Clinical features and prognostic factors in patients with nasopharyngeal carcinoma relapse after primary treatment
|
|
- Robert Malone
- 5 years ago
- Views:
Transcription
1 Page 1 of 7 Clinical features and prognostic factors in patients with nasopharyngeal carcinoma relapse after primary treatment X Peng 1, SF Chen 2, C Du 2 *, P Yang 2, SX Liang 2, G Zhang 3, X Dong 4 *, M Kwan 5 Abstract Nasopharyngeal carcinoma (NPC) relapse after primary treatment is a major cause of cancer-related deaths. There is little comprehensive information on long-term outcomes particularly pertaining to the site of relapse. Therefore, the aim of this study was to determine the clinicopathological features of NPC relapse after primary treatment of 1424 patients referred to our institution from 2000 to After initial treatment, patients were reviewed at 3 6 month intervals. Information was collected on demographics, pre- and post-management and patient outcomes. The median age was 48 years (range 3 77), with complete data for 82% patients. In total, 152 patients (13%) had a local relapse and 193 patients (16.5%) had a distant relapse. Among patients with distant metastasis, the most common site of first relapse was the bone (in 56 patients), followed by multiple organ involvement (50), lung (37) and liver (30). The median interval from primary treatment until recurrence was 28 months, and diseasefree intervals correlated to survival (P < ). If a relapse occurred, the 3-year survival was 51% for local * Corresponding authors s: ducaiwen@21cn.com; xiaoqun_dong@mail.uri.edu 1 Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, People s Republic of China 2 Department of Medical Oncology, Cancer Hospital of Shantou University Medical College, Shantou, People s Republic of China 3 Tumor Research Laboratory, Cancer Hospital of Shantou University Medical College, Shantou, People s Republic of China 4 Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, USA 5 Department of Surgery, The University of Hong Kong, Hong Kong, People s Republic of China recurrence and 29.2% for distant recurrence (P < ). There were four dominant prognostic variables that predicted the patient s clinical course: (1) stage of cancer (P = 0.008), (2) remission duration ( 24 months vs. >24 months, P = 0.043), (3) location of metastases (local recurrence vs. distant recurrence, P = 0.043) and (4) nodal status (P = 0.048). Factors that were not significant in the univariate analysis included the patients age and sex, tumour size and histology. This data provided information on treatment outcomes in NPC patients along with statistical information to inform NPC patients about their expectations after the diagnosis of a relapse. Introduction Nasopharyngeal carcinoma (NPC) is the most common malignancy in the head and neck and has unique histological features, epidemiology, progression behaviours and management approaches. It also has a high prevalence in Southeast Asia and southern China 1. With the introduction of new treatment modalities and earlier detection, survival has steadily improved over recent decades 2. However, cancer relapse is still the leading cause of cancer-related deaths in patients with NPC. The most common cause of death after radiotherapy is distant metastasis, followed by nasopharyngeal and cervical recurrence 3. Although much is known on the treatment and prognostic factors for this cancer, there has not been a systematic study on patterns of relapse and long-term outcomes after relapse occurs. Data from other cancers suggest that patients with bone metastasis have a better prognosis than those with visceral metastasis 4. Whether the same is applicable for NPC remains to be investigated. Additionally, we attempted to find any factors that best predict the clinical course of metastatic NPC. In this paper, we describe the occurrence, survival time and prognosis of relapsed NPC. Patients after initial treatment were followed prospectively for up to 12 years. This information is especially important for NPC because the high propensity for spreading to more sites has a more variable clinical course than most other head and neck cancers. Knowledge about the dominant prognostic variables is also important in designing optimal patient treatment. Methods and materials Patients Between January 1999 and July 2006, a total of 1424 patients (1015 men, 409 women) with NPC were diagnosed and treated with radiotherapy (RT) alone or concurrent chemoradiotherapy at Cancer Hospital of Shantou University Medical College, China. Of these 1424 patients, complete followup information was available for 82% patients. The median age was 48 years (range 3 78). Patient backgrounds are summarized in Table 1. TNM distribution was classified by the Union for International Cancer Control 1997 staging system. Pathology classification is based on the World Health Organization (WHO) with Grade I representing squamous cell carcinoma, Grade II representing non-keratinizing carcinoma and Grade III representing undifferentiated carcinoma. Initial treatment methods for NPC Initial treatment for patients with NPC included primary RT using a two-dimensional (2D) technique, with two lateral opposing faciocervical fields
2 Page 2 of 7 Table 1 Patient and disease characteristics (total) Characteristics Patients No. % Age, year Median 48 Range 3 77 <40 years years Sex Male Female AJCC T category T T AJCC N category N N AJCC stage I II III IV WHO histology Grades I II Grade III Metastasis Yes No for the first phase. The second phase consisted of two lateral opposing fields to cover the nasopharynx matched with a single anterior cervical field to cover the neck. The dose delivered to the nasopharynx was Gy. The radiation doses to the lymph nodepositive and -negative areas were Gy and Gy, respectively. Concurrent chemotherapy, mostly cisplatin-based, was given to patients with locally advanced disease. Follow-up procedures and evaluation method After initial treatment, patients were seen at 3-month intervals for the first two years, 6-month intervals for up to five years and annually thereafter, unless a recurrence was detected or the patient died. Chest radiography, abdominal ultrasonography, bone scan and contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) of the nasopharynx and cervical region were routine elements of each assessment. Followup data was completed in 82% patients. Recurrence sites were classified as local, bone, liver, lung and multiple organ metastases. Local recurrence was defined as recurrence in the nasopharynx or regional neck nodes according to the first or most significant site of relapse. Multiple metastases were defined as either relapse with local recurrence and one organ recurrence or more than two organs involved simultaneously. Statistics Data analysis was performed using the SPSS software package (version 11.0; SPSS, Chicago, IL). The survival time was defined as the time between the diagnosis of first relapse and death or the last follow-up. Univariate and multivariate analyses were performed using SPSS 17.0 software (IBM, Armonk, NY, USA). The Kaplan Meier method with a log-rank test was used for survival rate calculations and to reveal the cumulative incidence of metastasis. Cox proportional hazard models were used to analyse risk factors for survival time calculated from the time of recurrence. In the analysis for risk factors, univariate analysis was performed for the following factors: age at the time of NPC diagnosis ( 40 years vs. >40 years), sex (male vs. female), T factor (T1 2 vs. T3 4), N factor (N0 1 vs. N2 3), stage factor (stage I II vs. stage III IV), location of metastasis (local recurrence vs. bone vs. liver vs. lung vs. multiple organ vs. others), remission duration ( 2 years vs. >2 years) and pathological type (G1 2 vs. G3). All tests were two-sided, and P < 0.05 was considered statistically significant. Results Frequency and characteristics of recurrence after initial treatment for NPC At the end of the study, there were 256 patients (18%) with incomplete follow-ups, but complete follow-up information was available for 1168 patients with a median follow-up time of 45 months (range 1 103). Of the 1168 patients, the median age was 48 years (range 3 78) at the time of treatment. At the end of the study, 776 patients were alive and 392 were dead. The overall survival rate after 5 years was 67% (median survival: 66 months) (Figure 1). The anatomic
