Mechanisms of Tumor Suppressor Gene Demethylation in Colon Cancer by Berries

Size: px
Start display at page:

Download "Mechanisms of Tumor Suppressor Gene Demethylation in Colon Cancer by Berries"

Transcription

1 Mechanisms of Tumor Suppressor Gene Demethylation in Colon Cancer by Berries Li-Shu Wang, PhD Assistant Professor Department of Medicine Medical College of Wisconsin Cancer Center

2 Ten Leading Cancer Types for the Estimated New Cancer Cases and Deaths by Sex, 2010 Colorectal cancers are third most common cancer and third major cause of cancer mortality in U.S. 5-year survival ( ) = 66% Jemal, A. et al. CA Cancer J Clin 2010;0:caac.20073v1

3 Black Raspberries (BRBs) Freeze-dried powder

4 Some Chemopreventive Agents in Black Raspberries Vitamins: A, C, E, folic acid Minerals: calcium, selenium Simple phenols: ellagic acid, ferulic acid, coumaric acid, quercetin Complex phenols: anthocyanins Phytosterols: β-sitosterol, campesterol, stigmasterol Stoner GD, Cancer Prev Res. 2009;2:665.

5 Anthocyanins in Black Raspberries Cyanidin 3-O-glucoside Cyanidin 3-O-sambubioside Cyanidin 3-O-rutinoside Cyanidin 3-O-(2 G -xylosylrutinoside) Hecht SS et al., Carcinogenesis 2006;27:1617.

6 Effects of Whole BRBs and BRB Anthocyanins on Cellular Events and Associated Genes in NMBA- Treated Rat Esophagus Proliferation Ki-67/MIB-1 COX-2 PGE 2 Erk1/2 Inflammation COX-2 PGE 2 NF- 2 B CD45 Whole BRBs or BRB anthocyanins Apoptosis TUNEL Bcl-2 Bax Angiogenesis VEGF-1 HIF-1 CD34 CD45 leukocyte common antigen, CD34 Microvessel marker Wang LS et al., Cancer Prev Res. 2009;2:84.

7 DNA Methylation and Tumor Suppressor Gene Silencing Promoter CpG island CGCG CG CG Normal M CG M CG M CG M CG C: cytosine Cancer m C: methylcytosine X Cytosine C DNMT CH 3 5-MethylCytosine C DNMT: DNA methyltransferase DNMT family: DNMT1, DNMT3A, DNMT3B, etc DNA DNA

8 Wnt pathway WIF WNT L R P 5/ 6 Frizzled SFRP Ub Ub Proteasome Ub P GSK3 AXIN APC P AXIN GSK3 APC Degradation c-myc CYCD1 AXIN2 TCF/ LEF Target Genes

9

10 Colorectal Cancer Study Pre-surgical model 1. Pre-Treatment Colorectal Biopsies - Adjacent normal and tumor 2. Blood and Urine Samples 1. Post-Treatment Colorectal Biopsies - Adjacent normal and tumor 2. Blood and Urine Samples 20 Patients - Black Raspberry Slurry (20g/3x/day) Treatment Time (Range 1-9 wks, Average 3 wks)

11 Black Raspberry Slurry

12 Colorectal Cancer Patient Demographics No. of Patients (%) Gender Female 3 (15) Male 17 (85) Age <45 2 (10) (40) >60 10 (50) Average 59 Tumor location Transverse, descending, and sigmoid colon 3 (15) Cecum and ascending colon 3 (15) Rectum 14 (70) Metastatic disease Lymph node involved 2 (10) No evidence 18 (90)

13 Colon Cancer Patient Demographics (cont d) Berry treatment (wks) No. of Patients (%) 3 11 (55) (30) >4 3 (15) Range 1-9, Average 3 Berry doses (20g/dose, 3 doses/day) 50 8 (40) (50) >100 2 (10) Average 67 No. of Patients (%) Compliance (%) (5) (40) (55) Toxicities reported Diarrhea 3 (15) Constipation 4 (20) None 13 (65) Improved bowel movements 15 (75)

14 BRB Anthocyanins Were Detected in Urine and Tissue from Colorectal Cancer Patients After Average 3 Wks of BRB Treatment Pre-treatment Mean S.D. (Range) Post-treatment Mean S.D. (Range) Urine (pmol/ml) ( ) ( ) Adjacent normal (fmol/mg) Adenocarcinoma (fmol/mg) ( ) ( ) ( ) ( ) p=0.21 Wang LS et al., Clin Cancer Res. 2011;17:598.

15 Effects of BRBs on promoter methylation and on LINE-1 repetitive element in adjacent normal tissues and colorectal adenocarcinomas from 20 patients before and after 1-to-9 wks of berry treatment A. SFRP2 C. p16 E. WIF1 Methylation (%) * B. PAX6a D. SFRP5 F. LINE-1 Methylation (%) * Pre Post Pre Post Pre Post Pre Post Pre Post Pre Post N T N T N T Wang LS et al., Clin Cancer Res. 2011;17:598.

16 Percent Change from Baseline in DNMT1 Protein Expression in Adjacent Normal and Tumor Tissues in Colorectal Cancer Patients Who Were Treated with Berries High vs Low Doses Adjacent normal Berry doses p= N/H 52 N/L % change from baseline DNMT1 p= N/H DNMT1-11 N/L Adenocarcinoma Berry doses p= T/H 53 T/L % change from baseline DNMT1 p= T/H -8 DNMT1 T/L Wang LS et al., Clin Cancer Res. 2011;17:598.

17 Wang LS et al., Clin Cancer Res. 2011;17:598. Percent Change from Baseline in Promoter Methylation in Adjacent Normal Tissues in Colorectal Cancer Patients Who Were Treated with Berries High vs Low Doses SFRP2 PAX6a p16 p=0.008 p=0.004 p=0.620 % change from baseline % change from baseline N/H N/L N/H N/L N/H N/L SFRP5 WIF1 All p=0.283 p=0.488 p= Berry dose N/H = 83 N/L = 52 N/H N/L N/H N/L N/H N/L

18 Percent Change from Baseline in Promoter Methylation in Adenocarcinoma in Colorectal Cancer Patients Who Were Treated with Berries High vs Low Doses SFRP2 PAX6a p16 p=0.001 p=0.028 p=0.064 % change from baseline % change from baseline T/H T/L T/H T/L T/H T/L SFRP5 WIF1 All p=0.189 p=0.032 p< T/H T/L T/H T/L T/H T/L Berry dose T/H = 85 T/L = 53 Wang LS et al., Clin Cancer Res. 2011;17:598.

