Mir-138-5p acts as a tumor suppressor by targeting pyruvate dehydrogenase kinase 1 in human retinoblastoma
|
|
- Maximillian Park
- 5 years ago
- Views:
Transcription
1 European Review for Medical and Pharmacological Sciences 2017; 21: Mir-138-5p acts as a tumor suppressor by targeting pyruvate dehydrogenase kinase 1 in human retinoblastoma Z. WANG 1, Y.-J. YAO 1, F. ZHENG 1, Z. GUAN 1, L. ZHANG 1, N. DONG 2, W.-J. QIN 3 1 Department of Ophthalmology, Fuzhou Second Hospital, Fujian, China 2 Corneal Disease Clinic, Xiamen Eye Center Affiliated Xiamen University, Fujian, China 3 Department of Radiation Oncology, Zhongshan Hospital Affiliated Xiamen University, Fujian, China Abstract. OBJECTIVE: MicroRNAs have caught more attention for their role in tumor progression. Retinoblastoma (RB) is one of these ordinary malignant tumors. This study aims to identify whether mir-138-5p can regulate the development of RB, and find out its potential mechanism. MATERIALS AND METHODS: Mir-138-5p expression in RB cells was monitored by RT-qPCR. Besides, the role of mir-138-5p in RB development was explored through function experiments in vitro. The potential mechanism was further explored by RT-qPCR, luciferase assay, and Western blot assay. RESULTS: In our investigation, mir-138-5p was lower-expressed in RB cells than that in retinal pigment epithelial cells. Moreover, overexpression of mir-138-5p repressed cell viability, migration and invasion, and induced apoptosis of RB cells, while downregulated mir-138-5p increased cell viability, migration and invasion, and reduced apoptosis of RB cells. Furthermore, pyruvate dehydrogenase kinase 1 (PDK1) could be downregulated via overexpression of mir-138-5p, while PDK1 was upregulated via knockdown of mir-138-5p. CONCLUSIONS: Our results suggested that mir-138-5p could repress the development of RB via suppressing PDK1, which may offer a new vision for interpreting the mechanism of RB tumorigenesis. Key Words: MicroRNA, mir-138-5p, Retinoblastoma, PDK1. Introduction Retinoblastoma (RB) is a rare human malignant tumor. The incidence of RB accounts for most of children s intraocular tumors in the whole world 1. Although effective therapy is available for RB patients, children with RB have greater life-threatening risks 2. Therefore, it is urgent to find more potential regulators and targets for treatment of RB. Recently, aberrant non-coding RNAs expression is identified in most cancers and closely associated with patients prognosis. Moreover, mounting evidence indicates that micrornas contribute to regulating oncogene expression, which further acts on progression of malignant cancers, including RB 3-5. Accumulating evidence demonstrates that mir-138-5p participates in tumor carcinogenesis. Mir-138-5p knockdown promotes cell growth and invaded ability via suppressing survivin in bladder cancer 6. By targeting GPR124 in non-small cell lung cancer, mir-138-5p could reverse resistance to gefitinib 7. Moreover, mir-138-5p can inhibit autophagy via suppressing SIRT1 in pancreatic carcinoma 8. Mir-138-5p contributes to suppressing development and metastasis of colorectal carcinoma via targeting PD-L1 9. However, it remains unclear how mir-138-5p regulates the tumorigenesis of RB. Our present study firstly revealed a lower expression of mir-138-5p in RB cells. Besides, overexpressed mir-138-5p could repressed cell viability, invasion and migration, and induced cell apoptosis of RB in vitro. Further researches showed that pyruvate dehydrogenase kinase 1 (PDK1) could be a potential target spot of mir-138-5p. Materials and Methods Cell Lines The Institute of Biochemistry and Cell Biology, Chinese Academy of Science (Shanghai, China) provided us with RB cell line Y79 and retinal pigment epithelial cell line ARPE-19. Culture medium was consisted of penicillin, 10% fetal bovine serum (FBS, Invitrogen Life Technologies, Carlsbad, CA, USA) and Dulbecco s Modified Eagle Medium (DMEM, Thermo Fisher Scienti Corresponding Author: Nuo Dong, Ph.D; wangzhfz@126.com; Wenjuan Qin, Ph.D; proftomato@163.com
2 Mir-138-5p in retinoblastoma fic, Waltham, MA, USA). Besides, cells were cultured in humidified incubator, which contained 5% CO 2 and was set at 37 C. The mirna mimics and inhibitor provided by Genepharma Co., Ltd. (Shanghai, China) were used for transfection of RB cells. Negative control (NC) was transfected non-specific sirna. Quantitative RT-PCR Firstly, total RNA was separated with TRIzol reagent (Invitrogen, Carlsbad, CA, USA). Then, RNA was reverse-transcribed to cdnas via reverse Transcription Kit (TaKaRa, Dalian, China). Quantitative reverse transcriptase-polymerase chain reaction (qrt-pcr) was performed on ABI 7500 RT PCR detection system (Applied Biosystems, Foster City, CA, USA). The thermal cycle was as follows: 30 s at 95 C, 5 s at 95 C for 40 cycles, 35 s at 60 C. Western Blot Reagent radioimmunoprecipitation assay (RIPA) (Beyotime, Shanghai, China) was utilized to extract protein from cells. Bicinchoninic acid (BCA) protein assay kit (TaKaRa, Dalian, China) was chosen for quantifying protein concentrations. The target proteins were separated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). Next, they were transformed onto the polyvinylidene fluoride (PVDF) membrane and incubated with antibodies. Cell Signaling Technology (CST, Beverly, MA, USA) provided us with rabbit anti-pdk1 and rabbit anti-gapdh, as well as goat anti-rabbit secondary antibody. Chemiluminescent film was applied for assessment of protein expression with ImageJ software. Luciferase Assays The 3ʹ-UTR of PDK1 was cloned into the pgl3 vector (Promega, Madison, WI, USA) named wild-type (WT) 3 -UTR. Site-directed mutagenesis of the mir-138-5p binding site in PDK1 3 -UTR named mutant (MUT) 3ʹ-UTR was conducted with quick-change site-directed mutagenesis kit (Stratagene, Cedar Creek, TX, USA). Y79 RB cells were infected with WT-3 -UTR or MUT-3ʹ-UTR for 48 h and were performed on the dual Luciferase reporter assay system (Promega, Madison, WI, USA). Cell Counting Kit-8 (CCK8) Assay Cell viability of theses treated cells in 96- well plates was monitored every 24 h by CCK8 assay following the protocol (Dojindo Molecular Technologies, Inc. Kumamoto, Japan). The absorbance was measured at 450 nm on the spectrophotometer (Thermo Fisher Scientific, Waltham, MA, USA). Wound Healing Assay Cells were cultured in DMEM medium in 6-well plates overnight. After scratched with a plastic tip, cells were cultured in serum-free DMEM. Wound closure was viewed at different time points. Each assay was independently repeated in triplicate. Matrigel Assay To detect the invasion of RB cells, cells in 200 µl serum-free DMEM were transformed to the top chamber of an insert (8 μm pore size; Millipore, Billerica, MA, USA) coated with 50 µg Matrigel (BD Biosciences, San Jose, CA, USA). The bottom chamber was added with DMEM medium (10% FBS). 