3 Page 3 of 7 Figure 1: Overall survival rate after initial treatment for NPC. sites of the relapses were combined into two groups: distant (lung, liver, bone and others) versus local sites (nasopharynx or regional neck nodes). In this series, local recurrence was found in 152 patients. Metastases to the distant organ after initial treatment were found in 193 patients. Figure 2 shows that patients with local recurrence had a significantly better prognosis than those who developed distant recurrence. The 3-year-survival time for local relapse was 51% compared with 29.2% for distant metastasis (P = 0.000). Knowing the most frequent sites of distant metastases is important in the follow-up examinations of NPC patients. In our study, single bone was the most common first site of relapses, occurring in 29% (56/193) patients with distant metastasis. Further patient percentages for the first site of relapse included 19.2% (37/193) for single lung, 15.5% (30/193) for single liver, 25.9% (50/193) in multi-organ sites (including concurrent recurrence in both local and distant metastases) and 10% (20/193) in others. The median survival duration for this patient group was 12 months. For patients with any distant metastasis site, the survival rate did not show a statistical difference (Figure 2b). Remission duration We further studied if remission duration for NPC can be a factor in predicting the clinical course of the disease. Survival was calculated from the onset of relapse and the duration from the end of the primary treatment to the diagnosis of first recurrence ranged from 2 to 88 months. The median recurrent interval time was 28 months, in which recurrent interval time less than or equal to the first year accounted for 19.42% (67/345) and the second year accounted for 25.2% (87/345). The 2-year cumulative recurrence cases accounted for 44.6% (154/345). Recurrence from 25 to 60 months accounted for 45.5% (157/345) and more than 60 months accounted for 9.9% (34/345). Our study indicated that patients with remission duration greater than 24 months have a better survival than those with a shorter remission; this factor was significantly different using an analysis of the curves by single factor analysis (P = 0.043, Figure 3). We then compared the two groups (group A: remission duration 24 months, group B: remission duration >24 months) to identify if the survival differences between them were related with clinical characteristics. As shown in Table 2, the median age at the time of confirmed NPC was similar for both groups. Group A presented a higher male-to-female ratio than group B (P = 0.000). A significantly higher proportion of long-latent relapses originated from well-differentiated histology. The percentage of patients with G1 and G2 was 72% in group A and 90% in group B. Likewise, the percentage of patients diagnosed with an earlier stage was lower in group A. T1 2 was 48% in group A vs. 60% in group B (P = 0.001), N0 1 was 37% in group A vs. 48% in group B (P = 0.027) and stage I/II was 48% in group A vs. 60% in group B (P = 0.025). Multifactorial analysis Our final analysis examined the prognostic factors for the predictive value of survival rate. Table 3 presents the relative importance of each single factor, unadjusted for other factors by Cox regression analysis. Using univariate analysis, we found that sex, age (<40 years vs. 40 years) and histology (grade 1 2 vs. grade 3) were not associated with survival rates when metastasis occurred in patients with NPC (P > 0.05). The dominant factors that correlated with survival rates were: (1) nodal status (N0 1 vs. N2 3, P = 0.048), (2) metastatic sites (distant recurrence vs. local recurrence, P = 0.043), (3) stage (T1 2 vs. T3 4, P = 0.008) and (4) remission
4 Page 4 of 7 Figure 2: Survival curves from the onset of recurrence for NPC patients. Patients were grouped by metastatic location. (a) Patients with local recurrence showed a better prognosis than those with distant metastasis. (b) Patients with single organ metastasis had similar survival time regardless of visceral or bone metastasis. There was a trend for patients with multiorgan involvement to have a worse survival than those with single organ metastasis, but without a statistical significance. Figure 3: Overall survival after diagnosis of recurrent NPC. Patients were grouped by survival time from primary treatment to relapse. Patients with remission duration greater than 24 months had a better survival than those with shorter remission duration. duration (less than or greater than 24 months, P = 0.043). When these factors were analysed in multivariate analysis, we found that only metastatic sites (distant recurrence vs. local recurrence) were associated with survival times in metastatic NPC. Discussion Local recurrences and distant metastases are the main causes of treatment failures in NPC. With advances in imaging technology and the advent of modern radiation techniques, local control has substantially improved, and distant metastases has become the predominant pattern of treatment failure. In this study, majority (90.1%) of the relapses occurred within the first five years of primary treatment. Thus, if patients have no recurrence within 5 years, they are much less likely to have a recurrence at all. The frequency of death due to NPC in late follow-up was low, reflecting a reduced hazard risk for recurrence over time. This finding is consistent with previous studies 5. Our local recurrence rate of 13% (152/1168) after a median follow-up of 45 months is comparable to other studies 5,6. This indicates that local recurrences remain the greatest challenge for NPC treatment. The nasopharynx is surrounded by radiosensitive structures that consequently allow an NPC cell to easily infiltrate and spread towards surrounding normal organs. The results in NPC irradiation target volumes are very irregular, and conventional RT adopted lateral opposing fields for NPC rarely achieve the prerequisite dose and precision to tumour targets. Therefore, local relapse in the nasopharyx is common after primary treatment in an NPC patient. The treatment results in patients with locally recurrent NPC are unsatisfactory, with a 5-year
5 Page 5 of 7 Table 2 Patient and disease characteristics (relapse) grouped by remission duration Characteristics Remission duration 24 months (%) >24 months (%) χ 2 P Age (years) (19%) 41 (21%) > (81%) 151 (79%) Gender Male 136 (89%) 138 (72%) Female 17 (11%) 54 (28%) Histology G (72%) 173 (90%) G3 43 (28%) 19 (10%) Tumour size T (48%) 116 (60%) T (52%) 76 (40%) Nodal status N (37%) 93 (48%) N (63%) 99 (52%) Stage at first diagnosis I/II 74 (48%) 116 (60%) III/IV 79 (52%) 76 (40%) Table 3 Cox regression analysis of factors influencing overall survival Covariate Univariate analysis Multivariate analysis HR P 95% CI HR P 95% CI Sex ; ;1.257 Age ; ;1.277 Tumour size ; ;1.657 Node status ; ;1.746 Sites ; ;1.259 Stage ; ;2.002 Histology ; ;1.387 Remission duration ; ;1.736 actuarial local control rate ranging from 15% to 37.8% 6 9. Additionally, patients with locoregional failure have an increased risk of distant metastasis. Our data indicates that the 1-, 2- and 3-year survival rates in patients with local recurrence were 84.7%, 65% and 51%, respectively. Therefore, more aggressive primary treatment is required to secure a higher level of local control with a decrease in toxicity. Currently, intensity-modulated RT (IMRT) represents a technical innovation for NPC treatment because it can overcome the limitation of conventional 2D RT. It enables the delivery of high radiation dose to targets without jeopardizing the radiosensitive organs, and it has been proven to enhance the local control of NPC 10. IMRT, with or without chemotherapy, in NPC treatment has achieved benefits in reducing local progression and increasing overall survival 11. All patients in this study received conventional 2D RT, and the limited number of patients who received IMRT were excluded from the analysis because their follow-up time was not long enough. NPC comprises a heterogeneous group of tumours as defined by their morphologic appearances and molecular genetic characteristics. The development of distant metastases represents the most important prognostic indicator in patients diagnosed with NPC. In this series, the rate of distant metastases was 16.5% (193/1168), with 1-, 2- and 3-year survival rates being 59.9%, 29.1% and 29.2%, respectively. Compared with patients with local recurrence, our finding supports previous observations that patients with a distant recurrence have a significantly poorer prognosis than patients with a local recurrence. The remission duration was also an important prognostic variable. We made a comparison between the two groups (intervals of relapse-free 24 months and >24 months). The differences in the survival curves were significant between the two groups, which is consistent with Li s observation. Similarly, in a study by Lee, recurrence in patients with long latency had a significantly better survival than patients with short latency 12. The reason for the relatively better prognosis for a patient with long relapse-free intervals after primary treatment is unclear. To explain the favourable outcomes of female NPC patients, we first analysed the clinical characteristics of both groups in our study. We found a higher maleto-female ratio in the group with shorter remission durations. Our result
