Specialist gynaecologists and survival outcome in ovarian cancer: a Scottish national study of 1866 patients
|
|
- Juliet Arnold
- 5 years ago
- Views:
Transcription
1 British Journal of Obstetrics and Gynaecology November 1999, Vol106, pp Specialist gynaecologists and survival outcome in ovarian cancer: a Scottish national study of 1866 patients *E. J. Junor Consultant Oncologist, **D. J. Hole Epidemiologist, tl. McNulty Data Manager, TM. Mason Data Manager, tj. Young Computing Ofleer *Beatson Oncology Centre, Glasgow; **West of Scotland Cancer Surveillance Unit, Glasgow; +Scottish Cancer Therapy Network, Edinburgh Objective To determine whether specialist gynaecological surgeons improved survival in women with ovarian cancer when compared with s. Design Retrospective case note review. Population All women diagnosed with ovarian cancer in Scotland in 1987, 1992, 1993 and Methods Data on prognostic factors and surgical and post-operative management was extracted from case notes. Surgeons were classified as specialist gynaecologists, s or general surgeons by an independent committee with no knowledge of an individual's outcome. Cox's proportional hazards model was used to determine the relative risk of a patient dying, if managed by specialist and s, after adjustment for age, histology, tumour differentiation, presence of ascites and socio-economic status. Analysis was performed separately for each FIG0 stage. Main outcome measures Relative hazard ratios for survival up to three years. Results Survival benefit for specialists varied according to the stage of the disease. The greatest benefit was observed among women with Stage I11 disease (44% of women presented at this stage) where there was a 25% (relative hazard ratio = 0.75, P = 0.005) reduction in the rate of dying for women operated on by specialist gynaecologists, compared with women operated on by s. Differential use of platinum chemotherapy did not explain this survival advantage. Specialist gynaecologists more often debulked tumour to c 2 cm than s in Stage I11 cases (36.3% vs 28.7%, P = 0.07). In women with Stage I11 carcinoma with > 2 cm remaining, survival was significantly improved for women treated by specialist gynaecologists (relative hazard ratio = 0.7 1, P = 0.007). No significant differences were observed for patients with Stages I, I1 and IV disease, although there were fewer deaths in women with early stage disease. Conclusions Specialist gynaecologists improve survival for some women with ovarian cancer. INTRODUCTION Calman and Hine have proposed a network of cancer centres and cancer units for improving the outcome of cancer in the UK. Evidence exists for improved survival among patients undergoing surgery by specialist surgeons for breast' and bowel cancer2,', and as surgery is the major intervention in the management of ovarian cancer, with improved outcome for women in whom little or no macroscopic disease remains after operation4, it is important to ascertain what benefits might accrue from a similar approach in this disease. Several studies have shown that survival of women with ovarian cancer improves if they are operated on by gynae- Correspondence: Dr E. J. Junor, Beatson Oncology Centre, Western Infirmary, Dumbarton Road, Glasgow, UK. cologists compared with general but there is no clear evidence whether gynaecological oncologists (specialists) further improve outcome over general gynaecologists. The Royal College of Obstetricians and Gynaecologists has already indicated their preference for women with ovarian cancer to be managed by specialist g ynaecologists'. A previous study', which examined factors affecting outcome for all women diagnosed with ovarian cancer in Scotland in 1987, a nonstatistically significant but improved survival outcome for women operated on by specialists in the surgery of gynaecological cancer was observed, but not reported in the text. Thus the current study was specifically designed to test the hypothesis that improved survival would result if women with ovarian cancer were operated on by gynaecological RCOG 1999 British Journal of Obstetrics and Gynaecology
2 SURVIVAL OUTCOME IN OVARIAN CANCER 1131 oncologists with sample size sufficient to ensure a precise estimate of benefit. METHODS All women diagnosed with primary ovarian cancer in Scotland in the years 1987, 1992, 1993 and 1994 were eligible for the study. A list of 2101 registrations was obtained from the Scottish National Cancer Registry, and each case note was sought to validate the registry diagnosis, to ensure the woman was normally resident in Scotland, and was diagnosed in one of the specified years. One hundred and sixteen women (5.5%) were excluded because of an incorrect pathology or year of diagnosis. The medical records of a further 119 women (5.7%) could not be found. Detailed information for the remaining 1866 women was abstracted by two experienced data managers specially trained by and with support from one investigator (E.J.) to resolve disagreements and to check on the quality of the information. These data included presenting features; investigations; histological type of the carcinoma of the ovary; its stage; operative procedures; volume of residual disease and subsequent referral and treatment. Staging was performed using the standard FIGO classification on the basis of the operation notes, pathology report and the results of all available investigations. Sub-staging was only possible for Stage I and then incompletely. All histological reports were coded according to the International Classification of Disease for Oncology. All of the surgeons who operated were classified into one of three groups: gynaecological oncologist (specialist), (nonspecialist) or general surgeon. These classifications were made by the committee of gynaecologists who oversaw the 1987 study5. It was a subjective assessment determined by two criteria: 1. the group had no knowledge of the outcome for each of these groups in the 1987 or any other study; and 2. the classification was fixed for the period of the study. The records of the Registrar General (Scotland) were examined for the cause and date of death. All deaths until 31 December 1996 were included, providing a minimum follow up time of two years and a maximum follow up of 10 years. Statistical details The size of the current study was calculated from the results of the original 1987 Scottish study5. The intention was to be able to detect a relative hazard ratio of 0.82 with 90% power at the 5% significance level. The assumption was made that s would treat three times the number of women as special- ists. This required the accrual of 725 deaths. With approximately 185 deaths expected in three years of follow up in women treated by gynaecologists in each study year, data throughout Scotland for four years was required. Cases diagnosed in the years 1992, 1993 and 1994 were added to the 1987 