CURRICULUM VITAE. Post Address: West China Second University Hospital, Section 3, 20S, Renmin Road, Chengdu, Sichuan , China

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1 General Information: Name: Ling Gu Gender: Female Citizenship: P. R. China CURRICULUM VITAE Post Address: West China Second University Hospital, Section 3, 20S, Renmin Road, Phone Number: (mobile), (office) Objectives: To study the techniques for cytogenetics and MRD detection in hematologial malignances. Working Experience Jul present Associate Professor, Lab of Pediatric Hematology/Oncology, West China Second Hospital, West China University of Medical Science (now renamed Sichuan University), P.R.China Jul Jun Lecturer, Lab of Pediatric Hematology/Oncology, West China Second Hospital, Sichuan University, P.R.China Jun Jul Postdoctoral training, Lab of Hematology, National Key Lab of Biology Therapy, Sichuan University, P.R.China Jul Sept Lecturer, Department of Pathophysiology, West China School of preclinical and forensic medicine, Sichuan University, P.R.China Jul Jul Teaching Assitant, Department of Pathophysiology, West China School of preclinical and forensic medicine, Sichuan University, P.R.China Note: Ratified by the Ministry of National Education, Sichuan University and West China University of Medical Science were merged in Sept., 2000.

2 Education: Ph D, MD Sept Jun Dept. of Hematology, Lab of Hematology, West China Hospital, Sichuan University, P.R.China MS in Medicine Sept Jun Seven year undergraduate and post-graduation program, Dept. of Hematology, West China University of Medical Science, P.R.China BA in Medicine Sept Jun Seven year undergraduate and post-graduation program, West China University of Medical Science, P.R.China General Skills: Ability to do works focusing on molecular diagnosis, chromosome karotying and FISH analysis of acute leukemias Ability to think laterally and to develop alternative approaches to solve problems Computer literate with both Macintosh and PC. Being skilled at data entry, data analysis, statistics, word processing, report preparation and computerization of various experimental systems Proficiency in report and thesis writing. Developed skills in presentation and group discussion Laboratory Skills Flow cytometry techniques: immunopenotyping, cell cycle, apoptosis, etc Chromosome prepare, G Band and FISH analysis of hematologic malignances Cell culture: Hematological tumor cells and MSC Molecular biology techniques: Including DNA and RNA extraction, purification and electrophoresis, PCR, real-time PCR, plasmid preparation (recombination, restriction digests, subcloning, transformations) and cell transient and stable transfection Protein technique: Western Blot Animal experiments: Experienced in animal surgical and anesthetic techniques Immunology techniques: Immunohistochemistry, ELISA assays

3 Grants 1. National Natural Science Foudation of China ( ), The relationship of GC resistance and longitudinal activated of ALK/PI3K/AKT/mTOR in ALCL and it's clinical significance,principal Investigator 2. Doctoral Fund of Ministry of Education of China ( ), The relationship of GC resistance and mtor signaling pathway in ALL and it's molecular mechanism,principal Investigator 3. National Natural Science Foudation of China ( ), Role and mechanism of activation of mtor in gluticoticoid resistance in acute lyphoblastic leukemia, Main Researcher 4. National Natural Science Foudation of China ( ), Inducing apoptosis in leukemia cell lines by inhibiting the interaction of MLL and Menin, Main Researcher 5. Program for New Century Excellent Talents in University of China (NCET ), Expression of full length anaplastic lymphoma kinase in tumors, Main Researcher Publications 1. L Gu, J Gao, Q Li, et al. Rapamycin reverses NPM-ALK induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mtor signaling pathway, enhancing G1 cell cycle arrest and apoptosis. Leukemia, 2008, 22 (11): Y Chen, L Gu, C Zhou, et al. Relapsed APL patient with variant NPM-RARalpha fusion responded to arsenic trioxide-based therapy and achieved long-term survival. Int J Hematol, 2010; 91(4): X Lu, T Liu, Gu L, et al. Immunomodulatory effects of mesenchymal stem cells involved in favoring type 2 T cell subsets. Transpl Immunol, 2009; 22(1-2): L Gu, J Gao, Q Li, et al. Rapamycin sensitizes jurkat T-ALL cells to dexamethasone -induced apoptosis. Chinese Journal of Clinical Pediatrics, 2010; 5(28): L Gu, JF Li, ZG Ma, et al. Blockage of mtor signaling pathway by rapamycin contributes to inhibition of tumor cell proliferation in ALK-positive lymphoid cell

4 strains.chinese Journal of Hematology, 2008, 29(10): JF Li, L Gu, ZG Ma, et al. Activation AKT/mTOR pathway in ALK+ ALCL and its clinical significance. Chinese Journal of Hematology, 2008,29(10): L Gu, T Liu, YP Gong, and YM Xi. Study on RNA interference reversing the multidrug resistance of leukemia cell. Sichuan Da Xue Xue Bao Yi Xue Ban, 2007; 38(1): L Gu, T Liu, YP Gong, WT Meng. Effect of Mismatched shrna on Reversing the Multidrug Resistance of leukemia cell. Chinese Journal of Hematology, 2006; 27(11): L Gu, T Liu, YP Gong. Establishment of a drug resistant leukemia cell line caused by mdr1 gene. Sichuan Da Xue Xue Bao Yi Xue Ban, 2005; 36(4): YM Xi, T Liu, WT Meng, YH Wang, L Gu, XX Lu, and YP Gong. Construction of eukaryotic expression vector of sirna specific to bcr/abl fusion gene. Sichuan Da Xue Xue Bao Yi Xue Ban, 2005; 36(4): Y Huang, L Gu, S Wang, et al. Therapeutic effect of high-density lipoprotein of human plasma on rat endotoxemia. Hua Xi Yi Ke Da Xue Xue Bao, 2002; 33(1): L Gu, Z Yang, D Jing, et al. The influential factors in using cadmium reduction method for measurement of the stable products of NO nitrates and nitrites. Hua Xi Yi Ke Da Xue Xue Bao, 1999, 30 (3): L Gu, C Deng, Y Shi, et al. The influence of different thromboplastins upon the international normalised ratio (INR) and the prothrombin time ratio (PTR). Chinese Journal of Thrombosis and Hemostasis,1997,4(20): 63-4 Proceedings of Meetings Yuping Gong, Ling Gu, Ting Liu. Study on RNA interference reversing multidrug resistance in K562/A02 resistant leukemia cell. Blood (ASH Annual Meeting Abstracts), 2006; 108: 4362 L Gu, ZG Ma, J Gao. Rapamycin reverses NPM-ALK induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mtor signaling pathway, enhancing G 1 cell cycle arrest and apoptosis. ISEH 2008 meeting, poster presentation, July 9-12

5 Referees: Prof. Zhigui Ma Dept. of Hematology/Oncology, Lab of Pediatric Hematology/Oncology, West China Second Hospital, Sichuan University Tel: Prof. Ju Gao Dept. of Hematology/Oncology, West China Second Hospital, Sichuan University Tel: Prof. Yuping Gong Dept. of Hematology/Oncology, West China Hospital, Sichuan University Tel: