Yong Wu, Ph.D. Division of Cancer Research and Training (DCRT) Charles R. Drew University of Medicine & Science

Size: px
Start display at page:

Download "Yong Wu, Ph.D. Division of Cancer Research and Training (DCRT) Charles R. Drew University of Medicine & Science"

Transcription

1 Yong Wu, Ph.D. Division of Cancer Research and Training (DCRT) Charles R. Drew University of Medicine & Science Jay Vadgama, Ph.D Chief, Division of Cancer Research and Training

2 Background One in 8 women will develop breast cancer during the course of her life. Recent developments in the field of drug development have provided a significant increase in progression free survival and decrease in mortality of this disease. However, one of the main problems in breast cancer remains the development of resistance to current treatments and relapse of the disease.

3 What is triple negative breast cancers (TNBC)? A triple negative breast cancer (TNBC) diagnosis means that the offending tumor is estrogen receptor-negative (ER-), progesterone receptor-negative (PR-) and human epidermal growth factor receptor 2 (HER2)-negative (HER2-). These negative results mean that the growth of the cancer is not supported by the hormones estrogen and progesterone, nor by the presence of too many HER2 receptors. Therefore, triple-negative breast cancer does not respond to hormonal therapy (such as tamoxifen or aromatase inhibitors) or therapies that target HER2 receptors, such as Herceptin (chemical name: trastuzumab).

4 There is no known target for the treatment of TNBC subset, which is more aggressive than the other types of the disease. About 10-20% of breast cancers are found to be triple-negative. For doctors and researchers, there is intense interest in finding new medications that can treat this kind of breast cancer. Early studies are trying to find out whether certain medications can interfere with the processes that cause triple-negative breast cancer to grow.

5 Therefore, it is imperative to develop new drugs that can block the activity of pro-survival signaling within the cancer cells and inhibit their growth, particularly in the TNBC subset. In an attempt to identify such drugs, we screened a panel of Curcuminbased Compounds, 13 1,5-diheteroarylpenta-1,4-dien-3-ones (compounds 34 to 46), for their effectiveness in inhibiting the growth of both TNBC and ER+ breast cancers.

6 Curcumin Curcumin, extracted from Curcuma longa (turmeric) of the Zingiberaceae family, an ancient Indian herb used in curry powder, represents a typical example of dietary natural products displaying a wide range of interesting medicinal properties. The low cancer incidence in Asia has been, at least partly, demonstrated to be associated with the Asian diet (including turmeric). The anticancer potential of curcumin was first reported by Kuttan and coworkers in Curcumin has already entered several human clinical studies for potential prevention and treatment of cancer but its clinical development has been slown-down by its poor pharmacokinetic profile.

7 Structures of curcumin and its analogs

8 Results

9 Comp 34 Comp 45 Comp 39 Comp 44 Comp 46 Comp 42 Comp 36 Comp 43 Comp 37 Comp 41 Comp 40 Comp 35 Comp 38 IC50 nm MDA-MB MCF IC50 nm Comp 34 Comp 39 Comp 45 Comp 44 Comp 34 Comp 46 Comp 46 Comp 44 Comp 36 Comp 39 Comp 40 Comp 45 Comp 42 Comp 35 Comp 37 Comp 37 Comp 35 Comp 40 Compd 43 Comp 42 Comp 41 Comp 38 Comp 36 Comp 43 IC50 nm Comp 41 Comp T47D The IC 50 is a measure of how effective a drug is. It indicates how much of a particular drug is needed to inhibit a given biological process by half

10 Comp 34 Comp 45 Comp 39 Comp 44 Comp 46 Comp 42 Comp 36 Comp 43 Comp 37 Comp 41 Comp 40 Comp 35 Comp 38 IC50 nm MDA-MB-231 cell line treated with compounds

11 Con. Comp 34 Comp 35 Comp 36 Comp 37 Comp 38 Comp 39 Comp 40 Comp 41 Comp 42 Comp 43 Comp 44 Comp 45 Comp 46 MDA-MB-231 treated with compound DNA checkpoint associated kinases phosphorylate BRCA1 under conditions of DNA damage, making cells sensitive or resistant to various stresses. UV induced phosphorylation of particular residues of BRCA1 is crucial for activation of caspase 3. Mutant p53 in MDA-MB-231 breast cancer cells is stabilized by elevated phospholipase D activity and contributes to survival signals generated by phospholipase D p38 MAP Kinase Mediates Apoptosis through Phosphorylation of BimEL at Ser-65 p-brca1 p-p53 Total BRCA Total p53

12 Comp 34 Comp 39 Comp 45 Comp 44 Comp 46 Comp 36 Comp 40 Comp 42 Comp 37 Comp 35 Compd 43 Comp 41 Comp 38 IC50 nm IC50 = 8.3uM MCF-7 cell line treated with compounds

13 Con. Comp 34 Comp 35 Comp 36 Comp 37 Comp 38 Comp 39 Comp 40 Comp 41 Comp 42 Comp 43 Comp 44 Comp 45 Comp 46 MCF-7 treated with compound Wild type p53 in MCF-7 breast cancer cells induces cell cycle arrest and apoptosis p-brca1 p-p53 Total BRCA Total p53

14 Comp 34 Comp 46 Comp 44 Comp 39 Comp 45 Comp 35 Comp 37 Comp 40 Comp 42 Comp 41 Comp 38 Comp 36 Comp 43 IC50 nm IC50 = 6.1 μm T47D cell line treated with compounds

15 T47D treated with compound Con. Comp 34 Comp 35 Comp 36 Comp 37 Comp 38 Comp 39 Comp 40 Comp 41 Comp 42 Comp 43 Comp 44 Comp 45 Comp 46 T47D Cell line harbours a p53 missense mutation Mutant p53 mediates survival of breast cancer cells p-p53 P21 p-brca1 Total p53 Total BRCA ER+ T47D human breast cancer cells

