Non-Muscle Invasive Bladder Cancer BCG Failures: University of Iowa Hospitals and Clinics Experience. Paul Gellhaus Assistant Clinical Professor
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1 Non-Muscle Invasive Bladder Cancer BCG Failures: University of Iowa Hospitals and Clinics Experience Paul Gellhaus Assistant Clinical Professor
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6 Iowa???
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8 none Disclosures
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10 Caveats Dr. Michael O Donnell research / clinical experience NOT recommendations / guidelines / FDA approved Single university, small numbers Share experience & hypothesis generating discussion
11 University of Iowa Experience 1. Enhanced Bladder Surveillance (detection) 2. Clinic-based upper tract CIS treatment 3. Novel intravesical immune and sequential chemotherapy agent treatment options
12 Bladder cancer recurrence: is a Problem ~70% of bladder tumors will recur after TURBT alone Highest local recurrence rate of any solid malignancy Highest cost cancer from diagnosis to death 15-20% will progress to muscle invasion.
13 Bladder cancer recurrence: Risk factors Stage & Grade Size & Multiplicity Prior Recurrence Presence of CIS is a Problem UTUC is possible source of bladder seeding
14 Bladder cancer recurrence: is a Problem How can we improve?? Better detection of occult disease Multiple effective treatment options
15 1. Enhanced Bladder Surveillance Restaging bladder and upper tracts evaluation High grade/risk NMIBC After initial treatment (TURBT & intravesical induction)
16 UIHC Enhanced Surveillance Test Standard Surveillance Enhanced Surveillance White light Cystoscopy Urine Cytology Blue Light Cystoscopy Bilateral Retrograde Pyelograms* Bilateral Ureteral Wash Cytology Random Bladder Biopsies Prostatic urethral biopsy in men *no gross bladder tumor seen
17 UIHC: Enhanced Surveillance Outcomes n % Procedures Recurrences SS Positive SS Negative ES Positive Blue light: 7% Other methods each added ~1-2%
18 UIHC Enhanced Surveillance Enhanced only detection: 4.4% Upper tract CIS 69% Ta 16% T1 8.8% T2 1.5%
19 Surveillance Area Difference p-value Standard (Ref) Enhanced <0.01
20 UIHC Enhanced Surveillance Number needed to screen to detect one additional recurrence over the standard of care 4.6 restaging procedures
21 Oberle, AUA 2017 UIHC Enhanced Surveillance T1HG 93% Only 16% progressed to cystectomy
22 UIHC Enhanced Surveillance Rational: Detecting occult disease (primary CIS) Reduce seeding as a source of recurrence Upper tract Prostatic urethra
23 2. Upper Tract CIS Treatment Positive selective cytology, negative RPG / URS Induction topical agent Ureteral catheter (>90%) Nephrostomy tube (<10%)
24 Technique for Retrograde Instillation clinic fluoroscopy suite, topical lidocaine, flexible cystoscopy, 4 Fr whistle tip catheter, angled glide wire > 100 patients; safe and effective
25 Topical Therapy for CIS UTUC Induction (x 6 weeks) treatments Maintenance BCG: 1x 3 months Chemo: 6x monthly maintenance
26 Topical Therapy for CIS UTUC After induction Enhanced surveillance CT every 6 months for 2-3 years
27 Localizing POSITIVE HG Upper Tract Cytology 1 year RFS: BCG: 65% (n=43) Gemcitabine/Docetaxel: 90% (n=11) Unpublished
28 3. Intravesical Treatment BCG (with maintenance) Recommended for high-grade or high risk 30-40% reduction papillary recurrence 60-70% CIS complete response ~ 27% progression reduction
