Clinical management of BRCA mutation carriers and those at high risk of breast cancer. Provisional Program

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1 Clinical management of BRCA mutation carriers and those at high risk of breast cancer Provisional Program

2 Thursday, November Live operating session - Bilateral risk reducing mastectomy case (D and K) Pre-pectoral implant reconstruction Get together and pre-meeting drinks at Klíníkin Friday, November Welcome and opening remarks Kristján Skúli Ásgeirsson Session 1: Risk Reducing Surgery The route to surgery Moderator: Stephen McCulley The why of risk reducing surgery Kevin S. Hughes (Massachusetts General Hospital) Planning RRS The pathway before surgery The Geneticist - Diana Eccles The Specialist Nurse - Nicky Scott The Surgeons - Douglas Macmillan (Nottingham Breast Institute) Pre-mastectomy fat grafting and / or breast lift/reduction in RRS. Kristjan S. Asgeirsson (Nordic and Nottingham Breast Institute) Panel discussion

3 Coffee Break Session 2: Risk Reducing Surgery Implant Recon Moderator: Kristjan S. Asgeirsson Under or over Is over the way to go? Designing the pre-pectoral pocket Douglas Macmillan (Nottingham Breast Institute) Product selection Which implant / mesh Douglas Macmillan (Nottingham Breast Institute) Post-mastectomy fat grafting Susanna Kauhanen Panel Discussion Lunch

4 Session 3: BRCA related breast cancer Moderator: Douglas Macmillan Risk reducing strategies for the BRCA positive breast cancer survivor Douglas Macmillan BRCA gene mutations and clinical outcomes in young onset breast cáncer, results from the POSH study Professor Diana Eccles, University of Southampton An update on the systemic treatment of BRCA - related breast cáncer NIklas Loman The role of oophorectomy in reducing breast cancer mortality for BRCA mutation carriers after breast cancer Steve Narod Panel discussion and live web-based discussion Coffee break Advertising stands Invited lecture What is the origin of the BRCA mutation? TBA Bus trip and Dinner at the Blue Lagoon and Northern Lights

5 Saturday November 24 Session 4: Non BRCA women at high risk Moderator: Kristjan Asgeirsson What to do about non-brca pathogenic mutation carriers? Steve Narod (Toronto, Canada) Pathological risk lesions and their management. Kevin S. Hughes (Massachusetts General Hospital) What is the risk in women with a strong family history, but test negative for BRCA mutation Diana Eccles / Noomi A new view on DCIS Steve Narod Panel discussion and live web-based discussion Coffee Break Session 5: Identifying BRCA mutation carriers Moderator; Douglas Macmillan

6 Current and future best practice in clinical genetic testing Professor Diana Eccles, University of Southampton Genetic testing: What problem are we trying to solve? Kevin S, Hughes (Massachusetts General Hospital) Is population based genetic testing becoming a reality? Steve Narod (Toronto, Canada) Implications of identifying gene mutation carriers through whole genome studies Niklas Loman What are the caveats to population based genetic testing Diana Eccles (University of Southampton) The impact of more liberal genetic testing in Iceland Vigdís Stefánsdóttir (genetic counsellor, Landspitali University Hosppital, Iceland) Panel discussion and live web-based discussion

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