Genome Instability is Breathtaking
|
|
- Hilary Gilbert
- 5 years ago
- Views:
Transcription
1 Genome Instability is Breathtaking Effects of Alpha Radiation exposure on DNA at a molecular level and consequences to cell health Dr. Aaron Goodarzi A.Goodarzi@ucalgary.ca
2 Radiation what do you think of?
3 Radiation Exposure Radon gas inhalation accounts for most of our annual radiation exposure
4 Ionizing Radiation
5 Radiation Dosages Comic from: Radiation doses are commonly measured with three different units. The easiest way to conceptualize them is to think of Sir Isaac Newton under his apple tree. Becquerel (Bq) An absolute measure of radioactivity. Equivalent to 1 radioactive disintegration (particle emission) per second Gray (Gy) The dose of radiation absorbed by the object. Equivalent to 1 joule of energy per kilogram Sievert (Sv) The dose absorbed by a body which has an effect. Can be same as Gray.
6 Linear Energy Transfer Linear Energy Transfer (LET) is an important quality consideration for different types of radiation. LET = ionization events per unit length of a given ionization track Same dose = Image courtesy of: Low LET High LET
7 Radiation Dosages
8 Radiation and DNA damage All our DNA is found in our 2 copies (one from mom, one from dad) of 23 unique chromosomes.
9 DNA is packaged carefully DNA is wrapped around packaging proteins to form chromatin, keeping it generally stable and amenable for use by the cell
10 DNA Damage Figure adapted from:
11 DNA Double Strand Breaks
12 Radiation and DNA damage DNA damage is usually repaired by our cells correctly. However, errors are made... DNA damage = error = genetic mutation = cancer A = normal cell B = cancer cell
13 Life, Mutation or Death? Outcome depends on IR dose DNA DSBs 25 mgy IR = DSB/cell (low risk of cancer, +1% to lifetime risk) 250 mgy IR = 5-10 DSB/cell (significant increase in risk of cancer) 2,500 mgy IR = DSB/cell (radiation poisoning, cancer >95% sure) 25,000 mgy IR = DSB/cell (death is inevitable)
14 Radiation and Cancer When connecting radiation exposure to cancer, we stereotypically think of nuclear attack or disaster. Increased risk of solid cancer versus dose for atomic bomb survivors
15 Radiation and Cancer Following Chernobyl, thyroid cancer rates soared in children and young adults as radioactive iodine isotopes were absorbed by cows across Eastern Europe and concentrated into milk. The adult, mostly Ukrainian, clean-up workers ( liquidators ) from the army, plant staff and emergency services often went on to get leukemia. They generally received >100 msv exposures.
16 Radiation and Cancer Time will tell how cancer rates in Eastern Japan will change, following the 2011 Fukushima power plant meltdown.
17 Radon Exposure and Cancer In 2005, the WHO set up the International Radon Project, to outline risks and make recommendations.
18 Radon: a leading cause of lung cancer UN study concluded relative risk of lung cancer increases ~16% for every 100 Bq/m 3. WHO handbook on indoor Radon, Bq/m 3 = one hundred particles of alpha radiation emitted every second per cubic metre of air
19 Radon exposure in youth is serious Radon exposure during youth linearly increases risk of lung cancer. The younger you are at age of exposure, the greater is your chance of living long enough to get lung cancer. Chen, J. Canadian Lung Cancer relative Risk from Radon Exposure for Short Periods in Childhood Compared to a Lifetime. Int. J. Environ. Res. Public Health 2013, 10, e.g. exposure to 400 Bq/m 3 from ages 0-17 is same as a lifetime at 100 Bq/m 3
20 Radon = -particle radiation 234 Uranium For every atom of Rn 222 inhaled, four α-particles are emitted, three in the first week α α α 2.33x10 5 yrs 222 Radon α 3.8 days 218 Polonium 3.05 min 214 Polonium Remaining radioactive lead continues to emit alpha radiation for 22 years. α β β 1.5x10 4 sec 210 Lead α β β α 22.3 yrs β β Stable 206 Lead
21 -particles = High LET IR Low LINEAR ENERGY TRANSFER (LET) IR Resulting damage to DNA is more widely spaced, and is comparatively easier to repair High LINEAR ENERGY TRANSFER (LET) IR Resulting damage to DNA is clustered together, and is much more challenging to repair accurately.
22 -particles = clustered DNA damage The CLUSTERING of DNA damage can impact the accuracy of DNA repair substantially. Low LET IR Relatively straightforward rejoining During interphase, our chromosomes largely exist within independent territories, but do overlap to a degree.