16 Compound # 34 Control Map Growth assays and signaling effects of compounds MDA-MB-231 breast cancer cell lines

17 Changes in phosphoprotein levels induced by Comp #34 treatment % Change in phosphoprotein level p70 T389 TOR STAT3 HSP60 Akt T308 Src p53 S392 RSK1/2/3 ß-Catenin PRAS40 WNK1 p53 S406 p70 T421/S424 p53 S15 EGF AMPKa2 STAT2 Hck p38a Akt S473 STAT5a ERK1/2 MSK1/2 JNK GSK-3a/ß CREB Chk-2 Yes STAT5b STAT6 HSP27 c-jun FAK STAT5a/b

18 Genes with very low or not detectable level Changes in phosphoprotein levels induced by Comp #34 treatment Fyn AMPKa1 STAT3 p27 PLC-γ1 Lyn Lck Fgr PYK2 enos PDGF Log of % Change in phosphoprotein level

19 Con. 5 min. 15 min. 30 min. 1 hour 18 hours 6 hours 24 hours MDA-MB-231- Treatment with comp # 34 at different time points Comp # 34 Total - AKT p-mtor Total mtor p-p70 p-s6 p-p38 Total p-38 p-erk Total ERK p-p53 Total p-53 GAPDH

20 Con. 10 nm 50nM 250nM 1000nM MDA-MB-231- Treatment with different concentrations of Compound 34 p-p38 P38 Total mtor Total AKT P-ERK p-p53 Total P53 P-BRCA1 BRCA1 Tubulin

21 Con C # 34 C # 34 + MEKi MEKi Con C # 34 C # 34 + MEKi MEKi MDA-MB-231 cell line p-pi3k (p85/55) p-akt T308 p-gsk3α/β p-mtor Total AKT Total GSK Total mtor p-p70 p-s6 p-p38 Total p-38 p-c-jun p-p53 p-erk Total p53 Total ERK Tubulin Non specific band

22 mrna Down regulation of proteins by com#34 is not due to proteasome degradation Comp # 34 MG p-mtor p-p70 p-p38 p-p53 mtor P70 P38 P53

23 Acknowledgements Dr. Vadgama Dr. Yanyuan Wu Dr. Atefi Dr. Wang Dr. Wu Kevin kemp We acknowledge research support from UHI Research Award! Collaborators: Zhen Cheng, Ph.D. Associate Professor, Director of Cancer Molecular Imaging Chemistry Laboratory (CMICL) Stanford University Guangdi Wang, Ph.D., Professor of Chemistry Xavier s RCMI Cancer Research Center; Xavier University Qiao-Hong Chen, Ph.D. Assistant Professor (Tenured) California State University, Fresno, Fresno

24 Case-Based Question History: 33- year- old premenopausal woman with diagnosis of T1N1M0 breast cancer (left) Treated with breast conserving surgery and axillary lymphadenectomy No family history of breast cancer Pathology _ Invasive ductal carcinoma, grade 3 _ T size 1.2cm with clear margins _ Presence of lymphatic invasion _ ER and PR negative _ HER-2 negative with FISH _ Ki67: 60% Axillary lymph nodes 2/23 positive

25 QUESTION: Does the patient belong to a special category as far as risk of relapse is concerned? 1. No 2. Yes, but only due to her young age 3. Yes, but only due to the lymph nodes status 4. Yes, patients with triple negative tumors have higher risk of relapse but only the first three years after diagnosis 5. I do not know, I would evaluate the risk of relapse by Mammaprint or OncotypeDX

Transmits Survival Signals in Breast Cancer Cells

Transmits Survival Signals in Breast Cancer Cells Cancer Cell, 2 Supplemental Information Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs Qing Chen, Xiang H.-F. Zhang, and Joan Massagué Inventory

More information

Understanding PI3K/mTOR/MEK signalling in breast cancer. Euphemia Leung Auckland Cancer Society Research Centre University of Auckland

Understanding PI3K/mTOR/MEK signalling in breast cancer. Euphemia Leung Auckland Cancer Society Research Centre University of Auckland Understanding PI3K/mTOR/MEK signalling in breast cancer Euphemia Leung Auckland Cancer Society Research Centre University of Auckland Receptor status of human breast cancer On a popula>on basis ER+/PR+

More information

4/13/2010. Silverman, Buchanan Breast, 2003

4/13/2010. Silverman, Buchanan Breast, 2003 Tailoring Breast Cancer Treatment: Has Personalized Medicine Arrived? Judith Luce, M.D. San Francisco General Hospital Avon Comprehensive Breast Care Center Outline First, treatment of DCIS Sorting risk

More information

Supplementary Fig. 1: ATM is phosphorylated in HER2 breast cancer cell lines. (A) ATM is phosphorylated in SKBR3 cells depending on ATM and HER2

Supplementary Fig. 1: ATM is phosphorylated in HER2 breast cancer cell lines. (A) ATM is phosphorylated in SKBR3 cells depending on ATM and HER2 Supplementary Fig. 1: ATM is phosphorylated in HER2 breast cancer cell lines. (A) ATM is phosphorylated in SKBR3 cells depending on ATM and HER2 activity. Upper panel: Representative histograms for FACS

More information

My Personalized Breast Cancer Worksheet

My Personalized Breast Cancer Worksheet My Personalized Breast Cancer Worksheet KNOW For Early-Stage Breast Cancer. No Questions. Only Results. No two tumors are alike. What are the characteristics of your breast cancer and how will that effect

More information

Exosomal Del 1 as a potent diagnostic marker for breast cancer : A prospective cohort study

Exosomal Del 1 as a potent diagnostic marker for breast cancer : A prospective cohort study GBCC 2017: ABS-0017 Exosomal Del 1 as a potent diagnostic marker for breast cancer : A prospective cohort study Soo Jung Lee 1, Jeeyeon Lee 2, Jin Hyang Jung 2, Ho Yong Park 2, Chan Hyeong Lee 3, Pyong

More information

Breast Cancer. Excess Estrogen Exposure. Alcohol use + Pytoestrogens? Abortion. Infertility treatment?

