2-Amino-4-nitrophenol (cas ) MSDS

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1 Click for suppliers of this product 2-Amino-4-nitrophenol (cas ) MSDS MSDS : Phenol, 2-amino-4-nitro- CAS : SYNONYMS : * 1-Amino-2-hydroxy-5-nitrobenzene * 3-Amino-4-hydroxynitrobenzene * 2-Amino-4-nitrofenol * 2-Amino-4-nitrophenol * 1-Hydroxy-2-amino-4-nitrobenzene * 2-Hydroxy-5-nitroaniline * NCI-C55958 * p-nitroaminofenol * 4-Nitro-2-aminofenol * p-nitro-o-aminophenol * 4-Nitro-2-aminophenol * Rodol 42 Catalog of Chemical Suppliers, Buyers, Custom Synthesis Companies And Equipment Manufacturers [ Phenol, 2-amino-4-nitro ] *** CHEMICAL IDENTIFICATION *** RTECS NUMBER CHEMICAL NAME : SJ : Phenol, 2-amino-4-nitro- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : REFERENCE : (Beilstein Handbook Reference) LAST UPDATED : DATA ITEMS CITED : 25 MOLECULAR FORMULA : C6-H6-N2-O3 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : ZR BQ ENW COMPOUND DESCRIPTOR : Tumorigen Mutagen Primary Irritant SYNONYMS/TRADE NAMES : * 1-Amino-2-hydroxy-5-nitrobenzene * 3-Amino-4-hydroxynitrobenzene

2 * 2-Amino-4-nitrofenol * 2-Amino-4-nitrophenol * 1-Hydroxy-2-amino-4-nitrobenzene * 2-Hydroxy-5-nitroaniline * NCI-C55958 * p-nitroaminofenol * 4-Nitro-2-aminofenol * p-nitro-o-aminophenol * 4-Nitro-2-aminophenol * Rodol 42 *** HEALTH HAZARD DATA *** ** SKIN/EYE IRRITATION DATA ** REACTION SEVERITY : Standard Draize test : Administration into the eye : Rodent - rabbit : 100 mg/24h : Moderate 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,674,1986 ** ACUTE TOXICITY DATA ** : 2400 mg/kg Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, For publisher information, see FCTOD7. Volume(issue)/page/year: 15,607,1977 : Intraperitoneal : 246 mg/kg

3 Details of toxic effects not reported other than lethal dose value JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V /76- Volume(issue)/page/year: 2,657,1977 : 850 mg/kg Details of toxic effects not reported other than lethal dose value GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, Moscow, USSR) V.1-36, For publisher information, see MTPEEI Volume(issue)/page/year: 25(8),50,1981 : Intraperitoneal : 143 mg/kg Details of toxic effects not reported other than lethal dose value GPOLA4 Genetica Polonica. (Ars Polona, POB 1001, Warsaw 1, Poland) V Volume(issue)/page/year: 26,109,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA ** : mg/kg/15d-i : mg/kg/13w-i

4 liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) : mg/kg/15d-i : 65 mg/kg/13w-i Liver - changes in liver weight ** TUMORIGENIC DATA ** : mg/kg/2y-c Tumorigenic - neoplastic by RTECS criteria Endocrine - tumors

5 ** MUTATION DATA ** : Mutation in microorganisms : Bacteria - Salmonella typhimurium : 20 ug/plate CMMUAO Chemical Mutagens. Principles and Methods for Their Detection. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V Volume(issue)/page/year: 8,151,1983 : Mutation in microorganisms : Bacteria - Salmonella typhimurium : 100 ug/plate PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V Volume(issue)/page/year: 72,2423,1975 : Phage inhibition capacity : Bacteria - Escherichia coli : 100 mmol/l MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see EXMMAV. (Ars Polona, POB 1001, Warsaw 1, Poland) V Volume(issue)/page/year: 31,11,1979 : Cytogenetic analysis : Rodent - hamster Ovary : 249 mg/l : Sister chromatid exchange : Rodent - hamster Ovary : 5 mg/l *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence

6 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V Volume(issue)/page/year: 57,167,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V Volume(issue)/page/year: 57,167,1993 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V Volume(issue)/page/year: 57,167,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0280 No. of Facilities: 2232 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: (estimated) No. of Female Employees: (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; N crassa-aneuploidy EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NTP Carcinogenesis Studies (gavage);some evidence:rat Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-339,88 NTP Carcinogenesis Studies (gavage);no evidence:mouse Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-339,88

7 *** END OF RECORD ***

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