23 % unrepaired DNA breaks DNA repair kinetics for low LET IR Gy 0.5 hr 2 hr 8 hr 24 hr 48 hr 72 hr >7 days Hours after irradiation
24 -particles = Clustered DNA damage The CLUSTERING of DNA damage can impact the accuracy of DNA repair substantially. Severe fragmentation and proximity of breaks from multiple chromosomes makes accurate re-joining difficult High LET IR
25 % unrepaired DNA breaks DNA repair kinetics for high LET IR Hours after irradiation >7 days
26 Clustered DNA damage Figure adapted from Moore S, Stanley FK, Goodarzi AA. The repair of DNA double strand breaks caused by high linear energy transfer irradiation - no simple task. DNA Repair : Review.
27 Influence of Genetics Your genetics plays a huge role in your likelihood of getting cancer following a trigger For breast/cervical cancer, mutation of BRCA1/BRCA2 are well known risk factors But what about radiation-induced lung cancer? GSTM1, GSTT1 Ruano-Ravina et al., 2014 (J. Thorac Oncol.) SIRT1 Leng et al., 2013 (Carcinogenesis) MGMT Pulling et al., 2003 (Cancer Research)????????????????????????????????????
28 Influence of Genetics The ATM gene is one of the more commonly mutated factors known to contribute to cancer and radio-sensitivity Basically, a lot more research is required to define the genetic risks of lung cancer following radon exposure. Riballo, E. et al. Molecular Cell 16, (2004)
29 ACKNOWLEDGEMENTS GOODARZI LAB Rami Abou-Zeinab, PhD Alex Anikin, BSc Karolin Klement, PhD Shaun Moore, BSc Dustin Pearson, MSc Carin Pihl, BSc Shilpa Salgia, MSc Fintan Stanley, BSc
RADON and Alpha Radiation Exposure
RADON and Alpha Radiation Exposure A historical perspective of radon, Alpha Radiation biology and household radon levels in the greater Calgary area Aaron Goodarzi, PhD Fintan Stanley, BSc A.Goodarzi@ucalgary.ca
More informationRadiation Carcinogenesis
Radiation Carcinogenesis November 11, 2014 Dhyan Chandra, Ph.D. Pharmacology and Therapeutics Roswell Park Cancer Institute Email: dhyan.chandra@roswellpark.org Overview - History of radiation and radiation-induced
More informationRADIATION RISK ASSESSMENT
RADIATION RISK ASSESSMENT EXPOSURE and TOXITY ASSESSMENT Osipova Nina, associated professor, PhD in chemistry, Matveenko Irina, Associate professor, PhD in philology TOMSK -2013 The contents 1.What is
More information1. The Accident of Chernobyl Unit 4 of 1,000 MWe Graphite-Moderated Boiling Water Pressure Tube Reactor in 1986
April 12, 2011 The Lesson learned from the Chernobyl Accident and the Data from Atomic Bomb Survivors For Understanding the Fukushima Daiichi Accident and the Robustness of the Human Body to Ionizing Radiation
More informationRadiation Health Effects
Radiation Health Effects Elena Buglova Incident and Emergency Centre Department of Nuclear Safety and Security Content Historical background Primary target for cell damage Deterministic effects Stochastic
More informationCancer Risk Factors in Ontario. Other Radiation
Cancer Risk Factors in Ontario Other Radiation OTHer radiation risk factor/ exposure Radon-222 and decay products X-radiation, gamma radiation Cancer The context where high risks were reported Magnitude
More informationCore Concepts in Radiation Exposure 4/10/2015. Ionizing Radiation, Cancer, and. James Seward, MD MPP
Ionizing Radiation, Cancer, and Causation James P. Seward, MD MPP FACOEM Clinical Professor of Medicine, UCSF American Occupational Health Conf May 4, 2015 Ionizing Radiation, Cancer, and Causation James
More informationErnest Rutherford:
November 1895: Roentgen discovers x rays February 1896: Becquerel discovers radioactivity Ernest Rutherford 1898-99 Ernest Rutherford: 1898-99 The Electromagnetic Spectrum Interaction of Charged Particles
More informationIONIZING RADIATION, HEALTH EFFECTS AND PROTECTIVE MEASURES
May 2011 IONIZING RADIATION, HEALTH EFFECTS AND PROTECTIVE MEASURES KEY FACTS Ionizing radiation is a type of energy released by atoms in the form of electromagnetic waves or particles. People are exposed
More informationBiological Effects of Radiation KJ350.