6 Page 6 of 7 supports a previous study that female patients have a better survival than males 13. Gonadal hormones and their related receptors may play an important part in regulating the biological behaviour of NPC. Evidence suggests that testosterone negatively affects the immune function of male patients, whereas female sex steroids show a protective immune role 14. Additionally, we found that a higher proportion of long-latent relapse occurred in patients with T1 2, N0 1 status and stages I II at initial diagnosis. Therefore, it is not surprising that relapse with short latency showed a worse prognosis. The proportion of patients who develop metastases after primary treatment is reported to vary from 15% to 25% 6 9. In this study, the rate of distant metastases was 16.5%, with bone being the first and most frequent distant metastatic site occurring in 29% the patients. We further examined whether specific organ metastasis at the time of presentation had a prognostic significance for NPC patients. Our results revealed that there was a significant difference in survival among patients with local metastasis compared with those with distant metastasis. However, among patients with distant metastases, the site of involvement did not appear to have an impact on survival. The presence of bone, liver and lung metastasis, as well as multi-organ metastases, did not demonstrate a statistically significant correlation with survival time. The median survival time in these patients was 12 months. This result is not consistent with studies of other cancer types, which have identified that specific organ metastasis is related to a poor prognosis. For example, the distant organ that breast cancer preferentially metastasizes is also the bone. However, breast cancer patients with bone metastasis remain relatively indolent. These patients often have prolonged survival and usually benefit from palliative systemic therapy 15. In this study, factors that correlated with survival rates included nodal status, metastatic sites, stage and the remission duration. When these factors were analysed in multivariate analysis, we found that only metastatic sites (distant vs. local recurrence) were associated with survival time in metastatic NPC. Although data from literature indicates that tumour size, pathology, sex and age are prognostic variables 16 for NPC patients, our study indicated that once NPC patients have progressed to metastases, these factors are not correlated with survival time. This is an interesting clinical phenomenon and has not previously been studied. Why these well-recognized prognostic factors lose their predictive value in metastatic NPC is unknown and remains unclear. Perhaps, a breakthrough at the gene and protein level comparing NPC patients before and after metastasis will reveal this phenomenon. More research is needed to improve the knowledge of recurrent NPC to discover a prevention or radical cure for the disease. In conclusion, this report reviews NPC recurrence data after primary treatment. Rates of local and distant relapse were comparable with those previously reported, and the majority of recurrences occurred within the first five years. The prognosis after relapse varied with nodal status, stage at the first diagnosis as well as the remission duration after treatment. Local recurrences had a better prognosis than distant recurrences, while distant metastases to the bone had a similar prognosis with those to liver and multi-organ involvement. Sex, age, tumour size and pathology did not seem to impact the survival time in patients with recurrence. Despite these significant findings, there were some limitations because a retrospective design consists of complications such as lead-time and length time biases. Regardless of these limitations, this study showed patterns of metastases in NPC patients after primary treatment. This has a clinical utility, such as determining the duration of follow-up, frequency of followup and sites of first metastases. Acknowledgements This work was supported by funds from the Major State Basic Research Development Program (No. 2011CB707705), National Natural Science Foundation of China (No and No ), Key Laboratory of Breast Cancer Prevention and Treatment of Guangdong Province, People s Republic of China. References 1. Cao SM, Simons MJ, Qian CN. The prevalence and prevention of nasopharyngeal carcinoma in China. Chin J Cancer Feb;30(2): Liu Q, Chen JO, Huang QH, Li YH. Trends in the survival of patients with nasopharyngeal carcinoma between 1976 and 2005 in Sihui, China: a population-based study. Chin J Cancer Dec. 3. Wang R, Wu F, Lu H, Wei B, Feng G, Li G, et al. Definitive intensity-modulated radiation therapy for nasopharyngeal carcinoma: long-term outcome of a multicenter prospective study. J Cancer Res Clin Oncol Jan;139(1): Wei S, Li Y, Siegal GP, Hameed O. Breast carcinomas with isolated bone metastases have different hormone receptor expression profiles than those with metastases to other sites or multiple organs. Ann Diagn Pathol Apr;15(2): Li JX, Lu TX, Huang Y, Han F. Clinical characteristics of recurrent nasopharyngeal carcinoma in high-incidence area. The Scientific World J. 2012;2012: Leung TW, Tung SY, Sze WK, Sze WM, Wong VY, Wong CS, et al. Salvage radiation therapy for locally recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys Dec;48(5): Teo PM, Kwan WH, Chan AT, Lee WY, King WW, Mok CO. How successful is highdose (> or = 60 Gy) reirradiation using mainly external beams in salvaging local failures of nasopharyngeal carcinoma? Int J Radiat Oncol Biol Phys Mar; 40(4):
7 Page 7 of 7 8. Lee AW, Foo W, Law SC, Poon YF, Sze WM, O SK, et al. Reirradiation for recurrent nasopharyngeal carcinoma: factors affecting the therapeutic ratio and ways for improvement. Int J Radiat Oncol Biol Phys Apr;38(1): Chua DT, Sham JS, Kwong DL, Wei WI, Au GK, Choy D. Locally recurrent nasopharyngeal carcinoma: treatment results for patients with computed tomography assessment. Int J Radiat Oncol Biol Phys May;41(2): Taheri-Kadkhoda Z, Pettersson N, Björk-Eriksson T, Johansson KA. Superiority of intensity-modulated radiotherapy over three-dimensional conformal radiotherapy combined with brachytherapy in nasopharyngeal carcinoma: a planning study. Br J Radiol May;81(965): Lee N, Harris J, Garden AS, Straube W, Glisson B, Xia P, et al. Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial J Clin Oncol Aug;27(22): Lee AW, Foo W, Law SC, Poon YF, Sze WM, O SK, et al. Recurrent nasopharyngeal carcinoma: the puzzles of long latency. Int J Radiat Oncol Biol Phys Apr;44(1): Lu X, Wang FL, Guo X, Wang L, Zhang HB, Xia WX, et al. Favorable survival of female patients with nasopharyngeal carcinoma. Chin J Cancer Sep. 14. Derwinger K, Gustavsson B. A study of aspects on gender and prognosis in synchronous colorectal cancer. Clin Med Insights Oncol. 2011;5: Plunkett TA, Smith P, Rubens RD. Risk of complications from bone metastases in breast cancer. implications for management. Eur J Cancer Mar;36(4): Hu S, Xu X, Xu J, Xu Q, Liu S. Prognostic factors and long-term outcomes of nasopharyngeal carcinoma in children and adolescents. Pediatr Blood Cancer Jan.