data to complete the four years. These years were chosen to provide a balance between current practice and sufficient follow up to produce a reliable three-year estimate of survival in ovarian cancer. All analyses are based on survival to three years, as the majority of relapses and deaths occur within this period, and three of the four diagnostic years in the study have been followed for this length of time. Kaplan-Meier survival curves have been used to provide a graphical presentation of the survival pattern of patients treated by gynaecological oncologists, general gynaecologists and general surgeons. This technique does not allow for any statistical adjustment for prognostic factors. Survival comparison taking into account prognostic and other explanatory variables has been undertaken using Cox s proportional hazards model. Five prognostic factors have been used, in addition to FIGO staging, to allow for confounding variables seen by each category of surgeon. These were degree of differentiation (well, moderate, poor and not recorded), age (< 55,55-64,65-74,75+), presence of ascites (yes, no), histology (reduced from 11 to 3 categories on the basis of prognosis) and Carstairs deprivation category (affluent, intermediate and deprived). In order to explore differences between category of surgeon, two explanatory variables have been used in the analysis: volume of residual disease after operation and type of chemotherapy given. Volume of residual disease was recorded as: bulky; > 2 cm; c 2 cm or minimal; or no disease on the basis of entries in the casenotes. After preliminary analysis, this variable was simplified to two categories (< 2 cm or > 2 cm) because of the lack of any additional discrimination in survival analysis with four levels. Chemotherapy was classified into four groups: platinum alone; platinum in combination with a second drug; alkylating agent alone; or no chemotherapy. At this time taxanes were not used as first line chemotherapy. Models have first been fitted using category of surgeon with the standard prognostic variables. Where differences exist, the additional variables of type of chemotherapy and extent of residual disease have been added to the model to see whether this removes (i.e. explains) the effect of category of surgeon. Because Cox s analysis produced a significant interaction (P = 0.04) between stage and category of surgeon (implying that differences between categories of surgeon varied according to the stage of the disease), results have been reported separately for each stage. 0 RCOG 1999 Br J Obstet Gynaecol 106,
3 ~~ ~ ~ 1132 E. J. JUNOR ET AL RESULTS Table 1 presents the characteristics and the distribution of prognostic factors of women operated on by different categories of surgeon. Specialist gynaecologists tended to see more late stage cases (FIGO Stages 111, IV) than s, with general surgeons seeing the highest proportion. This pattern was also apparent for age of the women, differentiation of the cancer and presence of ascites. In general, s cared for women with a better prognosis, specialist gynaecologists an intermediate group, and general surgeons women with the poorest prognosis. The importance of Stage III cases on overall outcome in ovarian cancer can be appreciated from the fact that 44% (830/1866) of women present at this stage. Figure 1 shows the unadjusted Kaplan-Meier survival curves for women operated on by specialist gynaecologists, s and general surgeons for each FIGO stage. The hazard ratios for each of these comparisons are shown in Table 2, with adjustment made for five prognostic factors (e.g. age, differentiation, histology, presence of ascites and deprivation category). A highly significant difference is apparent for women with Stage III disease, based on 621 deaths, with a reduction in the death rate of 25% (P = 0.005) for women operated on by a specialist gynaecologist and an increase of 32% (P = 0.009) in the rate of dying in women operated on by a general surgeon, taking the pattern of survival of those treated by s as the baseline. The median survival among women with Stage I11 carcinoma was 18 months for those treated by specialist gynaecologists and 13 months for those treated by s. An interesting feature of the survival curves for these women is that the difference seems to be greatest at about 18 months following surgery and thereafter appears to diminish. In contrast, the survival curve in women treated by general surgeons shows increasing divergence for the whole three years of follow up. Inferences relating to Stage I, Stage II and Stage IV cases cannot be drawn as the number of deaths within each of these stages is small. No Table 1. Characteristics of women operated on by specialist, nonspecialist gynaecologists and general surgeons. No. of 3 year Specialist Nonspecialist General patients survival gynaecologist (%) gynaecologist (%) surgeon (%) (n = 1866*) rate (%) (n = 351) (n = 1032) (n = 216) Stage I I I IV Unstaged** Age < Differentiation Well Moderate Poor Not known Histology Good prognosis Intermediate Poor Ascites Absent Present Deprivation Affluent Intermediate Deprived A11 patients All surgical patients *Includes 267 patients in whom no operation was performed. **Insufficient information. 0 RCOG 1999 BrJ Obstet Gynaecol 106,
4 ~ -u Staae I surgeon 0' I I I -" SURVIVAL OUTCOME IN OVARIAN CANCER 1133 Staae II 100 \-I--- -_ 9 t :""i... : -- I- specialist ' al.- >... ~ c I \ 40 surgeon E t 0' I I I 100 Stage r Stage IV 9 2 a 60 0).- > c specialist t surgeon I I 0 I 9.E a > 5 m surgeon... I Fig. 1. Kaplan-Meier survival curves by stage and specialty of person performing initial surgery. significant differences are seen for women in relation to surgical category, and the confidence intervals are wide (e.g. relative hazard ratio for Stage I1 cases treated by a general surgeon is 0.67, but this is based on only six deaths and the confidence interval is 0.25 to 1.75). Is the observed difference between specialist and genera1 gynaecologists for Stage I11 cases due to the extent of surgery or the type of chemotherapy? This is Table 2. Analysis of pattern of survival for women treated by specialist and nonspecialist gynaecologists and general surgeons. Values are given as hazard ratio (95% CI), unless otherwise indicated. Specialist Nonspecialist General gynaecologist gynaecologist (baseline) surgeon Stage 1(79 deaths) (n) Unadjusted Adjusted for 5 factors* 0.83 ( ) 1 1.O 1 ( ) Stage I1 (80 deaths) (n) Unadjusted Adjusted for 5 factors 1.00 ( ) ( ) Stage I and I1 (159 deaths) (n) Adjusted for 5 factors 0.93 ( ) ( ) Stage I11 (621 deaths) (n) Unadjusted Adjusted for 5 factors 0.75 ( ) ( ) Pi Stage IV (194 deaths) (n) Unadjusted Adjusted for 5 factors 1.01 ( ) ( ) *5 prognostic factors were age, degree of differentiation, histological type, presence of ascites and deprivation category. 'Only Stage III women showed differences which were statistically significant. 0 RCOG 1999 Br JObstet Gynaecol 106,