Biological Effects of Radiation KJ350 deborah.oughton@nmbu.no 2111 2005 Radiation Biology Interaction of radiation with biological material Doses (Gy, Sv) and effects Scientific Controversy Radiation Protection
More informationBiological Effects of Ionizing Radiation & Commonly Used Radiation Units
INAYA MEDICAL COLLEGE (IMC) RAD 232 - LECTURE 2 & 3 Biological Effects of Ionizing Radiation & Commonly Used Radiation Units DR. MOHAMMED MOSTAFA EMAM How does radiation injure people? - High energy radiation
More informationHealth Physics and the Linear No-Threshold Model
Health Physics and the Linear No-Threshold Model Understanding Radiation and Its Effects John Baunach Vanderbilt University Nashville, TN What is health physics? Outline What organizational bodies govern
More informationBiological Effects of Ionizing Radiation & Commonly Used Radiation Units
INAYA MEDICAL COLLEGE (IMC) RAD 232 - LECTURE 3, 4 & 5 Biological Effects of Ionizing Radiation & Commonly Used Radiation Units DR. MOHAMMED MOSTAFA EMAM How does radiation injure people? - High energy
More informationRadioactivity. Lecture 8 Biological Effects of Radiation
Radioactivity Lecture 8 Biological Effects of Radiation Studies of impact of ionizing radiation on the human body - Hiroshima - US-Japanese teams medical tests, autopsies, human organ analysis, on-site
More informationRadon in Florida: Current Status
Radon in Florida: Current Status Clark Eldredge, M.S. Bureau of Environmental Health Florida Department of Health (DOH) April 1, 2015 3/1/2016 1 Current Status The current understanding of radon risk and
More informationREVIEW Nuclear Disaster after the Earthquake and Tsunami of March 11
REVIEW Nuclear Disaster after the Earthquake and Tsunami of March 11 Naoyuki Shigematsu, Junichi Fukada, Toshio Ohashi, Osamu Kawaguchi and Tetsuya Kawata Department of Radiology, School of Medicine, Keio
More informationFukushima: What We All Should Know about Radiation
Fukushima: What We All Should Know about Radiation Peter N. Saeta, Harvey Mudd College Physics, 25 March 2011 Outline Radioactivity: what is it, what causes it, and what s a half life? How does ionizing
More informationRadiation Safety Information for Students in Courses given by the Nuclear Physics Group at KTH, Stockholm, Sweden
Radiation Safety Information for Students in Courses given by the Nuclear Physics Group at KTH, Stockholm, Sweden September 2006 The aim of this text is to explain some of the basic quantities and units
More informationThe Linear No-Threshold Model (LNT): Made to Be Tested, Made to Be Questioned. Richard C. Miller, PhD Associate Professor The University of Chicago
The Linear No-Threshold Model (LNT): Made to Be Tested, Made to Be Questioned Richard C. Miller, PhD Associate Professor The University of Chicago Regulatory Organizations NCRP (Nat l Council on Radiation
More informationPublic and Worker Health Impacts from the Fukushima Nuclear Plant Accident Thomas McKone, PhD & James Seward, MD, MPP
Public and Worker Health Impacts from the Fukushima Nuclear Plant Accident JAPAN EARTHQUAKE & TSUNAMI RELIEF ORGANIZATIONS Doctors Without Borders/Médecins Sans Frontières: Doctorswithoutborders.org The
More informationIndoor emissions. foams) > CH 2 =O; plasticizers, especially dialkyl phthalates. Especially a problem with mobile homes. - Regulations in Sweden
CHEM/TOX 336 Lecture 9 Indoor Air Emissions Radioisotopes in the Environment Indoor emissions From synthetic materials (carpets, plywood, ureaformaldehyde foams) > CH 2 =O; plasticizers, especially dialkyl
More informationRadiologic Units: What You Need to Know
Radiologic Units: What You Need to Know TODD VAN AUKEN M.ED. RT (R)(MR) Agenda Greys, Sieverts, Coulombs per kg, & Becquerel's Conventional Units Other Concepts (LET, Q-Factor, Effective Dose, NCRP Report
More informationIonizing Radiation. Michael J. Vala, CHP. Bristol-Myers Squibb
Ionizing Radiation Michael J. Vala, CHP Bristol-Myers Squibb michael.vala@bms.com 732-227-5096 2013 American Industrial Hygiene Association, New Jersey Section, Inc. Course Objectives At the end of this
More informationWilliam F. Morgan. Ph.D., D.Sc.
Biological Responses at Low Radiation Doses: Advances in Radiation Biology and Potential ti Implications for Radiation Exposure Regulations. William F. Morgan. Ph.D., D.Sc. Pacific Northwest National Laboratory
More informationRadiation Safety in the Workplace. v1.0
Radiation Safety in the Workplace v1.0 Outline What is radiation? Different types of radiation Activity and Half-life Units of radiation dose Health effects of exposure to radiation Dose limits Common
More informationSources of Data of Stochastic Effects of Radiation. Michael K O Connor, Ph.D. Dept. of Radiology, Mayo Clinic
Sources of Data of Stochastic Effects of Radiation Michael K O Connor, Ph.D. Dept. of Radiology, Mayo Clinic Biological Effects of Ionizing Radiation (BEIR) 2007 National Academy of Science National Research
More informationHiroshima / Fukushima: Gender Matters in the Atomic Age
Hiroshima / Fukushima: Gender Matters in the Atomic Age Mary Olson, Nuclear Information and Resource Service (NIRS) www.nirs.org / maryo@nirs.org Presentation posted: http://tinyurl.com/olson2016 Original
More informationEpidemiologic Studies. The Carcinogenic Effects of Radiation: Experience from Recent Epidemiologic Studies. Types of Epidemiologic Studies
Division Of Cancer Epidemiology And Genetics Radiation Epidemiology Branch The Carcinogenic Effects of Radiation: Experience from Recent Epidemiologic Studies Elaine Ron Columbia University Radiation Course
More informationRadiation Physiology and Effects
Sources and types of space radiation Effects of radiation Shielding approaches 1 2011 David L. Akin - All rights reserved http://spacecraft.ssl.umd.edu The Electromagnetic Spectrum Ref: Alan C. Tribble,
More informationProgress in understanding radon risk
Progress in understanding radon risk D LAURIER Institute for Radiological Protection and Nuclear Safety (IRSN) Fontenay-aux-Roses, France EU Scientific Seminar 2010 "Issues with internal emitters Luxembourg,
More informationDetermination of Radon Concentration in Some Types of Cigarettes
Determination of Radon Concentration in Some Types of Cigarettes Tarfa.H.Alsheddi 1, Amal Mohamed 2 and Shaffa.Al.Mansour 3 1 Department of physics, King Faisal University, Saudi Arabia. 2 Department of
More informationPresentation. To the BAPE Panel on Uranium Mining In Quebec. by Gordon Edwards, Ph.D. November 17, 2014
1 Presentation To the BAPE Panel on Uranium Mining In Quebec by Gordon Edwards, Ph.D. November 17, 2014 2 Radioactivity is invisible... but do the facts have to hidden as well? A critique of Strateco s
More informationDose-equivalent equivalent = absorbed
UCSF General Surgery 2010 Radiation Risks of Diagnostic Radiology in Trauma Robert A. Izenberg, M.D., FACS University of California, San Francisco San Francisco General Hospital Context Increasingly liberal
More informationAn Open Letter To IAEA
An Open Letter To IAEA Exposure to Low Level of Radiation Research Group Citizen Science Initiative Japan (CSIJ) 3-1-1 Sendagi, Bunkyo-ku P.O.BOX 113-0022 Tokyo, Japan 22 February 2016 Yukiya Amano Director
More informationWHAT IS RADON? FIGURE 1
FIGURE 1 Health Canada, the World Health Organization, the US Environmental Protection Agency, and many other respected international authorities all agree Radon is the number 1 cause of lung cancer for
More informationnuclear science and technology
EUROPEAN COMMISSION nuclear science and technology Gene-radiation interactions: their influence on pre-menopausal breast cancer risk after Chernobyl (GENE-RAD-INTERACT) Contract N o FIGH-CT2002-00215 Final
More informationWhat is the current risk of radiation-related health problems in Japan to those near the reactor at the time, and those in other parts of Japan?