Breast Cancer. Excess Estrogen Exposure. Alcohol use + Pytoestrogens? Abortion. Infertility treatment? Breast Cancer Breast Cancer Excess Estrogen Exposure Nulliparity or late pregnancy + Early menarche + Late menopause + Cystic ovarian disease + External estrogens exposure + Breast Cancer Excess Estrogen

More information

DOWNLOAD OR READ : UNDERSTANDING BREAST CANCER CELL BIOLOGY AND THERAPY A VISUAL APPROACH PDF EBOOK EPUB MOBI

DOWNLOAD OR READ : UNDERSTANDING BREAST CANCER CELL BIOLOGY AND THERAPY A VISUAL APPROACH PDF EBOOK EPUB MOBI DOWNLOAD OR READ : UNDERSTANDING BREAST CANCER CELL BIOLOGY AND THERAPY A VISUAL APPROACH PDF EBOOK EPUB MOBI Page 1 Page 2 understanding breast cancer cell biology and therapy a visual approach understanding

More information

Index. Note: Page numbers of article titles are in boldface type.

Index. Note: Page numbers of article titles are in boldface type. Note: Page numbers of article titles are in boldface type. A Adjuvant therapy, for early-stage triple-negative breast cancer, 740 742 in older early-stage breast cancer patients, 790 795 anti-her2-directed

More information

Your Guide to the Breast Cancer Pathology. Report. Key Questions. Here are important questions to be sure you understand, with your doctor s help:

Your Guide to the Breast Cancer Pathology. Report. Key Questions. Here are important questions to be sure you understand, with your doctor s help: Your Guide to the Breast Cancer Pathology Report Key Questions Here are important questions to be sure you understand, with your doctor s help: Your Guide to the Breast Cancer Pathology Report 1. Is this

More information

What is Cancer? Petra Ketterl, MD Medical Oncology and Functional Medicine

What is Cancer? Petra Ketterl, MD Medical Oncology and Functional Medicine What is Cancer? Petra Ketterl, MD Medical Oncology and Functional Medicine What is Cancer? Layman s terms: cancer starts when cells grow out of control (in any place in the body) and crowd out normal cells

More information

Breast Cancer. Most common cancer among women in the US. 2nd leading cause of death in women. Mortality rates though have declined

Breast Cancer. Most common cancer among women in the US. 2nd leading cause of death in women. Mortality rates though have declined Breast Cancer Most common cancer among women in the US 2nd leading cause of death in women Mortality rates though have declined 1 in 8 women will develop breast cancer Breast Cancer Breast cancer increases

More information

Understanding and Optimizing Treatment of Triple Negative Breast Cancer

Understanding and Optimizing Treatment of Triple Negative Breast Cancer Understanding and Optimizing Treatment of Triple Negative Breast Cancer Edith Peterson Mitchell, MD, FACP Clinical Professor of Medicine and Medical Oncology Program Leader, Gastrointestinal Oncology Department

More information

Supplemental Table S1: Inhibition of HDAC class I and class II family by CUDC-101 (IC50 in nm)

Supplemental Table S1: Inhibition of HDAC class I and class II family by CUDC-101 (IC50 in nm) Supplemental Table S1: Inhibition of HDAC class I and class II family by CUDC-101 (IC50 in nm) Class I Class II HDAC1 HDAC2 HDAC3 HDAC8 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDAC10 4.5 12.6 9.1 79.8 13.2 11.4

More information

Ductal Carcinoma-in-Situ: New Concepts and Controversies

Ductal Carcinoma-in-Situ: New Concepts and Controversies Ductal Carcinoma-in-Situ: New Concepts and Controversies James J. Stark, MD, FACP Medical Director, Cancer Program and Palliative Care Maryview Medical Center Professor of Medicine, EVMS Case Presentation

More information

SFMC Breast Cancer Site Study: 2011

SFMC Breast Cancer Site Study: 2011 SFMC Breast Cancer Site Study: 2011 Introduction Breast cancer is the most frequently diagnosed cancer among American women, except for skin cancers. It is the second leading cause of cancer death in women,

More information

Intro to Cancer Therapeutics

Intro to Cancer Therapeutics An Intro to Cancer Therapeutics Christopher R. Chitambar, MD Professor of Medicine Division of Hematology & Oncology Froedtert and Medical College of Wisconsin Clinical Cancer Center cchitamb@mcw.edu Intro

More information

Assessment of Risk Recurrence: Adjuvant Online, OncotypeDx & Mammaprint

Assessment of Risk Recurrence: Adjuvant Online, OncotypeDx & Mammaprint Assessment of Risk Recurrence: Adjuvant Online, OncotypeDx & Mammaprint William J. Gradishar, MD Professor of Medicine Robert H. Lurie Comprehensive Cancer Center of Northwestern University Classical

More information

BREAST CANCER. Dawn Hershman, MD MS. Medicine and Epidemiology Co-Director, Breast Program HICCC Columbia University Medical Center.

BREAST CANCER. Dawn Hershman, MD MS. Medicine and Epidemiology Co-Director, Breast Program HICCC Columbia University Medical Center. BREAST CANCER Dawn Hershman, MD MS Florence Irving Assistant Professor of Medicine and Epidemiology Co-Director, Breast Program HICCC Columbia University Medical Center Background Breast cancer is the

More information

Bio-Plex Pro Cell Signaling Assays

Bio-Plex Pro Cell Signaling Assays Acute Phase Response Cancer Cardiovascular Disease Diabetes Cytokines, Chemokines, Growth Factors Immunology/Inflammation Immunoglobulin Isotyping Cell Signaling Toxicology Bio-Plex Pro Cell Signaling

More information

2016 CANCER PROGRAM REPORT. Bay Medical Sacred Heart Health System 615 North Bonita Avenue Panama City, FL

2016 CANCER PROGRAM REPORT. Bay Medical Sacred Heart Health System 615 North Bonita Avenue Panama City, FL 2016 CANCER PROGRAM REPORT Bay Medical Sacred Heart Health System 615 North Bonita Avenue Panama City, FL 32401 850.769.1511 www.baymedical.org 2016 Cancer Program Report Bay Medical Sacred Heart provides

More information

Targeting CDK 4/6. Jee Hyun Kim, M.D., Ph.D. Seoul National University College of Medicine

Targeting CDK 4/6. Jee Hyun Kim, M.D., Ph.D. Seoul National University College of Medicine 2016.04.30 GBCC Education Symposium Targeting CDK 4/6 Jee Hyun Kim, M.D., Ph.D. Seoul National University College of Medicine Contents Cyclins -CDKs in cell cycle control CDK 4/6 in breast cancer Preclinical