19 Wang LS et al., Clin Cancer Res. 2011;17:598. Heat-maps of Promoter Methylation Changes from Baseline of SFRP2, PAX6a, p16, SFRP5 and WIF1, and Protein Expression Change of DNMT1 Promoter methylation Protein Adjacent normal Adenocarcinoma N/H N/L T/H T/L SFRP2 PAX6a p16 SFRP5 WIF1 DNMT1 pts pts % change from baseline

20 Correlation of Methylation Change with Total Berry Dose Berry dose p=0.035 R 2 =0.118 N/H N/L T/H T/L Promoter methylation % change from baseline Wang LS et al., Clin Cancer Res. 2011;17:598.

21 BRB Treatment Did Not Affect Global Methylation LINE-1 % change from baseline p=0.303 p= N/H N/L N/H+N/L T/H T/L T/H+T/L Wang LS et al., Clin Cancer Res. 2011;17:598.

22 Correlation of Methylation Change with DNMT1 Changes DNMT1 protein % change from baseline Promoter methylation % change from baseline DNMT1, P = 0.006, R 2 = 0.181

23 Representative Immunohistochemical Staining in Adjacent Normal and Colorectal Tumors -catenin E-cadherin c-myc Ki-67 TUNEL p16 CD105 N T Wang LS et al., Clin Cancer Res. 2011;17:598.

24 Percent Change from Baseline in Protein Expression in Adjacent Normal Tissues in Colorectal Cancer Patients Who Were Treated with Berries High vs Low Doses -catenin E-cadherin c-myc p=0.03 p=0.042 p=0.110 % change from baseline Berry dose N/H = 83 N/L = 52 N/H N/L N/H N/L N/H N/L Ki-67 TUNEL p16 p=0.045 p=0.024 p=0.229 CD105 p=0.531 % change from baseline N/H N/L N/H N/L N/H N/L N/H N/L Wang LS et al., Clin Cancer Res. 2011;17:598.

25 Percent Change from Baseline in Protein Expression in Adenocarcinoma in Colorectal Cancer Patients Who Were Treated with Berries High vs Low Doses -catenin E-cadherin c-myc p=0.011 p=0.34 p=0.413 % change from baseline Berry dose T/H = 85 T/L = 53 T/H T/L T/H T/L T/H T/L Ki-67 TUNEL p16 p=0.034 p=0.006 p=0.004 CD105 p=0.043 % change from baseline T/H T/L T/H T/L T/H T/L T/H T/L Wang LS et al., Clin Cancer Res. 2011;17:598.

26 Differential Responses of Adenocarcinoma from the Colon and Rectum to Berry Treatment p=0.105 p=0.011 p=0.656 Methylation % change from baseline Methylation % change from baseline N/H C T/H C p=0.790 N/H R T/H R N/L C p< p=0.025 N/L R N/H normal / high dose N/L normal / low dose T/H Tumor / high dose T/L Tumor / low dose C, Colon R, Rectum T/L C T/L R Wang LS et al., Clin Cancer Res. 2011;17:598.

27 Summary The methylation of three Wnt inhibitors, SFRP2, SFRP5 and WIF1, upstream genes in the Wnt pathway, and PAX6a, a developmental regulator, was modulated in a protective direction by BRBs in adjacent normal colon and in colorectal tumors. This was associated with decreased expression of DNMT1. BRBs also modulated the expression of genes downstream of the Wnt pathway as well as cell proliferation, apoptosis and angiogenesis in a protective direction. Rectal adjacent normal and adenocarcinomas were less responsive to short-term (~2 wks) berry treatment. Wang LS et al., Clin Cancer Res. 2011;17:598.

28 Conclusions Pilot study in humans indicate that black raspberries (BRBs): Are well tolerated. Protectively modulated DNA methylation markers. This was associated with decreased expression of DNMT1 and protective modulation of cellular functions e.g. cell proliferation and apoptosis. Could be chemopreventive in human colorectal cancer.

29 Acknowledgments Ohio State University Stoner Lab Gary Stoner Cassandra Henry Chieh-Ti Kuo Bethany Larue Claudio Rocha Christine Sardo Claire Seguin Kristen Stoner Dept. of Surgery Mark Arnold Edward Martin Dept. of Pathology Wendy Frankel Human Cancer Genetics Yi-Wen Huang Tim Huang Dept. of Food Science & Technology Ken Riedl Steven Schwartz Ohio State University Dept. of Biomedical Informatics Victor Jin Xun Lan Univ. of Minnesota Stephen Hecht Steve Carmella All patients who participated in berry trials Supported by USDA NCI R01 CA (Wang) NCI R01 CA (Stoner)

30

Cancer Prevention with Berries. Gary Stoner, PhD Professor Emeritus Department of Medicine Ohio State University

Cancer Prevention with Berries. Gary Stoner, PhD Professor Emeritus Department of Medicine Ohio State University Cancer Prevention with Berries Gary Stoner, PhD Professor Emeritus Department of Medicine Ohio State University Factors Causing Cancer Pollution Alcohol Radiation Genetics Viruses 4% 4% 3% 4% Occupation

More information

Black raspberries in cancer clinical trials: Past, present and future

Black raspberries in cancer clinical trials: Past, present and future Journal of Berry Research 6 (2016) 251 261 DOI:10.3233/JBR-160125 IOS Press Black raspberries in cancer clinical trials: Past, present and future 251 Laura A. Kresty a,, Susan R. Mallery b and Gary D.