EFFICACY OF NECK DISSECTION FOR LOCOREGIONAL FAILURES VERSUS ISOLATED NODAL FAILURES IN NASOPHARYNGEAL CARCINOMA
ORIGINAL ARTICLE EFFICACY OF NECK DISSECTION FOR LOCOREGIONAL FAILURES VERSUS ISOLATED NODAL FAILURES IN NASOPHARYNGEAL CARCINOMA Raymond King Yin Tsang, FRCSEd, Joseph Chun Kit Chung, MRCSEd, Yiu Wing
More informationCACA. Original Article
Chinese Journal of Cancer Original Article Xing Lu 1,2*, Fei 鄄 Li Wang 1,2*, Xiang Guo 1,2, Lin Wang 1,2, Hai 鄄 Bo Zhang 1,2, Wei 鄄 Xiong Xia 1,2, Si 鄄 Wei Li 1,2, Ning 鄄 Wei Li 1,2, Chao 鄄 Nan Qian 1,2
More informationAccepted 24 October 2007 Published online 22 January 2008 in Wiley InterScience (www.interscience.wiley.com). DOI: /hed.
ORIGINAL ARTICLE PHASE II STUDY OF GEFITINIB FOR THE TREATMENT OF RECURRENT AND METASTATIC NASOPHARYNGEAL CARCINOMA Daniel T. T. Chua, MD, 1 William I. Wei, MD, 2 Maria P. Wong, MD, 3 Jonathan S. T. Sham,
More informationCharacteristics and prognostic factors of synchronous multiple primary esophageal carcinoma: A report of 52 cases
Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Characteristics and prognostic factors of synchronous multiple primary esophageal carcinoma: A report of 52 cases Mei Li & Zhi-xiong Lin Department of Radiation
More informationPrognostic value of pretreatment and recovery duration of cranial nerve palsy in nasopharyngeal carcinoma
Mo et al. Radiation Oncology 2012, 7:149 RESEARCH Open Access Prognostic value of pretreatment and recovery duration of cranial nerve palsy in nasopharyngeal carcinoma Hao-Yuan Mo 1,2, Rui Sun 1,2, Jian
More informationNew modalities in the salvage of recurrent nasopharyngeal carcinoma
New modalities in the salvage of recurrent nasopharyngeal carcinoma Dr Jeeve Kanagalingam FRCS Eng (ORL-HNS) Department of Otorhinolaryngology Tan Tock Seng Hospital SINGAPORE Nasopharyngeal carcinoma
More informationInt J Clin Exp Med 2017;10(1): /ISSN: /IJCEM Jun Lv, Lingjiang Pan, Jiamei Lu, Wen Qin, Tingting Zhang
Int J Clin Exp Med 2017;10(1):1193-1198 www.ijcem.com /ISSN:1940-5901/IJCEM0037899 Original Article Effective radiotherapy dose for suspicious positive cervical lymph nodes for N0 nasopharyngeal carcinoma
More informationOriginal article: Department of Oncology, Third Affiliated Hospital of Third Military Medical University, Chongqing, China
Original article: THE PREDICTIVE VALUE OF PRE- AND POST-INDUCTION CHEMOTHERAPY PLASMA EBV DNA LEVEL AND TUMOR VOLUME FOR THE RADIOSENSITIVITY OF LOCALLY ADVANCED NASOPHARYNGEAL CARCINOMA Yang Song *, He
More informationABSTRACT INTRODUCTION
/, 2017, Vol. 8, (No. 26), pp: 43450-43457 The challenge in treating locally recurrent T3-4 nasopharyngeal carcinoma: the survival benefit and severe late toxicities of reirradiation with intensity-modulated
More informationFate of patients with nasopharyngeal cancer who developed distant metastasis as first failure after definitive radiation therapy
ORIGINAL ARTICLE Fate of patients with nasopharyngeal cancer who developed distant metastasis as first failure after definitive radiation therapy Ji Hyun Chang, MD, 1,3 Yong Chan Ahn, MD, PhD, 1 * Hyojung
More informationSummary. Joanna Terlikiewicz 1,2, Roman Makarewicz 1,2, Andrzej Lebioda 1,2, Renata Kabacińska 2,3, Marta Biedka 2
Original Paper Received: 2004.11.23 Accepted: 2005.06.15 Published: 2005.09.20 An analysis of outcomes, after re-irradiation by HDR (high-dose-rate) brachytherapy, among patients with locally recurrent
More informationCURRENT STANDARD OF CARE IN NASOPHARYNGEAL CANCER
CURRENT STANDARD OF CARE IN NASOPHARYNGEAL CANCER Jean-Pascal Machiels Department of medical oncology Institut I Roi Albert II Cliniques universitaires Saint-Luc Université catholique de Louvain, Brussels,
More informationSurvival impact of cervical metastasis in squamous cell carcinoma of hard palate
Vol. 116 No. 1 July 2013 Survival impact of cervical metastasis in squamous cell carcinoma of hard palate Quan Li, MD, a Di Wu, MD, b,c Wei-Wei Liu, MD, PhD, b,c Hao Li, MD, PhD, b,c Wei-Guo Liao, MD,
More informationRevisit of Primary Malignant Neoplasms of the Trachea: Clinical Characteristics and Survival Analysis
Jpn J Clin Oncol 1997;27(5)305 309 Revisit of Primary Malignant Neoplasms of the Trachea: Clinical Characteristics and Survival Analysis -, -, - - 1 Chest Department and 2 Section of Thoracic Surgery,
More informationTreatment outcomes and prognostic factors of gallbladder cancer patients after postoperative radiation therapy
Korean J Hepatobiliary Pancreat Surg 2011;15:152-156 Original Article Treatment outcomes and prognostic factors of gallbladder cancer patients after postoperative radiation therapy Suzy Kim 1,#, Kyubo
More informationTreatment and prognosis of patients with recurrent laryngeal carcinoma: a retrospective study
Page 1 of 7 Treatment and prognosis of patients with recurrent laryngeal carcinoma: a retrospective study T Jin 1, H Lin 2,3, HX Lin 2,3, XY Cai 2,3, HZ Wang 2,3, WH Hu 2,3, LB Guo 4, JZ Zhao 5 * Abstract
More informationNasopharyngeal Cancer/Multimodality Treatment