What is the current risk of radiation-related health problems in Japan to those near the reactor at the time, and those in other parts of Japan? The actions proposed by the Government of Japan are in line
More informationRADIATION HAZARDS. A dabbler s perspective. Jess H. Brewer
RADIATION HAZARDS A dabbler s perspective by Jess H. Brewer Mortality Paraphrased from memory: Front page of special HEALTH edition of LA Free Press (around 1970): No matter how much money you have, how
More informationLecture 14 Exposure to Ionizing Radiation
Lecture 14 Exposure to Ionizing Radiation Course Director, Conrad Daniel Volz, DrPH, MPH Assistant Professor, Environmental & Occupational Health, University of Pittsburgh, Graduate School of Public Health
More informationLET, RBE and Damage to DNA
LET, RBE and Damage to DNA Linear Energy Transfer (LET) When is stopping power not equal to LET? Stopping power (-de/dx) gives the energy lost by a charged particle in a medium. LET gives the energy absorbed
More informationRadiopharmaceuticals. Radionuclides in NM. Radionuclides NUCLEAR MEDICINE. Modes of radioactive decays DIAGNOSTIC THERAPY CHEMICAL COMPOUND
Univerzita Karlova v Praze - 1. Lékařská fakulta Radiation protection NUCLEAR MEDICINE Involving the application of radioactive substances in the diagnosis and treatment of disease. Nuclear medicine study
More informationFrom Epidemiology to Risk Factors aka DDREF: Light and Shadows
From Epidemiology to Risk Factors aka DDREF: Light and Shadows MELODI 2011, Rome November 2, 2011 Dale L. Preston Hirosoft International Eureka, CA Outline DDREF Origins and Background DDREF in Practice
More informationThe health risks of exposure to internal radiation. Korea National Assembly Seoul 22 nd August 2015
The health risks of exposure to internal radiation Korea National Assembly Seoul 22 nd August 2015 Christopher Busby Green Audit UK/ Environmental Research SIA, Riga, Latvia Scientific Secretary: European
More informationIonizing Radiation. Alpha Particles CHAPTER 1
CHAPTER 1 Ionizing Radiation Ionizing radiation is radiation that has sufficient energy to remove electrons from atoms. In this document, it will be referred to simply as radiation. One source of radiation
More informationCHAPTER TWO MECHANISMS OF RADIATION EFFECTS
10-2 densely ionizing radiation CHAPTER TWO MECHANISMS OF RADIATION EFFECTS 2.0 INTRODUCTION Cell survival curves describe the relationship between the fractional survival, S, of a population of radiated
More informationBEIR VII: Epidemiology and Models for Estimating Cancer Risk
National Cancer Institute U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health BEIR VII: Epidemiology and Models for Estimating Cancer Risk Ethel S. Gilbert National Cancer Institute
More informationBIOLOGICAL EFFECTS OF
BIOLOGICAL EFFECTS OF RADIATION Natural Sources of Radiation Natural background radiation comes from three sources: Cosmic Radiation Terrestrial Radiation Internal Radiation 2 Natural Sources of Radiation
More informationAnnex X of Technical Volume 4 RADIATION AND HEALTH EFFECTS AND INFERRING RADIATION RISKS FROM THE FUKUSHIMA DAIICHI ACCIDENT
Annex X of Technical Volume 4 RADIATION AND HEALTH EFFECTS AND INFERRING RADIATION RISKS FROM THE FUKUSHIMA DAIICHI ACCIDENT Anxieties about the risk of harm from radiation are often out of proportion
More informationRADON: IS IT IN YOUR HOME? Information for Health Professionals
RADON: IS IT IN YOUR HOME? Information for Health Professionals Health Canada recently announced a lowering of the Canadian guideline for indoor exposure to radon. This reduction was the result of new
More informationMedical Physics 4 I3 Radiation in Medicine
Name: Date: 1. This question is about radiation dosimetry. Medical Physics 4 I3 Radiation in Medicine Define exposure. A patient is injected with a gamma ray emitter. The radiation from the source creates
More informationLYMHOCYTE CHROMOSOMAL ABERRATION ASSAY IN RADIATION BIODOSIMETRY
LYMHOCYTE CHROMOSOMAL ABERRATION ASSAY IN RADIATION BIODOSIMETRY Dr. Birutė Gricienė 1,2 1 Radiation Protection Centre 2 Vilnius University Introduction Ionising radiation is a well-known mutagenic and
More informationFukushima nuclear power plant and your health
Fukushima nuclear power plant and your health Contents (5) Radiation and radioactive materials released from the nuclear power plant (6) Contamination of air, water, and food with radioactive materials.
More informationRadiobiology Hall 14: Radiologic Terrorism (Completed)
Radiobiology Hall 14: Radiologic Terrorism (Completed) What are a few of the possible scenarios of radiologic terrorism? 1. Detonation of a nuclear major city 2. An attack on a nuclear power station 3.