More information

A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis

A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis Downloaded from cancerpreventionresearch.aacrjournals.org on June 13, 218. 214 merican ssociation for Cancer Published OnlineFirst pril 24, 214; DOI: 1.1158/194-627.CPR-14-52 Research rticle Cancer Prevention

More information

Inhibition of cell migration and endothelial cell tubulogenesis by compounds. found in black raspberries. A Senior Honors Thesis

Inhibition of cell migration and endothelial cell tubulogenesis by compounds. found in black raspberries. A Senior Honors Thesis Inhibition of cell migration and endothelial cell tubulogenesis by compounds found in black raspberries A Senior Honors Thesis Presented in Partial Fulfillment of the Requirements for Graduation with research

More information

Development of Carcinoma Pathways

Development of Carcinoma Pathways The Construction of Genetic Pathway to Colorectal Cancer Moriah Wright, MD Clinical Fellow in Colorectal Surgery Creighton University School of Medicine Management of Colon and Diseases February 23, 2019

More information

Virchow s Hypothesis lymphorecticular infiltration of cancer reflected the origin of cancer at sites of inflammation

Virchow s Hypothesis lymphorecticular infiltration of cancer reflected the origin of cancer at sites of inflammation Virchow s Hypothesis 1863 lymphorecticular infiltration of cancer reflected the origin of cancer at sites of inflammation Barrett s esophagus/ Esophageal adenocarcinoma PSC / Cholangiocarcinoma Viral hepatitis

More information

R. Piazza (MD, PhD), Dept. of Medicine and Surgery, University of Milano-Bicocca EPIGENETICS

R. Piazza (MD, PhD), Dept. of Medicine and Surgery, University of Milano-Bicocca EPIGENETICS R. Piazza (MD, PhD), Dept. of Medicine and Surgery, University of Milano-Bicocca EPIGENETICS EPIGENETICS THE STUDY OF CHANGES IN GENE EXPRESSION THAT ARE POTENTIALLY HERITABLE AND THAT DO NOT ENTAIL A

More information

The silence of the genes: clinical applications of (colorectal) cancer epigenetics

The silence of the genes: clinical applications of (colorectal) cancer epigenetics The silence of the genes: clinical applications of (colorectal) cancer epigenetics Manon van Engeland, PhD Dept. of Pathology GROW - School for Oncology & Developmental Biology Maastricht University Medical

More information

Colorectal adenocarcinoma leading cancer in developed countries In US, annual deaths due to colorectal adenocarcinoma 57,000.

Colorectal adenocarcinoma leading cancer in developed countries In US, annual deaths due to colorectal adenocarcinoma 57,000. Colonic Neoplasia Remotti Colorectal adenocarcinoma leading cancer in developed countries In US, annual incidence of colorectal adenocarcinoma 150,000. In US, annual deaths due to colorectal adenocarcinoma

More information

Cancer prevention with freeze-dried berries and berry components

Cancer prevention with freeze-dried berries and berry components Seminars in Cancer Biology 17 (2007) 403 410 Invited article Cancer prevention with freeze-dried berries and berry components Gary D. Stoner a,, Li-Shu Wang a, Nancy Zikri b, Tong Chen c, Stephen S. Hecht

More information

NIH Public Access Author Manuscript Semin Cancer Biol. Author manuscript; available in PMC 2008 October 1.

NIH Public Access Author Manuscript Semin Cancer Biol. Author manuscript; available in PMC 2008 October 1. NIH Public Access Author Manuscript Published in final edited form as: Semin Cancer Biol. 2007 October ; 17(5): 403 410. Cancer Prevention with Freeze-dried Berries and Berry Components Gary D. Stoner

More information

Basic tumor nomenclature

Basic tumor nomenclature Jonas Nilsson jonas.a.nilsson@surgery.gu.se Sahlgrenska Cancer Center Bilder gjorda av Per Holmfeldt och Jonas Nilsson Benign tumor Basic tumor nomenclature Malignant tumor = cancer Metastasis Carcinoma:

More information

BLACK RASPBERRIES SUPERIOR NUTRACEUTICAL PROPERTIES

BLACK RASPBERRIES SUPERIOR NUTRACEUTICAL PROPERTIES BLACK RASPBERRIES SUPERIOR NUTRACEUTICAL PROPERTIES Wanted: All natural food - high in antioxidants, phenolic compounds and vitamin C. Must have ability to prevent the onset of some cancers as well as

More information

Type of file: PDF Size of file: 0 KB Title of file for HTML: Supplementary Information Description: Supplementary Figures

Type of file: PDF Size of file: 0 KB Title of file for HTML: Supplementary Information Description: Supplementary Figures Type of file: PDF Size of file: 0 KB Title of file for HTML: Supplementary Information Description: Supplementary Figures Supplementary Figure 1 mir-128-3p is highly expressed in chemoresistant, metastatic

More information

BIOLOGY OF CANCER. Definition: Cancer. Why is it Important to Understand the Biology of Cancer? Regulation of the Cell Cycle 2/13/2015

BIOLOGY OF CANCER. Definition: Cancer. Why is it Important to Understand the Biology of Cancer? Regulation of the Cell Cycle 2/13/2015 BIOLOGY OF CANCER Why is it Important to Understand the Biology of Cancer? Cynthia Smith, RN, BA, MSN, AOCN Oncology Clinical Nurse Specialist Harrison Medical Center Definition: Cancer Regulation of the

More information

Neoplasia 18 lecture 6. Dr Heyam Awad MD, FRCPath

Neoplasia 18 lecture 6. Dr Heyam Awad MD, FRCPath Neoplasia 18 lecture 6 Dr Heyam Awad MD, FRCPath ILOS 1. understand the role of TGF beta, contact inhibition and APC in tumorigenesis. 2. implement the above knowledge in understanding histopathology reports.

More information

Carcinogenesis in IBD

Carcinogenesis in IBD Oxford Inflammatory Bowel Disease MasterClass Carcinogenesis in IBD Dr Simon Leedham, Oxford, UK Oxford Inflammatory Bowel Disease MasterClass Carcinogenesis in Inflammatory Bowel Disease Dr Simon Leedham

More information

Jayanti Tokas 1, Puneet Tokas 2, Shailini Jain 3 and Hariom Yadav 3

Jayanti Tokas 1, Puneet Tokas 2, Shailini Jain 3 and Hariom Yadav 3 Jayanti Tokas 1, Puneet Tokas 2, Shailini Jain 3 and Hariom Yadav 3 1 Department of Biotechnology, JMIT, Radaur, Haryana, India 2 KITM, Kurukshetra, Haryana, India 3 NIDDK, National Institute of Health,

More information

Negative Regulation of c-myc Oncogenic Activity Through the Tumor Suppressor PP2A-B56α

Negative Regulation of c-myc Oncogenic Activity Through the Tumor Suppressor PP2A-B56α Negative Regulation of c-myc Oncogenic Activity Through the Tumor Suppressor PP2A-B56α Mahnaz Janghorban, PhD Dr. Rosalie Sears lab 2/8/2015 Zanjan University Content 1. Background (keywords: c-myc, PP2A,

More information

B eta catenin was first identified as a protein associated

B eta catenin was first identified as a protein associated 347 ORIGINAL ARTICLE Nuclear b catenin as a potential prognostic and diagnostic marker in patients with colorectal cancer from Hong Kong S C C Wong, E S F Lo, A K C Chan, K C Lee, W L Hsiao... See end

More information

Effect of Black Raspberry Extracts on Colon Cancer Cell Proliferation. Thesis

Effect of Black Raspberry Extracts on Colon Cancer Cell Proliferation. Thesis Effect of Black Raspberry Extracts on Colon Cancer Cell Proliferation Thesis Presented in Partial Fulfillment of the Requirements for the Degree Master of Science in the Graduate School of The Ohio State

More information

Term: FIMS Week: CBL SESSION Surgery

Term: FIMS Week: CBL SESSION Surgery Term: FIMS Week: CBL SESSION Surgery CBL Title: Colo-Rectal Cancer CBL Session Coordinators: Coordinators email/phone: Key issues that may be addressed in CBL sessions: SUGGESTED LIKELY CASES FOR DISCUSSION

More information

Epigenetics & cancer. Present by : Sanaz Zebardast Under supervision : Dr. Gheibi. 31 December 2016

Epigenetics & cancer. Present by : Sanaz Zebardast Under supervision : Dr. Gheibi. 31 December 2016 Epigenetics & cancer Present by : Sanaz Zebardast Under supervision : Dr. Gheibi 31 December 2016 1 contents Introduction Epigenetic & signaling pathways Epigenetic & integral protein Epigenetic & apoptosis

More information

VIII Curso Internacional del PIRRECV. Some molecular mechanisms of cancer

VIII Curso Internacional del PIRRECV. Some molecular mechanisms of cancer VIII Curso Internacional del PIRRECV Some molecular mechanisms of cancer Laboratorio de Comunicaciones Celulares, Centro FONDAP Estudios Moleculares de la Celula (CEMC), ICBM, Facultad de Medicina, Universidad

More information

Supplementary Table S1. List of PTPRK-RSPO3 gene fusions in TCGA's colon cancer cohort. Chr. # of Gene 2. Chr. # of Gene 1

Supplementary Table S1. List of PTPRK-RSPO3 gene fusions in TCGA's colon cancer cohort. Chr. # of Gene 2. Chr. # of Gene 1 Supplementary Tale S1. List of PTPRK-RSPO3 gene fusions in TCGA's colon cancer cohort TCGA Case ID Gene-1 Gene-2 Chr. # of Gene 1 Chr. # of Gene 2 Genomic coordiante of Gene 1 at fusion junction Genomic

More information

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,700 108,500 1.7 M Open access books available International authors and editors Downloads Our

More information

James C. Fleet, PhD Professor Dept of Nutrition Science Purdue University

James C. Fleet, PhD Professor Dept of Nutrition Science Purdue University James C. Fleet, PhD Professor Dept of Nutrition Science Purdue University Overview What are we trying to model? Vitamin D biology Cancer Is there in vivo proof of principle for vitamin D/cancer relationship?

More information

Colon Cancer and Hereditary Cancer Syndromes

Colon Cancer and Hereditary Cancer Syndromes Colon Cancer and Hereditary Cancer Syndromes Gisela Keller Institute of Pathology Technische Universität München gisela.keller@lrz.tum.de Colon Cancer and Hereditary Cancer Syndromes epidemiology models

More information

Wendy L Frankel. Chair and Distinguished Professor

Wendy L Frankel. Chair and Distinguished Professor 1 Wendy L Frankel Chair and Distinguished Professor Case 1 59 y/o woman Abdominal pain No personal or family history of cancer History of colon polyps Colonoscopy Polypoid rectosigmoid mass Biopsy 3 4

More information

DISSERTATION. Junnan Gu, M.S. Graduate Program in The Ohio State University Nutrition. The Ohio State University. Dissertation Committee:

DISSERTATION. Junnan Gu, M.S. Graduate Program in The Ohio State University Nutrition. The Ohio State University. Dissertation Committee: Assessment of Black Raspberries for Prostate Cancer: Product Development for Clinical Intervention and Preclinical Study for Mechanism Investigation DISSERTATION Presented in Partial Fulfillment of the

More information

Biochemistry of Cancer

Biochemistry of Cancer 4/6/15 Biochemistry of Cancer Tumor Suppressor Genes 1 Tumor Suppressor Genes Recessive phenotype Oncogenes (viral or cellular) dominate a phenotype i.e. acfvafon of cancer like behaviors. Ras, Myc, Erb

More information

General Surgery Grand Grounds

General Surgery Grand Grounds General Surgery Grand Grounds University of Colorado Health Sciences Center Case Presentation December 24, 2009 Adam Lackey, PGY-5 J.L. - 2111609 27 YO female with chief complaint of abdominal pain. PMHx:

More information

Review Article Effect of mir-200b on metastasis of gastric cancer

Review Article Effect of mir-200b on metastasis of gastric cancer Am J Digest Dis 2017;4(1):1-5 www.ajdd.us /ISSN:2329-6992/AJDD0040112 Review Article Effect of mir-200b on metastasis of gastric cancer Leyu Chiu 1, Brock Humphries 2,3 1 College of Human Medicine, 2 Department

More information

Wnt signaling. Ramray Bhat.

Wnt signaling. Ramray Bhat. Wnt signaling Ramray Bhat ramray@mrdg.iisc.ernet.in Starting with animal biology and viral infections The discovery of certain laboratory murine strains that were highly susceptible to mammary gland cancer.