48 h later, top surface of chambers was wiped by cotton swab, immersed for 10 min with precooling and stained in crystal violet for 30 min. The data for invasion were counted from three fields per membrane. Statistical Analysis SPSS 21.0 (SPSS Inc., Armonk, NY, USA) was used in our study. Student t-text was selected. We present data as mean ± SD. All experiments were repeated three times. p values < 0.05 were considered statistically significant. Results Downregulated mir-138-5p in RB Cells Firstly, RT-qPCR was conducted for detecting mir-138-5p level in RB cell Y79 and retinal pigment epithelial cell line ARPE-19. As the result, mir-138-5p was significantly lower in Y79 compared with ARPE-19 (Figure 1A). Mir-138-5p Suppresses Cell Viability and Promoted RB cell Apoptosis Firstly, Y79 cells were infected with mir-138-5p mimics and inhibitor. Then the mir-138-5p level in treated cells was detected by qrt-pcr (Figure 1B and Figure 1C). The cell viability was examined by CCK8 assay. As the result, mir-138-5p mimics significantly reduced cell viability (Figure 2A) and mir-138-5p inhibitor significantly prompted cell viability (Figure 2B). Additional- 5625
3 Z. Wang, Y.-J. Yao, F. Zheng, Z. Guan, L. Zhang, N. Dong, W.-J. Qin Figure 1. Mir-138-5p expression level in RB cells. (A) mir-138-5p expression was significantly decreased in the RB cells (Y79) compared with retinal pigment epithelial cell line (ARPE-19). (B) The mir-138-5p expression level in cells transfected with mir-138-5p mimics and negative control was determined by qrt PCR. (C) The mir-138-5p expression level in cells transfected with mir-138-5p inhibitor and negative control was determined by qrt PCR. * p<0.05; ** p<0.01. ly, apoptosis assay was performed to detect cell apoptosis of Y79 cells. We found that mir-138-5p mimics increased apoptosis rate while mir-138-5p inhibitor reduced apoptosis rate in Y79 cells (Figure 2C and 2D). Mir-138-5p Suppresses Migrated and Invaded Ability of RB Cells The migration in mir-138-5p mimics cells was decreased (Figure 3A) and the migration in mir p inhibitor cells was increased (Figure 3B). Figure 2. Mir-138-5p suppressed cell viability and promoted apoptosis of RB cell. (A) mir-138-5p mimics significantly reduced cell viability compared with negative control. (B) mir-138-5p inhibitor significantly prompted cell viability compared with negative control. (C) Apoptosis assay showed that the apoptosis rate of cells transfected with mir-138-5p mimics was increased compared with those transfected with negative control. (D) Apoptosis assay showed that the apoptosis rate of cells transfected with mir-138-5p inhibitor was decreased compared with those transfected with negative control. Matrigel assay demonstrated that numbers of invading cells were reduced in pcdna-mir-138-5p cells compared with EV cells. The results represent the average of three independent experiments (mean ± standard error of the mean); *p<
4 Mir-138-5p in retinoblastoma Figure 3. Mir-138-5p suppressed cell migration and invasion of RB cells. (A) The migration in mir-138-5p mimics cells was decreased compared with negative control cells. (B) The migration in mir-138-5p inhibitor cells was increased compared with negative control cells. (C) Matrigel assay demonstrated that numbers of invading cells were reduced in mir-138-5p mimics cells compared with negative control cells. (D) Numbers of invading cells were increased in mir-138-5p inhibitor cells compared with negative control cells. *p<0.05. Besides, matrigel assay showed that numbers of invading cells were reduced in mir-138-5p mimics cells compared with negative control cells (Figure 3C). Numbers of invading cells were more in mir p mimics cells (Figure 3D). Correlation Between PDK1 and mir-138-5p To further understand how mir-138-5p participated in RB development, we searched the mir- NAs that contained mir-138-5p binding site by Starbase v2.0. The search results demonstrated that PDK1 was one of those candidate targets (Figure 4A). The luciferase assay revealed that Y79 cells transfected with WT-PDK1-3 -UTR had less luciferase activity than other groups (Figure 4B). Western blot assay showed that PDK1 could be suppressed at protein level by mir-138-5p mimics, and PDK1 could be upregulated at protein level by mir-138-5p inhibitor (Figure 4C and Figure 4D). PDK1 was upregulated in RB cells (Figure 4E). Discussion RB, as a rare malignant tumor, frequently happens in childhood. Recently, micrornas participate in development and metastasis of RB. For example, mir-497 suppresses proliferation and metastasis of human retinoblastoma cells via targeting VEGF 10. Moreover, mir-320 inhibits RB progression via repressing specificity protein In addition, microrna-34a, MicroRNA-183 and some other micrornas also play important role in the development of RB 12,13. Thus, more and more effort for exploring the function of micror- NAs in RB is really urgent. MicroRNAs, which are less than 20 bp in length, usually take effect by targeting the 3 - UTR section of genes 14. Then, the target genes will be degraded and the function will be lost. So, micrornas could affect diverse function of tumors, such as migration, proliferation, invasion, cell cycle, cell apoptosis and so on 15. This inspires us to make more efforts to explore the function of mirnas. In our study, mir-138-5p was lowly expressed in RB cells. Furthermore, the cell viability, migrated and invaded ability was inhibited and cell apoptosis was suppressed in RB cells after mir-138-5p was overexpressed. Data above suggested that mir-138-5p suppresses the progression and tumorigenesis of RB. Accumulating evidence revealed that PDK1 acts as an oncogene and in- 5627