5 ~ ~ 1134 E. J. JUNOR ET AL. Table 3. Hazard ratios (95% CI) for Stage III cases including chemotherapy as an explanatory factor for inter-surgical category differences. Specialist Nonspecialist General gynaecologist gynaecologist (baseline) surgeon (n = 192) (n = 454) (n = 151) Adjusting for 5 prognostic factors 0.75 ( ) P Additional adjustment for chemotherapy* 0.77 ( ) P 0.01 Additional adjustment for chemotherapy and extent of residual disease 0.78 ( ) P ( ) ( ) ( ) 0.54 *Adjustment for chemotherapy involves including an additional factor in the Cox s proportional hazards model which has 4 categories: platinum in combination; platinum alone; alkylating agents; no chemotherapy. Table 4. Chemotherapy received by Stage III women in relation to surgeon. Values are given as % (n). Surgeon Specialist gynaecologist (n = 192) General gynaecologist (n = 454) General surgeon (n = 15 1) Platinum + Platinum Alkylating No alkylating agent alone agent chemotherapy 27.6 (53) 43.2 (83) 14.6 (28) 14.6 (28) 23.3 (106) 35.2 (160) 18.3 (83) 23.1 (105) 13.9 (21) 34.4 (52) 17.9 (27) 33.8 (51) Comparison between specialist and : x2 = 9.1, P = addressed in Table 3. Substantial survival benefits are associated with the use of platinum chemotherapy and more so when it is used in combination with alkylating agents, but differential use of these agents in women treated by specialist and s and general surgeons (Table 4) makes only a small impact on the survival differences seen. Thus the difference would seem to be due to the surgical intervention. The ability of the surgeons to debulk Stage I11 tumours to < 2 cm in diameter is shown in Table 5. The specialist gynaecologists were the most successful, with 36.3% successfully debulked, although the difference between them and s (28.7%) was not large. In contrast, only 11.6% of Stage I11 cases operated on by general surgeons were debulked to < 2 cm diameter. The impact of successful debulking on survival differences for Stage I11 cases is shown in Table 3 (final line). The poorer survival seen in the women treated by general surgeons disappears substantially when extent of residual disease is included in the survival model, indicating that this is the explanation for their poorer survival. However, the hazard ratio for specialist compared with general gynaecologist (relative hazard ratio = 0-78, P = 0.02) is unchanged from that observed after fitting type of surgeon and chemotherapy (relative hazard ratio = 0.77, P = 0.02). Comparison of survival curves for Stage I11 cases who did and did not have tumour debulked to < 2 cm is presented in Fig. 2. A significant interaction term exists again (P = 0.02) for surgical category and extent of residual disease. No difference is apparent between specialist and s for those with tumour < 2 cm diameter remaining (relative hazard ratio = 1.09) but a clear difference is apparent for those with larger deposits of tumour remaining (relative hazard ratio = 0.71, P = 0.007). This would seem to indicate that it is the more difficult Stage 111 cases who benefit most in survival from being operated on by a specialist gynaecologist. This is a very large subgroup of all the women with ovarian cancer, with 480 deaths of the 975 deaths in our study. Table 5. Extent of residual disease after operation in Stage I11 women in relation to surgeon. Values are given as % (n). Residual tumour Surgeon c2cm >2cm Specialist gynaecologist (n = 190)* 36.3 (69) 63.7 (121) General gynaecologist (n = 432) 28.7 (124) 71.3 (308) General surgeon (n = 146) 11.6 (17) 88.4 (129) Comparison between specialist and : x2 = 3.2, P = *Information on volume of tumour remaining is unknown for 2,22 and 5 women operated on by specialist, and general surgeons, respectively. 0 RCOG 1999 Br J Obstet Gymecol 106,
6 SURVIVAL OUTCOME IN OVARIAN CANCER 1135 loo r\ : * 4 40 E, Stage residual disease < 2 cm specialist.i-.-..., surgeon... ~... c......_ I I 0 I 9 Z Stage residual disease > 2 cm 0 Fig. 2. Kaplan-Meier survival curves of Stage III patients by volume of residual disease and specialty of person performing the initial surgery. DISCUSSION This population-based study of all 1866 cases of ovarian cancer diagnosed in Scotland over four years demonstrates the benefit in survival of being treated by specialist gynaecologists. This benefit relates strongly to women with Stage III disease, is less evident for those with Stage I or 11 disease and was not found for those with Stage IV disease. This benefit to Stage III women was most pronounced between one and two years of follow up, with a maximum survival benefit of 12% at about 18 months. After two years there is a tendency for the two survival curves to come together. While benefit is significant in Stage 111 cases only, 44% of women present at this stage and 66% of ovarian cancer deaths occur in women with Stage III carcinoma of the ovary. It is also the group in which one might logically expect to see benefit with specialist care. In women with Stage I or 11 ovarian cancer it would be anticipated that resection of all or most of the tumour would be achieved by a total hysterectomy and bilateral salpingo-oophorectomy, unlike Stage III disease where tumour nodules are implanted outwith the pelvis. The survival benefit for Stage 111 cases is clearly associated with being managed by a specialist, although this can come about in two ways: it could be due to the extent of the surgery, or more effective chemotherapy, especially with platinum. More women treated by specialist gynaecologists received platinum compared with those managed by s (71% vs 59%). The impact on survival was assessed by adding a term in the Cox s model to represent the effect on survival of additional chemotherapy after fitting a model containing the category of surgeon. The hazard ratio changed very little from 0.75 to 0.77 (Table 3). Thus the part played by the specialist gynaecologist appears to account for the difference in survival and not any vanation in the prescription of platinum between the two groups. Our only direct measure of the extent of surgical intervention is the volume of residual tumour, although we can also use survival as an indicator of successful surgery. The specialist gynaecologists appear to be more successful in debulking tumour to c 2 cm diameter than the s (36% vs 29% P = 0.07). Having debulked to this level, survival was similar. Women with Stage 111 cancer with tumour > 2 cm diameter remaining after surgery showed the greatest survival benefit from specialist surgical care. It may be that specialists were more successful at debulking than general gynaecologists, but because of the imprecise way of measuring residual tumour (< 2 cm or > 2 cm) this could not be quantified. As residual tumour > 2 cm constituted 73% of the Stage III cases, any improvement in treatment in this group makes a substantial contribution to overall improvement in survival in ovarian cancer and would justify the need for specialist gynaecologists. The independent benefit of receiving platinum chemotherapy is again evident in this study, as in our earlier report. Women receiving platinum in combination with alkylating agents had a reduced risk of dying compared with those receiving platinum alone (relative hazard ratio = 0.75, 95% CI ) and the hazard ratio for alkylating agents relative to platinum alone was 1.62 (95% CI 1.3&2.01). This was based on an analysis of women who were aged younger than 75 years, with a survival time greater than 60 days and excluded Stage 1A cases. Women with Stage 1A carcinoma of the ovary may not need chemotherapy, and elderly women or women who are too ill may be considered unsuitable for chemotherapy. The role of multidisciplinary, combined clinics, evaluated in our 1987 study, was difficult to assess in relation to specialist surgeons because of the small number of cases operated on by specialists but not then treated in a combined clinic. However, if we restrict our analysis to the women who were operated on by general gynaecologists, it would appear that the benefits of the 0 RCOG 1999 Br J Obstet Gynaecof 106,
7 1136 E. J. JUNOR ET AL. combined clinic were less apparent in this study. We interpret this as increased awareness among general gynaecologists of the optimal treatment for ovarian cancer. Two cautionary points should be made. The first is that the follow up period for this analysis is only three years and much of the additional survival benefit due to specialist care is seen in women with tumour still remaining. Thus the benefit is unlikely to result in additional cures but is important as an opportunity for providing improved quality as well as length of life. The second is that the results are based on observational data. We have done our best to minimise selective bias concerning the classification of the surgeons. Surgeons were classified before the study started and the classification remained constant throughout the years of the study. The authors had no influence on the allocation of women to the surgeons. As in all observational studies, we can never be absolutely sure that bias has been completely avoided. However, no randomised trial has been performed to evaluate the benefit of being treated by a specialist gynaecologist, nor is it likely that such a trial will be performed. Few other studies have reported on specialisation in ovarian cancer. The largest, though not populationbased, has been the National Study of Ovarian Cancer which examined the care of 12,316 women from 904 hospitals between 1983 and 1988 with established cancer programmes in the United States. No overall significant survival advantage was found between specialist and general gynaecologi~ts~ although sub-stage analysis showed a significantly better survival in Stage IIB disease (P c 0.03). No adjustment was made for prognostic factors, but the large number of cases may well have led to fairly balanced groups. A smaller study from California (263 women) of Stage IIIC and N carinoma of the ovary did find benefit associated with care by a specialist gynaecologist but the comparison group included general sugeonsl0. A further study of 87 women receiving identical chemotherapy for Stage I or 11 ovarian cancer found improved survival in women operated on by specialists, but concluded that this was due to more comprehensive staging at operation, which ensured that the women included in the specialist group were truly Stage I or 11. Again the comparative group included general surgeons. In the UK the Royal College of Obstetricians and Gynaecologists recognises as specialists those fully accredited, subspecialty trained gynaecologists and the Directors of Training Programmes. All except two of our specialists complied with this definition. The additional two gynaecologists were deemed to merit inclusion by a committee of specialist and nonspecialists at the initiation of the 1987 study. We anticipate that the inclusion of the additional two gynaecologists may be disputed, but it is important to remember that the specialists were defined and designated prior to the collection of any data. Our results were unaffected by exclusion of these two specialists. At present there are insufficient specialist gynaecological oncologists to operate on all cases of ovarian cancer in Scotland and in the light of this additional evidence the future service provision may need to be reconsidered8. Acknowledgements This work was funded by grants from the Clinical Resource and Audit Group and the Scottish Cancer Therapy Network. We are grateful to Professor C. R. Gillis whose initial observations inspired the study. References Gillis CR, Hole DJ. Survival outcome of care by specialist surgeons in breast cancer: a study of 3786 patients in the west of Scotland. BMJ 1996; Rosen L, Stasik JJ, Reed JF, Olenwine JA, Aronoff IS, Sherman D. Variations in colon and rectal surgical mortality. Comparison of specialities with a state.-legislated database. Dis Colon Recrum 1996; Bokey EL, Chapuis PH, Dent OF et al. Factors affecting survival after excision of the rectum for cancer: a multivariate analysis. Dis Colon Rectum 1997; Griffiths CT. Surgical resection of tumour bulk in the primary treatment of ovarian carcinoma. Narl Cancer Inst Mono 1975; Junor EJ, Hole DJ, Gillis CR. Management of ovarian cancer: referral to a multidisciplinary team matters. Br J Cancer 1994; 70: Kehoe S, Powell J, Wilson S, Woodman C. The influence of the operating surgeon s specialisation on patient survival in ovarian carcinoma. Br JCancer 1994; 70: Woodman C, Baghdady A, Collins S, Clyma JA. What changes in the organisation of cancer services will improve the outcome for women with ovarian cancer? BrJObsfet Gynaecoll997; 104: A Framework for Commissioning Cancer Services. A Joint Working Group Response by the Royal College of Obstetricians and Gynaecologists and the British Gynaecological Cancer Society. London: RCOG Press, January Nguyen HN, Averette HE, Hoskins W, Penalver M, Sevin B-U, Steren A. National Survey of Ovarian Cancer part V. The impact of physi- cian s specialty onpatients survival. Cancer 1993; Eisenkop SM, Spirtos NM, Montag TW, Nalick RH, Wang H-J. The impact of subspecialty training on the management of advanced ovarian cancer. Gynecol Oncoll992; 47: Mayer AR, Chambers SK, Graves E et al. Ovarian cancer staging: does it require a gynaecologic oncologist? Gynecol Oncol 1992; 47: Accepted 16 June I999 0 RCOG 1999 Br J Obstet Gynaecol 106,
Ovarian cancer the need for change in service delivery in Northern Ireland
The Ulster Medical Ovarian Journal, cancer Volume the need 72, for No. change 2, pp. in 93-97, service November delivery in 2003. Northern Ireland 93 Ovarian cancer the need for change in service delivery
