Porfimer sodium PDT. Photodynamic diagnosis; PDT. Talaporfin sodium PDT PDT PDT PDT PDT

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1 Photodynamic diagnosis; PDT PDT Porfimer sodium PDT Talaporfin sodium PDT 2 Talaporfin sodium PDT Porfimer sodium PDT Talaporfin sodium PDT PDT PDT PDT PDT 23

2 Porfimer sodium Talaporfin sodium mthpc temoporfinfoscan Talaporfin sodium 0.15 mg/kg nm Photodynamic dosedrug dose x light dose Porfimer sodium 100 PDT European Union NorwayIceland FDA 2 5-ALA Protoporphyrin IX PDD Porfimer sodium PDT 1 Talaporfin sodium PDT PD 2 low grade dysplasia high grade dysplasia 2003 FDA high grade dysplasia Porfimer sodium PDT PDT PDT Porfimer sodium ALA Porfimer sodium PDT 14 ALA ALA 2 mm Lightdate 236 Porfimer sodium PDT Hd:YAG laser III 3 4 PDT 32 % Nd:YAG 20 % PDT Nd:YAG 7 % Porfimer sodium PDT 1 % Nd:YAG PDT Luketich 77 PDT % 6 PDT 4 CRT 10 % 40 % 24

3 1 20 % 30 CRT 13 Porfimer sodium PDT 62 % % T 1 : 20 T 2 : 17 Porfimer sodium PDT 59 %22/37 CR % % T % CR T % 51.5 % 5.4 % CRT PDT T 1 PDT II CR CR 76 % 17 %48 % 35 %24 % 25

4 PDT PDT % %3 45 % 7 Porfimer sodium PDT Talaporfin sodium : PD Talaporfin sodium PDT 8 CRT Talaporfin sodium PDT I 9 II UMIN I Talaporfin sodium PDT 100 J/cm 2 CRT Talaporfin sodium PDT % PDT Kahaleh PDT 7.4 PDT 16.2 p < Quyn n = %n = % PDT n = %

5 173 PDT 512 PDT 11 gemcitabine oxaliplatin 2 Talaporfin sodium PDT apoptosis necrosis 12 PDT TCA ATP Warburg 13 PET 14 Talaporfin sodium in vivo PDT Talaporfin sodium 15 M) M) 27

6 M] delivery PDT PDT Mitsunaga EGF HER2 IR nm Photoimunotherapy: PIT 16 PDT EGR HER2 Drug Delivery System DDS DDS 17 enhanced permeability and retention EPR 18 EPR 19 PDT PDT PDT photonics DDS : 28

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