5 Z. Wang, Y.-J. Yao, F. Zheng, Z. Guan, L. Zhang, N. Dong, W.-J. Qin Figure 4. Correlation between PDK1 and mir-138-5p in RB cells. (A) PDK1 was a possible target of mir-138-5p. (B) Luciferase assay revealed that Y79 cells transfected with WT-PDK1-3 -UTR and mir-138-5p had less luciferase activity than other groups. PDK1 was higher expressed in RB cell lines compared with 16HBE cells. (C) Western blot assay showed that PDK1 was downregulated at protein level after cells were transfected with mir-138-5p mimics. (D) Western blot assay showed that PDK1 was upregulated at protein level after cells were transfected with mir-138-5p inhibitor. (E) PDK1 was significantly higher expressed in RB cells (Y79) compared with retinal pigment epithelial cell line (ARPE-19). *p<0.05. duces tumor genesis of cancers. For instance, expression level of PDK1 is correlated to poor prognosis of hepatocellular cancer 16. PDK1 downregulated by mircrorna-379 suppresses tumor development of osteosarcoma 17. Moreover, PDK1, as a critical regulator of PDK1/Akt/NF-kappa B axis, can be repressed by mir-128b and further regulates cell proliferation of gastric cancer 18. In ovarian serous cancer, PDK1 is associated with better survival 19. Moreover, PDK1 emerges as an oncogene in lung cancer through enhancing Warburg effect 20. Besides, animal experiments reveal that PDK1 is associated with aggressiveness of bladder cancer mouse. A recent report 21 showed that upregulated PDK1 was discovered in RB and may be a potential therapeutic target. In our study, overexpression of mir-138-5p downregulated PDK1 in RB cells. Conclusions Downregulated mir-138-5p was firstly discovered in RB cells. Besides, overexpressed mir p could inhibit development and metastasis of RB through regulating PDK1. These findings implied that mir-138-5p could be a prospective therapeutic target for RB. Acknowledgements This study was supported by National Natural Science Foundation of China (No ), Xiamen Science and Technology Plan Projects (No. 3502Z ), Natural Science Foundation of Fujian Province of China (No. 2017J01331; No ZQN-ZD-34 and 2016D013) and Huaxia Translation Medicine funding (No A-02). Conflict of Interest The Authors declare that they have no conflict of interest. References 1) Zhou D, Liu P, Sun DW, Chen ZJ, Hu J, Peng SM, Liu YL. USP22 down-regulation facilitates human retinoblastoma cell aging and apoptosis via inhibiting TERT/P53 pathway. Eur Rev Med Pharmacol Sci 2017; 21: ) Yang Q, Tripathy A, Yu W, Eberhart CG, Asnaghi L. Hypoxia inhibits growth, proliferation, and increases response to chemotherapy in retinoblastoma cells. Exp Eye Res 2017; 162: ) Wei D, Yang L, Lv B, Chen L. Genistein suppresses retinoblastoma cell viability and growth and induces apoptosis by upregulating mir-145 and inhibiting its target ABCE1. Mol Vis 2017; 23: ) Xin ZC, Yang HQ, Wang XW, Zhang Q. Diagnostic value of micrornas in breast cancer: a meta-analysis. Eur Rev Med Pharmacol Sci 2017; 21:
6 Mir-138-5p in retinoblastoma 5) Huang W, Cui X, Chen J, Feng Y, Song E, Li J, Liu Y. Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition. Oncotarget 2016; 7: ) Yang R, Liu M, Liang H, Guo S, Guo X, Yuan M, Lian H, Yan X, Zhang S, Chen X, Fang F, Guo H, Zhang C. MiR-138-5p contributes to cell proliferation and invasion by targeting Survivin in bladder cancer cells. Mol Cancer 2016; 15: 82. 7) Gao Y, Fan X, Li W, Ping W, Deng Y, Fu X. MiR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124. Biochem Biophys Res Commun 2014; 446: ) Tian S, Guo X, Yu C, Sun C, Jiang J. MiR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1. Oncotarget 2017; 8: ) Zhao L, Yu H, Yi S, Peng X, Su P, Xiao Z, Liu R, Tang A, Li X, Liu F, Shen S. The tumor suppressor mir p targets PD-L1 in colorectal cancer. Oncotarget 2016; 7: ) Li J, Zhang Y, Wang X, Zhao R. MicroRNA-497 overexpression decreases proliferation, migration and invasion of human retinoblastoma cells via targeting vascular endothelial growth factor a. Oncol Lett 2017; 13: ) Zhao Y, Zhang S, Zhang Y. MicroRNA-320 inhibits cell proliferation, migration and invasion in retinoblastoma by targeting specificity protein 1. Mol Med Rep 2017; 16: ) Dalgard CL, Gonzalez M, DeNiro JE, O Brien JM. Differential microrna-34a expression and tumor suppressor function in retinoblastoma cells. Invest Ophthalmol Vis Sci 2009; 50: ) Wang J, Wang X, Li Z, Liu H, Teng Y. MicroRNA-183 suppresses retinoblastoma cell growth, invasion and migration by targeting LRP6. FEBS J 2014; 281: ) Beermann J, Piccoli MT, Viereck J, Thum T. Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches. Physiol Rev 2016; 96: ) Rupaimoole R, Calin GA, Lopez-Berestein G, Sood AK. MiRNA deregulation in cancer cells and the tumor microenvironment. Cancer Discov 2016; 6: ) Wang J, Liu F, Ao P, Li X, Zheng H, Wu D, Zhang N, She J, Yuan J, Wu X. Correlation of PDK1 expression with clinicopathologic features and prognosis of hepatocellular carcinoma. Onco Targets Ther 2016; 9: ) Li Z, Shen J, Chan MT, Wu WK. MicroRNA-379 suppresses osteosarcoma progression by targeting PDK1. J Cell Mol Med 2017; 21: ) Zhang L, Lei J, Fang ZL, Xiong JP. MiR-128b is down-regulated in gastric cancer and negatively regulates tumour cell viability by targeting PDK1/Akt/NF-kappaB axis. J Biosci 2016; 41: ) Lohneis P, Darb-Esfahani S, Dietel M, Braicu I, Sehouli J, Arsenic R. PDK1 is expressed in ovarian serous carcinoma and correlates with improved survival in high-grade tumors. Anticancer Res 2015; 35: ) Liu T, Yin H. PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer. Oncol Rep 2017; 37: ) Sradhanjali S, Tripathy D, Rath S, Mittal R, Reddy MM. Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: a potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions. PLoS One 2017; 12: e
Long noncoding RNA CASC2 inhibits metastasis and epithelial to mesenchymal transition of lung adenocarcinoma via suppressing SOX4
European Review for Medical and Pharmacological Sciences 2017; 21: 4584-4590 Long noncoding RNA CASC2 inhibits metastasis and epithelial to mesenchymal transition of lung adenocarcinoma via suppressing
More informationLong noncoding RNA linc-ubc1 promotes tumor invasion and metastasis by regulating EZH2 and repressing E-cadherin in esophageal squamous cell carcinoma
JBUON 2018; 23(1): 157-162 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE Long noncoding RNA linc-ubc1 promotes tumor invasion and metastasis
More informationCircHIPK3 is upregulated and predicts a poor prognosis in epithelial ovarian cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 3713-3718 CircHIPK3 is upregulated and predicts a poor prognosis in epithelial ovarian cancer N. LIU 1, J. ZHANG 1, L.-Y. ZHANG 1, L.