Nasopharyngeal Cancer/Multimodality Treatment PANAGIOTIS KATSAOUNIS Medical Oncologist IASO GENERAL HOSPITAL Athens, 22/10/2016 1 st Hellenic Multidisciplinary Conference on Head and Neck Cancer INTRODUCTION
More informationNasopharyngeal carcinoma time lapse before diagnosis and treatment
Nasopharyngeal carcinoma time lapse before diagnosis and treatment AWM Lee, WM Ko, W Foo, P Choi, Y Tung, J Sham, B Cheng, G Au, WH Lau, D Choy, SK O, WM Sze, KC Tse, CK Law, P Teo, TK Yau, WH Kwan This
More informationCycle number of neoadjuvant chemotherapy might influence survival of patients with T1-4N2-3M0 nasopharyngeal carcinoma
Original Article Cycle number of neoadjuvant chemotherapy might influence survival of patients with T1-4N2-3M0 nasopharyngeal carcinoma Jiawang Wei, Huixia Feng, Weiwei Xiao, Qiaoxuan Wang, Bo Qiu, Shiliang
More informationImpact of primary tumor volume and location on the prognosis of patients with locally recurrent nasopharyngeal carcinoma
Tian et al. Chinese Journal of Cancer (2015) 34:21 DOI 10.1186/s40880-015-0019-5 ORIGINAL ARTICLE Open Access Impact of primary tumor volume and location on the prognosis of patients with locally recurrent
More informationXiang Hu*, Liang Cao*, Yi Yu. Introduction
Original Article Prognostic prediction in gastric cancer patients without serosal invasion: comparative study between UICC 7 th edition and JCGS 13 th edition N-classification systems Xiang Hu*, Liang
More informationCancer incidence and patient survival rates among the residents in the Pudong New Area of Shanghai between 2002 and 2006
Chinese Journal of Cancer Original Article Cancer incidence and patient survival rates among the residents in the Pudong New Area of Shanghai between 2002 and 2006 Xiao-Pan Li 1, Guang-Wen Cao 2, Qiao
More informationRadiation therapy for locoregionally advanced nasopharyngeal carcinoma in elderly patients
J Radiat Oncol (2012) 1:323 332 DOI 10.1007/s13566-012-0069-0 ORIGINAL RESEARCH Radiation therapy for locoregionally advanced nasopharyngeal carcinoma in elderly patients Qiaojuan Guo & Weiping Jiang &
More informationLei Zeng 1,2,3., Yun-Ming Tian 1,2., Ying Huang 1, Xue-Ming Sun 1, Feng-Hua Wang 2, Xiao-Wu Deng 1, Fei Han 1 *, Tai-Xiang Lu 1 * Abstract
Retrospective Analysis of 234 Nasopharyngeal Carcinoma Patients with Distant Metastasis at Initial Diagnosis: Therapeutic Approaches and Prognostic Factors Lei Zeng 1,2,3., Yun-Ming Tian 1,2., Ying Huang
More informationBiomedical Research 2017; 28 (21): ISSN X
Biomedical Research 2017; 28 (21): 9497-9501 ISSN 0970-938X www.biomedres.info Analysis of relevant risk factor and recurrence prediction model construction of thyroid cancer after surgery. Shuai Lin 1#,
More informationCLINICAL OUTCOMES OF 174 NASOPHARYNGEAL CARCINOMA PATIENTS WITH RADIATION-INDUCED TEMPORAL LOBE NECROSIS
doi:10.1016/j.ijrobp.2010.11.070 Int. J. Radiation Oncology Biol. Phys., Vol. 82, No. 1, pp. e57 e65, 2012 Copyright Ó 2012 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/$ - see front
More informationGuo et al. BMC Cancer (2015) 15:977 DOI /s
Guo et al. BMC Cancer (2015) 15:977 DOI 10.1186/s12885-015-1964-8 RESEARCH ARTICLE Open Access The impact of the cumulative dose of cisplatin during concurrent chemoradiotherapy on the clinical outcomes
More information窑 Original Article 窑. Jun Ma 1,2 鄢. , Zhe Sheng Wen 1,2, Peng Lin 1,2, Xin Wang 1,2, Fang Yun Xie 1,3. 揖 Abstract 铱 Background and Objective: Methods:
窑 Original Article 窑 Chinese Journal of Cancer The results and prognosis of different treatment modalities for solitary metastatic lung tumor from nasopharyngeal carcinoma: a retrospective study of 5 cases
More informationClinical and imaging characteristics of 53 ulcers of post radiation nasopharyngeal necrosis in patients with nasopharyngeal carcinoma
MOLECULAR AND CLINICAL ONCOLOGY 5: 351-356, 2016 Clinical and imaging characteristics of 53 ulcers of post radiation nasopharyngeal necrosis in patients with nasopharyngeal carcinoma FENGQIN YAN *, ZHIMIN
More informationClinical Study Mucosal Melanoma in the Head and Neck Region: Different Clinical Features and Same Outcome to Cutaneous Melanoma
ISRN Dermatology Volume 2013, Article ID 586915, 5 pages http://dx.doi.org/10.1155/2013/586915 Clinical Study Mucosal Melanoma in the Head and Neck Region: Different Clinical Features and Same Outcome
More informationIs pretreatment Epstein-Barr virus DNA still associated with 6-year survival outcomes in locoregionally advanced nasopharyngeal carcinoma?
976 Ivyspring International Publisher Research Paper Journal of Cancer 2017; 8(6): 976-982. doi: 10.7150/jca.18124 Is pretreatment Epstein-Barr virus DNA still associated with 6-year survival outcomes
More informationRare Small Cell Carcinoma in Genitourinary Tract: Experience from E-Da Hospital
E-Da Medical Journal 20;():-5 Original Article Rare Small Cell Carcinoma in Genitourinary Tract: Experience from E-Da Hospital Wei-Ting Kuo, I-Wei Chang2, Kevin Lu, Hua-Pin Wang, Tsan-Jung u, Victor C.
