ACR TXIT TM EXAM OUTLINE
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1 ACR TXIT TM EXAM OUTLINE Major Domain Sub-Domain 1 Statistics 1.1 Study design 1.2 Definitions of statistical terms 1.3 General interpretation & analysis 1.4 Survival curves 1.5 Specificity/sensitivity 1.6 Tests of significance 1.7 Phase III studies (randomized) 1.8 Retrospective trials/historical controls 1.9 Phase I & II studies (nonrandomized case control studies) 1.10 Multiple trials/meta-analysis 2 Bone & Soft Tissue 2.1 Soft tissue sarcoma & brachytherapy 2.2 Bone sarcomas & bone tumors 2.3 Ewing s sarcoma 2.4 Desmoid tumor 2.5 Osteosarcoma and/or chondrosarcoma 2.6 Bone metastasis from other primary/include Bone SBRT 2.7 Heterotopic ossification 2.8 Kaposi s sarcoma 3 Breast 3.1 Early-stage breast cancer 3.2 Ductal carcinoma in situ (DCIS) & lobular carcinoma in situ (LCIS) 3.3 Metastatic breast cancer 3.4 Locally advanced breast cancer---possibly include inductive and pathologic CR 3.5 Inflammatory breast cancer 3.6 Recurrent breast cancer 3.7 Hypofractionated /APBI 3.8 breast brachytherapy/apbi 3.9 Mammography screening 3.10 Risk factors + genetics 3.11 Breast cancer staging 3.12 Post-mastectomy radiation therapy 3.13 Breast cancer biomarkers 3.14 Nodes---micrometastases 3.15 Toxicity (heart, lymphedema, cosmesis) 3.16 Anatomy (nodes or drainage) Page 1 of 5
2 4 CNS/Eye 4.1 Brain metastasis/leptomenigeal (CSR) 4.2 SRS Brain 4.3 Meningioma 4.4 Pituitary 4.5 Low-grade supratentorial astrocytoma 4.6 Glioblastoma/high grade astrocytomas Include MGMT methylation/systemic therapy 4.7 Intracranial Ependymoma 4.8 Primary Spinal Cord Tumor 4.9 CNS lymphoma 4.10 Anatomy 4.11 Medulloblastoma and Supratentorial PNET 4.12 Eye diseases [lymphoma, melanoma, benign conditions (e.g. pterygium, Graves disease)] Include question on eye plaques for melanoma 4.13 Oligodendroglioma (Anaplastic) 4.14 Quantec OARs/toxicity/technique 5 Gastrointestinal (GI) Tract 5.1 Esophagus 5.2 Stomach 5.3 Anus 5.4 Pancreas 5.5 Biliary tract 5.6 Liver include SBRT 5.7 Rectum 5.8 Quantec/toxicity OAR 6 Genitourinary (GU) Tract 6.1 Prostate include brachytherapy 6.2 Kidney and renal pelvis/ureter/urethra 6.3 Testes (Seminoma & non-seminoma) 6.4 Bladder 6.5 Penis 6.6 Toxicity/OAR/anatomy 6.7 Metastasis include radioisotopes 6.8 Kidney transplant rejection Page 2 of 5
3 7 Gynecology 7.1 Endometrium & uterus 7.2 Vulva 7.3 Fallopian tube/ovary 7.4 Quantec/OAR/toxicity 7.5 Uterine cervix 7.6 Vagina 7.7 Female urethra 7.8 Brachytherapy 8 Head, Neck & Skin 8.1 Nasopharynx 8.2 Oral cavity (RMT and OT) 8.3 Oropharynx 8.4 Thyroid gland 8.5 Larynx (supraglottic, larynx, subglottic) 8.6 Hypopharynx 8.7 Unknown primary 8.8 Salivary gland 8.9 Paranasal sinuses 8.10 Skin cancers 8.11 Anatomy and syndromes 8.12 Staging 8.13 Chemotherapy & chemoradiation 8.14 Risk factors/tobacco/alcohol/hpv, etc 8.15 Quantec OAR data 9 Lung/Mediastinum 9.1 SCLC 9.2 Prophylactic Cranial Irradiation 9.3 Early Stage NSCLC 9.4 Advanced NSCLC 9.5 Palliation 9.6 Chemotherapy 9.7 OAR 9.8 Thymoma 9.9 Mesothelioma Page 3 of 5
4 10 Leukemia & Lymphoma 10.1 Diffuse Large B cell 10.2 Follicular 10.3 MALT 10.4 Other NHL 10.5 Multiple myeloma and/or plasmacytomas 10.6 Hodgkin disease 10.7 Leukemia 10.8 Total body and/or skin irradiation/transplant 10.9 Radioimmunotherapy Toxicity 11 Pediatrics 11.1 Retinoblastoma 11.2 Lymphomas (including Hodgkin disease) 11.3 Neuroblastoma 11.4 Wilms 11.5 Rhabdomyosarcomas 11.6 Ewings 11.7 Leukemias 11.8 CNS tumors 11.9 Long term side effects 12 Biology 12.1 Interaction of Radiation with Biological Systems 12.2 Molecular Mechanisms of DNA Damage 12.3 Molecular Mechanisms of DNA Repair 12.4 Chromosome and Chromatid Damage 12.5 Mechanisms of Cell Death 12.6 Cell and Tissue Survival Assays 12.7 Models of Cell Survival 12.8 Modifiers of Cell Survival: RBE and LET 12.9 Modifiers of Cell Survival: Oxygen Effect Modifiers of Cell Survival: Cellular Recovery Tumor Biology Normal and Tumor Cell Kinetics Molecular Signaling Cancer Biology Total Body Irradiation Clinically Relevant Normal Tissue Responses to Radiation Mechanisms of Normal Tissue Radiation Responses Therapeutic Ratio Page 4 of 5
5 12.19 Time, Dose and Fractionation Effects Nonstandard Dose Delivery Systems Chemotherapy Agents and Radiation Therapy Radiosensitizers, Radioprotectors, and Bioreductive Drugs Hyperthermia Radiation Carcinogenesis Heritable Effects of Radiation Teratogenesis: Effects on the Embryo and Fetus Radiation Protection 13 Physics 13.1 Atomic and nuclear structure 13.2 Production of photons and electrons 13.3 Treatment machines & generators; simulators & simulation tools 13.4 Radiation interactions 13.5 Radiation beam quality & dose 13.6 Radiation measurement & calibrations 13.7 Photons and x-ray characteristics of dosimetry 13.8 Electron beam characteristics & planning 13.9 External beam QA Informatics Brachytherapy, radiation protection & shielding Imaging for Radiation Oncology D CRT Including ICRU concepts & beam related biology Assessment of patient setup & verification IMRT Special procedures Particle therapy (proton therapy) Page 5 of 5
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