented with endobronchial carcinoma or in case bronchial recurrence was suspected. and disease-free survival rates were calculated on the basis of the Kaplan-Meier method. The log-rank test was used to test for significant differences in survival and disease-free survival [12].
3 1744 RAVEGLIA ET AL Ann Thorac Surg PLEOMORPHIC CARCINOMA SURGICAL OUTCOMES 2004;78: Table 1. Summary of Clinical Data Patient No. Sex Smoker ptnm Histology Disease- Free (mo) 1 F Y T2 N1 Spindle/giant-cell large-cell carcinoma M Y T2 N1 Spindle/giant-cell squamous cell carcinoma M Y T1 N0 Spindle/giant-cell 32 a 32 b 4 F N T2 N1 Spindle/giant-cell M Y T2 N0 Spindle/giant-cell adenocarcinoma 22 a 22 b 6 M Y T2 N0 Spindle/giant-cell M Y T3 N1 Spindle/giant-cell M Y T2 N2 Spindle/giant-cell F N T2 N1 Spindle/giant-cell M Y T2 N1 Spindle/giant-cell squamous cell carcinoma F Y T2 N1 Spindle/giant-cell large-cell carcinoma M Y T2 N1 Spindle/giant-cell F N T2 N1 Spindle/giant-cell M Y T1 N0 Spindle/giant-cell 31 a 31 b 15 M Y T2 N0 Spindle/giant-cell M Y T2 N0 Spindle/giant-cell adenocarcinoma 21 a 21 b 17 M Y T3 N1 Spindle/giant-cell M Y T2 N2 Spindle/giant-cell F N T2 N1 Spindle/giant-cell M Y T2 N1 Spindle/giant-cell 6 4 a Patient still alive; b Absence of metastasis. ptnm pathologic tumor-node-metastasis stage. Results Clinical data were tabulated according to histologic findings, pathologic tumor-node-metastasis staging, and clinical disease behavior (Table 1). The tumors ranged from 2.1 to 9 cm. Nineteen lesions were intraparenchymal, and 8 showed intrabronchial components in the tumor. Twenty cases of primary pulmonary pleomorphic carcinoma were identified. Six cases had identifiable epithelial components. Fourteen cases were classified as pure pleomorphic carcinomas consisting only of spindle and giant cells (Table 1). All tumors expressed both cytokeratin and vimentin. Most cases expressed diffuse vimentin, as opposed to focal stain for cytokeratin [13]. We compared postoperative with preoperative diagnosis (8 cases), and 2 cases of squamous cell carcinoma were reclassified as pleomorphic carcinoma combined with squamous cell carcinoma. The other cases of squamous cell carcinoma were reclassified as spindle and giant-cell carcinoma combined with large-cell carcinoma. Four preoperative non small-cell lung cancers were reclassified as 2 pleomorphic carcinomas combined with adenocarcinoma and 2 pure pleomorphic carcinomas. According to the tumor-node-metastasis classification, cases were postoperatively classified as follows: 6 stage I (2 T1 N0 and 4 T2 N0), 12 stage II (10 T2 N1 and 2 T3 N1), and 2 stage IIIA (2 T2 N2). These findings matched the preoperative staging. The in-hospital and 30-day mortality rates were 0%. There were no severe postoperative operative complications. No re-resections were performed for neoplastic involvement of surgical edges. The overall survival was 20% (4/20) at the time of last follow-up (December 2003). The remaining 80% of these patients died because of recurrence of disease. The median duration of survival was 8 months (Fig 1; Table 2). The disease-free survival time was extremely short; in our series the median disease-free survival was 5 months (Fig 2; Table 3). Metastases involved different areas, Fig 1. Overall survival function estimates for pleomorphic carcinoma. Median survival was 8 months.
4 Ann Thorac Surg RAVEGLIA ET AL 2004;78: PLEOMORPHIC CARCINOMA SURGICAL OUTCOMES 1745 Table 2. Data Related to Figure 1 time (mo) Dead Rate including the mediastinal lymph nodes, brain, bone, adrenal glands, liver, and lung. At detection of metastatic disease, all patients presented more than 1 involved area. When we considered the nodal status, 4 patients of the 6 N0 cases were still alive and free from metastatic disease at last follow-up. The remaining 14 cases who had nodal involvement (12 N1 and 2 N2) at postoperative staging died of recurrence of disease. We used the Kaplan-Meier method to generate 1 set of survival curves that compared patients on the basis of nodal disease status (Fig 3; Table 4). We classified patients into 2 categories (stage I and stage II to III) to obtain survival curves for nodal involvement. We found a significant difference in survival for patients with nodal involvement when we compared those with N1 and N2 disease with those with N0 disease (log-rank test; p 0.001). Table 3. Data Related to Figure 2 Disease-Free (mo) Comment Relapse of Disease Disease-Free Rate Pulmonary pleomorphic cell carcinoma is a rare malignant lung tumor. This rarity has made its classification confusing and its diagnosis difficult. Before 1999 this tumor was classified as a variant of squamous cell carcinoma. In 1999 the WHO reclassified the pleomorphic carcinoma and set widely adopted criteria. According to these criteria, pleomorphic carcinoma is now considered a peculiar type of lung carcinoma. We reported our clinical experience with pulmonary pleomorphic carcinoma to add new information regarding the behavior and prognosis of this tumor and the role of surgery in its management. In accordance with other studies, we noted a male preponderance [14], a mean age of 60.3 years [15], and a high correlation with cigarette smoking. Most lesions were found in the upper lobes. Contrary to other series, most of our cases were pure spindle and giant-cell Fig 2. Overall disease-free survival function estimates for pleomorphic carcinoma. Median disease-free survival was 5 months. Fig 3. functions for postoperative stage I versus stage II or III (p 0.001). Data 1 patients with nodal involvement (stage II or III); data 2 patients without nodal involvement (stage I).