More informationRadioactivity. Alpha particles (α) :
Radioactivity It is the property of an element that causes it to emit radiation Discovered by Becquerel (1896) Radiation comes from the nucleus of the atom There are three types of radiation : alpha particles
More information"The Good Side of Radiation: Medical Applications"
"The Good Side of Radiation: Medical Applications" J. Battista, Ph.D. Medical Physicist London Regional Cancer Program LHSC http://www.macmillan.org.uk/images/cancerinfo Role of Medical Physicists Diagnostic
More informationComputer modeling of radiation effects
Computer modeling of radiation effects 20th International CODATA Conference 25 October 2006, Beijing Noriyuki B. Ouchi and Kimiaki Saito Radiation Effects Analysis Research Group, Nuclear Science and Engineering
More informationEveryday Radiation. David D. Dixon HDT Rally Hutchinson, KS October 15, 2014
Everyday Radiation David D. Dixon HDT Rally Hutchinson, KS October 15, 2014 Overview Types of radiation and radiation damage Sources of radiation Naturally Occurring Medical Energy Industry Other Man-Made
More informationReview of the Radiobiological Principles of Radiation Protection
1 Review of the Radiobiological Principles of Radiation Protection Cari Borrás, D.Sc., FACR, FAAPM Radiological Physics and Health Services Consultant Adjunct Assistant Professor (Radiology) GWU School
More informationHazards + uses of emissions; Background radiation
Hazards + uses of emissions; Background radiation Question Paper 1 Level GCSE (9-1) Subject Physics Exam Board AQA Topic 4.4 Atomic structure Sub-Topic Hazards uses of emissions; Background radiation Difficulty
More informationRADON RESEARCH IN MULTI DISCIPLINES: A REVIEW
RADON RESEARCH IN MULTI DISCIPLINES: A REVIEW PILLALAMARRI ILA Earth Atmospheric & Planetary Sciences Neutron Activation Analysis Laboratory Massachusetts Institute of Technology Cambridge, MA 02139 IAP
More informationRADON: IS IT IN YOUR HOME? Information for Health Professionals
RADON: IS IT IN YOUR HOME? Information for Health Professionals Health Canada recently announced a lowering of the Canadian guideline for indoor exposure to radon. This reduction was the result of new
More informationRadiation Safety for New Medical Physics Graduate Students
Radiation Safety for New Medical Physics Graduate Students John Vetter, PhD Medical Physics Department UW School of Medicine & Public Health Background and Purpose of This Training This is intended as
More informationQ&A: Health effects of radiation exposure
Page 1 of 10 HEALTH 30 March 2011 Last updated at 08:38 ET Q&A: Health effects of radiation exposure By Richard Warry BBC News Concern remains over the potential effect on human health from radiation leaks
More informationEffects of Radiation on Human In the Face of Fukushima Daiichi Nuclear Power Plant Accident
Effects of Radiation on Human In the Face of Fukushima Daiichi Nuclear Power Plant Accident At Sophia University 11 May 2011 Presented by: Tokyo Institute of Technology Research Laboratory for Nuclear
More informationPrinciples of Radiation
RADIOACTIVE AGENTS Principles of Radiation 2 types of radiation Non-ionizing (no tissue damage) Ionizing (tissue damage) 2010 MGH International Disaster Institute 1 2010 MGH International Disaster Institute
More informationNature of Radiation and DNA damage
Nature of Radiation and DNA damage Index 1. What is radiation? 2. Ionizing Radiation 3. Interaction of Gamma-radiation with Matter 4. Radiobiology 5. Direct and Indirect action of radiation 6. Steps of
More informationHoward Dickson President Emeritus Health Physics Society
Howard Dickson President Emeritus Health Physics Society Summary of accident experience Differentiation between nuclear & radiation accidents Categories of accidents Examples of accidents & their severity
More informationLab & Rad Safety Newsletter
Ohio UNIVERSITY Fall 2018 Lab & Rad Safety Newsletter Alan Watts Radiation Safety Officer In This Issue: Instruction Concerning Risks From Occupational Radiation Exposure... pg.1-5 = Required = Optional
More informationChronic cell death may play a crucial role in mutagenesis and carcinogenesis due to radon exposure
Chronic cell death may play a crucial role in mutagenesis and carcinogenesis due to radon exposure Balázs G. Madas, Imre Balásházy MTA Centre for Energy Research,, Hungary balazs.madas@energia.mta.hu Low
More informationRadiation Protection in the World of Modern Radiobiology: Time for A New Approach. R. E. J. Mitchel and D. R Boreham
Radiation Protection in the World of Modern Radiobiology: Time for A New Approach R. E. J. Mitchel and D. R Boreham Radiation Biology and Health Physics Branch, AECL, Chalk River Laboratories, Chalk River
More informationCancer risks following low-dose radiation from CT scans in childhood. John Mathews CSRP 2016
Cancer risks following low-dose radiation from CT scans in childhood New insights into effects of age at exposure and attained age John Mathews CSRP 2016 Acknowledgments Particular thanks are due to the
More informationBIOLOGY 111. CHAPTER 9: The Links in Life s Chain Genetics and Cell Division
BIOLOGY 111 CHAPTER 9: The Links in Life s Chain Genetics and Cell Division The Links in Life s Chain: Genetics and Cell Division 9.1 An Introduction to Genetics 9.2 An Introduction to Cell Division 9.3
More informationPam Warkentin. Radonmatters Indoor air quality workshop CIPHI National Meeting Winnipeg, MB June 23, 2013
Pam Warkentin Radonmatters Indoor air quality workshop CIPHI National Meeting Winnipeg, MB June 23, 2013 Outline Introduction What is RADON Sources Health effects Sampling and Interpretation Sampling methods
More informationACUTE RADIATION SYNDROME: Diagnosis and Treatment
ACUTE RADIATION SYNDROME: Diagnosis and Treatment Badria Al Hatali, MD Medical Toxicologist Department of Environmental and Occupational Health MOH - Oman Objectives Provide a review of radiation basics
More informationEveryday Radiation. David D. Dixon HDT Rally Hutchinson, KS October 13, 2015
Everyday Radiation David D. Dixon HDT Rally Hutchinson, KS October 13, 2015 Overview Nuclear Energy Industry Outlook Types of radiation and radiation damage Sources of radiation Naturally Occurring Medical
More informationICRP = International Commission on. recommendations and guidance on. Functioning since 1928.
