Oncology Pipeline Analytics

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1 Oncology Pipeline Analytics Trials, Drug Classes, Indications, Correlations and Strategies Report Brochure

2 O n c o l o g y P i p e l i n e A n a l y t i c s Greystone Research Associates is pleased to announce the publication of a new market assessment. Oncology Pipeline Analytics: Trials, Drug Classes, Indications, Correlations and Strategies is a comprehensive evaluation and analysis of the technology, products and participants providing the driving force behind the accelerating oncology clinical development market. The study is designed to provide drug company decision makers, healthcare marketers, and supply chain participants with a detailed understanding of the economics, technologies, disease segments, and commercial opportunities for oncology drug therapeutics. Provider organization business managers, healthcare administrators and investors will also benefit from this study. Converging Factors Driving the Oncology Drug Development Landscape As immunotherapeutics in general and immuno-oncology in particular - move to the forefront, the major oncology drug developers are beginning to align with specific therapeutic approaches, such as PARP and PD-1/PD-L1. Our analytics analysis of current active oncology trial data reveals these factors and how they are affecting the oncology drug development landscape. By combining data on the oncology drug delivery landscape with the relational power of analytics we ve created a unique information resource that provides insight and clarity to market sector activity and competitive positioning within the oncology therapeutics space. By grouping and formatting information into visualizations that are easy to digest, readers gain a new and revealing perspective on the oncology drug development market. Report Value Matrix Managed Care Managers Management Consultants Financial Analysts Product Developers Component Suppliers CMOs, CSOs Pharma Product Managers Device Suppliers Biotech Managers Drug Marketers & Strategists Clinical Managers Drug Distributors Pharma Regulators

3 T a b l e o f C o n t e n t s Executive Summary Drug Development Challenges in Oncology Therapeutics Biological Drugs Biosimilars Small Molecule Drugs Leading Development-stage Oncology Therapeutics atezolizumab PD-1 & PD-L1 durvalumab HDAC Inhibitors nivolumab BET Inhibitors CAR-T cell therapy Oncolytic Viruses STAT3 Inhibitors carbozantinib Anti-LAG3 mab BTK Inhibitor PARP Inhibitors Oncology Clinical Trial Activity by Sponsor & Disease Segment Bladder Cancer Brain Cancer Breast Cancer Colorectal Cancer Gastric Cancer Head and Neck Cancer Hematological Malignancies Hepatic Cancer Kidney Cancer Leukemia Lung Cancer Lymphoma Multiple Myeloma Ovarian Cancer Pancreatic Cancer Prostate Cancer Sarcomas Skin Cancer Solid Tumors Other Cancers Company Profiles

4 Tables, Charts and Visualizations 1. Pipeline Activity by Cancer Segment (Bubble 2. Sponsors of Active Oncology Trials (Heat 3. New BLAs by Application (Dot Matric) 4. Biological Drug Ecosystem (Global 5. atezolizumab Trials by Disease Segment (Circle Grid) 6. PD-1 / PD-L1 Inhibitors - Trials by Disease Segment (Circle Grid) 7. PD-1 / PD-L1 Inhibitors Active Trials by Sponsor (Pie 8. PD-1 / PD-L1 Inhibitors Active Trials by Disease Segment (Pie 9. durvalumab - Trials by Disease Segment (Circle Grid) 10. durvalumab - Active Trials by Sponsor (Pie 11. durvalumab - Active Trials by Disease Segment (Pie 12. HDAC Inhibitors Active Trials by Disease Segment (Circle Grid) 13. HDAC Inhibitors - Active Trials by Sponsor (Pie 14. HDAC inhibitors - Active Trials by Disease Segment (Pie 15. nivolumab Active Trials by Disease Segment (Circle Grid) 16. nivolumab Active Trials by Disease Segment (Pie 17. BET Inhibitors - - Active Trials by Disease Segment (Circle Grid) 18. BET Inhibitors - Active Trials by Sponsor (Pie 19. CAR-T cell therapy - Active Trials by Sponsor (Pie 20. CAR-T cell therapy - Active Trials by Disease Segment (Pie 21. Oncolytic Viruses Active Trials by Disease Segment (Circle Grid) 22. Oncolytic Viruses - Active Trials by Sponsor (Pie 23. Oncolytic Viruses Active Trials by Disease Segment (Circle Grid) 24. STAT3 Inhibitors Active Trials by Sponsor (Pie 25. STAT3 Inhibitors Active Trials by Disease Segment (Pie 26. carbozantinib - Active Trials by Disease Segment (Pie 27. Anti-LAG3 mab - Active Trials by Sponsor (Pie 28. Anti-LAG3 mab - Active Trials by Disease Segment (Pie 29. BTK Inhibitor - Active Trials by Sponsor (Pie 30. BTK Inhibitor - Active Trials by Disease Segment (Pie 31. PARP Inhibitors - Active Trials by Sponsor (Pie 32. PARP Inhibitors - Active Trials by Disease Segment (Pie 33. Bladder Cancer Active Oncology Trials by Phase (Bar Graph) 34. Brain Cancer - Active Trials by Disease Segment (Bar Graph) 35. Breast Cancer - Active Trials by Disease Segment (Bar Graph) 36. Colorectal Cancer - Active Trials by Disease Segment (Bar Graph) 37. Gastric Cancer - Active Trials by Disease Segment (Bar Graph) 38. Head and Neck Cancer - Active Trials by Disease Segment (Bar Graph) 39. Hematological Malignancies - Active Trials by Disease Segment (Bar Graph)

