TOTAL CANCER TREATMENT PROTOCOL:TCTP

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1 TOTAL CANCER TREATMENT PROTOCOL:TCTP SEISHINKAI medical corporation Takara clinic Director Tsuyoshi Takara

2 Treatment Strategy Diagnosis : 1Genetic analysis (knowing about one s combat efficiency and weak point ) 2PET-CT (knowing about the enemy and the war situation) Treatment:TCTP:Total Cancer Treatment Protocol

3 What is PET-CT?

4 Normal cells Full with little amount of glucose Cancer cells Eating more and more Glucose 3times~20times

5 Case of lung cancer PET examination CT examination PET CT examination

6 How to interpret the CT image Abdominal CT frout right left back

7 TCTP: Total Cancer Treatment Protocol Immunotherapy Dendritic cell treatment Stem cell treatment Radiationtherapy genetherapy Radiation Hormesistherapy cancer Cancer vaccine treatment thermotherapy Supplement Nutrition treatment

8 TCTP: TAKARACANCERTREATMENTPROTOCOL integral treatment of various methods gene therapy, radiation therapy, Dendritic cell treatment, etc Radiation therapy(including partied beam) Radiation hormesis therapy Stem cell treatment Thermotherapy Dendritic cell Supplement therapy Cytotoxlc T lymphocyte Vaccine treatment

9 IMRT(intensity-modulated radiation therapy)

10 Medipolis medical research institute particle beam cancer treatment research center

11 Proton beam treatment room

12 Examinations for early diagnosis of cancer gene examination SEISHINKAI medical corporation TAKARA Clinic Tsuyoshi Takara

13 Actual state of cancer treatment under the Japanese health /medical insurances system One of two men and one of three women contract cancer 700,000people in japan are diagnosed with cancer in 1year One of three Japanese dies of cancer approximately 340,000 people(about 1,000 a day)in 1year One of two suffers from recurrence of cancer even getting continuous treatment With the conventional medical insurance treatment the treatment results are poor in cancers of pancreas, bile duct, lung and esophagus

14 Questionnaire to radiotherapists in the university of Tokyo Hospital 80% of the terminal cancer patients expect to receive treatments to the last moment VS Only 20% of the doctors wish to treat these patients until the very end Big awareness gap

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16 What is Takara clinic s Gene examinations? Takara Clinic

17 Takara clinic s gene examinations RNAmicroarray (Target:stomach cancer colon cancer liver cancer bile duct cancer pancreas cancer) examinations of circulating tumor cells and cancer stem cells (target:breast cancer prostate cancer colon cancer melanoma lung cancer sarcoma gastrointestinal cancer)

18 RNAmicroarray Target:digestive cancer Stomach cancer colon cancer Bile duct cancer pancreas cancer

19 What is RNA microarray blood test? Microarray is the latest technology which allow us to measure on the gene level the reaction of the body to alien substances such as cancer It is possible to seize the circumstances of blood reacting to cancer cells on the gene level for the first time in the world. Microarray blood test has been developed by using this technology

20 Gene detection and verification in clinical trials Cancer detection group Group in order to look for necessary genes For discriminating between healthy people and cancer patients Evaluation group Group in order to verify if the genes found in the Cancer detection group can be applicable for Different cancer cases Digestive cancer case Healthy people case Verifying different group by using genes found in the cancer detection group

21 Another study by adding bile duct cancer cases Group with the clear diagnosis of localized cancer 72cases Cancer case 59 Healthy people 13 Set verification 81cases Cancer case 67 Healthy people 14 Stomach cancer 22 Colon cancer 12 Pancreas cancer 17 Bile dust cancer 8 Healthy people 13 2,665genes Cancer sensitivity 66/67 (98.5%) Specificity 13/14 (92.9%)

22 sensitivity specificity(number of the determined genes included) sensitivity specificity number of the determined genes Distinction of digestive cancer s presence Bile dust cancer 98.5% 92.9% 62.5% 94.9% 2, Judgement of the type of cancer Pancreas cancer 60.9% 79.5% Stomach colon cancer 75.0% 80.6% 306 7

23 Case: 50 years-old man CEA 2.2 CA ( medical check up) PET-CT MRI MRCP No tumor lesion detected RNA check

24 Image diagnosis PET-CT MRI MRCP 腫瘍病変は検知されず No tumor lesion detected

25 Result of blood RNA check analysis Judgement of digestive cancer no found Judgement of bile dust cancer no found Judgement of pancreas cancer no found Judgement of stomach/colon no found Result of clustering analysis Casa of colon cancer 14 Casa of stomach cancer 22 Case of pancreas cancer 23 Case of bile dust cancer 8 Healthy people 14 Clustering by 2665 genes recorded in BBRC Result of PCA analysis Casa of colon cancer14 Casa of stomach cancer 22 Case of pancreas cancer 23 Case of bile dust cancer 8 Healthy people 14 Sample of this time Clustering by 2665 genes on custom array Sample of this time Sample of this time

26 Endoscopy of upper and lower parts and the results ulcer trace at the upper digestive canal 2 polyps at sigmoid colon execution of endoscopic polyp resection pathological examination Carcinoma in adenoma CA19-9:47 22 Tub1,M0,ly0,v0 Cancer in adenoma

27 Circulation cancer cell & examination of cancer stem cell Peripheral blood circulating tumor cell circulation cancer stem cell

28 cancer cell cancer stem cell almost no growth repetition of grown

29 angiogenesis

30 IMRT Intensity modulated radiotherapy) Takara Clinic

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32 What is immunotherapy at TAKARA clinic?

33 Apheresis room

34 REAL TREATMENT SCENE Takara Clinic

35 POSITIONING Takara Clinic

36 INTRA-TUMORAL INJECTION Takara Clinic

37 Conclusion By complexly combining Takara clinic s advanced treatments :TCTP (gene therapy dendritic cell treatment stem cell treatment cancer vaccine treatment radiation therapy etc) Terminal stage patients who need hospice care could be possibly rehabilitated

38 In conclusion Anti-cancer agents are unable to cure a cancer They rather increase cancer 1988NCI(national cancer institute )report pathology of cancer