5 1746 RAVEGLIA ET AL Ann Thorac Surg PLEOMORPHIC CARCINOMA SURGICAL OUTCOMES 2004;78: Table 4. Data Related to Figure 3 (mo) Data 2 Data 1 Dead Rate Dead Rate carcinomas. Clinically most of the patients presented with nonspecific symptoms such as coughing and dyspnea, ranging from 2 to 4 months before the diagnosis of pulmonary disease. Our data showed that establishing a pathologic preoperative diagnosis was complicated. We obtained an adequate specimen only in case of proximal endobronchial disease involvement. The similarity to other tumors and the intimate mixture in foci of different elements made differential diagnosis of pleomorphic carcinoma difficult when based on endoscopic sampling. Preoperative diagnosis, when available, was significant in detecting malignancy; a correct differential diagnosis of pleomorphic carcinoma has always been established on the basis of definitive postoperative specimen examination. Our experience indicated that the prognosis of patients with pleomorphic carcinoma was poor despite surgery and adjuvant chemotherapy, even in case of local disease (stage I). Pleomorphic carcinoma presented an aggressive clinical behavior, and most patients experienced early multiple disease spreading (Fig 2). The overall median postoperative survival was 8 months (Fig 1). Some investigators who have described the malignant behavior of sarcomatoid carcinomas did not find significant differences with patients with nonsarcomatoid non small-cell carcinoma of the lung [16]. However, our data, in accordance with those of Fishback and colleagues [10], suggest that the prognosis of this pulmonary tumor in terms of median survival is poorer than in conventional non small-cell lung carcinoma (according to literature [17]: 20 months for adenocarcinoma, 18.5 months for squamous cell carcinoma, and 12.6 months for large cell carcinoma). Our figures showed that survival was even more unfavorable than in small-cell lung cancer when compared with many series of patients surgically treated for small-cell lung cancer before the chemotherapy era [18]. We noted that multiple distant metastases occurred earlier and worsened prognosis in patients with nodal involvement. No patient with lymph node involvement survived. Comparison between the survival curve in case of nodal disease and the survival curve in N0 patients showed that the nodal status had statistical significance in determining prognosis (p 0.001; Fig 3). Previous reports have indicated different findings about the effect of nodal metastasis on the length of survival. Some studies found that nodal status did not have a statistical effect on prognosis [9], but others found that nodal involvement shortened patient survival [10, 11, 16]. In contrast to other studies, our data showed that stage based on lymph node status was a significant prognostic variable in these patients. rate was strictly related to lymph node involvement, with significant differences between N0 and N1 and N2. On the basis these data, distinctive for poor prognosis, the question in the management of pleomorphic carcinoma of the lung is whether surgical resection should be considered. We think that, when dealing with this malignant entity, the most important issue is to obtain an accurate preoperative diagnosis and a correct clinical stage definition. Preoperative diagnosis is the most demanding item in the management of biphasic lung tumors; its correct definition requires intensive collaboration between pathologist and surgeon. Because survival curves showed that recurrences were more likely for patients with nodal involvement, our experience suggests that the goal for surgery should be complete tumor resection before nodal disease involvement occurs. We think that surgery for preoperatively proven pulmonary pleomorphic carcinoma should be restricted to N0 patients. with nodal disease should be considered for hypothetical neoadjuvant therapy, but nowadays chemotherapy is contraindicated by the generally experienced poor sensibility of these types of tumors. The clinical behavior of this biphasic malignant tumor, comparable to that of poorly differentiated carcinoma, is probably due to the presence of carcinomatous and sarcomatous elements originating from a single stem cell of multipotential lung tissue [9, 19]. In our clinical experience, we noted that the frequency of biphasic tumors (non small-cell lung carcinoma/small-cell lung cancer or squamocellular carcinoma/adenocarcinoma) [20] seems to have increased. This is disturbing, because universally adopted surgical algorithms and prognoses are actually based on monophasic tumor types. The authors are grateful for the valuable collaboration of Alberto G. L. Luporini, MD, Director of the Division of Medical Oncology, Policlinico San Donato Institute, San Donato Milanese, Milan, Italy. References 1. Ishida T, Tateuishi M, Kaneko S. Carcinoma and spindle cell carcinoma of the lung: clinicopathologic and immunohistochemical studies. J Thorac Cardiovasc Surg 1990;100: Munakata R, Cheng J, Nakajima T. Spindle cell carcinoma of the gingiva: report of an autopsy case. J Oral Pathol Med 1998;27: Torenbeek R, Blomjous CEM, Bruin P. Sarcomatoid carci-
6 Ann Thorac Surg RAVEGLIA ET AL 2004;78: PLEOMORPHIC CARCINOMA SURGICAL OUTCOMES 1747 noma of urinary bladder. Clinicopathologic analysis of 18 cases with immunohistochemical and electron microscopic findings. Am J Surg Pathol 1994;18: World Health Organization. Histological typing of lung tumors and pleural tumors. 3rd ed. Geneva: World Health Organization, Przygodzki RM, Koss MN, Moran CA, et al. Pleomorphic (giant and spindle cell) carcinoma is genetically distinct from adenocarcinoma and squamous cell carcinoma by K-ras-2 and p53 analysis. Am J Clin Pathol 1996;106: Lee YC, Chang YL, Luh SP. Significance of p53 and Rb protein expression in surgically treated non small cell lung cancers. Ann Thorac Surg 1999;68: World Health Organization. Histological typing of lung tumors. Geneva: World Health Organization, Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato Y. The new World Health Organization classification of lung tumours. Eur Respir J 2001;18: Yih-Leon Chang, Yung-Chie Lee, Jin-Yuan Shih, Chen-Tu Wu. Pulmonary pleomorphic (spindle) cell carcinoma: peculiar clinicopathologic manifestations different from ordinary non small cell carcinoma. Lung Cancer 2001;34: Fishback NF, Travis WD, Moran CA, et al. Pleomorphic (spindle/giant cell) carcinoma of the lung. A clinicopathologic correlation of 78 cases. Cancer 1994;73: Rossi G, Cavazza A, Sturm N, et al. Pulmonary carcinomas with pleomorphic, sarcomatoid or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol 2003;27: Kaplan EL, Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc 1958;53: Kazuhiro M, Masanobu K. Spindle cell carcinoma of the lung. A clinicopathologic study of three cases. Cancer 1991; 67: Haque S. Carcinosarcoma of the lung: report of a case and review of the literature. J Pak Med Assoc 1980;30: Bull JC, Grimes OF. Pulmonary carcinosarcoma. Chest 1974; 65: Nakajima M, Kasai T, Hashimoto H, Iwata Y, Manabe H. Sarcomatoid carcinoma of the lung. A clinicopathologic study of 37 cases. Cancer 1999;86: Kaiser K, Bulzebruck H, Probst G, Vogt-Moykopf I. Retrospective and prospective tumor staging evaluating prognostic factors in operated bronchus carcinoma patients. Cancer 1987;59: Lad T. Surgery for small cell lung cancer. In: Franco KL, Putnam JB Jr, eds. Advanced therapy in thoracic surgery. Hamilton, Ontario, Canada: B. C. Decker, 1998: Oscar N, Mark RW. Sarcomatoid neoplasms of the respiratory tract. Semin Diagn Pathol 1993;10: Shimizu J, Oda M, Hayashi Y, et al. A clinicopathologic study of resected cases of adenosquamous carcinoma of the lung. Chest 1996;109:
Pleomorphic carcinoma of the lung: which CT findings predict poor prognosis?
