2015 Lab Animal 8/22/ Mouse. 2. Rat. 3. Mouse. Tissue from an Mouse: Morphologic Diagnosis: Rectal prolapse
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1 1. Mouse 2015 Lab Animal 2. Rat Tissue from an Mouse: Morphologic Diagnosis: Rectal prolapse Causes: 1. Syphacia obveluta 2. Citrobacter rodentum 3. Heicobacter sp 3. Mouse 2. Tissue from a Rat: Morphologic Diagnosis: Pituitary gland: Pituitary adenoma (carcinoma) 1
2 3. Tissue from a Mouse: Morphologic Diagnosis: Haired skin: Diffuse Hyperkeratosis 4. Rabbit Cause: Corynebacterium bovis Common Strain: Nude mouse 4. Tissue from a Rabbit: Morphologic Diagnosis: Multifocal to coalescing necrohemorrhagic typhlitis 5. Rat Name the Disease: Enteritis complex in rabbits Most likely Cause: Clostridium spiroforme_ 5. Tissue from a Rat: 6. Guinea Pig Morphologic Diagnosis: Mesenteric arteries: necrotizing and proliferative arteritis Name the disease: Polyarteritis nodosa Similar cause in another lab animal species: Beagle pain syndrome 2
3 6. Tissue from a Guinea Pig: 7. Squirrel monkey Morphologic Diagnosis: Bone: Osteochondrodysplasia with retention of cartilage cores, hemorrhage and microfractures Pathogenesis: Ascorbic acid def> lack of hydroxylation of proline and lysine> improper helical structure> inadequate support of vessel walls> loose attachment of periosteum to bone 8. Hamster 7. Tissue from a Squirrel Monkey: Morphologic diagnosis: Necrohemorrhagic cystitis 9. Rabbit 8. Tissue from a Hamster: Name the condition: Kidney: Renal amyloidosis Chronic nephropathy 3
4 10. Cynomolgus Monkey 9. Tissue from a Rabbit: Name the disease: Mucoid enteropathy 11. Rat 10. Tissue from a Cynomolgus Monkey: Morphologic Diagnosis: Liver: Diffuse hepatic lipidosis 11.Tissue from a Rat: 12. Rat Morphologic Diagnosis: Testicles: Interstitial tumor 4
5 12. Tissue from a Rat: 13. Mouse Morphologic Diagnosis: Liver: Multifocal cystercercoid cyts Cause: Cystircerus fasciolaris, Tenia teniaformis 13. Tissue from a Mouse: 14. Rabbit Name the disease: Ectromelia Two associated lesions: Necrotizing hepatitis, Necrotizing splenitis Cause: Mouse orthopoxvirus 14. Tissue from a Rabbit: 15. Rat Morphologic Diagnosis: Kidney: Lymphoma 5
6 16. Mouse 15. Tissue from a Rat: Morphologic Diagnosis: Mesothelioma 16. Tissue from a Mouse: 17. Ferret Morphologic Diagnosis: Liver: Multifocal necrotizing hepatitis Cause: Mouse coronavirus-2 Histologic lesion: Multifocal areas of necrosis with syncytica cells 17. Tissue from a Ferret: 18. Rat Morphologic Diagnosis: Colon: Diffuse proliferative colitis Cause: Lawsonia intracellularis 6
7 19. Macaque 18. Tissue from a Rat: Name the condition: Ringtail Cause: High temperature and low humidity 19. Tissue from a Macaque: Morphologic Diagnosis: Lung: Multifocal granulomatous pnuemonia 20. Ferret Cause: Pneumonyssus semicola Histologic lesions: Granulomatous inflammation, cavernous mite houses, anisotropic mite pigment, intralesional arthropods 21. Hamster 20. Tissue from an Ferret: Morphologic Diagnosis: Salivary gland: Unilateral sialocele 7