More informationLong noncoding RNA DARS-AS1 acts as an oncogene by targeting mir-532-3p in ovarian cancer
European Review for Medical and Pharmacological Sciences 2019; 23: 2353-2359 Long noncoding RNA DARS-AS1 acts as an oncogene by targeting mir-532-3p in ovarian cancer K. HUANG, W.-S. FAN, X.-Y. FU, Y.-L.
More informationLow levels of serum mir-99a is a predictor of poor prognosis in breast cancer
Low levels of serum mir-99a is a predictor of poor prognosis in breast cancer J. Li 1, Z.J. Song 2, Y.Y. Wang 1, Y. Yin 1, Y. Liu 1 and X. Nan 1 1 Tumor Research Department, Shaanxi Provincial Tumor Hospital,
More informationDecreased expression of mir-490-3p in osteosarcoma and its clinical significance
European Review for Medical and Pharmacological Sciences Decreased expression of mir-490-3p in osteosarcoma and its clinical significance B. TANG, C. LIU, Q.-M. ZHANG, M. NI Department of Orthopedics,
More informationMir-595 is a significant indicator of poor patient prognosis in epithelial ovarian cancer
European Review for Medical and Pharmacological Sciences 2017; 21: 4278-4282 Mir-595 is a significant indicator of poor patient prognosis in epithelial ovarian cancer Q.-H. ZHOU 1, Y.-M. ZHAO 2, L.-L.
More informationOriginal Article High serum mir-203 predicts the poor prognosis in patients with pancreatic cancer
Int J Clin Exp Pathol 2017;10(4):4688-4693 www.ijcep.com /ISSN:1936-2625/IJCEP0047128 Original Article High serum mir-203 predicts the poor prognosis in patients with pancreatic cancer Jun Ma, Xiaokun
More informationDownregulation of serum mir-17 and mir-106b levels in gastric cancer and benign gastric diseases
Brief Communication Downregulation of serum mir-17 and mir-106b levels in gastric cancer and benign gastric diseases Qinghai Zeng 1 *, Cuihong Jin 2 *, Wenhang Chen 2, Fang Xia 3, Qi Wang 3, Fan Fan 4,
More informationBerberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through mir-93/ PTEN/Akt Signaling Pathway
Chen Accepted: et al.: February Berberine 24, Sensitizes 2015 Ovarian Cancer Cells to Cisplatin www.karger.com/cpb 956 1421-9778/15/0363-0956$39.50/0 Original Paper This is an Open Access article licensed
More informationExpression of lncrna TCONS_ in hepatocellular carcinoma and its influence on prognosis and survival
European Review for Medical and Pharmacological Sciences 2017; 21: 5655-5660 Expression of lncrna TCONS_00027978 in hepatocellular carcinoma and its influence on prognosis and survival Q. CHEN 1, G.-D.
More informationmir-542-3p targets sphingosine-1-phosphate receptor 1 and regulates cell proliferation and invasion of breast cancer cells
European Review for Medical and Pharmacological Sciences 2017; 21: 108-114 mir-542-3p targets sphingosine-1-phosphate receptor 1 and regulates cell proliferation and invasion of breast cancer cells H.-X.
More informationMicroRNA-590-5p suppresses the proliferation and invasion of non-small cell lung cancer by regulating GAB1
European Review for Medical and Pharmacological Sciences 2018; 22: 5954-5963 MicroRNA-590-5p suppresses the proliferation and invasion of non-small cell lung cancer by regulating GAB1 B.-B. XU 1, Z.-F.
More informationOverexpression of long-noncoding RNA ZFAS1 decreases survival in human NSCLC patients
European Review for Medical and Pharmacological Sciences 2016; 20: 5126-5131 Overexpression of long-noncoding RNA ZFAS1 decreases survival in human NSCLC patients F.-M. TIAN 1, F.-Q. MENG 2, X.-B. WANG
More informationmir-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN
mir-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN J.W. Ling 1, P.R. Lu 2, Y.B. Zhang 1, S. Jiang 1 and Z.C. Zhang 1 1 Department of Ophthalmology, Third Hospital of Zhangjiagang,
More informationCircular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis
European Review for Medical and Pharmacological Sciences 2018; 22: 7178-7182 Circular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis T. ZOU, P.-L. WANG, Y.
More informationLncRNA LET function as a tumor suppressor in breast cancer development
European Review for Medical and Pharmacological Sciences 2018; 22: 6002-6007 LncRNA LET function as a tumor suppressor in breast cancer development C.-X. ZHOU, X. WANG, N. YANG, S.-K. XUE, W.-C. LI, P.-P.
More informationExpression of mir-1294 is downregulated and predicts a poor prognosis in gastric cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 5525-5530 Expression of mir-1294 is downregulated and predicts a poor prognosis in gastric cancer Y.-X. SHI, B.-L. YE, B.-R. HU, X.-J.
More informationmir 375 inhibits the proliferation of gastric cancer cells by repressing ERBB2 expression
EXPERIMENTAL AND THERAPEUTIC MEDICINE 7: 1757-1761, 2014 mir 375 inhibits the proliferation of gastric cancer cells by repressing ERBB2 expression ZHI YONG SHEN *, ZI ZHEN ZHANG *, HUA LIU, EN HAO ZHAO
More informationExpression of long non-coding RNA linc-itgb1 in breast cancer and its influence on prognosis and survival
European Review for Medical and Pharmacological Sciences 2017; 21: 3397-3401 Expression of long non-coding RNA linc-itgb1 in breast cancer and its influence on prognosis and survival W.-X. LI 1, R.-L.
More informationAssociation between downexpression of mir-1301 and poor prognosis in patients with glioma
European Review for Medical and Pharmacological Sciences 2017; 21: 4298-4303 Association between downexpression of mir-1301 and poor prognosis in patients with glioma Q.-L. BAI, C.-W. HU, X.-R. WANG, G.-F.
More informationONCOLOGY LETTERS 15: , 2018
10098 MicroRNA 154 functions as a tumor suppressor in non small cell lung cancer through directly targeting B cell specific Moloney murine leukemia virus insertion site 1 SIDA LIU 1, YANG YANG 2, LU CHEN
More informationAdvances in Computer Science Research, volume 59 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
7th International Conference on Education, Management, Computer and Medicine (EMCM 2016) Expression of Beta-Adrenergic Receptor in Glioma LN229 Cells and Its Effect on Cell Proliferation Ping Wang1, Qingluan
More informationOriginal Article Reduced expression of mir-506 in glioma is associated with advanced tumor progression and unfavorable prognosis
Int J Clin Exp Pathol 2016;9(1):181-185 www.ijcep.com /ISSN:1936-2625/IJCEP0017823 Original Article Reduced expression of mir-506 in glioma is associated with advanced tumor progression and unfavorable
More information95% CI: , P=0.037).