More information

Purpose. Encourage standard exchange of data between two key public health partners

Purpose. Encourage standard exchange of data between two key public health partners Reporting Pathology Protocols for Colorectal Cancer 2005 NAACCR Conference: June 9, 2005 Ken Gerlach: CDC-NPCR Bette Smith: Ohio Cancer Registry Kathleen Davidson-Allen: PHI/California Cancer Registry

More information

Supplementary Information Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

Supplementary Information Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice Supplementary Information Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice Wang et. al. IL-6 in plasma (pg/ml) Rac1/HPRT (% of control) PSD9/HPRT

More information

Cancer Biology Course. Invasion and Metastasis

Cancer Biology Course. Invasion and Metastasis Cancer Biology Course Invasion and Metastasis 2016 Lu-Hai Wang NHRI Cancer metastasis Major problem: main reason for killing cancer patients, without it cancer can be cured or controlled. Challenging questions:

More information

DOCTORAL THESIS SUMMARY

DOCTORAL THESIS SUMMARY UNIVERSITY OF MEDICINE AND PHARMACY CRAIOVA DOCTORAL THESIS HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF GASTRIC CARCINOMAS SUMMARY Scientific Coordinator: Univ. Prof. Dr. SIMIONESCU CRISTIANA EUGENIA

More information

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle   holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/32781 holds various files of this Leiden University dissertation. Author: Benard, Anne Title: Epigenetic prognostic biomarkers in colorectal cancer Issue

More information

Supplementary Appendix

Supplementary Appendix Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Kaminski MF, Regula J, Kraszewska E, et al. Quality indicators

More information

The Hallmarks of Cancer

The Hallmarks of Cancer The Hallmarks of Cancer This illustration encompasses the six hallmark capabilities originally proposed in our 2000 perspective. The past decade has witnessed remarkable progress toward understanding the

More information

DNA methylation & demethylation

DNA methylation & demethylation DNA methylation & demethylation Lars Schomacher (Group Christof Niehrs) What is Epigenetics? Epigenetics is the study of heritable changes in gene expression (active versus inactive genes) that do not

More information

Clinical Colon Cancer Abby Siegel MD COLON CANCER. 1. Epidemiology 2. Risk factors 3. Manifestations 4. Treatment

Clinical Colon Cancer Abby Siegel MD COLON CANCER. 1. Epidemiology 2. Risk factors 3. Manifestations 4. Treatment Clinical Colon Cancer 2008 Abby Siegel MD COLON CANCER 1. Epidemiology 2. Risk factors 3. Manifestations 4. Treatment 1 1. EPIDEMIOLOGY - Colorectal cancer is the third most common cancer in the United

More information

Colon Cancer , The Patient Education Institute, Inc. oc Last reviewed: 05/17/2017 1

Colon Cancer , The Patient Education Institute, Inc.  oc Last reviewed: 05/17/2017 1 Colon Cancer Introduction Colon cancer is fairly common. About 1 in 15 people develop colon cancer. Colon cancer can be a life threatening condition that affects the large intestine. However, if it is

More information

A916: rectum: adenocarcinoma

A916: rectum: adenocarcinoma General facts of colorectal cancer The colon has cecum, ascending, transverse, descending and sigmoid colon sections. Cancer can start in any of the r sections or in the rectum. The wall of each of these

More information

Two Topics: Tobacco Control and Dietary Chemoprevention Stephen S. Hecht, Ph.D. February 3-5, 2016 Lansdowne Resort, Leesburg, VA

Two Topics: Tobacco Control and Dietary Chemoprevention Stephen S. Hecht, Ph.D. February 3-5, 2016 Lansdowne Resort, Leesburg, VA Two Topics: Tobacco Control and Dietary Chemoprevention Stephen S. Hecht, Ph.D. February 3-5, 2016 Lansdowne Resort, Leesburg, VA Outline Tobacco Control Policy Research Dietary Chemoprevention Percentage

More information

Exploitation of Epigenetic Changes to Distinguish Benign from Malignant Prostate Biopsies

Exploitation of Epigenetic Changes to Distinguish Benign from Malignant Prostate Biopsies Exploitation of Epigenetic Changes to Distinguish Benign from Malignant Prostate Biopsies Disclosures MDxHealth Scientific Advisor 2 Case Study 54-year-old man referred for a PSA of 7 - Healthy, minimal

More information

Carcinoembryonic Antigen

Carcinoembryonic Antigen Other Names/Abbreviations CEA 190.26 - Carcinoembryonic Antigen Carcinoembryonic antigen (CEA) is a protein polysaccharide found in some carcinomas. It is effective as a biochemical marker for monitoring

More information

Gut Microbial Metabolism of Plant-Food Bioactives: Impact on Dietary Exposure and Cancer Risk

Gut Microbial Metabolism of Plant-Food Bioactives: Impact on Dietary Exposure and Cancer Risk 5th Better Food for Better Health Microbiota & Health: The Challenges of a Promising Approach Les Pensières, Veyrier-du-Lac, April 6-8, 2016 Gut Microbial Metabolism of Plant-Food Bioactives: Impact on

More information

Summary and Concluding Remarks

Summary and Concluding Remarks Summary and Concluding Remarks Chapter 6 The intestinal epithelium provides an excellent model system for investigating molecular mechanisms regulating cell lineage establishment, stem cell proliferation,

More information

mirna Dr. S Hosseini-Asl

mirna Dr. S Hosseini-Asl mirna Dr. S Hosseini-Asl 1 2 MicroRNAs (mirnas) are small noncoding RNAs which enhance the cleavage or translational repression of specific mrna with recognition site(s) in the 3 - untranslated region

More information

Metastatic Colorectal Cancer

Metastatic Colorectal Cancer Helpful Information for People With Metastatic Colorectal Cancer and Their Families WHAT YOU SHOULD KNOW ABOUT Metastatic Colorectal Cancer Learning the basics of metastatic colorectal cancer If you or

More information

EPIGENETIC MODIFICATIONS ON WNT GENES BY DIETARY GENISTEIN DURING COLON CANCER DEVELOPMENT YUKUN ZHANG DISSERTATION

EPIGENETIC MODIFICATIONS ON WNT GENES BY DIETARY GENISTEIN DURING COLON CANCER DEVELOPMENT YUKUN ZHANG DISSERTATION EPIGENETIC MODIFICATIONS ON WNT GENES BY DIETARY GENISTEIN DURING COLON CANCER DEVELOPMENT BY YUKUN ZHANG DISSERTATION Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy

More information

Table S2 Study group sample sizes for CEA, CYFRA21-1 and CA125 determinations.