8 21. Tissue from a Hamster: 22. Rabbit Morphologic Diagnosis: Haired skin: Transmissible Trichepithelioma Cause: Hamster polyoma virus 22. Tissue from a Rabbit: 23. NHP Name the disease: Shope fibroma Histologic lesions: Atypical fibroblast proliferation, epithelial hyperplasia, rete ridges, eosinophilic intracytoplasmic inclusions within the mesenchymal and epithelial cells 24. Ferret 23. Tissue from a NHP: Morphologic Diagnosis: Diffuse suppurative prostatitis and urethrtits 8
9 24. Tissue from a Ferret: 25. Rat Morphologic Diagnosis (2): Diffuse alopecia and vulvar enlargement Cause: Adrenal tumor 25. Tissue from an Rat: 26. NHP Morphologic Diagnosis: Diffuse urolithiasis 26. Tissue from a NHP: 27. Rat Morphologic Diagnosis: Retroperitoneal fibromatosis 9
10 27. Tissue from a Rat: 28. Hamster Cause: Rat parvovirus (RV virus) Cause in the Mouse: Minute virus of mice 29. Rabbit 28. Tissue from an Hamster: Morphologic Diagnosis: Pheochromocytoma 29. Tissue from a Rabbit: 30. Ferret Cause: Cheyletiella parasitovorax 10
11 30. Tissue from an Ferret : 31. NHP Morphologic Diagnosis: Chordoma C33_ Tissue from a NHP: 32. Rhesus macaque Morphologic diagnosis: Ovarian teratoma C33_ Tissue from a Rhesus macaque: 33. NHP Morphologic Diagnosis: Endometriosis C33_53 11
12 33. Tissue from a NHP: 34. Rabbit Cause: Armillifer armillatus 35. Rat 34.Tissue from a Rabbit: Morphologic Diagnosis: Multiple oral papillomas Cause: Rabbit oralpapilloma virus (Shope papilloma) 35. Tissue from a Rat: 36. Guinea pig Morphologic Diagnosis: Chylothorax 12
13 36. Tissue from a Guinea pig: 37. Rabbit Morphologic Diagnosis: Tympanic bullae: Bilateral suppurative otitis Causes: Streptococcus pneumoniae, S. zzoepidemicus, Bordetella bronchiseptica 38. NHP 37. Tissue from a Rabbit: Morphologic Diagnosis: Nasal cavity: Diffuse chronic rhinitis with turbinate atrophy Cause: Pasteurella multocida C33_ Tissue from a NHP: 39. Rat Morphologic Diagnosis: Heart: Diffuse fat atrophy 13
14 39. Tissue from a Rat: 40. NHP Morphologic Diagnosis: Multifocal suppurative bronchopneumonia Cause: Mycoplasma pulmonis 41. NHP 40. Tissue from a NHP: Morphologic Diagnosis: Cerebrum and meninges: Diffuse suppurative meningoencephalitis Cause: Streptococcus pneumonia 41. Tissue from an NHP: 42. Rat Morphologic Diagnosis: Colon: Multifocal necroulcerative or necrohemorrhagic colitis Cause(s): Yersinia enterocolitica or Shigella flexnuri 14
15 42. Tissue from a Rat: 43. NHP Morphologic Diagnosis: Lung: Multifocal embolic (suppurative) pneumonia Cause: Corynebacterium kutcheri 44. NHP 43. Tissue from a NHP: Cause: Nochtia nochtii (Gastric hyperplasia) 45. Rabbit 44. Tissue from an NHP: Morphologic Diagnosis: Gastric dilation 15
16 45. Tissue from a Rabbit: 46. NHP Morphologic Diagnosis: Focally extensive proliferative dermatitis and chelitis Cause: Treponema paraluiscaniculi 46. Tissue from a NHP: 47. Rabbit Morphologic Diagnosis: Pericalvarial hemorrhages Cause: Vit C def 48. Squirrel monkey 47. Tissue from a Rabbit: Morphologic Diagnosis: Uterus: Multiple hemocysts (aneurysm) 16
17 48. Tissue from a Squirrel Monkey: 49. Rat Morphologic Diagnosis: Intercostal bone/muscle: Pericostal hemorrhage Cause: Vit C def 50. Rat 49. Tissue from a Rat: Morphologic Diagnosis: Mammary gland : Fibroadenoma 50. Tissue from a rat: Morphologic Diagnosis: Clitoral gland adenoma 17
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