More informationClinical Study Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma
BioMed Research International Volume 2015, Article ID 617949, 5 pages http://dx.doi.org/10.1155/2015/617949 Clinical Study Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally
More informationClinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05
Abstract No.: ABS-0075 Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer 2018/04/05 Cheol Min Kang Department of surgery, University of Ulsan
More informationPatient age and cutaneous malignant melanoma: Elderly patients are likely to have more aggressive histological features and poorer survival
MOLECULAR AND CLINICAL ONCOLOGY 7: 1083-1088, 2017 Patient age and cutaneous malignant melanoma: Elderly patients are likely to have more aggressive histological features and poorer survival FARUK TAS
More informationAdvanced primary pulmonary lymphoepithelioma-like carcinoma: clinical manifestations, treatment, and outcome
Original Article Advanced primary pulmonary lymphoepithelioma-like carcinoma: clinical manifestations, treatment, and outcome Chun-Yu Lin 1,2, Ying-Jen Chen 1,2, Meng-Heng Hsieh 2,3, Chih-Wei Wang 2,4,
More informationAfter primary tumor treatment, 30% of patients with malignant
ESTS METASTASECTOMY SUPPLEMENT Alberto Oliaro, MD, Pier L. Filosso, MD, Maria C. Bruna, MD, Claudio Mossetti, MD, and Enrico Ruffini, MD Abstract: After primary tumor treatment, 30% of patients with malignant
More informationSupplementary Information
Supplementary Information Prognostic Impact of Signet Ring Cell Type in Node Negative Gastric Cancer Pengfei Kong1,4,Ruiyan Wu1,Chenlu Yang1,3,Jianjun Liu1,2,Shangxiang Chen1,2, Xuechao Liu1,2, Minting
More information290 Clin Oncol Cancer Res (2009) 6: DOI /s
290 Clin Oncol Cancer Res (2009) 6: 290-295 DOI 10.1007/s11805-009-0290-9 Analysis of Prognostic Factors of Esophageal and Gastric Cardiac Carcinoma Patients after Radical Surgery Using Cox Proportional
More informationResearch and Reviews Journal of Medical and Clinical Oncology
Comparison and Prognostic Analysis of Elective Nodal Irradiation Using Definitive Radiotherapy versus Chemoradiotherapy for Treatment of Esophageal Cancer Keita M 1,2, Zhang Xueyuan 1, Deng Wenzhao 1,
More informationSubdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system
DOI 10.1186/s40880-015-0031-9 ORIGINAL ARTICLE Open Access Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system Lu Jun Shen 1,
More informationDr Sneha Shah Tata Memorial Hospital, Mumbai.
Dr Sneha Shah Tata Memorial Hospital, Mumbai. Topics covered Lymphomas including Burkitts Pediatric solid tumors (non CNS) Musculoskeletal Ewings & osteosarcoma. Neuroblastomas Nasopharyngeal carcinomas
More informationDetection of bone metastasis in nasopharyngeal carcinoma by bone scintigraphy: A retrospective study in perspective of limited resource settings
Original Article Detection of bone metastasis in nasopharyngeal carcinoma by bone scintigraphy: A retrospective study in perspective of limited resource settings Akhil Kapoor, Ashok Kalwar 1, Narender
More informationINTRODUCTION. KEY WORDS: nasopharyngeal carcinoma, recurrence, intensitymodulated radiotherapy (IMRT), endoscopic nasopharyngectomy
ORIGINAL ARTICLE Salvage endoscopic nasopharyngectomy and intensity-modulated radiotherapy versus conventional radiotherapy in treating locally recurrent nasopharyngeal carcinoma Xiong Zou, MD, 1,2 Fei
More informationHyponatremia in small cell lung cancer is associated with a poorer prognosis
Original Article Hyponatremia in small cell lung cancer is associated with a poorer prognosis Wenxian Wang 1, Zhengbo Song 1,2, Yiping Zhang 1,2 1 Department of Chemotherapy, Zhejiang Cancer Hospital,
More informationLocoregional treatment Session Oral Abstract Presentation Saulo Brito Silva
Locoregional treatment Session Oral Abstract Presentation Saulo Brito Silva Background Post-operative radiotherapy (PORT) improves disease free and overall suvivallin selected patients with breast cancer
More informationNasopharyngeal Cancer:Role of Chemotherapy
Nasopharyngeal Cancer:Role of Chemotherapy PANAGIOTIS KATSAOUNIS Medical Oncologist IASO GENERAL HOSPITAL Athens, 16/9/2017 2 nd Hellenic Multidisciplinary Conference on Head and Neck Cancer INTRODUCTION
More informationLong term survival study of de-novo metastatic breast cancers with or without primary tumor resection
Long term survival study of de-novo metastatic breast cancers with or without primary tumor resection Dr. Michael Co Division of Breast Surgery Queen Mary Hospital The University of Hong Kong Conflicts
More informationPlasma EBV DNA Clearance Rate as a Novel Prognostic Marker for Metastatic/Recurrent Nasopharyngeal Carcinoma
Imaging, Diagnosis, Prognosis Plasma EBV DNA Clearance Rate as a Novel Prognostic Marker for Metastatic/Recurrent Nasopharyngeal Carcinoma Clinical Cancer Research Wen-Yi Wang 1, Chih-Wen Twu 2,5, Hsin-Hong
More informationThe Prognostic Value of Ratio-Based Lymph Node Staging in Resected Non Small-Cell Lung Cancer
Original Article The Prognostic Value of Ratio-Based Lymph Node Staging in Resected Non Small-Cell Lung Cancer Chen Qiu, MD,* Wei Dong, MD,* Benhua Su, MBBS, Qi Liu, MD,* and Jiajun Du, PhD Introduction:
More informationRadiotherapy and Conservative Surgery For Merkel Cell Carcinoma - The British Columbia Cancer Agency Experience
Radiotherapy and Conservative Surgery For Merkel Cell Carcinoma - The British Columbia Cancer Agency Experience Poster No.: RO-0003 Congress: RANZCR FRO 2012 Type: Scientific Exhibit Authors: C. Harrington,
More informationLymph node ratio as a prognostic factor in head and neck cancer patients
Chen et al. Radiation Oncology (2015) 10:181 DOI 10.1186/s13014-015-0490-9 RESEARCH Open Access Lymph node ratio as a prognostic factor in head and neck cancer patients Chien-Chih Chen 1*, Jin-Ching Lin
More informationCombining chemotherapy and radiotherapy of the chest
How to combine chemotherapy, targeted agents and radiotherapy in locally advanced NSCLC? Dirk De Ruysscher, MD, PhD Radiation Oncologist Professor of Radiation Oncology Leuven Cancer Institute Department
More informationClinical Study T4-Locally Advanced Nasopharyngeal Carcinoma: Prognostic Influence of Cranial Nerve Involvement in Different Radiotherapy Techniques
The Scientific World Journal Volume 2013, Article ID 439073, 6 pages http://dx.doi.org/10.1155/2013/439073 Clinical Study T4-Locally Advanced Nasopharyngeal Carcinoma: Prognostic Influence of Cranial Nerve
More informationOriginal Article. Yuri Jeong, MD 1, Sang-wook Lee, MD, PhD 2. Introduction
Original Article Radiat Oncol J 218;36(4):295-33 https://doi.org/1.3857/roj.218.43 pissn 2234-19 eissn 2234-3156 Tumor volume/metabolic information can improve the prognostication of anatomy based staging
More informationThe prognosis of different distant metastases pattern in prostate cancer: A population based retrospective study
Received: 21 September 2017 Accepted: 22 January 2018 DOI: 10.1002/pros.23492 ORIGINAL ARTICLE The prognosis of different distant metastases pattern in prostate cancer: A population based retrospective
More informationPrognostic significance of nemo like kinase in nasopharyngeal carcinoma
MOLECULAR MEDICINE REPORTS 10: 131-136, 2014 Prognostic significance of nemo like kinase in nasopharyngeal carcinoma SIZE CHEN 1,2*, ZHIJIAN MA 3*, XUEMEI CHEN 4 and JIREN ZHANG 1 1 Department of Oncology,
More informationBone Metastases in Muscle-Invasive Bladder Cancer
Journal of the Egyptian Nat. Cancer Inst., Vol. 18, No. 3, September: 03-08, 006 AZZA N. TAHER, M.D.* and MAGDY H. KOTB, M.D.** The Departments of Radiation Oncology* and Nuclear Medicine**, National Cancer