More information

Molecular Characterization of Breast Cancer: The Clinical Significance

Molecular Characterization of Breast Cancer: The Clinical Significance Molecular Characterization of : The Clinical Significance Shahla Masood, M.D. Professor and Chair Department of Pathology and Laboratory Medicine University of Florida College of Medicine-Jacksonville

More information

SYSTEMIC THERAPY OPTIONS FOR BREAST CANCER IN 2014

SYSTEMIC THERAPY OPTIONS FOR BREAST CANCER IN 2014 SYSTEMIC THERAPY OPTIONS FOR BREAST Oncology Day 2014 CANCER IN 2014 Dr. Katherine Enright, M.D., M.P.H., F.R.C.P.(C) Katherine.enright@Trilliumhealthpartners.ca OBJECTIVES 1. Outline an approach to the

More information

Breast Cancer. Saima Saeed MD

Breast Cancer. Saima Saeed MD Breast Cancer Saima Saeed MD Breast Cancer Most common cancer among women in the US 2nd leading cause of death in women 1 in 8 women will develop breast cancer Incidence/mortality rates have declined Breast

More information

Kevin R. Fox, MD Rena Rowan Breast Center Abramson Cancer Center University of Pennsylvania Perelman School of MedicineR

Kevin R. Fox, MD Rena Rowan Breast Center Abramson Cancer Center University of Pennsylvania Perelman School of MedicineR Kevin R. Fox, MD Rena Rowan Breast Center Abramson Cancer Center University of Pennsylvania Perelman School of MedicineR Treatment of early stage, HER2 positive breast cancer Treatment of early stage,

More information

Breast Imaging: Multidisciplinary Approach. Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina

Breast Imaging: Multidisciplinary Approach. Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina Breast Imaging: Multidisciplinary Approach Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina No Disclosures Objectives Discuss a multidisciplinary breast

More information

Case Scenario 1. 2/15/2011 The patient received IMRT 45 Gy at 1.8 Gy per fraction for 25 fractions.

Case Scenario 1. 2/15/2011 The patient received IMRT 45 Gy at 1.8 Gy per fraction for 25 fractions. Case Scenario 1 1/3/11 A 57 year old white female presents for her annual mammogram and is found to have a suspicious area of calcification, spread out over at least 4 centimeters. She is scheduled to

More information

Response and resistance to BRAF inhibitors in melanoma

Response and resistance to BRAF inhibitors in melanoma Response and resistance to BRAF inhibitors in melanoma Keith T. Flaherty, M.D. Massachusetts General Hospital Cancer Center Disclosures Roche/Genentech: consultant GlaxoSmithKline: consultant BRAF mutations

More information

Supplementary Figures

Supplementary Figures Supplementary Figures Supplementary Figure 1 DOT1L regulates the expression of epithelial and mesenchymal markers. (a) The expression levels and cellular localizations of EMT markers were confirmed by

More information

UK Interdisciplinary Breast Cancer Symposium. Should lobular phenotype be considered when deciding treatment? Michael J Kerin

UK Interdisciplinary Breast Cancer Symposium. Should lobular phenotype be considered when deciding treatment? Michael J Kerin UK Interdisciplinary Breast Cancer Symposium Should lobular phenotype be considered when deciding treatment? Michael J Kerin Professor of Surgery National University of Ireland, Galway and Galway University

More information

Phosphorylation Site Company Cat #

Phosphorylation Site Company Cat # Supplemental Table 1. Antibodies used for RPPA analysis. Label Protein Phosphorylation Site Company Cat # Used on MDA_CLSS Used on MDA_Pilot 4EBP1 4EBP1 Cell Signaling 9452 No 4EBP1.pS65 4EBP1 S65 Cell

More information

Breast Cancer. Dr. Andres Wiernik 2017

Breast Cancer. Dr. Andres Wiernik 2017 Breast Cancer Dr. Andres Wiernik 2017 Agenda: The Facts! (Epidemiology/Risk Factors) Biological Classification/Phenotypes of Breast Cancer Treatment approach Local Systemic Agenda: The Facts! (Epidemiology/Risk

More information

Contemporary Classification of Breast Cancer

Contemporary Classification of Breast Cancer Contemporary Classification of Breast Cancer Laura C. Collins, M.D. Vice Chair of Anatomic Pathology Professor of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School Boston, MA Outline

More information

Tratamiento neoadyuvante: Enfermedad residual como marcador de resistencia Carlos L. Arteaga, MD Vanderbilt-Ingram Cancer Center Vanderbilt

Tratamiento neoadyuvante: Enfermedad residual como marcador de resistencia Carlos L. Arteaga, MD Vanderbilt-Ingram Cancer Center Vanderbilt Tratamiento neoadyuvante: Enfermedad residual como marcador de resistencia Carlos L. Arteaga, MD Vanderbilt-Ingram Cancer Center Vanderbilt University Neoadjuvant (preoperative) therapy Surgery Systemic

More information

w ª wy xvwz A ª vw xvw P ª w} xvw w Æ w Æ V w,x Æ w Æ w Æ y,z Æ { Æ y,z, w w w~ w wy}æ zy Æ wyw{ xæ wz w xywæ xx Æ wv Æ } w x w x w Æ w Æ wy} zy Æ wz

w ª wy xvwz A ª vw xvw P ª w} xvw w Æ w Æ V w,x Æ w Æ w Æ y,z Æ { Æ y,z, w w w~ w wy}æ zy Æ wyw{ xæ wz w xywæ xx Æ wv Æ } w x w x w Æ w Æ wy} zy Æ wz w ª wy xvwz A ª vw xvw P ª w} xvw w Æ w Æ V w,x Æ w Æ w Æ y,z Æ { Æ y,z, w w w~ w wy}æ zy Æ wyw{ xæ wz w xywæ xx Æ wv Æ } w x w x w Æ w Æ wy} zy Æ wz {w Æ Æ wyw{ x w Germ-line mutations in BRCA1 are associated