Biomedical Research 2017; 28 (21): 9248-9252 Reduced expression level of mir-205 predicts poor prognosis in Qiang Yang 1*#, Peng Sun 2#, Haotian Feng 1, Xin Li 1, Jianmin Li 1 1 Department of Orthopedics,
More informationMicroRNA-132 inhibits migration, invasion and epithelial-mesenchymal transition by regulating TGFβ1/Smad2 in human non-small cell lung cancer
European Review for Medical and Pharmacological Sciences MicroRNA-132 inhibits migration, invasion and epithelial-mesenchymal transition by regulating TGFβ1/Smad2 in human non-small cell lung cancer J.-X.
More informationmir-132 inhibits lung cancer cell migration and invasion by targeting SOX4
Original Article inhibits lung cancer cell migration and invasion by targeting SOX4 Yang Li, Lingling Zu, Yuli Wang, Min Wang, Peirui Chen, Qinghua Zhou Tianjin Key Laboratory of Lung Cancer Metastasis
More informationPrognostic significance of overexpressed long non-coding RNA TUG1 in patients with clear cell renal cell carcinoma
European Review for Medical and Pharmacological Sciences 2017; 21: 82-86 Prognostic significance of overexpressed long non-coding RNA TUG1 in patients with clear cell renal cell carcinoma P.-Q. WANG, Y.-X.
More informationOriginal Article MicroRNA-27a acts as a novel biomarker in the diagnosis of patients with laryngeal squamous cell carcinoma
Int J Clin Exp Pathol 2016;9(2):2049-2053 www.ijcep.com /ISSN:1936-2625/IJCEP0014841 Original Article MicroRNA-27a acts as a novel biomarker in the diagnosis of patients with laryngeal squamous cell carcinoma
More informationDownregulation of long non-coding RNA LINC01133 is predictive of poor prognosis in colorectal cancer patients
European Review for Medical and Pharmacological Sciences 2017; 21: 2103-2107 Downregulation of long non-coding RNA LINC01133 is predictive of poor prognosis in colorectal cancer patients J.-H. ZHANG 1,
More informationKnockdown of long noncoding RNA linc-it- GB1 suppresses migration, invasion of hepatocellular carcinoma via regulating ZEB1
European Review for Medical and Pharmacological Sciences 2017; 21: 5089-5095 Knockdown of long noncoding RNA linc-it- GB1 suppresses migration, invasion of hepatocellular carcinoma via regulating ZEB1
More informationEffect of lncrna LET on proliferation and invasion of osteosarcoma cells
European Review for Medical and Pharmacological Sciences 2018; 22: 1609-1614 Effect of lncrna LET on proliferation and invasion of osteosarcoma cells G. KONG 1, X.-J. QI 2, J.-F. WANG 3 1 Department of
More informationOriginal Article B7-H3 repression by mir-539 suppresses cell proliferation in human gliomas
Int J Clin Exp Pathol 2017;10(4):4363-4369 www.ijcep.com /ISSN:1936-2625/IJCEP0043994 Original Article B7-H3 repression by mir-539 suppresses cell proliferation in human gliomas Rong-Gang Li 1, Zhuo Gao
More informationOriginal Article Tissue expression level of lncrna UCA1 is a prognostic biomarker for colorectal cancer
Int J Clin Exp Pathol 2016;9(4):4241-4246 www.ijcep.com /ISSN:1936-2625/IJCEP0012296 Original Article Tissue expression level of lncrna UCA1 is a prognostic biomarker for colorectal cancer Hong Jiang,
More informationOriginal Article Increased LincRNA ROR is association with poor prognosis for esophageal squamous cell carcinoma patients
Int J Clin Exp Pathol 2017;10(4):4654-4660 www.ijcep.com /ISSN:1936-2625/IJCEP0048142 Original Article Increased LincRNA ROR is association with poor prognosis for esophageal squamous cell carcinoma patients
More informationLncRNA RGMB-AS1 is activated by E2F1 and promotes cell proliferation and invasion in papillary thyroid carcinoma
European Review for Medical and Pharmacological Sciences 2018; 22: 1979-1986 LncRNA RGMB-AS1 is activated by E2F1 and promotes cell proliferation and invasion in papillary thyroid carcinoma Z. ZHANG 1,
More informationLncRNA NKILA suppresses colon cancer cell proliferation and migration by inactivating PI3K/Akt pathway
Original Article LncRNA NKILA suppresses colon cancer cell proliferation and migration by inactivating PIK/Akt pathway Jian Huang #, Lingfeng Zhao #, Wei Chen #, Jian Duan 4, Dibesh Shrestha, Ruize Zhou,
More informationmir-135a inhibits glioma cell proliferation and invasion by directly targeting FOXO1
European Review for Medical and Pharmacological Sciences 2018; 22: 4215-4223 mir-135a inhibits glioma cell proliferation and invasion by directly targeting FOXO1 H.-Z. SHI 1, D.-N. WANG 2, F. XU 3, J.-H.
More informationmir-218 tissue expression level is associated with aggressive progression of gastric cancer
mir-218 tissue expression level is associated with aggressive progression of gastric cancer X.X. Wang 1, S.J. Ge 2, X.L. Wang 2, L.X. Jiang 1, M.F. Sheng 2 and J.J. Ma 2 1 Department of General Surgery,
More informationUp-regulation of long non-coding RNA BCAR4 predicts a poor prognosis in patients with osteosarcoma, and promotes cell invasion and metastasis
European Review for Medical and Pharmacological Sciences 2016; 20: 4445-4451 Up-regulation of long non-coding RNA BCAR4 predicts a poor prognosis in patients with osteosarcoma, and promotes cell invasion
More informationmir-19a promotes invasion and epithelial to mesenchymal transition of bladder cancer cells by targeting RhoB
JBUON 2019; 24(2): 797-804 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE mir-19a promotes invasion and epithelial to mesenchymal transition of
More informationExpression of mir-146a-5p in patients with intracranial aneurysms and its association with prognosis
European Review for Medical and Pharmacological Sciences 2018; 22: 726-730 Expression of mir-146a-5p in patients with intracranial aneurysms and its association with prognosis H.-L. ZHANG 1, L. LI 2, C.-J.