Pleomorphic carcinoma of the lung: which CT findings predict poor prognosis? Poster No.: C-1887 Congress: ECR 2015 Type: Scientific Exhibit Authors: A. Fujisaki, T. Aoki, S. Kinoshita, Y. Hayashida, Y.
More informationSuperior and Basal Segment Lung Cancers in the Lower Lobe Have Different Lymph Node Metastatic Pathways and Prognosis
ORIGINAL ARTICLES: Superior and Basal Segment Lung Cancers in the Lower Lobe Have Different Lymph Node Metastatic Pathways and Prognosis Shun-ichi Watanabe, MD, Kenji Suzuki, MD, and Hisao Asamura, MD
More informationCT Findings of Surgically Resected Pleomorphic Carcinoma of the Lung in 30 Patients
Kim et al. CT of Pleomorphic Carcinoma of the Lung Chest Imaging Clinical Observations Tae Sung Kim 1 Joungho Han 2 Kyung Soo Lee 1 Yeon Joo Jeong 1 Seo Hyun Kwak 1 Hong Sik Byun 1 Myung Jin Chung 1 Hojoong
More informationVenissac et al General Thoracic Surgery Sarcomatoid lung cancer (spindle/giant cells): An aggressive disease? Objective: Methods: GTS Results:
Sarcomatoid lung cancer (spindle/giant cells): An aggressive disease? Nicolas Venissac, MD a, Daniel Pop, MD a, Sandra Lassalle, MD b, Frederic Berthier, MD c, Paul Hofman, MD, PhD b, and Jérôme Mouroux,
More informationAlthough ipsilateral intrapulmonary metastasis (PM), Evaluation of TMN Classification for Lung Carcinoma With Ipsilateral Intrapulmonary Metastasis
Evaluation of TMN Classification for Lung Carcinoma With Ipsilateral Intrapulmonary Metastasis Morihito Okada, MD, Noriaki Tsubota, MD, Masahiro Yoshimura, MD, Yoshifumi Miyamoto, MD, and Reiko Nakai,
More informationCombined Large Cell Neuroendocrine Carcinoma and Spindle Cell Carcinoma of the Lung
Case Reports Jpn J Clin Oncol 2011;41(6)797 802 doi:10.1093/jjco/hyr034 Advance Access Publication 16 March 2011 Combined Large Cell Neuroendocrine Carcinoma and Spindle Cell Carcinoma of the Lung Taichiro
More informationRevisit of Primary Malignant Neoplasms of the Trachea: Clinical Characteristics and Survival Analysis
Jpn J Clin Oncol 1997;27(5)305 309 Revisit of Primary Malignant Neoplasms of the Trachea: Clinical Characteristics and Survival Analysis -, -, - - 1 Chest Department and 2 Section of Thoracic Surgery,
More informationLung cancer pleural invasion was recognized as a poor prognostic
Visceral pleural invasion classification in non small cell lung cancer: A proposal on the basis of outcome assessment Kimihiro Shimizu, MD a Junji Yoshida, MD a Kanji Nagai, MD a Mitsuyo Nishimura, MD
More informationThe right middle lobe is the smallest lobe in the lung, and
ORIGINAL ARTICLE The Impact of Superior Mediastinal Lymph Node Metastases on Prognosis in Non-small Cell Lung Cancer Located in the Right Middle Lobe Yukinori Sakao, MD, PhD,* Sakae Okumura, MD,* Mun Mingyon,
More informationBronchial carcinosarcoma
Bronchial carcinosarcoma Carolina Carcano 1*, Edward Savage 2, Maria Julia Diacovo 3, Jacobo Kirsch 1 1. Division of Radiology, Cleveland Clinic Florida, Weston, Fl, USA 2. Department of Thoracic and Cardiovascular
More informationBronchogenic Carcinoma
A 55-year-old construction worker has smoked 2 packs of ciggarettes daily for the past 25 years. He notes swelling in his upper extremity & face, along with dilated veins in this region. What is the most
More informationLYMPH NODE METASTASIS IN SMALL PERIPHERAL ADENOCARCINOMA OF THE LUNG
LYMPH NODE METASTASIS IN SMALL PERIPHERAL ADENOCARCINOMA OF THE LUNG Tsuneyo Takizawa, MD a Masanori Terashima, MD a Teruaki Koike, MD a Takehiro Watanabe, MD a Yuzo Kurita, MD b Akira Yokoyama, MD b Keiichi
More informationAlthough the international TNM classification system
Prognostic Significance of Perioperative Serum Carcinoembryonic Antigen in Non-Small Cell Lung Cancer: Analysis of 1,000 Consecutive Resections for Clinical Stage I Disease Morihito Okada, MD, PhD, Wataru
More informationLymph node dissection for lung cancer is both an old
LOBE-SPECIFIC EXTENT OF SYSTEMATIC LYMPH NODE DISSECTION FOR NON SMALL CELL LUNG CARCINOMAS ACCORDING TO A RETROSPECTIVE STUDY OF METASTASIS AND PROGNOSIS Hisao Asamura, MD Haruhiko Nakayama, MD Haruhiko
More informationBasaloid Carcinoma of the Lung: A Really Dismal Histologic Variant?