More information

Phospho-AKT Sampler Kit

Phospho-AKT Sampler Kit Phospho-AKT Sampler Kit E 0 5 1 0 0 3 Kits Includes Cat. Quantity Application Reactivity Source Akt (Ab-473) Antibody E021054-1 50μg/50μl IHC, WB Human, Mouse, Rat Rabbit Akt (Phospho-Ser473) Antibody

More information

Breast Cancer: Who Gets It? Who Survives? The Latest Information

Breast Cancer: Who Gets It? Who Survives? The Latest Information Breast Cancer: Who Gets It? Who Survives? The Latest Information James J. Stark, MD, FACP Medical Director, Cancer Program and Director of Palliative Care Maryview Medical Center Professor of Medicine

More information

UNIVERSITY TEKNOLOGI MARA THE ANTI PROLIFERATIVE PROPERTIES OF TINOSPORA CRISPA ON TRIPLE NEGATIVE BREAST CANCER CELL LINES

UNIVERSITY TEKNOLOGI MARA THE ANTI PROLIFERATIVE PROPERTIES OF TINOSPORA CRISPA ON TRIPLE NEGATIVE BREAST CANCER CELL LINES UNIVERSITY TEKNOLOGI MARA THE ANTI PROLIFERATIVE PROPERTIES OF TINOSPORA CRISPA ON TRIPLE NEGATIVE BREAST CANCER CELL LINES REYADH RADHI AL-RASHIDI Thesis submitted in fulfillment of the requirements for

More information

Thomas Jefferson University Annual Progress Report: 2008 Formula Grant

Thomas Jefferson University Annual Progress Report: 2008 Formula Grant Thomas Jefferson University Annual Progress Report: 2008 Formula Grant Reporting Period July 1, 2012 December 31, 2012 Formula Grant Overview The Thomas Jefferson University received $3,455,597 in formula

More information

It is a malignancy originating from breast tissue

It is a malignancy originating from breast tissue 59 Breast cancer 1 It is a malignancy originating from breast tissue including both early stages which are potentially curable, and metastatic breast cancer (MBC) which is usually incurable. Most breast

More information

RESEARCH ARTICLE. Eight Year Survival Analysis of Patients with Triple Negative Breast Cancer in India

RESEARCH ARTICLE. Eight Year Survival Analysis of Patients with Triple Negative Breast Cancer in India APJCP.2016.17.6.2995 RESEARCH ARTICLE Eight Year Survival Analysis of Patients with Triple Negative Breast Cancer in India Dinesh Chandra Doval 1,2 *, P Suresh 1, Rupal Sinha 2, Saud Azam 2, Ullas Batra

More information

Therapeutic Resistance to HER2 Targeted Therapies. Neil Spector, M.D Duke Cancer Institute Duke University Medical Center

Therapeutic Resistance to HER2 Targeted Therapies. Neil Spector, M.D Duke Cancer Institute Duke University Medical Center Therapeutic Resistance to HER2 Targeted Therapies Neil Spector, M.D Duke Cancer Institute Duke University Medical Center Relevant Financial Disclosures Millennium/Takeda Pharmaceuticals (consultant, sponsored

More information

Manejo do câncer de mama RH+ na adjuvância: o que há de novo?

Manejo do câncer de mama RH+ na adjuvância: o que há de novo? II Simpósio Internacional de Câncer de Mama para o Oncologista Clínico Manejo do câncer de mama RH+ na adjuvância: o que há de novo? INGRID A. MAYER, MD, MSCI Assistant Professor of Medicine Director,

More information

How to Use MRI Following Neoadjuvant Chemotherapy (NAC) in Locally Advanced Breast Cancer

How to Use MRI Following Neoadjuvant Chemotherapy (NAC) in Locally Advanced Breast Cancer Global Breast Cancer Conference 2016 & 5 th International Breast Cancer Symposium April 29 th 2016, 09:40-10:50 How to Use MRI Following Neoadjuvant Chemotherapy (NAC) in Locally Advanced Breast Cancer

More information

MRI-Based Biomarkers of Therapeutic Response in Triple-Negative Breast Cancer

MRI-Based Biomarkers of Therapeutic Response in Triple-Negative Breast Cancer MRI-Based Biomarkers of Therapeutic Response in Triple-Negative Breast Cancer Daniel Golden Postdoctoral Scholar (Radiology) Stanford University Daniel Rubin Laboratory NCI Cancer Imaging Fellowship Seminar

More information

Multimedia Appendix 6 Educational Materials Table of Contents. Intervention Educational Materials Audio Script (version 1)

Multimedia Appendix 6 Educational Materials Table of Contents. Intervention Educational Materials Audio Script (version 1) Multimedia Appendix 6 Educational Materials Table of Contents Intervention Educational Materials... 1 Audio Script (version 1)... 1 Text (version 1)... 5 Slides (version 1)... 17 Audio Script (version

More information

Gene Expression Profiling for Managing Breast Cancer Treatment. Policy Specific Section: Medical Necessity and Investigational / Experimental

Gene Expression Profiling for Managing Breast Cancer Treatment. Policy Specific Section: Medical Necessity and Investigational / Experimental Medical Policy Gene Expression Profiling for Managing Breast Cancer Treatment Type: Medical Necessity and Investigational / Experimental Policy Specific Section: Laboratory/Pathology Original Policy Date:

More information

Cell Biology and Cancer

Cell Biology and Cancer Name: Cell Biology and Cancer Date: Questions 1. BRCA1 and BRCA2 are what types of genes? 2. List two ways that cancerous and healthy cells differ. 3. Which organelle makes proteins? 4. At what phase of

More information

Clinico- Pathological Features And Out Come Of Triple Negative Breast Cancer

Clinico- Pathological Features And Out Come Of Triple Negative Breast Cancer Clinico- Pathological Features And Out Come Of Triple Negative Breast Cancer Dr. HassanAli Al-Khirsani, MBChB, CABM, F.I.C.M.S AL-Sadder teaching hospital, oncology unit Dr. Nasser Ghaly Yousif, MBChB,G.P.

More information

Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression

Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression Mona A. Abd-Elazeem, Marwa A. Abd- Elazeem Pathology department, Faculty of Medicine, Tanta

More information

Maram Abdaljaleel, MD Dermatopathologist and Neuropathologist University of Jordan, School of Medicine

Maram Abdaljaleel, MD Dermatopathologist and Neuropathologist University of Jordan, School of Medicine Maram Abdaljaleel, MD Dermatopathologist and Neuropathologist University of Jordan, School of Medicine The most common non-skin malignancy of women 2 nd most common cause of cancer deaths in women, following

More information

Evolving Practices in Breast Cancer Management

Evolving Practices in Breast Cancer Management Evolving Practices in Breast Cancer Management The Georgia Tumor Registrars Association 2016 Priscilla R. Strom, MD, FACS Objectives 1. understand newer indications for neoadjuvant treatment 2. understand

More information

Presenter: Dr. Suman Rao May 13, 2016

Presenter: Dr. Suman Rao May 13, 2016 Presenter: Dr. Suman Rao May 13, 2016 1 2010 Breast Cancer Estimates 207,090 NEW CASES 4% Melanoma of Skin 2% Thyroid 31% Breast 13% Lung & Bronchus 2% Pancreas 11% Colon & Rectum 4% Ovary 6% Uterus 3%

More information

Supplementary Figure 1

Supplementary Figure 1 A B D Relative TAp73 mrna p73 Supplementary Figure 1 25 2 15 1 5 p63 _-tub. MDA-468 HCC1143 HCC38 SUM149 MDA-468 HCC1143 HCC38 SUM149 HCC-1937 MDA-MB-468 ΔNp63_ TAp73_ TAp73β E C Relative ΔNp63 mrna TAp73

More information

Pathology Report Patient Companion Guide

Pathology Report Patient Companion Guide Pathology Report Patient Companion Guide Breast Cancer - Understanding Your Pathology Report Pathology Reports can be overwhelming. They contain scientific terms that are unfamiliar and might be a bit

More information

Systemic Treatment of Breast Cancer. Hormone Therapy and Chemotherapy, Curative and Palliative

Systemic Treatment of Breast Cancer. Hormone Therapy and Chemotherapy, Curative and Palliative Systemic Treatment of Breast Cancer Hormone Therapy and Chemotherapy, Curative and Palliative Systemic Therapy Invasive breast cancers Two forms Curative Palliative Curative Systemic Therapy Adjuvant Therapy

More information

Table S7B- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 expressers

Table S7B- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 expressers Table S7B- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 expressers ListHits ListTotal PopulationHits PopulationTotal Terms 3 72 10 1429 Glycolysis Pathway 3 72 11 1429 Regulation

More information

Novel Strategies in Systemic Therapies: Overcoming Endocrine Therapy Resistance

Novel Strategies in Systemic Therapies: Overcoming Endocrine Therapy Resistance Novel Strategies in Systemic Therapies: Overcoming Endocrine Therapy Resistance Richard S. Finn, MD Division of Hematology/ Oncology Director, Translational Oncology Laboratory Geffen School of Medicine

More information

INDIVIDUALIZED THERAPY OF METASTATIC BREAST CANCER Lance A. Liotta MD PhD

INDIVIDUALIZED THERAPY OF METASTATIC BREAST CANCER Lance A. Liotta MD PhD INDIVIDUALIZED THERAPY OF METASTATIC BREAST CANCER Lance A. Liotta MD PhD A vision for Combining proteomic mapping with genomic analysis of the metastatic lesion 57 year old women TNBC locally recurrent

More information

ESMO SUMMIT MIDDLE EAST 2018

ESMO SUMMIT MIDDLE EAST 2018 ESMO SUMMIT MIDDLE EAST 2018 Breast Clinical Cases Presentation Hampig Raphael Kourie, MD, MSc, MBioethics Faculty of Medicine, Saint Joseph University of Beirut, Lebanon 6-7 April 2018, Dubai, UAE CONFLICT

More information

OUTLINE PAST PRESENTFUTURE BREAST CANCER INCIDENCE AND MORTALITY CURRENT STATE OF MEDICAL ONCOLOGY SECOND ANNUAL BREAST CANCER SYMPOSIUM

OUTLINE PAST PRESENTFUTURE BREAST CANCER INCIDENCE AND MORTALITY CURRENT STATE OF MEDICAL ONCOLOGY SECOND ANNUAL BREAST CANCER SYMPOSIUM OUTLINE CURRENT STATE OF MEDICAL ONCOLOGY SECOND ANNUAL BREAST CANCER SYMPOSIUM October 11, 2014 SARA M GARRIDO, M.D., F.A.C.P Chief Medical Officer at AMS Miami, October 11, 2014 PAST PRESENTFUTURE -BRIEF

More information

Breast Cancer Basics. Clinical Oncology for Public Health Professionals. Ben Ho Park, MD, PhD

Breast Cancer Basics. Clinical Oncology for Public Health Professionals. Ben Ho Park, MD, PhD This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this

More information

MAPK Pathway

MAPK Pathway MAPK Pathway Mitogen-activated protein kinases (MAPK) are proteins that are serine/ threonine specific kinases which are activated by a wide range of stimuli including proinflammatory cytokines, growth

More information

Growth and Differentiation Phosphorylation Sampler Kit

Growth and Differentiation Phosphorylation Sampler Kit Growth and Differentiation Phosphorylation Sampler Kit E 0 5 1 0 1 4 Kits Includes Cat. Quantity Application Reactivity Source Akt (Phospho-Ser473) E011054-1 50μg/50μl IHC, WB Human, Mouse, Rat Rabbit

More information

SUPPLEMENTAY FIGURES AND TABLES

SUPPLEMENTAY FIGURES AND TABLES SUPPLEMENTAY FIGURES AND TABLES Supplementary Figure S1: Validation of mir expression by quantitative real-time PCR and time course studies on mir- 29a-3p and mir-210-3p. A. The graphs illustrate the expression

More information

BreastScreen Aotearoa Annual Report 2015

BreastScreen Aotearoa Annual Report 2015 BreastScreen Aotearoa Annual Report 2015 EARLY AND LOCALLY ADVANCED BREAST CANCER PATIENTS DIAGNOSED IN NEW ZEALAND IN 2015 Prepared for Ministry of Health, New Zealand Version 1.0 Date November 2017 Prepared