More informationLong non-coding RNA XLOC_ correlates with poor prognosis and promotes tumorigenesis of hepatocellular carcinoma
European Review for Medical and Pharmacological Sciences 2017; 21: 4867-4874 Long non-coding RNA XLOC_010235 correlates with poor prognosis and promotes tumorigenesis of hepatocellular carcinoma F. YANG,
More informationMiR-508-5p is a prognostic marker and inhibits cell proliferation and migration in glioma
European Review for Medical and Pharmacological Sciences MiR-508-5p is a prognostic marker and inhibits cell proliferation and migration in glioma Y.-H. LIU 1, B. LI 1, F.-G. MENG 1, L. QIU 2 2017; 21:
More informationUp-regulation of long non-coding RNA SNHG6 predicts poor prognosis in renal cell carcinoma
European Review for Medical and Pharmacological Sciences 2018; 22: 8624-8629 Up-regulation of long non-coding RNA SNHG6 predicts poor prognosis in renal cell carcinoma H.-X. AN 1, B. XU 2, Q. WANG 3, Y.-S.
More informationThe diagnostic value of determination of serum GOLPH3 associated with CA125, CA19.9 in patients with ovarian cancer
European Review for Medical and Pharmacological Sciences 2017; 21: 4039-4044 The diagnostic value of determination of serum GOLPH3 associated with CA125, CA19.9 in patients with ovarian cancer H.-Y. FAN
More informationPUMA gene transfection can enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells
PUMA gene transfection can enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells C.-G. Sun 1 *, J. Zhuang 1 *, W.-J. Teng 1, Z. Wang 2 and S.-S. Du 3 1 Department of Oncology,
More informationIncreased expression of the lncrna BANCR and its prognostic significance in human osteosarcoma
Increased expression of the lncrna BANCR and its prognostic significance in human osteosarcoma Z.Q. Peng 1, R.B. Lu 2, D.M. Xiao 3 and Z.M. Xiao 1 1 Department of Orthopedics, The First Affiliated Hospital
More informationLong non-coding RNA UCA1 regulates the proliferation, migration and invasion of human lung cancer cells by modulating the expression of microrna-143
European Review for Medical and Pharmacological Sciences 2018; 22: 8343-8352 Long non-coding RNA UCA1 regulates the proliferation, migration and invasion of human lung cancer cells by modulating the expression
More informationmicrorna 761 regulates glycogen synthase kinase 3β expression and promotes the proliferation and cell cycle of human gastric cancer cells
ONCOLOGY LETTERS 16: 3459-3464, 2018 microrna 761 regulates glycogen synthase kinase 3β expression and promotes the proliferation and cell cycle of human gastric cancer cells XINFANG SUN, HONGTAO HOU,
More informationCircMTO1 inhibits cell proliferation and invasion by regulating Wnt/β-catenin signaling pathway in colorectal cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 8203-8209 CircMTO1 inhibits cell proliferation and invasion by regulating Wnt/β-catenin signaling pathway in colorectal cancer Z. GE,
More informationhttp / /cjbmb. bjmu. edu. cn Chinese Journal of Biochemistry and Molecular Biology A431 . Western aza-dC FUT4-siRNA
ISSN 1007-7626 CN 11-3870 / Q http / /cjbmb bjmu edu cn Chinese Journal of Biochemistry and Molecular Biology 2015 8 31 8 836 ~ 842 DOI 10 13865 /j cnki cjbmb 2015 08 09 FUT4-siRNA 5-aza-dC 1 3 * 1 1 3
More informationLINC00324 exerts tumor-promoting functions in lung adenocarcinoma via targeting mir-615-5p/akt1 axis
European Review for Medical and Pharmacological Sciences 2018; 22: 8333-8342 LINC00324 exerts tumor-promoting functions in lung adenocarcinoma via targeting mir-615-5p/akt1 axis Z.-H. PAN 1, X.-Q. GUO
More informationMicroRNA 761 is downregulated in colorectal cancer and regulates tumor progression by targeting Rab3D
EXPERIMENTAL AND THERAPEUTIC MEDICINE MicroRNA 761 is downregulated in colorectal cancer and regulates tumor progression by targeting Rab3D YUPENG REN, GANG SHI, PENG JIANG and QINGKAI MENG Department
More informationMicroRNA 98 suppresses cell growth and invasion of retinoblastoma via targeting the IGF1R/k Ras/Raf/MEK/ERK signaling pathway
INTERNATIONAL JOURNAL OF ONCOLOGY 54: 807-820, 2019 MicroRNA 98 suppresses cell growth and invasion of retinoblastoma via targeting the IGF1R/k Ras/Raf/MEK/ERK signaling pathway LONG GUO 1, YU BAI 2, SHUZHE
More informationA circulating serum mirna panel as early detection biomarkers of cervical intraepithelial neoplasia
European Review for Medical and Pharmacological Sciences 2016; 20: 4846-4851 A circulating serum mirna panel as early detection biomarkers of cervical intraepithelial neoplasia F. XIN 1, P. LIU 1, C-F.
More informationA549 and A549-fLuc cells were maintained in high glucose Dulbecco modified
Cell culture and animal model A549 and A549-fLuc cells were maintained in high glucose Dulbecco modified Eagle medium supplemented with 10% fetal bovine serum at 37 C in humidified atmosphere containing
More informationMiR-100 up-regulation enhanced cell autophagy. and apoptosis induced by cisplatin in osteosarcoma by targeting mtor
European Review for Medical and Pharmacological Sciences 2018; 22: 5867-5873 MiR-100 up-regulation enhanced cell autophagy and apoptosis induced by cisplatin in osteosarcoma by targeting mtor Z. YU, N.