5 40. Hepatic Cancer - Active Trials by Disease Segment (Bar Graph) 41. Kidney Cancer - Active Trials by Disease Segment (Bar Graph) 42. Leukemia - Active Trials by Disease Segment (Bar Graph) 43. Lung Cancer - Active Trials by Disease Segment (Bar Graph) 44. Lymphoma - Active Trials by Disease Segment (Bar Graph) 45. Multiple Myeloma - Active Trials by Disease Segment (Bar Graph) 46. Ovarian Cancer - Active Trials by Disease Segment (Bar Graph) 47. Pancreatic Cancer - Active Trials by Disease Segment (Bar Graph) 48. Prostate Cancer - Active Trials by Disease Segment (Bar Graph) 49. Sarcomas - Active Trials by Disease Segment (Bar Graph) 50. Skin Cancer - Active Trials by Disease Segment (Bar Graph) 51. Solid Tumors - Active Trials by Disease Segment (Bar Graph) 52. Other Cancers - Active Trials by Disease Segment (Bar Graph) 53. AbbVie Clinical Trial Activity by Disease Segment (Bubble 54. AbbVie Active Oncology Trial Details (Table) 55. AbbVie Number of Active Oncology Trials by Drug Class (Heat 56. Amgen Clinical Trial Activity by Disease Segment (Bubble 57. Amgen Active Oncology Trial Details (Table) 58. Amgen Number of Active Oncology Trials by Drug Class (Heat 59. AstraZeneca Clinical Trial Activity by Disease Segment (Bubble 60. AstraZeneca Active Oncology Trial Details (Table) 61. AsetraZeneca Number of Active Oncology Trials by Drug Class (Heat 62. Bayer Pharmaceuticals Clinical Trial Activity by Disease Segment (Bubble 63. Bayer Pharmaceuticals - Active Oncology Trial Details (Table) 64. Bayer Pharmaceuticals Number of Active Oncology Trials by Drug Class (Heat 65. Boehringer Ingelheim Clinical Trial Activity by Disease Segment (Bubble 66. Boehringer Ingelheim Active Oncology Trial Details (Table) 67. Boston Biomedical Clinical Trial Activity by Disease Segment (Bubble 68. Boston Biomedical - Active Oncology Trial Details (Table) 69. Bristol-Myers Squibb Clinical Trial Activity by Disease Segment (Bubble 70. Bristol-Myers Squibb Active Oncology Trial Details (Table) 71. Bristol-Myers Squibb Active Oncology Trial Details (Table) 72. Bristol Myers Squibb Number of Active Oncology Trials by Drug Class (Heat 73. Celgene Clinical Trial Activity by Disease Segment (Bubble 74. Celgene Active Oncology Trial Details (Table)

6 75. Celgene Number of Active Oncology Trials by Drug Class (Heat 76. Celldex Therapeutics Clinical Trial Activity by Disease Segment (Bubble 77. Celldex Therapeutics Active Oncology Trial Details (Table) 78. Eisai Clinical Trial Activity by Disease Segment (Bubble 79. Eisai Active Oncology Trial Details (Table) 80. Eli Lilly Clinical Trial Activity by Disease Segment (Bubble 81. Eli Lily Active Oncology Trial Details (Table) 82. Eli Lilly Number of Active Oncology Trials by Drug Class (Heat 83. EMD Serono- Clinical Trial Activity by Disease Segment (Bubble 84. EMD Serono Active Oncology Trial Details (Table) 85. EMD Serono Number of Active Oncology Trials by Drug Class (Heat 86. Exelxis Clinical Trial Activity by Disease Segment (Bubble 87. Exelixis Active Oncology Trial Details (Table) 88. Genentech Clinical Trial Activity by Disease Segment (Bubble 89. Genentech Active Oncology Trial Details (Table) 90. Genentech Active Oncology Trial Details (Table) 91. Genentech Number of Active Oncology Trials by Drug Class (Heat 92. Gilead Sciences Clinical Trial Activity by Disease Segment (Bubble 93. Gilead Sciences Active Oncology Trial Details (Table) 94. GlaxoSmithKline Clinical Trial Activity by Disease Segment (Bubble 95. GlaxoSmithKline - Active Oncology Trial Details (Table) 96. Incyte Clinical Trial Activity by Disease Segment (Bubble 97. Incyte 98. Janssen Research & Development Clinical Trial Activity by Disease Segment (Bubble 99. Janssen Research & Development Active Oncology Trial Details (Table) 100. Janssen Research & Development Number of Active Oncology Trials by Drug Class (Heat 101. Karyopharm Therapeutics - Clinical Trial Activity by Disease Segment (Bubble 102. Karyopharm Therapeutics - Active Oncology Trial Details (Table) 103. Leap Therapeutics Clinical Trial Activity by Disease Segment (Bubble 104. Leap Therapeutics Active Oncology Trial Details (Table) 105. MacroGenics Clinical Trial Activity by Disease Segment (Bubble