Carcinoma of the Lung: A Really Dismal Histologic Variant? Dae Joon Kim, MD, Kil Dong Kim, MD, Dong Hwan Shin, MD, Jae Y Ro, MD, and Kyung Young Chung, MD Departments of Thoracic and Cardiovascular Surgery,
More informationThoracic Surgery; An Overview
Thoracic Surgery What we see Thoracic Surgery; An Overview James P. Locher, Jr, MD Methodist Cardiovascular and Thoracic Surgery Lung cancer Mets Fungus and TB Lung abcess and empyema Pleural based disease
More informationMEDIASTINAL LYMPH NODE METASTASIS IN PATIENTS WITH CLINICAL STAGE I PERIPHERAL NON-SMALL-CELL LUNG CANCER
MEDIASTINAL LYMPH NODE METASTASIS IN PATIENTS WITH CLINICAL STAGE I PERIPHERAL NON-SMALL-CELL LUNG CANCER Tsuneyo Takizawa, MD a Masanori Terashima, MD a Teruaki Koike, MD a Hideki Akamatsu, MD a Yuzo
More informationThe International Association for the Study of Lung Cancer (IASLC) Lung Cancer Staging Project, Data Elements
Page 1 Contents 1.1. Registration... 2 1.2. Patient Characteristics... 3 1.3. Laboratory Values at Diagnosis... 5 1.4. Lung Cancers with Multiple Lesions... 6 1.5. Primary Tumour Description... 10 1.6.
More informationPredictive risk factors for lymph node metastasis in patients with small size non-small cell lung cancer
Original Article Predictive risk factors for lymph node metastasis in patients with small size non-small cell lung cancer Feichao Bao, Ping Yuan, Xiaoshuai Yuan, Xiayi Lv, Zhitian Wang, Jian Hu Department
More informationMarcel Th. M. van Rens, MD; Aart Brutel de la Rivière, MD, PhD, FCCP; Hans R. J. Elbers, MD, PhD; and Jules M. M. van den Bosch, MD, PhD, FCCP
Prognostic Assessment of 2,361 Patients Who Underwent Pulmonary Resection for Non-small Cell Lung Cancer, Stage I, II, and IIIA* Marcel Th. M. van Rens, MD; Aart Brutel de la Rivière, MD, PhD, FCCP; Hans
More informationThe Spectrum of Management of Pulmonary Ground Glass Nodules
The Spectrum of Management of Pulmonary Ground Glass Nodules Stanley S Siegelman CT Society 10/26/2011 No financial disclosures. Noguchi M et al. Cancer 75: 2844-2852, 1995. 236 surgically resected peripheral
More informationMediastinal Staging. Samer Kanaan, M.D.
Mediastinal Staging Samer Kanaan, M.D. Overview Importance of accurate nodal staging Accuracy of radiographic staging Mediastinoscopy EUS EBUS Staging TNM Definitions T Stage Size of the Primary Tumor
More informationDiagnosis and Staging of Non-Small Cell Lung Cancer Carlos Eduardo Oliveira Baleeiro, MD. November 18, 2017
Diagnosis and Staging of Non-Small Cell Lung Cancer Carlos Eduardo Oliveira Baleeiro, MD November 18, 2017 Disclosures I do not have a financial interest/arrangement or affiliation with one or more organizations
More informationCharles Mulligan, MD, FACS, FCCP 26 March 2015
Charles Mulligan, MD, FACS, FCCP 26 March 2015 Review lung cancer statistics Review the risk factors Discuss presentation and staging Discuss treatment options and outcomes Discuss the status of screening
More informationPrognostic value of visceral pleura invasion in non-small cell lung cancer q
European Journal of Cardio-thoracic Surgery 23 (2003) 865 869 www.elsevier.com/locate/ejcts Prognostic value of visceral pleura invasion in non-small cell lung cancer q Jeong-Han Kang, Kil Dong Kim, Kyung
More informationWe are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,800 116,000 120M Open access books available International authors and editors Downloads Our
More informationCarcinoma of the Lung
THE ANNALS OF THORACIC SURGERY Journal of The Society of Thoracic Surgeons and the Southern Thoracic Surgical Association VOLUME 1 I - NUMBER 3 0 MARCH 1971 Carcinoma of the Lung M. L. Dillon, M.D., and
More informationPleomorphic Carcinoma of the Lung: Relationship Between CT Findings and Prognosis
Cardiopulmonary Imaging Original Research Fujisaki et al. CT of Pleomorphic Carcinoma of the Lung Cardiopulmonary Imaging Original Research Akitaka Fujisaki 1 Takatoshi Aoki 1 Takahiko Kasai 2,3 Shunsuke
More informationTreatment Strategy for Patients With Surgically Discovered N2 Stage IIIA Non-Small Cell Lung Cancer
Treatment Strategy for Patients With Surgically Discovered N2 Stage IIIA Non-Small Cell Lung Cancer Ryoichi Nakanishi, MD, Toshihiro Osaki, MD, Kozo Nakanishi, MD, Ichiro Yoshino, MD, Takashi Yoshimatsu,
More informationAmerican Journals of Cancer Case Reports. A Rare Case of Rectal Metastasis from Sarcomatoid Variant of Urothelial Carcinoma: A Case Report
American Journals of Cancer Case Reports Lin JYJ et al. American Journals of Cancer Case Reports 2014, 3:1-5 http://ivyunion.org/index.php/ajccr Page 1 of 5 Vol 3 Article ID 20140539, 5 pages Case Report
More informationTHYMIC CARCINOMAS AN UPDATE
THYMIC CARCINOMAS AN UPDATE Mark R. Wick, M.D. University of Virginia Medical Center Charlottesville, VA CARCINOMA OF THE THYMUS General Clinical Features No apparent gender predilection Age range of 35-75
More informationSlide 1. Slide 2. Slide 3. Investigation and management of lung cancer Robert Rintoul. Epidemiology. Risk factors/aetiology
Slide 1 Investigation and management of lung cancer Robert Rintoul Department of Thoracic Oncology Papworth Hospital Slide 2 Epidemiology Second most common cancer in the UK (after breast). 38 000 new
More informationCase Scenario 1. The patient has now completed his neoadjuvant chemoradiation and has been cleared for surgery.