More information

Open Clinical Trials: What s Out There Now Paula D. Ryan, MD, PhD

Open Clinical Trials: What s Out There Now Paula D. Ryan, MD, PhD Open Clinical Trials: What s Out There Now Paula D. Ryan, MD, PhD Hanahan and Weinberg, 2000 Acquired Capabilities of Cancer Clinical Trials When should I consider a clinical trial? How do I find the right

More information

CANCER THERAPEUTICS: A NOVEL APPROACH

CANCER THERAPEUTICS: A NOVEL APPROACH CANCER THERAPEUTICS: A NOVEL APPROACH Mary Dwyer, Ph.D. HBRI and ChemRegen, Inc. SCDMDG Meeting October 23, 212 Outline Introduction Hit, HBRI1: identification & characterization Leads, HBRI2 & HBRI3:

More information

Prof. R. V. Skibbens

Prof. R. V. Skibbens Prof. R. V. Skibbens December 2, 2011 BIOS 10: BioScience in the 21 st Century Cell Cycle, Cell Division and Cancer (Part 2) Directionality The Cell Cycle clock goes in only one direction S-phase cells

More information

Signaling Through Immune System Receptors (Ch. 7)

Signaling Through Immune System Receptors (Ch. 7) Signaling Through Immune System Receptors (Ch. 7) 1. General principles of signal transduction and propagation. 2. Antigen receptor signaling and lymphocyte activation. 3. Other receptors and signaling

More information

Dox. R26-rtTA Tyr-CreERT2. any ink/arf, no rtta (n=8) ink/arf +/+ (n=5) Day 0 Day 11 Day 18 Day 28

Dox. R26-rtTA Tyr-CreERT2. any ink/arf, no rtta (n=8) ink/arf +/+ (n=5) Day 0 Day 11 Day 18 Day 28 A 4OHT Dox hraf iip tumors inras ddh 2 O -RT Ink/Arf / Pten l/ l R26-lsl-rtTA Tyr-reERT2 TetO-hRAF V6E Ink/Arf / Pten / R26-rtTA Tyr-reERT2 TetO-hRAF V6E Ink/Arf / Pten / R26-rtTA Tyr-reERT2 TetO-hRAF

More information

Intergenic Fusions in Advanced HR+ Breast Cancer

Intergenic Fusions in Advanced HR+ Breast Cancer Intergenic Fusions in Advanced HR+ Breast Cancer Leif W. Ellisen, MD, PhD Program Director, Breast Medical Oncology Disclosures: Lief W. Ellisen, MD, PhD, has disclosed no relevant financial relationships.

More information

Founded in 2016 to develop life-changing therapies against debilitating aggressive cancers that have limited treatment options

Founded in 2016 to develop life-changing therapies against debilitating aggressive cancers that have limited treatment options Founded in 2016 to develop life-changing therapies against debilitating aggressive cancers that have limited treatment options Integrated platform technology for discovery of novel molecular targets and

More information

6/22/2017 TARGETING THE TARGETS IN 2017 TARGETING THE TARGETS IN 2017

6/22/2017 TARGETING THE TARGETS IN 2017 TARGETING THE TARGETS IN 2017 TARGETING THE TARGETS IN 2017 Primary Care Focus Symposium July 1, 2017 Grace Wang MD I do not have any relevant financial relationships to disclose at this time TARGETING THE TARGETS IN 2017 What are

More information

Implications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers

Implications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers 日大医誌 75 (1): 10 15 (2016) 10 Original Article Implications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers Naotaka Uchida 1), Yasuki Matsui 1), Takeshi Notsu 1) and Manabu

More information

Current Status and Future Development of Tools for Prognosis and Prediction - USA

Current Status and Future Development of Tools for Prognosis and Prediction - USA Current Status and Future Development of Tools for Prognosis and Prediction - USA John H. Ward, MD Professor of Medicine University of Utah School of Medicine Huntsman Cancer Institute October18, 2009

More information

Supplemental Figure 1

Supplemental Figure 1 1 Supplemental Figure 1 Effects of DATE shortening on HGF promoter activity. The HGF promoter region (-1037 to +56) containing wild-type (30As) or truncated DATE (26As, 27As, 28A, 29As) from breast cancer

More information

One Breast Cancer Annual Report

One Breast Cancer Annual Report One 2015 Breast Cancer Annual Report One OVERVIEW The Breast Program at Carolinas HealthCare System s Levine Cancer Institute, offers comprehensive care. Patients with benign and malignant disease of the

More information

Ets-1 identifying polynucleotide sequence for targeted delivery of anti-cancer drugs

Ets-1 identifying polynucleotide sequence for targeted delivery of anti-cancer drugs Ets-1 identifying polynucleotide sequence for targeted delivery of anti-cancer drugs Indian Patent Application No. 1623/DEL/2014 Inventors: Prof. Kulbhushan Tikoo and Jasmine Kaur Department of Pharmacology

More information

Q&A. Fabulous Prizes. Collecting Cancer Data: Breast 4/4/13. NAACCR Webinar Series Collecting Cancer Data Breast

Q&A. Fabulous Prizes. Collecting Cancer Data: Breast 4/4/13. NAACCR Webinar Series Collecting Cancer Data Breast Collecting Cancer Data Breast NAACCR 2012 2013 Webinar Series Q&A Please submit all questions concerning webinar content through the Q&A panel. Reminder: If you have participants watching this webinar

More information

HEALTH CARE DISPARITIES. Bhuvana Ramaswamy MD MRCP The Ohio State University Comprehensive Cancer Center

HEALTH CARE DISPARITIES. Bhuvana Ramaswamy MD MRCP The Ohio State University Comprehensive Cancer Center HEALTH CARE DISPARITIES Bhuvana Ramaswamy MD MRCP The Ohio State University Comprehensive Cancer Center Goals Understand the epidemiology of breast cancer Understand the broad management of breast cancer

More information

Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05

Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05 Abstract No.: ABS-0075 Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer 2018/04/05 Cheol Min Kang Department of surgery, University of Ulsan

More information

Barriers to Understanding

Barriers to Understanding Behind the Scenes: The Critical Importance of Cancer Cell Pathology and the Pathologist Sherry T. Emery, M.D., Chief of Pathology Northeast Health System Barriers to Understanding Questions for 2010 What

More information

Objectives Critically review presentations on 1. Local therapy 2. Adjuvant chemotherapy for isolated local regional recurrence 3. The optimal duration

Objectives Critically review presentations on 1. Local therapy 2. Adjuvant chemotherapy for isolated local regional recurrence 3. The optimal duration Objectives Critically review presentations on 1. Local therapy 2. Adjuvant chemotherapy for isolated local regional recurrence 3. The optimal duration of endocrine therapy 4. Advances in HER2 directed

More information

So, Who are the appropriate individuals that should consider genetic counseling and genetic testing?