7 106. MacroGenics Active Oncology Trial Details (Table) 107. MedImmune Clinical Trial Activity by Disease Segment (Bubble 108. MedImmune Active Oncology Trial Details (Table) 109. MedImmune Number of Active Oncology Trials by Drug Class (Heat 110. Merck Clinical Trial Activity by Disease Segment (Bubble 111. Merck Active Oncology Trial Details (Table) 112. Merck Number of Active Oncology Trials by Drug Class (Heat 113. Novartis Oncology Clinical Trial Activity by Disease Segment (Bubble 114. Novartis Oncology Active Oncology Trial Details (Table) 115. Novartis Oncology Active Oncology Trial Details (Table) 116. Novartis Oncology Active Oncology Trial Details (Table) 117. Novartis Oncology Number of Active Oncology Trials by Drug Class (Heat 118. Pfizer Clinical Trial Activity by Disease Segment (Bubble 119. Pfizer Active Oncology Trial Details (Table) 120. Pfizer Number of Active Oncology Trials by Drug Class (Heat 121. Roche Clinical Trial Activity by Disease Segment (Bubble 122. Roche Active Oncology Trial Details (Table) 123. Seattle Genetics Clinical Trial Activity by Disease Segment (Bubble 125. Seattle Genetics Active Oncology Trial Details (Table) 126. Takeda Technology Clinical Trial Activity by Disease Segment (Bubble 127. Takeda Technology Active Oncology Trial Details (Table) 128. Tesaro Clinical Trial Activity by Disease Segment (Bubble 129. Tesaro - Active Oncology Trial Details (Table)

8 Comprehensive Assessments & Forecasts What You Will Learn Who are the leading developers in the current crop of oncology drugs in development? What are their activities and what is their position in therapeutic oncology markets? What are the most frequently trailed therapeutic oncology drugs? What is the clinical strategy? How many trials are under way? What are the major factors driving the oncology pipeline development market landscape? What is the size of the oncology clinical trial market today, who are the market share leaders, and what will the market share look like in 2024? How important are drug partnership relationships in the oncology drug development space? Which indications are the focus of the highest level of clinical trial activity? How well-positioned are the leading oncology drug suppliers as the pace of oncology product introductions accelerates? What are the significant economic, technology, and regulatory factors affecting the market? Report Format and Availability This report is available electronic format. A site license for a single physical location and a corporate license are also available. Custom licensing options to address specific company user requirements are available by calling client services at , or by ing Methodology Research methodology is based on primary research in the form of in-depth interviews with key market participants, technology developers, distributors, industry experts, and market influencers, a list that includes regulatory officials, industry trade groups, and materials standards organizations. Primary data is evaluated and normalized against secondary sources including trade journal articles, technical literature, industry publications, company data sheets and published information, and statistical data from government agencies and trade associations. Forecasts and projections of market demand and future market activity are derived using standard modeling and statistical techniques. About Greystone Associates Greystone Associates is a medical technology consulting firm focused on the areas of medical market strategy, product commercialization, venture development, and market research. We assist medical and healthcare market participants in achieving their business objectives through the creation of detailed development strategies, product commercialization programs, and comprehensive market and technology research and analysis. Our market research publications are designed, researched and written to provide timely and insightful information and data on focused market segments, with the aim of providing market participants with the essential knowledge to refine and execute their marketing plans and financial targets.

9 How To Order Ordering Information Orders may be placed via postal mail, or fax. Orders not accompanied by a purchase order must contain a telephone number for verification, and clearly indicate the physical shipping address and billing address. Payment We accept the following forms of payment: Company Check: Please make checks payable to Greystone Associates Credit Cards: We accept MasterCard, Visa and American Express to Wire Transfers: See Wire Transfers below for more information Orders Outside the U.S. Orders must be prepaid via credit card, company check in US funds and drawn on a US bank, or wire transfer. Wire Transfers: TD Banknorth 300 Franklin Street Manchester, NH (Call for Account Information) Mailing Address: Greystone Research Associates Client Services P.O. Box 1362 Amherst, NH Oncology Pipeline Analytics Trials, Drug Classes, Indications, Correlations and Strategies Select Format License Price (U.S. Funds) Total PDF Single User License $2, PDF Site License $4, PDF Corporate License $6, Total Payment (U.S. funds) Method of Payment: Company Check Wire Transfer (International) Card Number: Name on Card Expiration Date: Card CVV Signature Billing Information Name: Title: Company: Street Address: City,State/Province: Country/Postal Code: Phone: Fax: Shipping Information Click here if same as Billing Information Name: Title: Company: Street Address: City,State/Province: Country/Postal Code: Phone: Fax: 98 Route 101A P.O. Box 1362 Amherst, NH

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