Table S2 Study group sample sizes for CEA, CYFRA21-1 and CA125 determinations. Supplementary Data Table S Clinico-pathological data associated with malignant and benign cases Primary site Early stage Late stage Caecum 3 (5%) 4 (20%) (5%) Ascending colon 6 (30%) 2 (0%) 0 (0%) Transverse

More information

Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP. thus showing therapeutic potential in colorectal carcinoma

Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP. thus showing therapeutic potential in colorectal carcinoma Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP thus showing therapeutic potential in colorectal carcinoma Hao-Wei Teng, Man-Hsin Hung, Li-Ju Chen, Mao-Ju Chang, Feng-Shu Hsieh, Ming-Hsien Tsai,

More information

Karyotype analysis reveals transloction of chromosome 22 to 9 in CML chronic myelogenous leukemia has fusion protein Bcr-Abl

Karyotype analysis reveals transloction of chromosome 22 to 9 in CML chronic myelogenous leukemia has fusion protein Bcr-Abl Chapt. 18 Cancer Molecular Biology of Cancer Student Learning Outcomes: Describe cancer diseases in which cells no longer respond Describe how cancers come from genomic mutations (inherited or somatic)

More information

Açai (Euterpe oleracea Mart.) Polyphenolics in Their Glycoside and Aglycone Forms Induce Apoptosis of HL-60 Leukemia Cells

Açai (Euterpe oleracea Mart.) Polyphenolics in Their Glycoside and Aglycone Forms Induce Apoptosis of HL-60 Leukemia Cells Below are several Abstracts of studies done on Açai that have been published in peer-review journals. These are only the abstracts, but they give the gist of the study, and where you can find and/or purchase

More information

COLORECTAL CANCER FAISALGHANISIDDIQUI MBBS; FCPS; PGDIP-BIOETHICS; MCPS-HPE

COLORECTAL CANCER FAISALGHANISIDDIQUI MBBS; FCPS; PGDIP-BIOETHICS; MCPS-HPE COLORECTAL CANCER FAISALGHANISIDDIQUI MBBS; FCPS; PGDIP-BIOETHICS; MCPS-HPE PROFESSOR OF SURGERY & DIRECTOR, PROFESSIONAL DEVELOPMENT CENTRE J I N N A H S I N D H M E D I C A L U N I V E R S I T Y faisal.siddiqui@jsmu.edu.pk

More information

[A RESEARCH COORDINATOR S GUIDE]

[A RESEARCH COORDINATOR S GUIDE] 2013 COLORECTAL SURGERY GROUP Dr. Carl J. Brown Dr. Ahmer A. Karimuddin Dr. P. Terry Phang Dr. Manoj J. Raval Authored by Jennifer Lee A cartoon about colonoscopies. 1 [A RESEARCH COORDINATOR S GUIDE]

More information

Impact of NM23-M1 "knock-out" on metastatic potential of hepatocellular carcinoma: a transgenic approach

Impact of NM23-M1 knock-out on metastatic potential of hepatocellular carcinoma: a transgenic approach Impact of NM23-M1 "knock-out" on metastatic potential of hepatocellular carcinoma: a transgenic approach NM23-M1 "knock- out" mice (without NDPK A) Experimental models of hepatocarcinogenesis Chemical

More information

Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer

Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer Samaei et al. Journal of Biomedical Science 2014, 21:73 RESEARCH Open Access Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal

More information

Berries and Cancer Prevention

Berries and Cancer Prevention Berries and Cancer Prevention Gary D. Stoner Navindra P. Seeram Editors Berries and Cancer Prevention 123 Editors Gary D. Stoner, Ph.D Department of Medicine Medical College of Wisconsin Milwaukee, WI

More information

From crypt stem cell to colorectal cancer

From crypt stem cell to colorectal cancer 19 3 2007 6 Chinese Bulletin of Life Sciences Vol. 19, No. 3 Jun., 2007 1004-0374(2007)03-0321-05 ( 510405) Wnt Notch BMP R735.35; R730.21 A From crypt stem cell to colorectal cancer WEN Bin*, CHEN Weiwen

More information

The Challenges of Chemoprevention: How Can We Develop Drugs to Treat Cancer Risk Instead of Metastases?

The Challenges of Chemoprevention: How Can We Develop Drugs to Treat Cancer Risk Instead of Metastases? The Challenges of Chemoprevention: How Can We Develop Drugs to Treat Cancer Risk Instead of Metastases? Moderator: Gary Kelloff, MD, Special Advisor, Division of Cancer Treatment and Diagnosis, National

More information

Ulcerative Colitis. ulcerative colitis usually only affects the colon.

Ulcerative Colitis. ulcerative colitis usually only affects the colon. Ulcerative Colitis Introduction Ulcerative colitis is an inflammatory bowel disease. It is one of the 2 most common inflammatory bowel diseases. The other one is Crohn s disease. Ulcerative colitis and

More information

UNDERSTANDING X-RAYS: ABDOMINAL IMAGING THE ABDOMEN

UNDERSTANDING X-RAYS: ABDOMINAL IMAGING THE ABDOMEN UNDERSTANDING X-RAYS: ABDOMINAL IMAGING THE ABDOMEN Radiology Enterprises radiologyenterprises@gmail.com www.radiologyenterprises.com STOMACH AND SMALL BOWEL STOMACH AND SMALL BOWEL Swallowed air is a

More information

FAMILIAL ADENOMATOUS POLYPOSIS SBS11QHG-06 DANIEL KANTER PERIOD 6 #9

FAMILIAL ADENOMATOUS POLYPOSIS SBS11QHG-06 DANIEL KANTER PERIOD 6 #9 FAMILIAL ADENOMATOUS POLYPOSIS SBS11QHG-06 DANIEL KANTER PERIOD 6 #9 PHYSIOLOGY The colon plays one of the most important roles in the body, extracting salt and water from the wastes and eventually creating

More information

CEA (CARCINOEMBRYONIC ANTIGEN)

CEA (CARCINOEMBRYONIC ANTIGEN) (CARCINOEMBRYONIC ANTIGEN) 428 C15.3 Malignant neoplasm of upper third of esophagus C15.4 Malignant neoplasm of middle third of esophagus C15.5 Malignant neoplasm of lower third of esophagus C15.8 Malignant