ICRP = International Commission on Radiological Protection; An advisory body providing recommendations and guidance on radiation protection; Functioning since 1928. While the use of ionising radiation
More informationRadiation Dose in Pediatric Imaging
Radiation Dose in Pediatric Imaging A Brief History of Radiology Dose: Why Does It Matter? Measuring Exposure and Dose Deterministic Effects Stochastic Effects Common Exams: What is the Risk? Reducing
More informationWhere does the estimate of 29,000 cancers come from? Based on Table 12D from BEIR VII, + risk estimates for 56,900,000 patients
BEIR VII: What It Does and Doesn t Say Michael K O Connor, Ph.D. Dept. of Radiology, Mayo Clinic Using BEIR VII report, estimated radiation-related incident cancers Estimated that 29,000 future cancers
More informationAN INTRODUCTION TO NUCLEAR MEDICINE
AN INTRODUCTION TO NUCLEAR MEDICINE WITH RESPECT TO THYROID DISORDERS By: B.Shafiei MD Nuclear Physician Taleghani Medical Center Radioactive: An element with Unstable Nucleus (Excess Energy), can achieve
More informationBasics of biological effects of ionizing radiation
ANSN Regional Workshop on Medical Response to Radiological Emergency Handling Complex Situations 1-4 October 2013, Chiba, Japan Basics of biological effects of ionizing radiation Hideo Tatsuzaki, M.D.,
More informationRadiation Exposure 1980 to 2006
Radiation Exposure 1980 to 2006 Background 3-6 msv/yr Natural (85% 45%) Radon Cosmic Rays Air travel Living at Altitude Man-made (15% 55%) Medical Imaging** mgy Radiation Therapy cgy Radiation Whole Body
More informationHazard 8: Radiation. Healthy Home Rating System (HHRS)
Hazard 8: Radiation Healthy Home Rating System (HHRS) 2015 1 Description of the Hazard This hazard covers the threats to health caused by exposure to radiation. Radiation is the process of energy emission
More informationRadiation in Everyday Life
Image not found Rincón http://www.rinconeducativo.org/sites/default/files/logo.jpg Educativo Published on Rincón Educativo (http://www.rinconeducativo.org) Inicio > Radiation in Everyday Life Recursos
More informationLaboratory Safety 197/405. Types of Radiation 198/405
Laboratory Safety 197/405 Types of Radiation 198/405 Particle Radiation Alpha He nucleus (heavy particle) +2 charge Internal hazard only Beta Electron -1 charge Internal and external hazard Neutron 199/405
More informationFISH and PNA-FISH. FISH and PNA-FISH. Stochastic effect. Radiation and cancer. 1) chromosome 2) FISH 3) PNA-FISH. Chromosome translocations.