More informationOutcome following surgery for colorectal cancer
Outcome following surgery for colorectal cancer Colin S McArdle* and David J Hole *University Department of Surgery, Glasgow Royal Infirmary, Glasgow and Department of Public Health, University of Glasgow,
More informationSurveillance report Published: 17 March 2016 nice.org.uk
Surveillance report 2016 Ovarian Cancer (2011) NICE guideline CG122 Surveillance report Published: 17 March 2016 nice.org.uk NICE 2016. All rights reserved. Contents Surveillance decision... 3 Reason for
More information17 th December 2008 Glasgow eprints Service
McMillan, D.C. and Hole, D.J. and McArdle, C.S. (2008) The impact of old age on cancer-specific and non-cancer-related survival following elective potentially curative surgery for Dukes A/B colorectal
More informationPDF hosted at the Radboud Repository of the Radboud University Nijmegen
PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a publisher's version. For additional information about this publication click this link. http://hdl.handle.net/2066/24096
More informationOvarian cancer: patterns of care in Victoria during
RESEARCH Ovarian cancer: patterns of care in Victoria during 1993 1995 Marisa Grossi, Michael A Quinn, Vicky J Thursfield, Prudence A Francis, Robert M Rome, Robert S Planner and Graham G Giles IN VICTORIA,
More informationEpithelial ovarian cancer
Scottish Intercollegiate Guidelines Net work 75 Epithelial ovarian cancer A na tion al clinical guideline 1 Introduction 1 2 Screening and the role of prophylactic oophorectomy 3 3 Diagnosis 6 4 Surgical
More informationLung cancer: the importance of seeing a respiratory physician
Eur Respir J 2003; 21: 606 610 DOI: 10.1183/09031936.03.00060803 Printed in UK all rights reserved Copyright #ERS Journals Ltd 2003 European Respiratory Journal ISSN 0903-1936 Lung cancer: the importance
More informationAn Example of Business Analytics in Healthcare
An Example of Business Analytics in Healthcare Colleen McGahan Biostatistical Lead Cancer Surveillance & Outcomes BC Cancer Agency cmcgahan@bccancer.bc.ca Improve Ovarian Cancer Outcomes Business relevancy
More informationTrends and outcomes for women diagnosed with ovarian cancer in Australia
CLINICAL PRACTICE: Clinical update Trends and outcomes for women diagnosed with ovarian cancer in Australia Crystal L Laurvick, BA, MPH, is Research Associate, Centre for Health Services Research, School
More informationAudit Report Report of the 2010 Clinical Audit Data
Gynaecological Cancer Managed Clinical Network Audit Report Report of the Clinical Audit Data Nick Reed Consultant Clinical Oncologist MCN Clinical Lead (Joint) Nadeem Siddiqui Consultant Gynaecological
More informationSUBSPECIALIST TRAINING PROGRAMME
EUROPEAN BOARD AND COLLEGE OF OBSTETRICIANS AND GYNAECOLOGISTS (EBCOG) AND EUROPEAN SOCIETY OF GYNAECOLOGICAL ONCOLOGY (ESGO) SUBSPECIALIST TRAINING PROGRAMME IN GYNAECOLOGICAL ONCOLOGY This Programme
More informationPrognostic factors in women with breast cancer: distribution by socioeconomic status and evect on diverences in survival
308 Scottish Cancer Intelligence Unit, Information and Statistics Division, Trinity Park House, Edinburgh EH5 3SQ, UK C S Thomson D H Brewster R J Black West of Scotland Cancer Surveillance Unit, Department
More informationThe role of neoadjuvant chemotherapy in patients with advanced (stage IIIC) epithelial ovarian cancer
Radiology and Oncology Ljubljana Slovenia www.radioloncol.com research article 341 The role of neoadjuvant chemotherapy in patients with advanced (stage IIIC) epithelial ovarian cancer Erik Škof 1, Sebastjan
More informationOvarian Cancer Quality Performance Indicators
Ovarian Cancer Quality Performance Indicators Patients diagnosed between October 2013 and September 2016 Publication date 20 February 2018 An Official Statistics publication for Scotland This is an Official
More informationImpact of deprivation and rural residence on treatment of colorectal and lung cancer
British Journal of Cancer (00) 87, 8 90 ª 00 Cancer Research UK All rights reserved 0007 090/0 $.00 www.bjcancer.com Impact of deprivation and rural residence on treatment of colorectal and lung cancer
More informationOVARIAN CANCER 2011 COMPARATIVE AUDIT REPORT
SOUTH EAST SCOTLAND CANCER NETWORK PROSPECTIVE CANCER AUDIT OVARIAN CANCER 2011 COMPARATIVE AUDIT REPORT Dr Melanie Mackean, NHS Lothian SCAN Lead Ovarian Cancer Clinician Dr Jane Macnab, NHS Fife Dr Scott
More informationClinical guideline Published: 27 April 2011 nice.org.uk/guidance/cg122
Ovarian cancer: recognition and initial management Clinical guideline Published: 27 April 2011 nice.org.uk/guidance/cg122 NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationAudit Report Report of the 2012 Clinical Audit Data
Gynaecological Cancer Managed Clinical Network Audit Report Report of the 2012 Clinical Audit Data Nadeem Siddiqui Consultant Gynaecological Oncologist MCN Clinical Lead Kevin Campbell MCN Manager Julie
More informationSurgeon workload and survival from breast cancer
British Journal of Cancer (2003) 89, 487 491 All rights reserved 0007 0920/03 $25.00 www.bjcancer.com Surgeon workload and survival from breast cancer J Stefoski Mikeljevic*,1, RA Haward 2,4, C Johnston
More informationOvarian Cancer Audit Comparative Annual Report 01/01/ /12/2009
SE Scotland Cancer Network SCAN AUDIT Ovarian Cancer Audit Comparative Annual Report 01/01/2009 31/12/2009 S E Scotland Cancer Network (SCAN) (Excluding Dumfries and Galloway) NHS Borders NHS Fife NHS
More informationMorphological effects of chemotherapy on ovarian carcinoma
27 ORIGINAL ARTICLE Morphological effects of chemotherapy on ovarian carcinoma W G McCluggage, R W Lyness, R J Atkinson, S P Dobbs, I Harley, H R McClelland, J H Price... See end of article for authors
More informationAdjuvant Chemotherapy in High Risk Patients after Wertheim Hysterectomy 10-year Survivals
6 Adjuvant Chemotherapy in High Risk Patients after Wertheim Hysterectomy 0-year Survivals V Sivanesaratnam,*FAMM, FRCOG, FACS Abstract Although the primary operative mortality following radical hysterectomy
More informationAudit. Public Health Monitoring Report on 2006 Data. National Breast & Ovarian Cancer Centre and Royal Australasian College of Surgeons.
National Breast & Ovarian Cancer Centre and Royal Australasian College of Surgeons Audit Public Health Monitoring Report on 2006 Data November 2009 Prepared by: Australian Safety & Efficacy Register of
More informationProf. Dr. Aydın ÖZSARAN
Prof. Dr. Aydın ÖZSARAN Adenocarcinomas of the endometrium Most common gynecologic malignancy in developed countries Second most common in developing countries. Adenocarcinomas, grade 1 and 2 endometrioid
More informationSetting The setting was secondary care. The economic study was carried out in Belgium.
Cost effectiveness of paclitaxel/cisplatin compared with cyclophosphamide/cisplatin in the treatment of advanced ovarian cancer in Belgium Neymark N, Gorlia T, Adriaenssen I, Baron B, Piccart M Record
More informationIn the United States, ovarian cancer is the leading
Aggressive Surgical Effort and Improved Survival in Advanced-Stage Ovarian Cancer Giovanni D. Aletti, MD, Sean C. Dowdy, MD, Bobbie S. Gostout, MD, Monica B. Jones, MD, C. Robert Stanhope, MD, Timothy
More informationResidual Tumor Following Surgery: The Strongest Prognostic Factor or a Myth? Philipp Harter, MD Kliniken Essen Mitte Essen, Germany
Residual Tumor Following Surgery: The Strongest Prognostic Factor or a Myth? Philipp Harter, MD Kliniken Essen Mitte Essen, Germany What Are Our Questions Q1: Prognostic factor residual disease? Q2: Differences
More informationCoversheet for Network Site Specific Group Agreed Documentation
Coversheet for Network Site Specific Group Agreed Documentation This sheet is to accompany all documentation agreed by Pan Birmingham Cancer Network Site Specific Groups. This will assist the Network Governance
More informationreceive adjuvant chemotherapy
Women with high h risk early stage endometrial cancer should receive adjuvant chemotherapy Michael Friedlander The Prince of Wales Cancer Centre and Royal Hospital for Women The Prince of Wales Cancer
More informationColorectal Cancer Demographics and Survival in a London Cancer Network
Cancer Research Journal 2017; 5(2): 14-19 http://www.sciencepublishinggroup.com/j/crj doi: 10.11648/j.crj.20170502.12 ISSN: 2330-8192 (Print); ISSN: 2330-8214 (Online) Colorectal Cancer Demographics and
More informationTHE BIRMINGHAM OVARIAN CANCER SURGERY MASTERCLASS
Pan-Birmingham Gynaecological Cancer Centre THE BIRMINGHAM OVARIAN CANCER SURGERY MASTERCLASS FOR GYNAECOLOGICAL ONCOLOGISTS AND TRAINEES Date 17-19 February 2014 Venue Pan-Birmingham Gynaecological Cancer
More informationOvarian Cancer Quality Performance Indicators (QPI) Comparative Report
SOUTH EAST SCOTLAND CANCER NETWORK (SCAN) PROSPECTIVE CANCER AUDIT Ovarian Cancer Quality Performance Indicators (QPI) Comparative Report Dr Cameron Martin, SCAN Lead Ovarian Cancer Clinician Dr Scott
More informationJ 13 (10) : , 1995 STUDY DESIGN AND CONDUCT
High-Dose Chemotherapy With Hematopoietic Rescue as Primary Treatment for Metastatic Breast Cancer: A Randomized Trial. Bezwoda WR, Seymour L and Dansey RD. J Clin Oncology, 13 (10) : 2483-2489, Oct 1995
More informationHEAD AND NECK CANCERS
SE Scotland Cancer Network HEAD AND NECK CANCERS COMPARATIVE ANNUAL REPORT PATIENTS DIAGNOSED 1 January 31 December 2008 Final Report Sign off 31 st August 2010 Chair of Head & Neck Group: - Dr EJ Junor
More informationHow to carry out health technology appraisals and guidance. Learning from the Scottish experience Richard Clark, Principal Pharmaceutical
The Managed Introduction of New Medicines How to carry out health technology appraisals and guidance. Learning from the Scottish experience Richard Clark, Principal Pharmaceutical Analyst July 10 th 2009,
More informationOVARIAN CANCER ANNUAL REPORT
ITEM 6.2 South East Scotland Cancer Network OVARIAN CANCER ANNUAL REPORT Data collected: 1 ST JANUARY TO 31 ST DECEMBER 2011 Dr K S Fegan Consultant Gynaecological Oncologist Victoria Hospital Kirkcaldy
More informationSquamous cell carcinoma arising in a dermoid cyst of the ovary: a case series
DOI: 10.1111/j.1471-0528.2007.01478.x www.blackwellpublishing.com/bjog Gynaecological oncology Squamous cell carcinoma arising in a dermoid cyst of the ovary: a case series JL Hurwitz, a A Fenton, a WG
More informationClinical Audit Data: 01 October 2015 to 30 September West of Scotland Cancer Network. Gynaecological Cancer Managed Clinical Network
Gynaecological Cancer Managed Clinical Network Audit Report Ovarian Cancer Quality Performance Indicators Cervical Cancer Quality Performance Indicators Endometrial Cancer Quality Performance Indicators
More informationDeposited on: 4 November 2009
Roxburgh, C.S.D. and Crozier, J.E.M. and Maxwell, F. and Foulis, A.K. and Brown, J. and McKee, R.F. and Anderson, J.H. and Horgan, P.G. and McMillan, D.C. (2009) Comparison of tumour-based (Petersen Index)
More informationC aring for patients with interstitial lung disease is an
980 INTERSTITIAL LUNG DISEASE Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK J Gribbin, R B Hubbard, I Le Jeune, C J P Smith, J West, L J Tata... See end of article
More informationSurvival after breast cancer treatment: the impact of provider volume
Blackwell Publishing LtdOxford, UKJEPJournal of Evaluation in Clinical Practice1356 1294 2006 The Authors; Journal compilation 2006 Blackwell Publishing Ltd2006135749757Original Article Provider volume
More informationCancer Genetics Services in Scotland
abcdefghijklm Cancer Genetics Services in Scotland Guidance to support the Implementation of Genetics Services for Breast, Ovarian and Colorectal Cancer Predisposition Scottish Cancer Group Cancer Genetics
More informationReport prepared on behalf of the Scottish Head and Neck Cancer Networks by the WoSCAN Information Team
Scottish Head and Neck Cancer Networks Report of the 2011 Clinical Audit Data Presented at the National Head and Neck Cancer Education Day 26th October 2012 Report prepared on behalf of the Scottish Head
More informationThe role of cytoreductive. nephrectomy in elderly patients. with metastatic renal cell. carcinoma in an era of targeted. therapy
The role of cytoreductive nephrectomy in elderly patients with metastatic renal cell carcinoma in an era of targeted therapy Dipesh Uprety, MD Amir Bista, MD Yazhini Vallatharasu, MD Angela Smith, MA David
More informationAfter primary tumor treatment, 30% of patients with malignant
ESTS METASTASECTOMY SUPPLEMENT Alberto Oliaro, MD, Pier L. Filosso, MD, Maria C. Bruna, MD, Claudio Mossetti, MD, and Enrico Ruffini, MD Abstract: After primary tumor treatment, 30% of patients with malignant
More informationUK Liver Transplant Audit
November 2012 UK Liver Transplant Audit In patients who received a Liver Transplant between 1 st March 1994 and 31 st March 2012 ANNUAL REPORT Advisory Group for National Specialised Services Prepared
More informationENDOMETRIAL CANCER. Endometrial cancer is a great concern in UPDATE. For personal use only. Copyright Dowden Health Media
For mass reproduction, content licensing and permissions contact Dowden Health Media. UPDATE ENDOMETRIAL CANCER Are lymphadenectomy and external-beam radiotherapy valuable in women who have an endometrial
More informationI have ovarian cancer
I have ovarian cancer Everything you need to know about BRCA1/2 gene mutations (Scotland only) 1 An introduction to BRCA1/2 gene mutations BRCA1 and BRCA2 are genes that repair damage in cells and prevent
More informationTraining in Gynaecological Oncology LOG BOOK
Training in Gynaecological Oncology LOG BOOK Approved by The European Board and College of Obstetrics and Gynaecology (EBCOG) and the European Society of Gynaecological Oncology (ESGO) TO BE COMPLETED