So, Who are the appropriate individuals that should consider genetic counseling and genetic testing? Hello, I m Banu Arun, Professor of Breast Medical Oncology and Co-Director of Clinical Cancer Genetics at the University of Texas MD Anderson Cancer Center. Today I will be discussing with you Hereditary

More information

Supplementary Information. Targeting BRK-positive Breast Cancer with Small

Supplementary Information. Targeting BRK-positive Breast Cancer with Small Supplementary Information Targeting BRK-positive Breast Cancer with Small Molecule Kinase Inhibitors Jie Jiang 1#, Fu Gui 1#, Zhixiang He 1#, Li Li 1, Yunzhan Li 1, Shunying Li 2, Xinrui Wu 1, Zhou Deng

More information

Johns Hopkins Clinical Update Webinar

Johns Hopkins Clinical Update Webinar Johns Hopkins Clinical Update Webinar Ben Ho Park, M.D., Ph.D. Department of Oncology Johns Hopkins University February 2015 This presentation is the intellectual property of the author/presenter. Contact

More information

SCIENCE CHINA Life Sciences

SCIENCE CHINA Life Sciences SCIENCE CHINA Life Sciences RESEARCH PAPER April 2013 Vol.56 No.4: 335 340 doi: 10.1007/s11427-013-4435-y Risk factors of recurrence in small-sized, node negative breast cancer in young women: a retrospective

More information

A Study to Evaluate the Effect of Neoadjuvant Chemotherapy on Hormonal and Her-2 Receptor Status in Carcinoma Breast

A Study to Evaluate the Effect of Neoadjuvant Chemotherapy on Hormonal and Her-2 Receptor Status in Carcinoma Breast Original Research Article A Study to Evaluate the Effect of Neoadjuvant Chemotherapy on Hormonal and Her-2 Receptor Status in Carcinoma Breast E. Rajesh Goud 1, M. Muralidhar 2*, M. Srinivasulu 3 1Senior

More information

Diabetes Mellitus and Breast Cancer

Diabetes Mellitus and Breast Cancer Masur K, Thévenod F, Zänker KS (eds): Diabetes and Cancer. Epidemiological Evidence and Molecular Links. Front Diabetes. Basel, Karger, 2008, vol 19, pp 97 113 Diabetes Mellitus and Breast Cancer Ido Wolf

More information

Figure S4. 15 Mets Whole Exome. 5 Primary Tumors Cancer Panel and WES. Next Generation Sequencing

Figure S4. 15 Mets Whole Exome. 5 Primary Tumors Cancer Panel and WES. Next Generation Sequencing Figure S4 Next Generation Sequencing 15 Mets Whole Exome 5 Primary Tumors Cancer Panel and WES Get coverage of all variant loci for all three Mets Variant Filtering Sequence Alignments Index and align

More information

Supplementary Figure 1. IHC and proliferation analysis of pten-deficient mammary tumors

Supplementary Figure 1. IHC and proliferation analysis of pten-deficient mammary tumors Wang et al LEGENDS TO SUPPLEMENTARY INFORMATION Supplementary Figure 1. IHC and proliferation analysis of pten-deficient mammary tumors A. Induced expression of estrogen receptor α (ERα) in AME vs PDA

More information

Triple Negative Breast Cancer

Triple Negative Breast Cancer Triple Negative Breast Cancer Prof. Dr. Pornchai O-charoenrat Division of Head-Neck & Breast Surgery Department of Surgery Faculty of Medicine Siriraj Hospital Breast Cancer Classification Traditional

More information

Cryoablation in the Management of Early Stage Breast Cancer

Cryoablation in the Management of Early Stage Breast Cancer 13 th Annual Pacific Northwest Breast and Gynecologic Care Conference Cryoablation in the Management of Early Stage Breast Cancer Dennis R. Holmes, M.D., Inc. Int. Director, Margie Peterson Breast Center

More information

Monitoring Metastatic Breast Cancer with Serum HER-2/neu: Individual Patient Profiles

Monitoring Metastatic Breast Cancer with Serum HER-2/neu: Individual Patient Profiles Siemens Healthcare Diagnostics, a global leader in clinical diagnostics, provides healthcare professionals in hospital, reference, and physician office laboratories and point-of-care settings with the

More information

Discovery and Optimization of Inhibitors of STAT3 Activation for the Treatment of Squamous Cell Carcinoma of the Head and Neck

Discovery and Optimization of Inhibitors of STAT3 Activation for the Treatment of Squamous Cell Carcinoma of the Head and Neck Discovery and ptimization of Inhibitors of STAT3 Activation for the Treatment of Squamous Cell Carcinoma of the Head and Neck Feng Zhang Wipf Group Research Topic Seminar 02-09-2013 1 Feng Zhang @ Wipf

More information

Part-4. Cell cycle regulatory protein 5 (Cdk5) A novel target of ERK in Carb induced cell death

Part-4. Cell cycle regulatory protein 5 (Cdk5) A novel target of ERK in Carb induced cell death Part-4 Cell cycle regulatory protein 5 (Cdk5) A novel target of ERK in Carb induced cell death 95 1. Introduction The process of replicating DNA and dividing cells can be described as a series of coordinated

More information

The Changing Landscape of Breast Cancer Management and Treatment

The Changing Landscape of Breast Cancer Management and Treatment The Changing Landscape of Breast Cancer Management and Treatment Nathalie Johnson, MD, FACS Medical Director of the Legacy Cancer Institute and Breast Health Centers Objectives Review current screening

More information

Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer

Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer Young Investigator Award, Global Breast Cancer Conference 2018 Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer ㅑ Running head: Revisiting estrogen positive tumors

More information