More information

COLORECTAL CANCER SCREENING

COLORECTAL CANCER SCREENING COLORECTAL CANCER SCREENING APPLICATIONS OBJECTIVE Purpose of Measure: ELIGIBLE POPULATION Which members are included? STANDARD OF CARE NCQA ACCEPTED CODES DOCUMENTATION REQUIREMENTS What documentation

More information

CHAPTER 6 SUMMARIZING DISCUSSION

CHAPTER 6 SUMMARIZING DISCUSSION CHAPTER 6 SUMMARIZING DISCUSSION More than 20 years ago the founding member of the Wnt gene family, Wnt-1/Int1, was discovered as a proto-oncogene activated in mammary gland tumors by the mouse mammary

More information

Interrogating mtor Inhibition in Patients with HRPC

Interrogating mtor Inhibition in Patients with HRPC Interrogating mtor Inhibition in Patients with HRPC Daniel George, John Madden, Andrew Armstrong, Mark Dewhirst, Nancy Major, and Phillip Febbo Divisions of Medical Oncology, Urology, Pathology, Radiology,

More information

Drinking Water with Red Beetroot Food Color Antagonizes Esophageal Carcinogenesis in N-Nitrosomethylbenzylamine-Treated Rats

Drinking Water with Red Beetroot Food Color Antagonizes Esophageal Carcinogenesis in N-Nitrosomethylbenzylamine-Treated Rats JOURNAL OF MEDICINAL FOOD J Med Food 13 (3) 2010, 733 739 # Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition DOI: 10.1089=jmf.2008.0280 Drinking Water with Red Beetroot Food Color

More information

Supplemental Digital Content 1. Endoscopic and histolological findings in INR and FR study subjects

Supplemental Digital Content 1. Endoscopic and histolological findings in INR and FR study subjects Supplemental Digital Content 1. Endoscopic and histolological findings in INR and FR study subjects Patient Group Macroscopic examination Ileum Histology Colon/rectum Histology 1 INR Normal Acute and chronic

More information

Principles of Genetics and Molecular Biology

Principles of Genetics and Molecular Biology Cell signaling Dr. Diala Abu-Hassan, DDS, PhD School of Medicine Dr.abuhassand@gmail.com Principles of Genetics and Molecular Biology www.cs.montana.edu Modes of cell signaling Direct interaction of a

More information

WNT signalling pathways as therapeutic targets in cancer

WNT signalling pathways as therapeutic targets in cancer WNT signalling pathways as therapeutic targets in cancer Jamie N. Anastas 1,2,3,4 and Randall T. Moon 1,2,4 Abstract Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands,

More information

PATHOBIOLOGY OF NEOPLASIA

PATHOBIOLOGY OF NEOPLASIA PATHOBIOLOGY OF NEOPLASIA Department of Pathology Gadjah Mada University School of Medicine dr. Harijadi Blok Biomedis, 6 Maret 2009 [12] 3/17/2009 1 The pathobiology of neoplasia Normal cells Malignant

More information

Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma

Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma Research article Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma Diego F. Calvisi, 1,2 Sara Ladu, 1 Alexis Gorden, 1 Miriam

More information

AN EPIDEMIOLOGICAL STUDY ON PATIENTS WITH COLORECTAL CANCER ADMITTED TO ONE REFERRAL CENTER IN NORTH OF IRAN FROM 2006 TO 2015

AN EPIDEMIOLOGICAL STUDY ON PATIENTS WITH COLORECTAL CANCER ADMITTED TO ONE REFERRAL CENTER IN NORTH OF IRAN FROM 2006 TO 2015 WCRJ 2017; 4 (1): e841 AN EPIDEMIOLOGICAL STUDY ON PATIENTS WITH COLORECTAL CANCER ADMITTED TO ONE REFERRAL CENTER IN NORTH OF IRAN FROM 2006 TO 2015 G. JANBABAEI 1, A. HEDAYATIZADEH-OMRAN 1, R. ALIZADEH-NAVAEI

More information

Metastatic Colorectal Cancer

Metastatic Colorectal Cancer Helpful Information for People With Metastatic Colorectal Cancer and Their Families What you should know about Metastatic Colorectal Cancer Learning the basics of metastatic colorectal cancer If you or

More information

Advanced colon cancer icd 10

Advanced colon cancer icd 10 Advanced colon cancer icd 10 rules, notes, synonyms, ICD -9-CM conversion, index and annotation crosswalks, DRG grouping and. Survive bowel cancer for 10 or more years, 2010-11, England and Wales. Icd

More information

Colonic Polyp. Najmeh Aletaha. MD

Colonic Polyp. Najmeh Aletaha. MD Colonic Polyp Najmeh Aletaha. MD 1 Polyps & classification 2 Colorectal cancer risk factors 3 Pathogenesis 4 Surveillance polyp of the colon refers to a protuberance into the lumen above the surrounding

More information

National Cancer Institute

National Cancer Institute National Cancer Institute Office of Cancer Complementary and Alternative Medicine ANNUAL REPORT ON COMPLEMENTARY AND ALTERNATIVE MEDICINE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes

More information

Obtaining the diagnosis:

Obtaining the diagnosis: CANCER SURGERY Obtaining the diagnosis: Most cancers are first biopsied in order to determine tumor type. Incisional biopsies extract small portions of tumor for microscopic examination. Excisional biopsies

More information

Cancer-Fighting Super Foods

Cancer-Fighting Super Foods To reduce your risk of cancer, look no further than your fridge. "All the studies on cancer and nutrition point to eating plant-based foods for their phytonutrients and other special compounds," says Richard

More information

Study of expression of P53 in Gastric Carcinoma As a prognostic indicator

Study of expression of P53 in Gastric Carcinoma As a prognostic indicator Original Research Article Study of expression of P53 in Gastric Carcinoma As a prognostic indicator K. Padma Malini 1*, Srivani 2, O. Shravan Kumar 3 1 Assistant Professor, 2 Associate Professor, 3 Professor