More informationLocoregional treatment Session Oral Abstract Presentation Saulo Brito Silva
Locoregional treatment Session Oral Abstract Presentation Saulo Brito Silva Background Post-operative radiotherapy (PORT) improves disease free and overall suvivallin selected patients with breast cancer
More informationGuideline for the Follow-up of Patients with Gynaecological Malignancies
Guideline for the Follow-up of Patients with Gynaecological Malignancies Version History Version Date Summary of Change/Process 2.0 20.02.08 Endorsed by the Governance Committee 2.1 18.11.10 Circulated
More informationCausal mediation analysis of observational, population-based cancer survival data
Causal mediation analysis of observational, population-based cancer survival data Bernard Rachet & Ruoran Li Cancer Survival Group, Faculty of Epidemiology and Population Health, LSHTM Twitter: @CSG_LSHTM
More informationTechnology appraisal guidance Published: 29 June 2011 nice.org.uk/guidance/ta227
Erlotinib monotherapy for maintenance treatment of non-small-cell lung cancer Technology appraisal guidance Published: 29 June 2011 nice.org.uk/guidance/ta227 NICE 2018. All rights reserved. Subject to
More informationSignificance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma
ORIGINAL STUDY Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma Jeong-Yeol Park, MD, PhD, Dae-Yeon Kim, MD, PhD, Dae-Shik Suh, MD, PhD, Jong-Hyeok Kim, MD, PhD, Yong-Man
More informationTrends in Cancer Survival in NSW 1980 to 1996
Trends in Cancer Survival in NSW 19 to 1996 Xue Q Yu Dianne O Connell Bruce Armstrong Robert Gibberd Cancer Epidemiology Research Unit Cancer Research and Registers Division The Cancer Council NSW August
More informationA clinical risk score to predict 3-, 5- and 10-year survival in patients undergoing surgery for Dukes B colorectal cancer
British Journal of Cancer (2010) 103, 970 974 All rights reserved 0007 0920/10 www.bjcancer.com A clinical risk score to predict 3-, 5- and 10-year survival in patients undergoing surgery for Dukes B colorectal
More informationAudit Report. Report of the 2010 Clinical Audit Data. West of Scotland Cancer Network. Lung Cancer Managed Clinical Network
West of Scotland Cancer Network Lung Cancer Managed Clinical Network Audit Report Report of the 2010 Clinical Audit Data Dr Richard Jones Consultant Clinical Oncologist MCN Clinical Lead Tracey Cole MCN
More informationStudy Title The SACS trial - Phase II Study of Adjuvant Therapy in CarcinoSarcoma of the Uterus
Study Title The SACS trial - Phase II Study of Adjuvant Therapy in CarcinoSarcoma of the Uterus Investigators Dr Bronwyn King, Peter MacCallum Cancer Centre Dr Linda Mileshkin, Peter MacCallum Cancer Centre
More informationWinship Cancer Institute of Emory University Optimizing First Line Treatment of Advanced Ovarian Cancer
Winship Cancer Institute of Emory University Optimizing First Line Treatment of Advanced Ovarian Cancer Ira R. Horowitz, MD, SM, FACOG, FACS John D. Thompson Professor and Chairman Department of Gynecology
More informationAudit Report Endometrial & Cervical Cancer Quality Performance Indicators
Gynaecological Cancer Managed Clinical Network Audit Report Endometrial & Cervical Cancer Quality Performance Indicators Clinical Audit Data: 01 October 2014 to 30 September 2015 Nadeem Siddiqui Consultant
More informationDebulking Surgery and HIPC to Treat Ovarian Cancer
Transcript Details This is a transcript of an educational program accessible on the ReachMD network. Details about the program and additional media formats for the program are accessible by visiting: https://reachmd.com/programs/clinicians-roundtable/debulking-surgery-and-hipc-to-treat-ovariancancer/3690/
More informationTrends in Cancer Survival in Scotland
Scottish Cancer Intelligence Unit Trends in Cancer Survival in Scotland - Trends in survival are presented for the half million adult cancer patients diagnosed in Scotland between and. The Results show,
More informationNational Cancer Peer Review Sarcoma. Julia Hill Acting Deputy National Co-ordinator
National Cancer Peer Review Sarcoma Julia Hill Acting Deputy National Co-ordinator Improving Outcomes Guidance The Intentions of Improving Outcomes for People with Sarcoma Changes in the provision of care
More informationSCOTTISH ONCOLOGY SUMMIT Double Tree by Hilton, Dunblane Hydro, Dunblane 1 st - 2 nd September 2017
Friday 1 st September 1300h 1400h Lunch (arrival, registration at conference foyer, coffee and sponsors exhibition) 1400h 1420h Prof Robert Jones Welcome/Announcements 1430h 1600h Parallel sessions: Lung
More informationAdvice Statement. Advice Statement November Advice for NHSScotland. Why is SHTG looking at this topic?
Advice Statement 014-18 November 2018 Advice Statement Colon capsule endoscopy (CCE-2) for the detection of colorectal polyps and cancer in adults with signs or symptoms of colorectal cancer or at increased
More informationScottish Medicines Consortium
Scottish Medicines Consortium cetuximab 2mg/ml intravenous infusion (Erbitux ) (279/06) MerckKGaA No 9 June 2006 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product
More informationThe DiSC assay: a cost-effective guide to treatment for chronic lymphocytic leukemia? Mason J M, Drummond M F, Bosanquet A G, Sheldon T A
The DiSC assay: a cost-effective guide to treatment for chronic lymphocytic leukemia? Mason J M, Drummond M F, Bosanquet A G, Sheldon T A Record Status This is a critical abstract of an economic evaluation
More informationStage IIIC transitional cell carcinoma and serous carcinoma of the ovary have similar outcomes when treated with platinum-based chemotherapy
Original Investigation 33 Stage IIIC transitional cell carcinoma and serous carcinoma of the ovary have similar outcomes when treated with platinum-based chemotherapy Gökhan Boyraz, Derman Başaran, Mehmet
More informationManagement and survival of patients with lung cancer in Scotland diagnosed in 1995: results of a national population based study
212 Lothian University Hospitals NHS Trust, Edinburgh EH4 2XU, UK A Gregor R J Fergusson Scottish Cancer Intelligence Unit, Information and Statistics Division, Trinity Park House, Edinburgh EH5 3SQ, UK
More informationContent must not be changed in any way or reproduced in any format or medium without the formal permission of the copyright holder(s)
n Lim, D., Ramsay, A., Small, D., and Conn, I. (2014) Socioeconomic demographics of patients referred to the Scottish National Service: sacral nerve stimulation for urinary dysfunction. Journal of Clinical
More informationNational Breast Cancer Audit next steps. Martin Lee
National Breast Cancer Audit next steps Martin Lee National Cancer Audits Current Bowel Cancer Head & Neck Cancer Lung cancer Oesophagogastric cancer New Prostate Cancer - undergoing procurement Breast
More informationBreast Cancer After Treatment of Hodgkin's Disease.