More informationRESEARCH ARTICLE Jianjun Han, et al.: mir-361-5p in breast cancer
The Bosnian Journal of Basic Medical Sciences publishes an Advanced online manuscript format as a free service to authors in order to expedite the dissemination of scientific findings to the research community
More informationRegulatory role of microrna184 in osteosarcoma cells
Regulatory role of microrna184 in osteosarcoma cells G.R. Yin 1,2, Q. Wang 3, X.B. Zhang 2 and S.J. Wang 1 1 Department of Joint Surgery, The Second Hospital of Shandong University, Jinan, China 2 Department
More informationMiRNA-485-5p, inhibits esophageal cancer cells proliferation and invasion by down-regulating O-linked N-acetylglucosamine transferase
European Review for Medical and Pharmacological Sciences 2019; 23: 2809-2816 MiRNA-485-5p, inhibits esophageal cancer cells proliferation and invasion by down-regulating O-linked N-acetylglucosamine transferase
More informationOriginal Article mir-338-3p inhibits the proliferation and migration of gastric cancer cells by targeting ADAM17
Int J Clin Exp Pathol 2015;8(9):10922-10928 www.ijcep.com /ISSN:1936-2625/IJCEP0011715 Original Article mir-338-3p inhibits the proliferation and migration of gastric cancer cells by targeting ADAM17 Jiang-Tao
More informationmir-101, downregulated in retinoblastoma, functions as a tumor suppressor in human retinoblastoma cells by targeting EZH2
ONCOLOGY REPORTS 32: 261-269, 2014 mir-101, downregulated in retinoblastoma, functions as a tumor suppressor in human retinoblastoma cells by targeting EZH2 QIONG LEI 1, FENGMEI SHEN 1, JIE WU 1, WEISHAN
More informationOriginal Article Long non-coding RNA PANDAR overexpression serves as a poor prognostic biomarker in oral squamous cell carcinoma
Int J Clin Exp Pathol 2018;11(5):2728-2734 www.ijcep.com /ISSN:1936-2625/IJCEP0073509 Original Article Long non-coding RNA PANDAR overexpression serves as a poor prognostic biomarker in oral squamous cell
More informationAn epithelial-to-mesenchymal transition-inducing potential of. granulocyte macrophage colony-stimulating factor in colon. cancer
An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer Yaqiong Chen, Zhi Zhao, Yu Chen, Zhonglin Lv, Xin Ding, Renxi Wang, He Xiao,
More informationIncreased long noncoding RNA LINP1 expression and its prognostic significance in human breast cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 8749-8754 Increased long noncoding RNA LINP1 expression and its prognostic significance in human breast cancer X.-M. LIU 1, B. YANG 2,
More informationExpression and functions of microrna-139 in osteosarcoma.
Biomedical Research 2017; 28 (22): 9879-9884 ISSN 0970-938X www.biomedres.info Expression and functions of microrna-139 in osteosarcoma. Qi Liao *, Jianghua Ming, Geliang Hu, Yaming Li, Chun Zhang, Yanchao
More informationLong non coding RNA GAS5 suppresses pancreatic cancer metastasis through modulating mir 32 5p/PTEN axis
https://doi.org/10.1186/s13578-017-0192-0 Cell & Bioscience RESEARCH Open Access Long non coding RNA GAS5 suppresses pancreatic cancer metastasis through modulating mir 32 5p/PTEN axis Zhi Qiang Gao *,
More informationClinical significance of serum mir-196a in cervical intraepithelial neoplasia and cervical cancer
Clinical significance of serum mir-196a in cervical intraepithelial neoplasia and cervical cancer P. Liu 1, F. Xin 1 and C.F. Ma 2 1 Department of Obstetrics & Gynecology, Baoding Second Central Hospital,
More informationLong non-coding RNA TUSC7 expression is independently predictive of outcome in glioma
European Review for Medical and Pharmacological Sciences 2017; 21: 3605-3610 Long non-coding RNA TUSC7 expression is independently predictive of outcome in glioma X.-L. MA 1, W.-D. ZHU 2, L.-X. TIAN 2,
More informationOriginal Article Artemin promotes proliferation and metastasis in human laryngeal squamous cell carcinoma
Int J Clin Exp Pathol 2017;10(10):10413-10418 www.ijcep.com /ISSN:1936-2625/IJCEP0058793 Original Article Artemin promotes proliferation and metastasis in human laryngeal squamous cell carcinoma Chao-Bing
More informationSafranal inhibits the migration and invasion of human oral squamous cell carcinoma cells by overcoming epithelial-mesenchymal transition.
Biomedical Research 2017; 28 (2): 817-821 ISSN 0970-938X www.biomedres.info Safranal inhibits the migration and invasion of human oral squamous cell carcinoma cells by overcoming epithelial-mesenchymal
More informationLncRNA AB promotes the proliferation and inhibits apoptosis of cervical cancer cells by repressing RBM5
European Review for Medical and Pharmacological Sciences 2019; 23: 2374-2379 LncRNA AB073614 promotes the proliferation and inhibits apoptosis of cervical cancer cells by repressing RBM5 L.-Y. GUO 1, C.-F.
More informationReview Article Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features
BioMed Research International Volume 2016, Article ID 4863609, 8 pages http://dx.doi.org/10.1155/2016/4863609 Review Article Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association
More informationMicroRNA 124 3p inhibits cell growth and metastasis in cervical cancer by targeting IGF2BP1
EXPERIMENTAL AND THERAPEUTIC MEDICINE 15: 1385-1393, 2018 MicroRNA 124 3p inhibits cell growth and metastasis in cervical cancer by targeting IGF2BP1 PING WANG 1, LI ZHANG 1, JUNHUI ZHANG 1 and GANGSHU
More informationmir 140 5p inhibits cell proliferation and invasion in colorectal carcinoma by targeting SOX4
ONCOLOGY LETTERS mir 140 5p inhibits cell proliferation and invasion in colorectal carcinoma by targeting SOX4 ZHONGSONG ZHAO, WEIWEI LIU and JIANHUA LI Digestive System Department, Shandong Provincial
More informationOriginal Article microrna-217 was downregulated in ovarian cancer and was associated with poor prognosis
Int J Clin Exp Pathol 2016;9(8):8555-8559 www.ijcep.com /ISSN:1936-2625/IJCEP0026997 Original Article microrna-217 was downregulated in ovarian cancer and was associated with poor prognosis Qiong Pan,
More informationMiR-1271 as a tumor suppressor in breast cancer proliferation and progression via targeting SPIN1
European Review for Medical and Pharmacological Sciences 2018; 22: 2697-2706 MiR-1271 as a tumor suppressor in breast cancer proliferation and progression via targeting SPIN1 H.-Y. DU, B. LIU Breast and
More informationOriginal Article MiR-130a regulates the proliferation and metastasis of HCC cells through targeting ZEB1/2
Int J Clin Exp Pathol 2017;10(3):2744-2753 www.ijcep.com /ISSN:1936-2625/IJCEP0046135 Original Article MiR-130a regulates the proliferation and metastasis of HCC cells through targeting ZEB1/2 Ting Wang
