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1 ٣ ﻣﺠﻴﺪ ﻟﻄﻴﻔﻲ ﻧﻮﻳﺪ ٢ ١ ﺑﺎﺷﺪ ﻳﺎﻓﺘﻪ ﻫﺎ ( ﻣﻴﻠﻲ ﻣﺘﺮ ٢١/٥ ١٩/٧ ( ﻣﻴﻠﻲ ﻣﺘﺮ ١٠٥ ١١١ ١٣ ١٩ ( -١-٢ -٣
2 ١٣٨١ ﻣﺠﻠﻪ ﻋﻠﻤﻲ ۲۰ ﻣﻘﺪﻣﻪ ٢ ١ ١٩٨٠ ﮔﺎﺳﺘﺮﻳﺖ ﻣ ﺮﻓﺘﻪ ﺑﺎﺷﺪ [١-٥] [۱٠] ﺑﺎﺷﺪ ٣ ﻮ [۷ ۶] ﺑﺎﺷﺪ [۱١] ﻳﻲ VacA ﺗﻮﻛﺴﻴـﻦ ﺑﻪ ﺧﺎﻃﺮ ﻧﻘﺶ ﻣﻬﻤﻲ VacA [۱٢] [۱٣] Omprazole (ﻳﻚ ﻣﻤﺎﻧﻌﺖ ﻛﻨﻨ Micronized [۹ ۸] Vero VacA ﺗﻮﻛﺴﻴﻦ 1- Warren 2- Marshal 3- Urease
3 ۲۱ ﻧﻤﻮﻧﻪ ۴ ۴ ۶۰ ۲ ( ( ١٥٠ ١٠٠ ٥٠ ﻴ %۵ ﺑﻪ ٣٥٠ ٤٠٠ ٣٠٠ ٢٥٠ ٢٠٠ %۵ B ﻣﻴﻜﺴﻴﻦ ۱۰ ﻣﻴﻠﻲ ۵ ۸ ﭘﻠﻲ ۳ ۱۰ ۰/۲۵ ۲ B ۵ ﭘﺲ ﺷﺪﻧﺪ Gaspack ۳-۷ ﺗﻌﻴﻴﻦ ﻫﻮﻳﺖ ﻛﻠﻮﻧﻲ Gaspack %۵ ۳۷ ۵ ١ ۳۷ [۱٥ ١٤] ( MIC [۱٦] ﮔﺮﻓﺘﻪ ﺷﺪ ( ١٠ ١٠ ١٠ Disk Diffusion ٣٢ % ۵ ٢٤ ﺑﻌﺪ ﺑﺎﻛﺘﺮ ٢٤ ۳ ۱۰۸ ﻲ ﻟﻴﺘﺮ ﺗﻬﻴﻪ ﺷﺪ ۵۰ ﺳﭙﺲ ٤٠ %۵ [١٦] ۴۰۰ ﻏﻠﻈﺖ ۱۰ 1- Minimum Inhibitory Concentration ﻧﻤـﻮﻧـﻪ ۱۰ Agar Dilution ( ﺗﺴﺖ ﻫـ ﻣﻴـﺨﻚ
4 ١٣٨١ ۲۲ ﻣﺠﻠﻪ ﻋﻠﻤﻲ ﻫﻤـﻪ ۲ ] [۱٦ ﻣﺜـﺒـ ﻫﻤﭽﻨﻴــﻦ ﺑـﻪ ﺳﻔﺎﻟــ ﻳﺎﻓﺘﻪ ﻫﺎ ۴۰ ﻧﻤﻮﻧﻪ ﻛﺸﺖ ۱ ١ ٢ ٣ ٤ ٥ ٧ ٩ ٢٢ ٢٤ ٢٢ ٢٦ ٢١/٥ ١٥ ١٦ ١٥ ١٤ ١٧/٨ ﻣﻴﺨﻚ ۱۵ ۱۵ ۱۸ ۱۷ ۱۵ ۸ ۹ ۷ ﻪ ٢ ۱۰/۶ ﻣﻴﺨﻚ ﺷﺎﻫﺪ ﻣﻴﺎﻧﮕﻴﻦ ١ ٢ ٣ ٤ ٥ ٧ ٩ ﺷﺎﻫﺪ ﻣﻴﺎﻧﮕﻴﻦ ١٦ ١٧ ١٨/٧ ١٧ ٢٣ ١٧ ١٩/٧ ١٤ ١٥ ١٤ ١٣ ١٦ ١٢ ١٣ ١١ ١٦ ١٥/٣ ٧ ١٢ ٨/٥ ۳ ١ ٢ ٣ ٤ ٥ ٧ ٩ ﻣﻴﺨﻚ ۱۷ ۱۷ ۱۹ ۱۵ ۱۸ ۱۹ ۱۱/۱ ۸ ۲۰ ۲۰ ۱۸ ۸ ۲۱ ۲۰ ۱۸ ﺷﺎﻫﺪ ﻣﻴﺎﻧﮕﻴﻦ ۱۹ ۱۰/۵ ۶۰ ﭘﺎﺗﻮﻟـ ـﺪ %۸۰
5 ۲۳ ١ (*۱۰۰۰ ٢ (*۱۰۰۰ ﻣﻴﺨﻚ ﻌﻪ ۳ 10 5 ﻣﻲ
6 ١٣٨١ ﻣﺠﻠﻪ ﻋﻠﻤﻲ ۲۴ %۹۰ ﻣﺸﺨﺺ (٢ ١ [۱٧] MIC ۳۰۰-۳۵۰ ۲۰۰-۳۵۰ ۳۵۰-۴۰۰ ۴۰۰ ٣ ۳ ۲ ۱ [۱١ ] ﻣﻴﻠﻲ ۲۶ ﺗﺎ ۱۸ ( ﻣﺘﺮ ( ﻣﻴﻠﻲ ﻣﺘﺮ ۲۳ ﺗﺎ ۱۷ ( ﻣﻴﻠﻲ ﻣﺘﺮ ۲۱ ﺗﺎ ۱۷ [۱٣] in vitro ﺑﺤﺚ %۴۰ [۱٢] ﺿﺪ ﻫ [۱٠]
7 ۲۵ infection and chronic gastritis in gastric cancer J Clin Pathol1992 Apr; 45( Smoot DT, Hamieton FA, Summary of the National Institutes of Health Consensus Development Conference on Helicobacter pylori Gastrointestinal Diseases Today 1995; Latifi Navid S, Siavoshi F, Malekzadeh R, Sohrabi M, Mokhtari-Azad T, Safar-Alizadeh R, Massarrat S Prevalence of Helicobacter pylori infection in distal esophagus and its etiologic role in esophageal injury Gut 2002;51A68 6- Reyes VE,Fan X, Gunasena H, Cheng Z, Espejo R, Crowe SE, Ernest PB Helicobacter pylori urease binds to class II MHC on gastric epithelial cells on gastric epithelial cells and induces their apoptosis The J of Immunol 2000; Krishnamurthy PM, Parlow JB, Zitzer NB, Vakil HI Helicobacter Containing only cytoplasmic urease is susceptible to acid Immun 1998; Latifi Navid S, Siavoshi F, Mokhtari-Azad T, Malekzadeh R, Sohrabi M, Massarrt