29 BCG failure x 1 are a problem BCG failures X1 ~35% response 2nd course of BCG How can we improve this response?
30 BCG failure x 2 are another problem BCG failures x 2: <20% response another course of BCG offered cystectomy before progression unwilling or unfit for cystectomy Clinical trial Intravesical chemotherapy
31 BCG failures are a problem How can we improve this response? 1.BCG with immune stimulating agents 2.Sequential chemotherapy
32 BCG + immunostimulation 1. IFN (50 million units) Stimulate a synergistic immune response Increase efficacy of bladder cancer suppression
33 BCG + Interferon for BCG Failures HR~1.6 BCG Failure HR~1.6 x 1 HR~1.8 = 3 years DFS ~50% BCG Naïve Age 80yo: 2 yr DFS 40% DFS (vs 60%) HR~1.6
34 BCG + immunostimulation Quad BCG: IFN: 50 million units IL-2: 22 million units GM-CSF [sargramostim]: 250 mcg SQ
35 Steinberg RL, Urol Oncol 2017 Quad BCG : Intravesical BCG + Interferon + IL-2 plus subq GM-CSF ~50% failed within 6 months HR~1.0 HR~1.6 HR~1.8 1&2 year DFS ~50% 55% 53% No apparent disadvantage to age >80
36 Intravesical Chemotherapy Mitomycin: alkylating agent Doxorubicin(Adriamycin): topoisomerase inhibitor & DNA intercalator Valrubicin Gemcitabine: Pyrimidine (Cytosine) analog Docetaxel: Microtubular stabilizing agent
37 Intravesical Chemotherapy Single agent chemotherapy (MMC, Adriamycin) +/- maintenance low to intermediate risk (low-grade) to reduce recurrence No effect on reducing progression Vesicants
38 Intravesical Chemotherapy Vesicant Causes vesicles (blisters) Contact irritant Mild to severe bladder irritation and symptoms Rarely permanent dysfunction Dystrophic calcification (MMC)
39 Intravesical Chemotherapy Newer agents (gemcitabine, docetaxel) Gemcitabine more effective than MMC 72% vs 61% (Addeo JCO 2010) Single post op dose (Messing, JAMA 2018) Non-vesicants Well tolerated
40 Sequential Chemotherapy Combined vesicant agent Promising results Poorly tolerated High discontinuation rate
41 Sequential Chemotherapy Gemcitabine & Docetaxel: Non-vesicant: Very well tolerated Nearly no side effects
42 Sequential Chemotherapy 1.Gemcitabine: 1g 50ml NS & Docetaxel: 37mg in 50ml NS
43 Sequential Chemotherapy Single drug instilled via catheter Clamped for 90 minutes and drained Second drug instilled Catheter removed, patient can leave clinic Voids 2 hours later
44 BCG Failures: Gemcitabine-Docetaxel Unpublished > 24 months: Durable responders
45 Sequential Chemotherapy 2. Quad Chemo: One vesicant + one non-vesicant agent Adriamycin 50mg in 50ml NS & Gemcitabine one week Docetaxel + Mitomycin 40mg 20ml water next week 4x 2-week cycles = 8 total weeks
46 BCG Failure and/or Gem-Doce Failure Quad Chemo: AG-DM X 8 >12 months durable response N=12
47 Gemcitabine-Docetaxel BCG-Naïve 2 years 7/7 (100%) intermediate risk 10/11 (92%) CIS 8/12 (67%) Ta/T1 HG >80 yo: Equivalent response n = 30 Unpublished
48 Take Home Messages 1. Improve detection by Enhanced Surveillance Cysview (Blue light) Assessing for occult CIS Upper tract and prostatic urethra
49 Take Home Messages 2. Reduce recurrence by treating upper tract CIS Topical immune or chemotherapy agents Consider clinic cysto placed ureteral catheters
50 Take Home Messages 3. Improve efficacy of topical bladder agents BCG with immunostimulation IFN Quad IFN + IL2 and subq GM-CSF
51 Take Home Messages 3. Improve efficacy of topical bladder agents Sequential chemotherapy Gemcitabine/Docetaxel Quad Chemo: Adriamycin + Gemcitabine then Docetaxel + Mitomycin X 4 cycles (8 weeks total)
52 Take Home Messages 3. Improve efficacy of topical bladder agents >80 years old: immunosenescence Quad BCG IFN + IL2 and subq GM-CSF Gemcitabine/docetaxel
53 Take Home Messages 3. Improve efficacy of topical bladder agents BCG ineligible, intolerant, or unavailable Gemcitabine/docetaxel Promising alternative first line intermediate/high risk
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55 If I were to be invited back
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