More informationGLI-1 facilitates the EMT induced by TGF-β1 in gastric cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 6809-6815 GLI-1 facilitates the EMT induced by TGF-β1 in gastric cancer M. LIANG 1, X.-C. LIU 1, T. LIU 2, W.-J. LI 3, J.-G. XIANG 1,
More informationAnalysis of circulating long non-coding RNA UCA1 as potential biomarkers for diagnosis and prognosis of osteosarcoma
European Review for Medical and Pharmacological Sciences 2017; 21: 498-503 Analysis of circulating long non-coding RNA UCA1 as potential biomarkers for diagnosis and prognosis of osteosarcoma J.-J. WEN
More informationKnockdown of Long Noncoding RNA LUCAT1 Inhibits Cell Viability and Invasion by Regulating mir-375 in Glioma
Oncology Research, Vol. 26, pp. 307 313 0965-0407/18 $90.00 +.00 Printed in the USA. All rights reserved. DOI: https://doi.org/10.3727/096504017x15088061795756 Copyright Ó 2018 Cognizant, LLC. E-ISSN 1555-3906
More informationmir-204 suppresses non-small-cell lung carcinoma (NSCLC) invasion and migration by targeting JAK2
mir-204 suppresses non-small-cell lung carcinoma (NSCLC) invasion and migration by targeting JAK2 P. Wang 1, H.Y. Lv 2, D.M. Zhou 1 and E.N. Zhang 1 1 Department of Oncology, the Yantaishan Hospital, Yantai,
More informationOriginal Article MiR-506 suppresses proliferation and invasion of bladder cancer by targeting FOXQ1
Int J Clin Exp Pathol 2017;10(4):4538-4544 www.ijcep.com /ISSN:1936-2625/IJCEP0021257 Original Article MiR-506 suppresses proliferation and invasion of bladder cancer by targeting FOXQ1 Xiang Sun, Longhua
More informationAssociation of mir-21 with esophageal cancer prognosis: a meta-analysis
Association of mir-21 with esophageal cancer prognosis: a meta-analysis S.-W. Wen 1, Y.-F. Zhang 1, Y. Li 1, Z.-X. Liu 2, H.-L. Lv 1, Z.-H. Li 1, Y.-Z. Xu 1, Y.-G. Zhu 1 and Z.-Q. Tian 1 1 Department of
More informationmir 483-5p promotes prostate cancer cell proliferation and invasion by targeting RBM5
ORIGINAL ARTICLE Vol. 43 (6): 1060-1067, November - December, 2017 doi: 10.1590/S1677-5538.IBJU.2016.0595 mir 483-5p promotes prostate cancer cell proliferation and invasion by targeting RBM5 Zhi-Gang
More informationLong non-coding RNA ROR is a novel prognosis factor associated with non-small-cell lung cancer progression
European Review for Medical and Pharmacological Sciences 2017; 21: 4087-4091 Long non-coding RNA ROR is a novel prognosis factor associated with non-small-cell lung cancer progression C.-H. QU 1, Q.-Y.
More informationMiR-218 suppresses metastasis and invasion of endometrial cancer via negatively regulating ADD2
European Review for Medical and Pharmacological Sciences 2019; 23: 1408-1417 MiR-218 suppresses metastasis and invasion of endometrial cancer via negatively regulating ADD2 X.-C. LI 1, J.-J. HAI 1, Y.-J.
More informationLong non-coding RNA CCHE1 overexpression predicts a poor prognosis for cervical cancer
European Review for Medical and Pharmacological Sciences 2017; 20: 479-483 Long non-coding RNA CCHE1 overexpression predicts a poor prognosis for cervical cancer Y. CHEN, C.-X. WANG, X.-X. SUN, C. WANG,
More informationOriginal Article Reduced serum mir-138 is associated with poor prognosis of head and neck squamous cell carcinoma
Int J Clin Exp Pathol 2017;10(10):10276-10281 www.ijcep.com /ISSN:1936-2625/IJCEP0059849 Original Article Reduced serum mir-138 is associated with poor prognosis of head and neck squamous cell carcinoma
More informationLong noncoding RNA LINC01510 is highly expressed in colorectal cancer and predicts favorable prognosis
European Review for Medical and Pharmacological Sciences 2018; 22: 7710-7715 Long noncoding RNA LINC01510 is highly expressed in colorectal cancer and predicts favorable prognosis J.-F. ZHOU, H.-G. WANG,
More informationDownregulation of microrna-196a inhibits human liver cancer cell proliferation and invasion by targeting FOXO1
2148 Downregulation of microrna-196a inhibits human liver cancer cell proliferation and invasion by targeting FOXO1 Liu Yang 1, Fei Peng 2, Jian Qin 3, Henghua Zhou 4 and Bing Wang 3 1 Department of Gastroenterology,
More informationLong non-coding RNA CCAT1/miR-218/ ZFX axis modulates the progression of laryngeal squamous cell cancer
699417TUB0010.1177/1010428317699417Tumor BiologyZhang and Hu research-article2017 Original Article Long non-coding RNA CCAT1/miR-218/ ZFX axis modulates the progression of laryngeal squamous cell cancer
More informationReduced mirna-218 expression in pancreatic cancer patients as a predictor of poor prognosis
Reduced mirna-218 expression in pancreatic cancer patients as a predictor of poor prognosis B.-S. Li, H. Liu and W.-L. Yang Department of Gastrointestinal and Pancreatic Surgery, The Third Xiangya Hospital
More informationExpression level of microrna-195 in the serum of patients with gastric cancer and its relationship with the clinicopathological staging of the cancer
European Review for Medical and Pharmacological Sciences 2016; 20: 1283-1287 Expression level of microrna-195 in the serum of patients with gastric cancer and its relationship with the clinicopathological
More informationClinical value of combined detection of mir 1202 and mir 195 in early diagnosis of cervical cancer
ONCOLOGY LETTERS 17: 3387-3391, 2019 Clinical value of combined detection of mir 1202 and mir 195 in early diagnosis of cervical cancer XIELAN YANG 1, ZHILING YAN 1, HONGYING YANG 1, HUIJING NI 1, LEI
More informationMicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2
ONCOLOGY LETTERS MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2 XIAORI HUANG, LEI WANG, WEI LIU and FEI LI Department of Respiratory Medicine, People's
More informationLncRNA AWPPH promotes the growth of triple-negative breast cancer by. up-regulating frizzled homolog 7 (FZD7)
Bioscience Reports: this is an Accepted Manuscript, not the final Version of Record. You are encouraged to use the Version of Record that, when published, will replace this version. The most up-to-date
More informationInhibition of microrna-218 promotes oral squamous cell carcinoma growth by targeting
European Review for Medical and Pharmacological Sciences 2018; 22: 7726-7734 Inhibition of microrna-218 promotes oral squamous cell carcinoma growth by targeting GLUT1 to affect glucose metabolism X.-J.
More informationOriginal Article Upregulation of mir-494 promotes cervical cancer cell proliferation, migration and invasion via the MAPK/ERK pathway
Int J Clin Exp Pathol 2017;10(3):3101-3108 www.ijcep.com /ISSN:1936-2625/IJCEP0035420 Original Article Upregulation of mir-494 promotes cervical cancer cell proliferation, migration and invasion via the
More information