More informationAll India Institute of Medical Sciences, New Delhi, INDIA. Department of Pediatric Surgery, Medical Oncology, and Radiology
All India Institute of Medical Sciences, New Delhi, INDIA Department of Pediatric Surgery, Medical Oncology, and Radiology Clear cell sarcoma of the kidney- rare renal neoplasm second most common renal
More informationIntroduction. pissn , eissn Open Access. Original Article
pissn 1598-2998, eissn 25-96 Cancer Res Treat. 216;48(3):928-941 Original Article http://dx.doi.org/1.4143/crt.215.2 Open Access The Clinical Usefulness of 18 F-Fluorodeoxyglucose Positron Emission Tomography
More informationIvyspring International Publisher. Introduction. Journal of Cancer 2017, Vol. 8. Abstract
417 Ivyspring International Publisher Research Paper Journal of Cancer 2017; 8(3): 417-424. doi: 10.7150/jca.17310 Pretreatment Alkaline Phosphatase and Epstein-Barr Virus DNA Predict Poor Prognosis and
More informationThe clinicopathological features and treatment modalities associated with survival of neuroendocrine cervical carcinoma in a Chinese population
Zhang et al. BMC Cancer (2019) 19:22 https://doi.org/10.1186/s12885-018-5147-2 RESEARCH ARTICLE Open Access The clinicopathological features and treatment modalities associated with survival of neuroendocrine
More informationHong-Yao Xu *, Sheng-Xi Wu, He-San Luo, Chu-Yun Chen, Lian-Xing Lin and He-Cheng Huang
Xu et al. Radiation Oncology (2018) 13:200 https://doi.org/10.1186/s13014-018-1145-4 RESEARCH Open Access Analysis of definitive chemo-radiotherapy for esophageal cancer with supra-clavicular node metastasis
More informationPrognostic effect of parotid area lymph node metastases after preliminary diagnosis of nasopharyngeal carcinoma: a propensity score matching study
Cancer Medicine ORIGINAL RESEARCH Open Access Prognostic effect of parotid area lymph node metastases after preliminary diagnosis of nasopharyngeal carcinoma: a propensity score matching study Yuanji Xu
More informationPILOT STUDY OF CONCURRENT CHEMO-RADIOTHERAPY FOR ADVANCED NASOPHARYNGEAL CARCINOMA (Forum for Nuclear Cooperation in Asia)
PILOT STUDY OF CONCURRENT CHEMO-RADIOTHERAPY FOR ADVANCED NASOPHARYNGEAL CARCINOMA (Forum for Nuclear Cooperation in Asia) Dr. Miriam Joy C. Calaguas Dept. of Radiation Oncology St. Luke s Medical Center
More informationRESEARCH ARTICLE. Jia-Xiang Ye 1, Xia Liang 2, Jian Wei 3, Jing Zhou 3, Yu Liao 3, Yu-Lei Lu 3, Xia-Quan Tang 3, An-Yu Wang 3, Yong Tang 1 * Abstract
DOI:10.22034/APJCP.2018.19.1.115 Treatment Compliance of Stage II IVB Nasopharyngeal Carcinoma RESEARCH ARTICLE Editorial Process: Submission:08/06/2017 Acceptance:12/02/2017 Compliance with National Guidelines
More informationMUSCLE - INVASIVE AND METASTATIC BLADDER CANCER
10 MUSCLE - INVASIVE AND METASTATIC BLADDER CANCER Recommendations from the EAU Working Party on Muscle Invasive and Metastatic Bladder Cancer G. Jakse (chairman), F. Algaba, S. Fossa, A. Stenzl, C. Sternberg
More informationTreatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study
ONCOLOGY LETTERS 10: 3145-3152, 2015 Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study PEIJING LI 1*, WEIHAN HU 1*, YUAN ZHU 2 and JIANJIANG LIU 3 1
More informationEffects of postmastectomy radiotherapy on prognosis in different tumor stages of breast cancer patients with positive axillary lymph nodes
Cancer Biol Med 2014;11:123-129. doi: 10.7497/j.issn.2095-3941.2014.02.007 ORIGINAL ARTICLE Effects of postmastectomy radiotherapy on prognosis in different tumor stages of breast cancer patients with
More informationEnterprise Interest None
Enterprise Interest None Cervical Cancer -Management of late stages ESP meeting Bilbao Spain 2018 Dr Mary McCormack PhD FRCR Consultant Clinical Oncologist University College Hospital London On behalf
More informationOriginal Article CREPT expression correlates with esophageal squamous cell carcinoma histological grade and clinical outcome
Int J Clin Exp Pathol 2017;10(2):2030-2035 www.ijcep.com /ISSN:1936-2625/IJCEP0009456 Original Article CREPT expression correlates with esophageal squamous cell carcinoma histological grade and clinical
More informationAnalysis of the outcome of young age tongue squamous cell carcinoma
Jeon et al. Maxillofacial Plastic and Reconstructive Surgery (2017) 39:41 DOI 10.1186/s40902-017-0139-8 Maxillofacial Plastic and Reconstructive Surgery RESEARCH Open Access Analysis of the outcome of
More informationOriginal Article Associations of serum CD62P and IL-6 levels with nasopharyngeal carcinoma staging and prognosis
Int J Clin Exp Pathol 2016;9(9):9631-9635 www.ijcep.com /ISSN:1936-2625/IJCEP0026014 Original Article Associations of serum CD62P and IL-6 levels with nasopharyngeal carcinoma staging and prognosis Weijuan
More informationCountry Presentations of FNCA FY2007 Workshop on Radiation Oncology
Country Presentations of FNCA FY2007 Workshop on Radiation Oncology Annex 3 Country presentations on CERVIX-III -China: Total Patients: 18, 8 alive: 1 with metastasis lung, another one metastasis to liver;
More informationPrognostic factors in squamous cell anal cancers
Prognostic factors in squamous cell anal cancers Zainul Abedin Kapacee Year 4-5 Intercalating Medical Student, University of Manchester Dr. Shabbir Susnerwala, Mr. Nigel Scott Dr. Falalu Danwata, Dr. Marcus
More informationSTUDY ON CHANGES OF PLASMA CELL-FREE DNA OF EPSTEIN-BARR VIRUS DURING CHEMORADIOTHERAPY OF NASOPHARYNGEAL CARCINOMA PATIENTS
Journal of military pharmacomedicine n o 12019 STUDY ON CHANGES OF PLASMA CELLFREE DNA OF EPSTEINBARR VIRUS DURING CHEMORADIOTHERAPY OF NASOPHARYNGEAL CARCINOMA PATIENTS Pham Quynh Huong 1 ; Vu Nguyen
More informationSalvage prostatectomy for post-radiation adenocarcinoma with treatment effect: Pathological and oncological outcomes
ORIGINAL RESEARCH Salvage prostatectomy for post-radiation adenocarcinoma with treatment effect: Pathological and oncological outcomes Michael J. Metcalfe, MD ; Patricia Troncoso, MD 2 ; Charles C. Guo,
More informationDoppler ultrasound of the abdomen and pelvis, and color Doppler
- - - - - - - - - - - - - Testicular tumors are rare in children. They account for only 1% of all pediatric solid tumors and 3% of all testicular tumors [1,2]. The annual incidence of testicular tumors
More informationImpact of esophageal cancer staging on overall survival and disease-free survival based on the 2010 AJCC classification by lymph nodes
Journal of Radiation Research, 2013, 54, 307 314 doi: 10.1093/jrr/rrs096 Advance Access Publication 2 November 2012 Impact of esophageal cancer staging on overall survival and disease-free survival based
More informationLog odds of positive lymph nodes is a novel prognostic indicator for advanced ESCC after surgical resection
Original Article Log odds of positive lymph nodes is a novel prognostic indicator for advanced ESCC after surgical resection Mingjian Yang 1,2, Hongdian Zhang 1,2, Zhao Ma 1,2, Lei Gong 1,2, Chuangui Chen
More informationThe clinical value of detecting circulating tumour cells in the peripheral blood of nasopharyngeal carcinoma patients
ONCOLOGY LETTERS 15: 6283-6290, 2018 The clinical value of detecting circulating tumour cells in the peripheral blood of nasopharyngeal carcinoma patients ZHUO CHEN 1*, LU XU 1*, XINHUA XU 1 and CHEN YUAN
More informationPeritoneal Involvement in Stage II Colon Cancer
Anatomic Pathology / PERITONEAL INVOLVEMENT IN STAGE II COLON CANCER Peritoneal Involvement in Stage II Colon Cancer A.M. Lennon, MB, MRCPI, H.E. Mulcahy, MD, MRCPI, J.M.P. Hyland, MCh, FRCS, FRCSI, C.