Breast Cancer After Treatment of Hodgkin's Disease. Hancock SL, Tucker MA, Hoppe R Journal of the National Cancer Institute 85(1):25-31, 1993 Introduction The risks of second malignancy are increased in
More informationConcomitant (without adjuvant) temozolomide and radiation to treat glioblastoma: A retrospective study
Concomitant (without adjuvant) temozolomide and radiation to treat glioblastoma: A retrospective study T Sridhar 1, A Gore 1, I Boiangiu 1, D Machin 2, R P Symonds 3 1. Department of Oncology, Leicester
More informationActivity Report April 2012 March 2013
Colorectal Cancer Managed Clinical Network Activity Report April 2012 March 2013 Paul Horgan Professor of Surgery MCN Clinical Lead Kevin Campbell Network Manager 1 CONTENTS EXECUTIVE SUMMARY 3 1. INTRODUCTION
More informationNATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE Single Technology Appraisal (STA) Dabrafenib for treating unresectable, advanced or metastatic
NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE Single Technology Appraisal (STA) Dabrafenib for treating unresectable, advanced or metastatic BRAF V600 mutation-positive melanoma mutation-positive melanoma
More informationTechnology appraisal guidance Published: 18 July 2018 nice.org.uk/guidance/ta531
Pembrolizumab for untreated PD- L1-positive metastatic non-small-cell lung cancer Technology appraisal guidance Published: 18 July 2018 nice.org.uk/guidance/ta531 NICE 2018. All rights reserved. Subject
More informationDear Colleagues, EXTENSION OF PAUSE TO THE USE OF VAGINAL MESH
29/03/2019 NHS Improvement and NHS England Wellington House 133-155 Waterloo Road London SE1 8UG 020 3747 0000 www.england.nhs.uk www.improvement.nhs.uk To: Regional Directors, Trust Medical Directors,
More informationSummary BREAST CANCER - Early Stage Breast Cancer... 3
ESMO 2016 Congress 7-11 October, 2016 Copenhagen, Denmark Table of Contents Summary... 2 BREAST CANCER - Early Stage Breast Cancer... 3 Large data analysis reveals similar survival outcomes with sequential
More informationNCIN Conference Feedback 2015
NCIN Conference Feedback 2015 Parallel Sessions Treatments (Black type is the topic; blue type are comments) The use of population and research data in the development of guidelines for cancer treatment
More informationTHE IMPORTANCE OF COMORBIDITY TO CANCER CARE AND STATISTICS AMERICAN CANCER SOCIETY PRESENTATION COPYRIGHT NOTICE
THE IMPORTANCE OF COMORBIDITY TO CANCER CARE AND STATISTICS AMERICAN CANCER SOCIETY PRESENTATION COPYRIGHT NOTICE Washington University grants permission to use and reproduce the The Importance of Comorbidity
More informationGynecologic Oncologist. Surgery Chemotherapy Radiation Therapy Hormonal Therapy Immunotherapy. Cervical cancer
Gynecologic Oncology Pre invasive vulvar, vaginal, & cervical disease Vulvar Cervical Endometrial Uterine Sarcoma Fallopian Tube Ovarian GTD Gynecologic Oncologist Surgery Chemotherapy Radiation Therapy
More informationSCREENING FOR OVARIAN CANCER: A SYSTEMATIC REVIEW 1998
SCREENING FOR OVARIAN CANCER: A SYSTEMATIC REVIEW 1998 EXECUTIVE SUMMARY Background Ovarian cancer is the seventh most common cancer in women world wide, and in England and Wales the mortality rate is
More informationNICE Single Technology Appraisal of cetuximab for the treatment of recurrent and /or metastatic squamous cell carcinoma of the head and neck
NICE Single Technology Appraisal of cetuximab for the treatment of recurrent and /or metastatic squamous cell carcinoma of the head and neck Introduction Merck Serono appreciates the opportunity to comment
More informationRisk group criteria for tailoring adjuvant treatment in patients with endometrial cancer : a validation study of the GOG criteria
Risk group criteria for tailoring adjuvant treatment in patients with endometrial cancer : a validation study of the GOG criteria Suk-Joon Chang, MD, Hee-Sug Ryu MD Gynecologic Cancer Center Department
More informationGuideline for the Management of Vulval Cancer
Version History Guideline for the Management of Vulval Cancer Version Date Brief Summary of Change Issued 2.0 20.02.08 Endorsed by the Governance Committee 2.1 19.11.10 Circulated at NSSG meeting 2.2 13.04.11
More informationAnal Sphincter Injuries: Acute Management
Anal Sphincter Injuries: Acute Management Dr Stephen Jeffery Urogynaecology Consultant Department of Obstetrics & Gynaecology Groote Schuur Hospital Colorectal Surgeons Gynaecologists Gynaecologists Colorectal
More informationHereditary Breast and Ovarian Cancer (HBOC) Information for individuals and families
Hereditary Breast and Ovarian Cancer (HBOC) Information for individuals and families What is Hereditary Breast and Ovarian Cancer (HBOC)? Hereditary Breast and Ovarian Cancer is a genetic condition which
More informationResearch Article Prognostic Value of Residual Disease after Interval Debulking Surgery for FIGO Stage IIIC and IV Epithelial Ovarian Cancer
Hindawi Publishing Corporation Obstetrics and Gynecology International Volume 2015, Article ID 464123, 7 pages http://dx.doi.org/10.1155/2015/464123 Research Article Prognostic Value of Residual Disease
More informationRECTAL CANCER APPARENT COMPLETE RESPONSE (acr) AFTER LONG COURSE CHEMORADIOTHERAPY
COLORECTAL CLINICAL SUBGROUP RECTAL CANCER APPARENT COMPLETE RESPONSE (acr) AFTER LONG COURSE CHEMORADIOTHERAPY Finalised by: Dr Simon Gollins Mr Andrew Renehan Dr Mark Saunders Mr Nigel Scott Dr Shabbir
More informationRacial Differences in Surgeons and Hospitals for Endometrial Cancer Treatment
University of Pennsylvania ScholarlyCommons Health Care Management Papers Wharton Faculty Research 2-2011 Racial Differences in Surgeons and Hospitals for Endometrial Cancer Treatment Katrina Armstrong
More informationMultimodal approach to predict ovarian malignancy prior to laparoscopy
2017; 3(2): 149-153 ISSN Print: 2394-7500 ISSN Online: 2394-5869 Impact Factor: 5.2 IJAR 2017; 3(2): 149-153 www.allresearchjournal.com Received: 24-12-2016 Accepted: 25-01-2017 Dr. Juhi Bhatti Dr. Shriraj
More informationOn-going and planned colorectal cancer clinical outcome analyses
On-going and planned colorectal cancer clinical outcome analyses Eva Morris Cancer Research UK Bobby Moore Career Development Fellow National Cancer Data Repository Numerous routine health data sources
More informationTriage of Ovarian Masses. Andreas Obermair Brisbane
Triage of Ovarian Masses Andreas Obermair Brisbane Why Triage? In ovarian cancer, best outcomes for patients can be achieved when patients are treated in tertiary centres by a multidisciplinary team led
More informationNorth of Scotland Cancer Network Clinical Management Guideline for Cancer of the Ovary
North of Scotland Cancer Network Cancer of the Ovary Based on WOSCAN CMG with further extensive consultation within NOSCAN UNCONTROLLED WHEN PRINTED DOCUMENT CONTROL Prepared by NOSCAN Gynaecology Cancer
More informationTechnology appraisal guidance Published: 16 May 2018 nice.org.uk/guidance/ta520
Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy Technology appraisal guidance Published: 16 May 2018 nice.org.uk/guidance/ta520 NICE 2018. All rights
More informationPROGNOSTIC FACTORS AND FIRST LINE CHEMOTHERAPY IN AOC
PROGNOSTIC FACTORS AND FIRST LINE CHEMOTHERAPY IN AOC Giorgia Mangili RUF ginecologia oncologica medica IRCCS San Raffaele Milano mangili.giorgia@hsr.it STANDARD CHEMOTHERAPY The standard chemotherapy
More informationLymphovascular space invasion in early-stage endometrial cancer: adjuvant treatment and patterns of recurrence
Southern 10 African African Journal Journal of Gynaecological of Gynaecological Oncology Oncology 2016; 8(1):10-15 2016; 1(1):1 6 http://dx.doi.org/10.1080/20742835.2016.1175708 Open Access article article
More informationBritain against Cancer APPG Cancer Meeting 2009 Research & Technologies Workshop
Britain against Cancer APPG Cancer Meeting 2009 Research & Technologies Workshop Researching inequality and cancer - what we know and what requires further research David Forman, Michael Chapman, Jon Shelton
More informationBevacizumab for the treatment of recurrent advanced ovarian cancer
Bevacizumab for the treatment of recurrent advanced ovarian cancer ERRATUM This report was commissioned by the NIHR HTA Programme as project number 11/40 Page 2 This document contains errata in respect
More information