BIODOSIMETRY IN THE 21 st CENTURY Training Meeting HICARE in collaboration with the International Atomic Energy Agency Hiroshima, Japan, June 10-14, 2013. FISH and FISH and Satoshi Tashiro Research Institute
More informationRadia%on and Human Health
Radia%on and Human Health Key Issues in Low Dose Radia%on Exposure for Fukushima Disaster James P. Seward, MD MPP Clinical Professor of Medicine, UCSF Medical Director Lawrence Livermore Na%onal Laboratory
More informationRADIATION AND CANCER 2011
RADIATION AND CANCER 2011 Molecular Oncology Michael Lea RADIATION AND CANCER - LECTURE OUTLINE 1. Types of radiation 2. Irradiation of water 3. Radiation-induced cancer 4. Radiation toxicity 5. Radiation
More informationUnderstanding Radiation and Its Effects
Understanding Radiation and Its Effects Prepared by Brooke Buddemeier, CHP University of California Lawrence Livermore National Laboratory Presented by Jeff Tappen Desert Research Institute 1 Radiation
More informationSTANDARDIZED RADIOGENIC CANCER RISK COEFFICIENTS: A REVIEW OF THE METHODOLOGY PRESENTED IN FEDERAL GUIDANCE REPORT NO. 13
STANDARDIZED RADIOGENIC CANCER RISK COEFFICIENTS: A REVIEW OF THE METHODOLOGY PRESENTED IN FEDERAL GUIDANCE REPORT NO. 13 ABSTRACT Michael Boyd and Christopher Nelson, U.S. Environmental Protection, Office
More informationIonizing Radiation. Nuclear Medicine
Ionizing Radiation Nuclear Medicine Somatic Deterministic Effect Erythema Somatic Stochastic Effect Leukemia Genetic Effects DNA BIOLOGICAL EFFECTS OF IONIZING RADIATION ON TISSUES, ORGANS AND SYSTEMS
More informationIssues to Discuss 2/28/2018. The Adverse Effects of Occupational and Environmental Ionizing Radiation: James Seward, MD MPP. Past, Present, and Future
The Adverse Effects of Occupational and Environmental Ionizing Radiation: Past, Present, and Future James P. Seward, MD MPP FACOEM Clinical Professor of Medicine UCSF Presented at UCSF OEM Conference March
More informationRADIATION BIOLOGY. 1. Radiation Units. 1.1 Absorbed Dose. 1.2 Equivalent Dose
Ing. Daniela Skibová, Ph.D., 1. Radiation Units The biological effect of radiation can be understood in terms of the transfer of energy from the radiation (photons and particles) to the tissue. When the
More informationNuclear Radiation Today
CHAPTER 10 13 SECTION Nuclear Changes Nuclear Radiation Today KEY IDEAS As you read this section, keep these questions in mind: Where are some common sources of radiation? What are some beneficial uses
More informationRADIOLOGY AN DIAGNOSTIC IMAGING
Day 2 p. 1 RADIOLOGY AN DIAGNOSTIC IMAGING Dr hab. Zbigniew Serafin, MD, PhD serafin@cm.umk.pl and Radiation Protection mainly based on: C. Scott Pease, MD, Allen R. Goode, MS, J. Kevin McGraw, MD, Don
More informationTESTIMONY OF John D. Boice, Jr., Sc.D.
TESTIMONY OF John D. Boice, Jr., Sc.D. BEFORE THE HOUSE COMMITTEE ON SCIENCE, SPACE AND TECHNOLOGY'S ENERGY & ENVIRONMENT AND INVESTIGATIONS & OVERSIGHT COMMITTEES HEARING ON NUCLEAR ENERGY RISK MANAGEMENT
More informationCONTENTS NOTE TO THE READER...1 LIST OF PARTICIPANTS...3
CONTENTS NOTE TO THE READER...1 LIST OF PARTICIPANTS...3 PREAMBLE...9 Background...9 Objective and Scope...9 Selection of Topics for Monographs...10 Data for Monographs...11 The Working Group...11 Working
More informationRadon Gas & What You Need to Know. Bob Caskanette, B.A.Sc., CEC, CAQS, CRS, CIEC, C.E.T., EP (C-NRPP Certified) Caskanette Udall Consulting Engineers
Radon Gas & What You Need to Know Bob Caskanette, B.A.Sc., CEC, CAQS, CRS, CIEC, C.E.T., EP (C-NRPP Certified) Caskanette Udall Consulting Engineers What is Radon? Naturally occurring radioactive soil
More informationA PROBLEM OF LOW DOSE EFFECTS:
Nuclear Free Now Global Conference Tokyo, Japan, December 14, 2012 A PROBLEM OF LOW DOSE EFFECTS: The Inadequacy of the Official Concept of Radiation Safety Alexey Yablokov Russian Academy of Science,
More informationRadon in Chelsea. September 2014 Louis-Marie Poissant, M. Sc. Env.
Radon in Chelsea September 2014 Louis-Marie Poissant, M. Sc. Env. Outline 1. Understanding radon 2. Health risks related to radon 3. Cancer and probability 4. Importance of taking long term measurements
More informationLOW DOSES OF RADIATION REDUCE RISK IN VIVO
Dose-Response: An International Journal Volume 5 Issue 1 ADAPTIVE BIOLOGICAL RESPONSES FOLLOWING EXPOSURES TO IONIZING RADIATION Article 4 3-2007 LOW DOSES OF RADIATION REDUCE RISK IN VIVO REJ Mitchel
More information