Case Scenario 1 July 10, 2010 A 67-year-old male with squamous cell carcinoma of the mid thoracic esophagus presents for surgical resection. The patient has completed preoperative chemoradiation. This
More informationMolly Boyd, MD Glenn Mills, MD Syed Jafri, MD 1/1/2010
LSU HEALTH SCIENCES CENTER NSCLC Guidelines Feist-Weiller Cancer Center Molly Boyd, MD Glenn Mills, MD Syed Jafri, MD 1/1/2010 Initial Evaluation/Intervention: 1. Pathology Review 2. History and Physical
More informationTHORACIC MALIGNANCIES
THORACIC MALIGNANCIES Summary for Malignant Malignancies. Lung Ca 1 Lung Cancer Non-Small Cell Lung Cancer Diagnostic Evaluation for Non-Small Lung Cancer 1. History and Physical examination. 2. CBCDE,
More informationThe roles of adjuvant chemotherapy and thoracic irradiation
Factors Predicting Patterns of Recurrence After Resection of N1 Non-Small Cell Lung Carcinoma Timothy E. Sawyer, MD, James A. Bonner, MD, Perry M. Gould, MD, Robert L. Foote, MD, Claude Deschamps, MD,
More informationRole of Surgery in Management of Non Small Cell Lung Cancer. Dr. Ahmed Bamousa Consultant thoracic surgery Prince Sultan Military Medical City
Role of Surgery in Management of Non Small Cell Lung Cancer Dr. Ahmed Bamousa Consultant thoracic surgery Prince Sultan Military Medical City Introduction Surgical approach Principle and type of surgery
More informationValidation of the T descriptor in the new 8th TNM classification for non-small cell lung cancer
Original Article Validation of the T descriptor in the new 8th TNM classification for non-small cell lung cancer Hee Suk Jung 1, Jin Gu Lee 2, Chang Young Lee 2, Dae Joon Kim 2, Kyung Young Chung 2 1 Department
More informationLung Cancer-a primer. Sai Yendamuri, MD Professor and Chair, Dept of Thoracic Surgery,RPCI,Buffalo
Lung Cancer-a primer Sai Yendamuri, MD Professor and Chair, Dept of Thoracic Surgery,RPCI,Buffalo CLINICAL CATEGORIES THE SOLITARY PULMONARY NODULE MULTIPLE PULMONARY NODULES Differential Diagnosis Malignant
More informationThe prognostic relevance of classifying neuroendocrine
Large Cell Neuroendocrine Carcinoma and Large Cell Carcinomas With Neuroendocrine Morphology of the Lung: Prognosis After Complete Resection and Systematic Nodal Dissection Joseph Zacharias, FRCS (CTh),
More informationVisceral pleural involvement (VPI) of lung cancer has
Visceral Pleural Involvement in Nonsmall Cell Lung Cancer: Prognostic Significance Toshihiro Osaki, MD, PhD, Akira Nagashima, MD, PhD, Takashi Yoshimatsu, MD, PhD, Sosuke Yamada, MD, and Kosei Yasumoto,
More informationUniversity Journal of Pre and Para Clinical Sciences
ISSN 2455 2879 Volume 2 Issue 1 2016 Metaplastic carcinoma breast a rare case report Abstract : Metaplastic carcinoma of the breast is a rare malignancy with two distinct cell lines described as a breast
More informationNeuroendocrine (NE) lung tumors represent a broad
Large Cell Neuroendocrine Carcinoma of the Lung: A 10-Year Clinicopathologic Retrospective Study Massimiliano Paci, MD, Alberto Cavazza, MD, Valerio Annessi, MD, Innocenza Putrino, MD, Guglielmo Ferrari,
More informationAdvanced primary pulmonary lymphoepithelioma-like carcinoma: clinical manifestations, treatment, and outcome
Original Article Advanced primary pulmonary lymphoepithelioma-like carcinoma: clinical manifestations, treatment, and outcome Chun-Yu Lin 1,2, Ying-Jen Chen 1,2, Meng-Heng Hsieh 2,3, Chih-Wei Wang 2,4,
More informationWHITE PAPER - SRS for Non Small Cell Lung Cancer
WHITE PAPER - SRS for Non Small Cell Lung Cancer I. Introduction This white paper will focus on non-small cell lung carcinoma with sections one though six comprising a general review of lung cancer from
More informationNon-Small Cell Lung Cancer: Disease Spectrum and Management in a Tertiary Care Hospital
Non-Small Cell Lung Cancer: Disease Spectrum and Management in a Tertiary Care Hospital Muhammad Rizwan Khan,Sulaiman B. Hasan,Shahid A. Sami ( Department of Surgery, The Aga Khan University Hospital,
More informationAfter primary tumor treatment, 30% of patients with malignant
ESTS METASTASECTOMY SUPPLEMENT Alberto Oliaro, MD, Pier L. Filosso, MD, Maria C. Bruna, MD, Claudio Mossetti, MD, and Enrico Ruffini, MD Abstract: After primary tumor treatment, 30% of patients with malignant
More informationMultifocal Lung Cancer
Multifocal Lung Cancer P. De Leyn, MD, PhD Department of Thoracic Surgery University Hospitals Leuven Belgium LEUVEN LUNG CANCER GROUP Department of Thoracic Surgery Department of Pneumology Department
More informationPrognostic Factors for Survival of Stage IB Upper Lobe Non-small Cell Lung Cancer Patients: A Retrospective Study in Shanghai, China
www.springerlink.com Chin J Cancer Res 23(4):265 270, 2011 265 Original Article Prognostic Factors for Survival of Stage IB Upper Lobe Non-small Cell Lung Cancer Patients: A Retrospective Study in Shanghai,
More informationClinicopathological characteristics and prognosis of resected cases of carcinoid tumors of the lung
Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Clinicopathological characteristics and prognosis of resected cases of carcinoid tumors of the lung Zhi Yang, Zitong Wang, Yong Duan & Shaofa Xu Department
More informationSurvival Comparison of Adenosquamous, Squamous Cell, and Adenocarcinoma of the Lung After Lobectomy
Survival Comparison of Adenosquamous, Squamous Cell, and Adenocarcinoma of the Lung After Lobectomy David T. Cooke, MD, Danh V. Nguyen, PhD, Ying Yang, MS, Steven L. Chen, MD, MBA, Cindy Yu, MD, and Royce
More informationcame from a carcinoma and in 12 from a sarcoma. Ninety lesions were intrapulmonary and the as the chest wall and pleura. Details of the primary
Thorax 1982;37:366-370 Thoracic metastases MARY P SHEPHERD From the Thoracic Surgical Unit, Harefield Hospital, Harefield ABSTRACI One hundred and four patients are reviewed who were found to have thoracic
More informationA Case of Locally Advanced Well-Differentiated Fetal Adenocarcinoma of the Lung Treated with Concurrent Chemoradiation Therapy
http://dx.doi.org/10.4046/trd.2013.74.5.226 ISSN: 1738-3536(Print)/2005-6184(Online) Tuberc Respir Dis 2013;74:226-230 CopyrightC2013. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights
More informationDiagnosis of thoracic endometriosis with immunohistochemistry
Original Article Diagnosis of thoracic endometriosis with immunohistochemistry Yo Kawaguchi 1,2, Jun Hanaoka 1, Yasuhiko Ohshio 1, Tomoyuki Igarashi 1, Keigo Okamoto 1, Ryosuke Kaku 1, Kazuki Hayashi 1,
More informationTitle. CitationLung Cancer, 68(2): Issue Date Doc URL. Type. File Information. Clinical characteristics of pleomorphic carcinoma of
Title Clinical characteristics of pleomorphic carcinoma of Ito, Kenichiro; Oizumi, Satoshi; Fukumoto, Shinichi; Author(s) Kojima, Tetsuya; Yokouchi, Hiroshi; Nishimura, Masah CitationLung Cancer, 68(2):
More informationCase Scenario 1. The patient agreed to a CT guided biopsy of the left upper lobe mass. This was performed and confirmed non-small cell carcinoma.
Case Scenario 1 An 89 year old male patient presented with a progressive cough for approximately six weeks for which he received approximately three rounds of antibiotic therapy without response. A chest
More informationAdam J. Hansen, MD UHC Thoracic Surgery
Adam J. Hansen, MD UHC Thoracic Surgery Sometimes seen on Chest X-ray (CXR) Common incidental findings on computed tomography (CT) chest and abdomen done for other reasons Most lung cancers discovered
More informationMediastinal Spread of Metastatic Lymph Nodes in Bronchogenic Carcinoma*
Mediastinal Spread of Metastatic Lymph Nodes in Bronchogenic Carcinoma* Mediastinal Nodal Metastases in Lung Cancer Yoh Watanabe, M.D., F.C.C.P.; ]unzo Shimizu, M.D.; Makoto Tsubota, M.D.; and Takashi
More informationPrognostic factors in curatively resected pathological stage I lung adenocarcinoma
Original Article Prognostic factors in curatively resected pathological stage I lung adenocarcinoma Yikun Yang 1, Yousheng Mao 1, Lin Yang 2, Jie He 1, Shugeng Gao 1, Juwei Mu 1, Qi Xue 1, Dali Wang 1,
More informationClinical significance of skipping mediastinal lymph node metastasis in N2 non-small cell lung cancer
Original Article Clinical significance of skipping mediastinal lymph node metastasis in N2 non-small cell lung cancer Jun Zhao*, Jiagen Li*, Ning Li, Shugeng Gao Department of Thoracic Surgery, National
More informationNavigational bronchoscopy-guided dye marking to assist resection of a small lung nodule
Case Report on Aerodigestive Endoscopy Navigational bronchoscopy-guided dye marking to assist resection of a small lung nodule Jennifer L. Sullivan 1, Michael G. Martin 2, Benny Weksler 1 1 Division of
More informationVisceral pleura invasion (VPI) was adopted as a specific
ORIGINAL ARTICLE Visceral Pleura Invasion Impact on Non-small Cell Lung Cancer Patient Survival Its Implications for the Forthcoming TNM Staging Based on a Large-Scale Nation-Wide Database Junji Yoshida,
More informationTumour size as a prognostic factor after resection of lung carcinoma
Tumour size as a prognostic factor after resection of lung carcinoma A. S. SOORAE AND R. ABBEY SMITH Thorax, 1977, 32, 19-25 From the Cardio-Thoracic Unit, Walsgrave Hospital, Clifford Bridge Road, Coventry
More informationRadiology Pathology Conference
Radiology Pathology Conference Sharlin Johnykutty,, MD, Cytopathology Fellow Sara Majewski, MD, Radiology Resident Friday, August 28, 2009 Presentation material is for education purposes only. All rights
More informationResected Synchronous Primary Malignant Lung Tumors: A Population-Based Study
ORIGINAL ARTICLES: SURGERY: The Annals of Thoracic Surgery CME Program is located online at http://cme.ctsnetjournals.org. To take the CME activity related to this article, you must have either an STS
More informationOBJECTIVES. Solitary Solid Spiculated Nodule. What would you do next? Case Based Discussion: State of the Art Management of Lung Nodules.
