IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH

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1 IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY AND MOLECULAR MEDICINE UNIVERSITY OF OULU, FINLAND 1

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4 BIPOLAR MOOD DISORDER SCHIZOPHRENIA

5 DIAGNOSTIC ROLE THERAPEUTIC ROLE PROGNOSTIC ROLE

6 DIAGNOSTIC ROLE PSYCHIATRIC DISORDERS SCHIZOPHRENIA INCREASED mirs mir-497, mir-34a, mir-449a, mir-548d, mir-564, mir-572, mir-652, let-7g, mir-181b, mir p, mir-1308 DECREASED mirs mir-195, mir-432, mir-31, mir-99b, mir-107, mir-134, mir-431, mir-433, mir-487b BIPOLAR MOOD DISORDER mir-29c - mir-132, mir-182, mir-107, mir-133a, mir-148a, mir-425-3p, mir-494, mir-579, mir-589, mir-652, mir-941, mir-200c, mir-381, mir-517b, mir-636, mir-1243

7 DIAGNOSTIC ROLE PSYCHIATRIC DISORDERS SCHIZOPHRENIA INCREASED mirs mir-497, mir-34a, mir-449a, mir-548d, mir-564, mir-572, mir-652, let-7g, mir-181b, mir p, mir-1308 DECREASED mirs mir-195, mir-432, mir-31, mir-99b, mir-107, mir-134, mir-431, mir-433, mir-487b BIPOLAR MOOD DISORDER mir-29c - mir-132, mir-182, mir-107, mir-133a, mir-148a, mir-425-3p, mir-494, mir-579, mir-589, mir-652, mir-941, mir-200c, mir-381, mir-517b, mir-636, mir-1243

8 DIAGNOSTIC ROLE PSYCHIATRIC DISORDERS SCHIZOPHRENIA INCREASED mirs mir-497, mir-34a, mir-449a, mir-548d, mir-564, mir-572, mir-652, let-7g, mir-181b, mir p, mir-1308 DECREASED mirs mir-195, mir-432, mir-31, mir-99b, mir-107, mir-134, mir-431, mir-433, mir-487b BIPOLAR MOOD DISORDER mir-29c - mir-132, mir-182, mir-107, mir-133a, mir-148a, mir-425-3p, mir-494, mir-579, mir-589, mir-652, mir-941, mir-200c, mir-381, mir-517b, mir-636, mir-1243

9 PROGNOSTIC ROLE SCHIZOPHRENIA BIPOLAR MOOD DISORDER Decreased mir-365 and mir-520c-3p after a 1-year treatment with risperidone 30 mirnas differentially expressed after a 12-weeks treatment with escitalopram Increased mir-20b-3p, mir-133a, mir-145, mir-409-3p, mir-410, mir-433, mir-485-3p decreased mir-331-5p after an 8-weeks treatment with different classes of drugs Increased mir-134 from baseline after a 4-weeks treatment

10 PROGNOSTIC ROLE SCHIZOPHRENIA BIPOLAR MOOD DISORDER Decreased mir-365 and mir-520c-3p after a 1-year treatment with risperidone 30 mirnas differentially expressed after a 12-weeks treatment with escitalopram Increased mir-20b-3p, mir-133a, mir-145, mir-409-3p, mir-410, mir-433, mir-485-3p decreased mir-331-5p after an 8-weeks treatment with different classes of drugs Increased mir-134 from baseline after a 4-weeks treatment

11 PROGNOSTIC ROLE SCHIZOPHRENIA BIPOLAR MOOD DISORDER Decreased mir-365 and mir-520c-3p after a 1-year treatment with risperidone 30 mirnas differentially expressed after a 12-weeks treatment with escitalopram Increased mir-20b-3p, mir-133a, mir-145, mir-409-3p, mir-410, mir-433, mir-485-3p decreased mir-331-5p after an 8-weeks treatment with different classes of drugs Increased mir-134 from baseline after a 4-weeks treatment

12 PROGNOSTIC ROLE SCHIZOPHRENIA BIPOLAR MOOD DISORDER Decreased mir-365 and mir-520c-3p after a 1-year treatment with risperidone 30 mirnas differentially expressed after a 12-weeks treatment with escitalopram Increased mir-20b-3p, mir-133a, mir-145, mir-409-3p, mir-410, mir-433, mir-485-3p decreased mir-331-5p after an 8-weeks treatment with different classes of drugs Increased mir-134 from baseline after a 4-weeks treatment

13 471 NFBC % MATERNAL SMOKING

14 ANALYSIS OF EXOSOME CONTENTS & MATCHING WITH NEUROPSYCHIATRIC DISORDERS AND ADDICTION IMAGING OF EXOSOMES WITH HYPER-SPRECTAL CAMERAS IMAGING OF EXOSOMES BY MRI AND PET

15 PURIFICATION OF EXOSOMES 12 PILOT SAMPLES 6 SMOKING MOTHERS, 6 NON SMOKING MOTHERS 12 SAMPLES ELECTRON MICROSCOPY PROTEIN ANALYSIS 12 SAMPLES

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17 THANK YOU