SMOOTH MUSCLE TUMOURS
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1 SMOOTH MUSCLE TUMOURS
2 NORMAL SMOOTH MUSCLE Cytology Immunohistochemistry Ultrastructure
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5 Masson Trichrome
6 Smooth Muscle Ultrastructure Many myofilaments running parallel to the long axis of the smooth muscle cell Myofilaments are of three types (thick myosin filaments, 12nm; these surrounded by thin actin filaments, 9nm) Actin and myosin filaments are contractile and aggregate into a myofibril. The intermediate filament desmin (10nm) is non contractile and is located in the dense body. There is a delicate basal lamina and many surface pinocytotic vesicles
7 LEIOMYOMAS Superficial: pilar (from arrector pilae muscle) or genital (vulva, nipple, scrotum) Deep
8 Pilar Leiomyoma Adolescents / young adults Solitary or multiple Extensor surfaces of limbs Confined to dermis Small (<20mm) Often painful
9 Pilar Leiomyoma Histology Confined to dermis Bundles / fascicles of smooth muscle Irregular border, non-encapsulated Occasionally mild degenerative atypia Very occasional mitosis (up to 1/10 hpf) Often epidermal hyperplasia
10 Pilar Leiomyoma Histology Confined to dermis Irregular border, not encapsulated Bundles of mature smooth muscle Occasional degenerative atypia Very occasional mitosis (up to 1 per 50 hpf) Often epidermal hyperplasia
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14 Familial Pilar Leiomyomas Germline fumarate hydratase mutation (Krebs cycle enzyme) Autosomal dominant inheritance, variable penetrance Multiple cutaneous and uterine leiomyomas Renal cell carcinoma (non-clear cell)
15 Differential Diagnosis Dermatomyofibroma Superficial dermal plaque Shoulder / trunk Spindle cells parallel to epidermis Adnexal structures preserved Myofibroblastic morphology Lacks desmin
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19 Differential Diagnosis Leiomyosarcoma Bigger (often > 20mm) Often infiltrates subcutis More atypia More mitoses Atypical mitoses Sometimes necrosis
20 Angioleiomyoma / Angiomyoma Middle aged adults, F>M Usually solitary Limbs, especially leg Painful Well demarcated Thick-walled blood vessels
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24 Deep Leiomyomas Deep leiomyomas will make more sense if we consider uterine smooth muscle tumours first
25 Uterine Leiomyomas Spindled Some epithelioid Some have fat (lipo-leiomyma) Often hyalinised Occasional atypia (degenerative) Some mitoses ER and PR Positive
26 Intravenous leiomyomatosis In pre-menopausal women Benign neoplastic smooth muscle invades myometrial veins Some extend into extra-uterine veins (or IVC or heart) Usually good prognosis with hysterectomy Persistent disease in 30% Occasionally fatal
27 Benign Metastasising Exclusively females Leiomyoma Benign smooth muscle tumour in lungs of women with uterine (or previous uterine) leiomyoma. A few are associated with intravenous leiomyoma Generally good prognosis. A few die of respiratory failure.
28 Leiomyomatosis Peritonealis Exclusively women Child-bearing age Disseminata Black females > white females Associated with hormone production (pregnancy, contraceptive hormone therapy) Myriad of sub-serosal smooth muscle nodules Clinically indolent
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31 H-caldesmon
32 Deep Leiomyomas Somatic soft tissue (limbs) (M =F) Virtually no mitotic activity Body cavity LM (pelvis, retroperitoneum, F >>> M) These often hyalinised and ER+ & PR+. Often many typical mitoses. These (particularly in pelvis) of hormonally driven uterine leiomyoma type.
33 Deep Leiomyoma Histology Subcutis / subfascial Bundles / fascicles of smooth muscle at right angles to each other No mitoses or very few (in non-uterine type) Little atypia (and if present degenerative without large nucleoli) No necrosis
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36 Immunosupression related soft tissue tumours?
37 Immunosuppression-related soft tissue tumours Kaposi sarcoma (HHV8) EBV-associated smooth muscle tumour
38 EBV-associated smooth muscle tumour HIV / AIDS Post-transplant immunosuppression Congenital immunosuppression Well-differentiated smooth muscle tumour 50% have foci of round myoid cells Little atypia, few mitoses SMA+ desmin +/-
39 EBV-associated SMT Multifocal Soft tissue Liver, lung, spleen, thyroid Dura Clinically indolent
40 Deep Soft Tissue Leiomyosarcoma Middle-aged adults. Rare in childhood Half arise in retroperitoneum (2/3 of these in women) Vena cava, a common site (3/4 of these in women) Limbs / trunk, M=F
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47 INTERMISSION
48 Haemangiopericytoma
49 Solitary Fibrous Tumour Not a smooth muscle or perivascular myocyte tumour. But the cellular subset of SFTs used to be considered a haemangiopericytoma. Actually myofibroblastic (CD34 pos, smooth muscle markers neg)
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55 Perivascular Smooth Muscle (Myopericyte) Tumours Sino-nasal haemangiopericytoma Myopericytoma Angiomyoma (Angioleiomyoma) Myofibroma Glomus tumour
56 Sinonasal Haemangiopericytoma
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60 Myopericyte tumours (myopericytoma, angiomyoma, myofibroma, glomus tumour) Superficial tumours May show some degenerative atypia Smooth muscle marker positive (SMA and H-caldesmon) Tend to be desmin negative
61 Myopericytoma Perivascular concentric growth Haemangiopericytic vasculature SMA pos, H-caldesmon pos Desmin neg Clinically indolent
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64 H-caldesmon
65 DESMIN
66 Myofibroma
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71 Glomus Tumours
72 Gnorma normal glomus body
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75 Glomangiomyoma
76 Classic Angiomyolipoma AML benign mesenchymal tumour comprising variable mixtures of fat spindled/epithelioid smooth muscle cells and thick-walled blood vessels Kidney is classic location Some related to tuberous sclerosis (M=F), in sporadic cases F>M (4:1) The muscle is of perivascular epithelioid type i.e. HMB45+ and melan A+
77 Classic AMLs (interesting facts) Clinically benign (but may result in catastrophic retroperitoneal haemorrhage) May be multifocal (especially in tuberous sclerosis) Occasional degenerative nuclear atypia Can invade renal vein / IVC Can be present in LNs (multifocal growth)
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81 Melan-A
82 Epithelioid AML >50% are associated with tuberous sclerosis Clinically more aggressive than classic AML Larger, sometimes necrotic, infiltrative margins, renal vein / IVC extension Approximately 1/3 metastasise (LN, liver, lungs, spine) Differential diagnosis (RCC, metastatic MM)
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85 Perivascular epithelioid cell proliferations (HMB45 pos, melan A pos) PECOMA Angiomyoplipoma Lymphangioleiomyomatosis
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