S Neutralization of Helicobacter pylori cytotoxicity on Vero cells by omeprazole micronized Gut 2002; 51A16 9- Tombola F, Oregana F, Brutsche S, Zabo IS, Giudice GD, Rappuoli R, Montecucco C, Papini E, Zoratti M Inhibition of the Vacuolating and aninon channel activities of the VacA toxin of Helicobacter pylori FEBS Lett 1999; Tabak M, Armon R, Potasman I, Neeman I In vitro inhibition of Helicobacter pylori by extracts of thyme J appl Bacteriol 1996;80( Sato Y, Oketani H, Singyouchi k, Ohtesuro T,Kihara M, shibata H, Higuti IExtraction and purification of effective antimicrobial constituents of Terminalia chebula Retz against methicillin resistance Staphylococcus aureus Biol Pharm Bull 1997;20( Negi PS, Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK Antibacterial activity of termuric oil A by-product from curcumin manifacture J agric Food Chem 1999; 47( Chen HC,Chang MD,Chang TJ Antibacterial properties of some spice plants ﻫﺎ [۱۸] [١٩] ﻣﻨﺎﺑﻊ 1- Blaser MJ Hypothese on the pathogenesis and natural history of Helicobacter pyloriinduced inflammation Gastroentero 1992 Feb;102( Blaser MJ Helicobacter pylori and the pathogenesis of gastrodeodenal inflammation J Infect Dis 1990 Apr; 161( Sipponen P, Sippon P, Kosunen TV, Valle J, Riihela M, Seppala k Helicobactr pylori
8 ١٣٨١ before and after heat treatment Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1985;18( Goodwin CS, Armstrong JA Microbiological aspects of Helicobacter pylori EurJ Clin- Microbiol Infect Dic 1990; Mobley HLT, Cortesia MJ, Roseuthal LE, Jones BD Characteization of urease from Campylobacter pylori J clin Microbiol 1998; Malekzadeh F, Ehsanifar H, Shahamat M, Levin M, Colwell RR Antibacterial activity of black myrobalan against Helicobacter pylori Intern J of Antimicrobiol agents 2001; ﻣﺠﻠﻪ ﻋﻠﻤﻲ ۲۶ 17- Hill DJ, O gara EA, Maslin DJ Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori Appl Environ Microbiol 2000;66( Cai L, Wu CD Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens; J Nat Prod 1996; 59( Elgayyar M, Draughon FA, Golden DA, Mount JR Antimicrobial activity of essential oils from plants against selected pathogenic and saprophytic microorganisms J Food Prot 2001;64(
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