Organ Imaging : September 25 2015 OBJECTIVES Case Based Discussion: State of the Art Management of Lung Nodules Dr. Elsie T. Nguyen Dr. Kazuhiro Yasufuku 1. To review guidelines for follow up and management
More informationKey words: Shoulder pain, Ribs, Pancoast syndrome, Neoplasms Radiation.
JOURNAL OF CASE REPORTS 2014;4(1):38-42 Pulmonary Sarcomatoid Carcinoma: A Rare Presentation with Fatal Outcome in a Young Male Ankur Krishna 1, Pooja Kadam 2 Prince of Wales Hospital Network Barker St
More informationLung Cancer. Current Therapy JEREMIAH MARTIN MBBCh FRCSI MSCRD
Lung Cancer Current Therapy JEREMIAH MARTIN MBBCh FRCSI MSCRD Objectives Describe risk factors, early detection & work-up of lung cancer. Define the role of modern treatment options, minimally invasive
More informationARTICLE IN PRESS. doi: /j.ijrobp METAPLASTIC CARCINOMA OF THE BREAST: A RETROSPECTIVE REVIEW
doi:10.1016/j.ijrobp.2005.08.024 Int. J. Radiation Oncology Biol. Phys., Vol. xx, No. x, pp. xxx, 2005 Copyright 2005 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/05/$ see front matter
More informationPulmonary resection for lung cancer with malignant pleural disease first detected at thoracotomy
European Journal of Cardio-Thoracic Surgery 41 (2012) 25 30 doi:10.1016/j.ejcts.2011.04.010 ORIGINAL ARTICLE Pulmonary resection for lung cancer with malignant pleural disease first detected at thoracotomy
More informationSurgical resection is the first treatment of choice for
Predictors of Lymph Node and Intrapulmonary Metastasis in Clinical Stage IA Non Small Cell Lung Carcinoma Kenji Suzuki, MD, Kanji Nagai, MD, Junji Yoshida, MD, Mitsuyo Nishimura, MD, and Yutaka Nishiwaki,
More informationLung Cancer: Diagnosis, Staging and Treatment
PATIENT EDUCATION patienteducation.osumc.edu Lung Cancer: Diagnosis, Staging and Treatment Cancer starts in your cells. Cells are the building blocks of your tissues. Tissues make up the organs of your
More informationT3 NSCLC: Chest Wall, Diaphragm, Mediastinum
for T3 NSCLC: Chest Wall, Diaphragm, Mediastinum AATS Postgraduate Course April 29, 2012 Thomas A. D Amico MD Professor of Surgery, Chief of Thoracic Surgery Duke University Health System Disclosure No
More informationThe tumor, node, metastasis (TNM) staging system of lung
ORIGINAL ARTICLE Peripheral Direct Adjacent Lobe Invasion Non-small Cell Lung Cancer Has a Similar Survival to That of Parietal Pleural Invasion T3 Disease Hao-Xian Yang, MD, PhD,* Xue Hou, MD, Peng Lin,
More informationLarry Tan, MD Thoracic Surgery, HSC. Community Cancer Care Educational Conference October 27, 2017
Larry Tan, MD Thoracic Surgery, HSC Community Cancer Care Educational Conference October 27, 2017 To describe patient referral & triage for the patient with suspected lung cancer To describe the initial
More informationThe Impact of Adjuvant Chemotherapy in Pulmonary Large Cell Neuroendocrine Carcinoma (LCNC)
The Impact of Adjuvant Chemotherapy in Pulmonary Large Cell Neuroendocrine Carcinoma (LCNC) Disclosure None Background Torino, Italy LCNC Rare tumor (2% to 3% all resected primary lung cancers) Preoperative
More informationSurgical treatment of synchronous multiple neuroendocrine lung tumours (case series): is more always better?
Case Report Page 1 of 5 Surgical treatment of synchronous multiple neuroendocrine lung tumours (case series): is more always better? Jury Brandolini, Luca Bertolaccini, Alessandro Pardolesi, Piergiorgio
More informationNumber of Metastatic Lymph Nodes in Resected Non Small Cell Lung Cancer Predicts Patient Survival
Number of Metastatic Lymph Nodes in Resected Non Small Cell Lung Cancer Predicts Patient Survival Jin Gu Lee, MD, Chang Young Lee, MD, In Kyu Park, MD, Dae Joon Kim, MD, Seong Yong Park, MD, Kil Dong Kim,
More informationIn the mid 1970s, visceral pleural invasion (VPI) was included
ORIGINAL ARTICLE Tumor Invasion of Extralobar Soft Tissue Beyond the Hilar Region Does Not Affect the Prognosis of Surgically Resected Lung Cancer Patients Hajime Otsuka, MD,* Genichiro Ishii, MD, PhD,*
More informationManagement of Neck Metastasis from Unknown Primary
Management of Neck Metastasis from Unknown Primary.. Definition Histologic evidence of malignancy in the cervical lymph node (s) with no apparent primary site of original tumour Diagnosis after a thorough
More informationUniportal video-assisted thoracic surgery for complicated pulmonary resections
Review Article on Thoracic Surgery Uniportal video-assisted thoracic surgery for complicated pulmonary resections Ding-Pei Han, Jie Xiang, Run-Sen Jin, Yan-Xia Hu, He-Cheng Li Jiaotong University School
More informationWell-differentiated Papillary Mesothelioma of the Pleura Diagnosed by Video-Assisted Thoracic Surgical Pleural Biopsy : A Case Report
Showa Univ J Med Sci 25 1, 67 72, March 2013 Case Report Well-differentiated Papillary Mesothelioma of the Pleura Diagnosed by Video-Assisted Thoracic Surgical Pleural Biopsy : A Case Report Yuri TOMITA
More informationIn 1989, Deslauriers et al. 1 described intrapulmonary metastasis
ORIGINAL ARTICLE Prognosis of Resected Non-Small Cell Lung Cancer Patients with Intrapulmonary Metastases Kanji Nagai, MD,* Yasunori Sohara, MD, Ryosuke Tsuchiya, MD, Tomoyuki Goya, MD, and Etsuo Miyaoka,
More informationTracheal Adenocarcinoma Treated with Adjuvant Radiation: A Case Report and Literature Review
Published online: May 23, 2013 1662 6575/13/0062 0280$38.00/0 This is an Open Access article licensed under the terms of the Creative Commons Attribution- NonCommercial-NoDerivs 3.0 License (www.karger.com/oa-license),
More informationA nonresponding small cell lung cancer combined with adenocarcinoma
Case Report A nonresponding small cell lung cancer combined with adenocarcinoma Hongyang Lu 1,2, Shifeng Yang 3 1 Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (Lung
More informationTreatment of Clinical Stage I Lung Cancer: Thoracoscopic Lobectomy is the Standard
Treatment of Clinical Stage I Lung Cancer: Thoracoscopic Lobectomy is the Standard AATS General Thoracic Surgery Symposium May 5, 2010 Thomas A. D Amico MD Professor of Surgery, Duke University Medical
More informationNew lung lesion in a 55 year-old male treated with chemoradiation for non-small cell lung carcinoma
July 2016 New lung lesion in a 55 year-old male treated with chemoradiation for non-small cell lung carcinoma Contributed by: Laurel Rose, MD, Resident Physician, Indiana University School of Medicine,
More informationExercise 15: CSv2 Data Item Coding Instructions ANSWERS
Exercise 15: CSv2 Data Item Coding Instructions ANSWERS CS Tumor Size Tumor size is the diameter of the tumor, not the depth or thickness of the tumor. Chest x-ray shows 3.5 cm mass; the pathology report
More informationPulmonary Carcinoma with
J Lung Cancer 2011;10(1):44-48 Pulmonary Carcinoma with β-human Chorionic Gonadotropin Expression: Further Understanding and Suggestions for This Entity from Six Cases Experience in a Single Institution
More informationPrimary Pulmonary Colloid Adenocarcinoma: How Can We Obtain a Precise Diagnosis?
doi: 10.2169/internalmedicine.1153-18 Intern Med 57: 3637-3641, 2018 http://internmed.jp CASE REPORT Primary Pulmonary Colloid Adenocarcinoma: How Can We Obtain a Precise Diagnosis? Shinsuke Ogusu 1, Koichiro
More informationPulmonary Metastasectomy for Pulmonary Metastases of Head and Neck Squamous Cell Carcinomas
ORIGINAL ARTICLES: SURGERY: The Annals of Thoracic Surgery CME Program is located online at http://cme.ctsnetjournals.org. To take the CME activity related to this article, you must have either an STS
More informationPDF hosted at the Radboud Repository of the Radboud University Nijmegen
PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a publisher's version. For additional information about this publication click this link. http://hdl.handle.net/2066/23566
More informationNorth of Scotland Cancer Network Clinical Management Guideline for Non Small Cell Lung Cancer
THIS DOCUMENT IS North of Scotland Cancer Network Clinical Management Guideline for Non Small Cell Lung Cancer [Based on WOSCAN NSCLC CMG with further extensive consultation within NOSCAN] UNCONTROLLED
More informationWhen to Integrate Surgery for Metatstatic Urothelial Cancers
When to Integrate Surgery for Metatstatic Urothelial Cancers Wade J. Sexton, M.D. Senior Member and Professor Department of Genitourinary Oncology Moffitt Cancer Center Case Presentation #1 67 yo male
More informationLung cancer Surgery. 17 TH ESO-ESMO MASTERCLASS IN CLINICAL ONCOLOGY March, 2017 Berlin, Germany
17 TH ESO-ESMO MASTERCLASS IN CLINICAL ONCOLOGY 24-29 March, 2017 Berlin, Germany Lung cancer Surgery Sven Hillinger MD, Thoracic Surgery, University Hospital Zurich Case 1 59 y, female, 40 py, incidental
More informationNon Small Cell Lung Cancer Histopathology ד"ר יהודית זנדבנק
Non Small Cell Lung Cancer Histopathology ד"ר יהודית זנדבנק 26.06.09 Lecture outlines WHO histological classification Macro/Micro assessment Early diagnosis Minimal pathology Main subtypes SCC, AdCa, LCLC
More informationQuality of Life (QOL) versus Curability for Lung Cancer Surgery
Quality of Life (QOL) versus Curability for Lung Cancer Surgery Hirokuni Yoshimura, MD Standard operations for lung cancer patients are generally accepted as performing lobectomy or pneumonectomy on the
More informationKey words: undifferentiated carcinoma of the esophagus, immunohistochemical stain, treatment for undifferentiated carcinoma of the esophaqus
Key words: undifferentiated carcinoma of the esophagus, immunohistochemical stain, treatment for undifferentiated carcinoma of the esophaqus Table 1 Clinical findings of undifferenciated carcinoma of the
More informationAdjuvant Chemotherapy in High Risk Patients after Wertheim Hysterectomy 10-year Survivals
6 Adjuvant Chemotherapy in High Risk Patients after Wertheim Hysterectomy 0-year Survivals V Sivanesaratnam,*FAMM, FRCOG, FACS Abstract Although the primary operative mortality following radical hysterectomy
More informationPreoperative Workup for Pulmonary Resection. Kristen Bridges, M.D. Richmond University Medical Center January 21, 2016
Preoperative Workup for Pulmonary Resection Kristen Bridges, M.D. Richmond University Medical Center January 21, 2016 Patient Presentation 50 yo male with 70 pack year smoking history Large R hilar lung
More information