CPRIT Overview. Cancer Centers Administrators Forum April 4, 2016

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Paula Bradley
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1 CPRIT Overview Cancer Centers Administrators Forum April 4, 2016

2 CPRIT s Unique Role in the Fight Against Cancer Overview: Created by the Texas Legislature and citizens in 2007 $3 billion over 10 years funded by revenue bonds Mission: Create and expedite innovation in cancer research into prevention and cures Attract, create, or expand research capabilities Enhance access to evidence-based prevention programs and services Create high-quality new jobs in Texas 2

3 Cancer Funding Sources in Texas Billions Pharma NCI Other federal Non-Profits CPRIT

4 CPRIT Action Award merit-based, peer reviewed grants to Texasbased entities and institutions for cancer-related research, product development and the delivery of cancer prevention programs and services. Academic Product Development Prevention 4

5 CPRIT Action Award merit-based, peer reviewed grants to Texasbased entities and institutions for cancer-related research, product development and the delivery of cancer prevention programs and services. Academic Product Development Prevention 70% 20% 10% 5

6 Peer Review Structure Oversight Committee Program Integration Committee Chief Scientific Officer Chief Prevention Officer Chief Product Development Officer Scientific Review Council Chair Prevention Review Council Chair Product Development Review Council Chair Peer Review Committee Chairs Peer Review Committee Chairs Peer Review Committee Chairs

7 Program Goals Grants Discover new information about cancer that can lead to prevention, early detection and cures Translate new and existing discoveries into practical advances in cancer diagnosis and treatment Increase the prominence and stature of Texas in the fight against cancer Mechanisms Grants: Individual Investigator Award (3 yrs., total $900,000) High Impact-High Risk Awards (2 yrs., total $200,000) Multi-Investigator Awards (5 yrs., total $7,500,000) Core Facilities Support Awards (4 yrs., total $6,000,000) Training Awards (5 yrs., total $4,000,000) 21

8 Program Goals Grants Discover new information about cancer that can lead to prevention, early detection and cures Translate new and existing discoveries into practical advances in cancer diagnosis and treatment Increase the prominence and stature of Texas in the fight against cancer Mechanisms Recruitment Grants*: Recruitment of First-Time, Tenure-Track ($2,000,000) Recruitment of Rising Stars ($4,000,000) Recruitment of Established Investigators ($6,000,000) * Requires 50% institutional match 21

9 : Current Portfolio Distribution of Funded Grants by Area 4% 3% 2% 1% Cancer Biology 12% 51% Treatment Early detection, diagnosis, and prognosis Etiology (causes of cancer) Prevention 27% Scientific model systems Cancer Control and Survivorship 9

10 CPRIT Funding in Perspective Billions $10.0 $9.0 $8.0 $7.0 $6.0 $5.0 $4.0 $3.0 $2.0 $1.0 $0.0 $9.2 $5.0 $3.0 $0.7 $0.3 Source: Report of the National Cancer Advisory Board AD Hoc Working Group, Dec Industry NCI Other Federal Foundations/Non-profits CPRIT *Does not include private philanthropy 10

11 Priorities Principles Scientific excellence and impact on cancer Targeting underfunded areas Increasing the life sciences infrastructure 2016 Program Priorities A broad range of innovative, investigatorinitiated research projects Prevention and early detection Rare and intractable cancers, including childhood cancers Cancers of importance in Texas Computational biology and analytic methods 16

12 Life Sciences Infrastructure Scholar Recruitment Awards As of Feb Award Mechanism # of Recruits Total Award Amounts Recruitment of Established Investigators 26 $148.7M Recruitment of First-Time, Tenure-Track Faculty 69 $137.6M Recruitment of Rising Stars 12 $42.0M TOTALS: 107 $328.3 M 12

13 Product Development Program Principles Development of commercial products to diagnose and treat cancer Creation of good, highpaying jobs for Texans Sound financial return on the monies invested Development of Texas high tech life sciences business environment 2016 Product Development Program Priorities Funding projects at Texas companies and relocating companies that are most likely to bring important products to the market Providing funding that promotes the translation of research at Texas institutions into new companies able to compete in the marketplace Identifying and funding projects to develop tools and technologies of special relevance to cancer research, treatment, and prevention 17

14 CPRIT s Unique Role in Fighting Cancer Stages Basic Translational Drug Discovery Preclinic al Phase I Clinical Trials Phase II Phase III FDA Review Phase IV Mfg. Clinic Drug Development Pipeline 5K-10K Compounds FDA Approved Drug Funding Sources Largely Public Funded e.g. NIH, DoD Public & Private (Underfunded) Largely Industry & For Profit Funded Valley of Death Timeline 3-6 Years 6-10 Years Years Ongoing/Indefinit e Average cost for approved drug: $1 Billion General timeframe to approved drug: years

15 CPRIT s Unique Role in Fighting Cancer CPRIT focuses on the basic and translational stages of cancer research. Stages Basic Translational Drug Discovery Preclinic al Phase I Clinical Trials Phase II Phase III FDA Review Phase IV Mfg. Clinic Drug Development Pipeline 5K-10K Compounds FDA Approved Drug Funding Sources Largely Public Funded e.g. NIH, DoD Public & Private (Underfunded) Largely Industry & For Profit Funded Valley of Death Timeline 3-6 Years 6-10 Years Years Ongoing/Indefinit e Average cost for approved drug: $1 Billion General timeframe to approved drug: years

Early Drug Development Award Supports projects that "bridge the gap" between promising new discoveries achieved in the research

demonstrate applicability to the planned clinical scenario.

16 Early Drug Development Award Supports projects that "bridge the gap" between promising new discoveries achieved in the research laboratory and commercial development for a therapeutic, device, or diagnostic assay preclinical proof-of-principle data that demonstrate applicability to the planned clinical scenario. Stages Basic Translational Drug Discovery Preclinical Clinical Trials Phase I Phase II Phase III FDA Review Phase IV Mfg. Clinic Drug Development Pipeline 5K-10K Compounds FDA Approved Drug Funding Sources Largely Public Funded e.g. NIH, DoD Public & Private (Underfunded) Largely Industry & For Profit Funded Valley of Death Timeline 3-6 Years 6-10 Years Years Ongoing/Indefinit e Average cost for approved drug: $1 Billion General timeframe to approved drug: years

areas of greatest need, greatest potential for impact Focus on underserved populations Increase targeting of

17 Prevention Program Principles Fund evidence-based interventions and their dissemination Support the continuum of primary, secondary and tertiary prevention interventions 2016 Prevention Program Priorities Prioritize areas of greatest need, greatest potential for impact Focus on underserved populations Increase targeting of preventive efforts to areas where significant disparities in cancer incidence or mortality in the state exist 18

18 Geographic Coverage 64 Active Projects; 2.7 million Texans served 18

19 CPRIT invests Texans money, working with the best minds, to beat cancer.

Program Priorities 2018

Program Priorities 2018 Blank Page 2 CONTENTS: About CPRIT Program Priorities Project...Page 5 Process to Develop Program Priorities...Page 6 Scope of Program Priorities Project...Page 6 CPRIT s Long-Term