More informationNasopharynx. 1. Introduction. 1.1 General Information and Aetiology
Nasopharynx 1. Introduction 1.1 General Information and Aetiology The nasopharynx is the uppermost, nasal part of the pharynx. It extends from the base of the skull to the upper surface of the soft palate.
More informationORIGINAL ARTICLE. among populations originating from southern China and their descendants who have emigrated to other parts of the world.
ORIGINAL ARTICLE Prognostic Factors and Outcome for Nasopharyngeal Carcinoma Terence P. Farias, MD; Fernando L. Dias, MD; Roberto A. Lima, MD; Jacob Kligerman, MD; Geraldo M. de Sá, MD; Mauro M. Barbosa,
More informationExtent of visceral pleural invasion and the prognosis of surgically resected node-negative non-small cell lung cancer
Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Extent of visceral pleural invasion and the prognosis of surgically resected node-negative non-small cell lung cancer Yangki Seok 1, Ji Yun Jeong 2 & Eungbae
More informationChinese Journal of Cancer. Open Access ORIGINAL ARTICLE
DOI 10.1186/s40880-017-0199-2 Chinese Journal of Cancer ORIGINAL ARTICLE Open Access Clinical treatment considerations in the intensity modulated radiotherapy era for patients with N0 category nasopharyngeal
More informationSurgical Management of Metastatic Colon Cancer: analysis of the Surveillance, Epidemiology and End Results (SEER) database
Surgical Management of Metastatic Colon Cancer: analysis of the Surveillance, Epidemiology and End Results (SEER) database Hadi Khan, MD 1, Adam J. Olszewski, MD 2 and Ponnandai S. Somasundar, MD 1 1 Department
More informationLong-term Follow-up for Patients with Papillary Thyroid Carcinoma Treated as Benign Nodules
Long-term Follow-up for Patients with Papillary Thyroid Carcinoma Treated as Benign Nodules YASUHIRO ITO, TAKUYA HIGASHIYAMA, YUUKI TAKAMURA, AKIHIRO MIYA, KAORU KOBAYASHI, FUMIO MATSUZUKA, KANJI KUMA
More informationIndex. Surg Oncol Clin N Am 16 (2007) Note: Page numbers of article titles are in boldface type.
Surg Oncol Clin N Am 16 (2007) 465 469 Index Note: Page numbers of article titles are in boldface type. A Adjuvant therapy, preoperative for gastric cancer, staging and, 339 B Breast cancer, metabolic
More informationSupplementary Material
1 Supplementary Material 3 Tumour Biol. 4 5 6 VCP Gene Variation Predicts Outcome of Advanced Non-Small-Cell Lung Cancer Platinum-Based Chemotherapy 7 8 9 10 Running head: VCP variation predicts NSCLC
More informationManagement of Neck Metastasis from Unknown Primary
Management of Neck Metastasis from Unknown Primary.. Definition Histologic evidence of malignancy in the cervical lymph node (s) with no apparent primary site of original tumour Diagnosis after a thorough
More informationLymph node ratio as a prognostic factor in stage III colon cancer
Lymph node ratio as a prognostic factor in stage III colon cancer Emad Sadaka, Alaa Maria and Mohamed El-Shebiney. Clinical Oncology department, Faculty of Medicine, Tanta University, Egypt alaamaria1@hotmail.com
More informationfollowing radiotherapy
British Journal of Cancer (1995) 72, 1536-154 r) 1995 Stockton Press All rights reserved 7-92/95 $12. Serum tumour markers in carcinoma of the uterine cervix and outcome following radiotherapy ARM Sproston',
More informationARTICLE IN PRESS. doi: /j.ijrobp METAPLASTIC CARCINOMA OF THE BREAST: A RETROSPECTIVE REVIEW
doi:10.1016/j.ijrobp.2005.08.024 Int. J. Radiation Oncology Biol. Phys., Vol. xx, No. x, pp. xxx, 2005 Copyright 2005 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/05/$ see front matter
More informationClinical Study Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication for Repeat Metastasectomy
Respiratory Medicine Volume 2015, Article ID 570314, 5 pages http://dx.doi.org/10.1155/2015/570314 Clinical Study Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication
More informationAdjuvant Therapy in Locally Advanced Head and Neck Cancer. Ezra EW Cohen University of Chicago. Financial Support
Adjuvant Therapy in Locally Advanced Head and Neck Cancer Ezra EW Cohen University of Chicago Financial Support This program is made possible by an educational grant from Eli Lilly Oncology, who had no
More informationPRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES GYNECOLOGIC CANCER CERVIX
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES GYNECOLOGIC CANCER CERVIX Site Group: Gynecology Cervix Author: Dr. Stephane Laframboise 1. INTRODUCTION 3 2. PREVENTION 3 3. SCREENING AND
More informationRevalidation of a prognostic score model based on complete blood count for nasopharyngeal carcinoma through a prospective study
Original Article Revalidation of a prognostic score model based on complete blood count for nasopharyngeal carcinoma through a prospective study Xiaohui Li 1,2*, Hui Chang 1*, Yalan Tao 1, Xiaohui Wang
More information