More information

THE DIGESTIVE SYSTEM THE FOUR STEPS OF DIGESTION

THE DIGESTIVE SYSTEM THE FOUR STEPS OF DIGESTION THE DIGESTIVE SYSTEM WHAT IS THE DIGESTIVE SYSTEM? the digestive system is a long, muscular tube The entire system is approximately 9m in length and is usually a one way tract WHY DO WE NEED A DIGESTIVE

More information

SUPPLEMENTARY FIGURES: Supplementary Figure 1

SUPPLEMENTARY FIGURES: Supplementary Figure 1 SUPPLEMENTARY FIGURES: Supplementary Figure 1 Supplementary Figure 1. Glioblastoma 5hmC quantified by paired BS and oxbs treated DNA hybridized to Infinium DNA methylation arrays. Workflow depicts analytic

More information

Beyond the APC era Alternative pathways to CRC. Jeremy R Jass McGill University

Beyond the APC era Alternative pathways to CRC. Jeremy R Jass McGill University Beyond the APC era Alternative pathways to CRC Jeremy R Jass McGill University Outline Limitations of APC model KRAS and serrated polyps CRC and CpG island methylation Serrated pathway to CRC Fusion pathways

More information

Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/β-catenin signaling pathway

Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/β-catenin signaling pathway Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/β-catenin signaling pathway Huidi Liu, M.D. & Ph.D Genomics Research Centre Harbin Medical University, China 15804606535@163.com

More information

Neoplastic Colon Polyps. Joyce Au SUNY Downstate Grand Rounds, October 18, 2012

Neoplastic Colon Polyps. Joyce Au SUNY Downstate Grand Rounds, October 18, 2012 Neoplastic Colon Polyps Joyce Au SUNY Downstate Grand Rounds, October 18, 2012 CASE 55M with Hepatitis C, COPD (FEV1=45%), s/p vasectomy, knee surgery Meds: albuterol, flunisolide, mometasone, tiotropium

More information

INTERNATIONAL COURSE ON THE PATHOLOGY OF THE DIGESTIVE SYSTEM VICTOR BABES NATIONAL INSTITUTE OF PATHOLOGY BUCHAREST 7-8 BUCHAREST 2014

INTERNATIONAL COURSE ON THE PATHOLOGY OF THE DIGESTIVE SYSTEM VICTOR BABES NATIONAL INSTITUTE OF PATHOLOGY BUCHAREST 7-8 BUCHAREST 2014 INTERNATIONAL COURSE ON THE PATHOLOGY OF THE DIGESTIVE SYSTEM VICTOR BABES NATIONAL INSTITUTE OF PATHOLOGY BUCHAREST 7-8 BUCHAREST 2014 Endoscopic biopsy samples of naïve colitides patients: Role of basal

More information

Caring for a Patient with Colorectal Cancer. Objectives. Poll question. UNC Cancer Network Presented on 10/15/18. For Educational Use Only 1

Caring for a Patient with Colorectal Cancer. Objectives. Poll question. UNC Cancer Network Presented on 10/15/18. For Educational Use Only 1 Caring for a Patient with Colorectal Cancer Tammy Triglianos RN, APRN-BC, AOCNP Nurse Practitioner, GI Oncology 10/15/2018 Objectives Describe common signs and symptoms of colorectal cancer Understand

More information

Serrated Polyps and a Classification of Colorectal Cancer

Serrated Polyps and a Classification of Colorectal Cancer Serrated Polyps and a Classification of Colorectal Cancer Ian Chandler June 2011 Structure Serrated polyps and cancer Molecular biology The Jass classification The familiar but oversimplified Vogelsteingram

More information

Novel Optical Research at UPMC

Novel Optical Research at UPMC Novel Optical Research at UPMC Randall Brand, MD Professor of Medicine Division of Gastroenterology, Hepatology, & Nutrition University of Pittsburgh Medical Center Background Patients with UC and CD of

More information

Original Article Expression of Ki-67 and pakt in colorectal cancer tissues and their clinical significance

Original Article Expression of Ki-67 and pakt in colorectal cancer tissues and their clinical significance Int J Clin Exp Med 2018;11(5):4623-4630 www.ijcem.com /ISSN:1940-5901/IJCEM0075475 Original Article Expression of Ki-67 and pakt in colorectal cancer tissues and their clinical significance Liang Li 1,

More information

Colorectal Cancer Structured Pathology Reporting Proforma DD MM YYYY

Colorectal Cancer Structured Pathology Reporting Proforma DD MM YYYY Colorectal Cancer Structured Pathology Reporting Proforma Mandatory questions (i.e. protocol standards) are in bold (e.g. S1.03). Family name Given name(s) Date of birth DD MM YYYY S1.02 Clinical details

More information

Commonly Encountered Neuro-Endocrine Tumors of the Gut

Commonly Encountered Neuro-Endocrine Tumors of the Gut Commonly Encountered Neuro-Endocrine Tumors of the Gut Moderators: Giuseppe Aliperti, MD Steven Edmundowicz, MD Panelists Douglas O. Faigel, MD Professor of Medicine Department of Gastroenterology Oregon

More information

Anticancer Effects of Red Raspberries on Immune Cells and Blood Parameters

Anticancer Effects of Red Raspberries on Immune Cells and Blood Parameters Clemson University TigerPrints All Dissertations Dissertations 8-2011 Anticancer Effects of Red Raspberries on Immune Cells and Blood Parameters Jannet Romero Clemson University, jromero@clemson.edu Follow

More information

A class of genes that normally suppress cell proliferation. p53 and Rb..ect. suppressor gene products can release cells. hyperproliferation.

A class of genes that normally suppress cell proliferation. p53 and Rb..ect. suppressor gene products can release cells. hyperproliferation. Tumor Suppressor Genes A class of genes that normally suppress cell proliferation. p53 and Rb..ect Mutations that inactivate the tumor suppressor gene products can release cells from growth suppression

More information

MicroRNA expression profiling and functional analysis in prostate cancer. Marco Folini s.c. Ricerca Traslazionale DOSL

MicroRNA expression profiling and functional analysis in prostate cancer. Marco Folini s.c. Ricerca Traslazionale DOSL MicroRNA expression profiling and functional analysis in prostate cancer Marco Folini s.c. Ricerca Traslazionale DOSL What are micrornas? For almost three decades, the alteration of protein-coding genes

More information