Topically Applicable Stromal Cell Growth Factors - Encapsulated Cosmeceuticals

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1 Topically Applicable Stromal Cell Growth Factors - Encapsulated Cosmeceuticals

2 Stem cells move to injured area, differentiate into neighboring cells, and replace the damaged cells Cell Eons Stem cells are get stressed and secrete diverse growth factors under hypoxia (non-oxygen) condition. Cell Eons are a lyophilized (freezingdrying process) powder of the diverse growth factors. Encapsulated Cell Eon Cosmeceuticals The lyophilized stem cell growth factors as signaling proteins are not stable at room temperature. Liposomal treated (encapsulated) stem cell growth factors are Cell Eon cosmeceuticals, very stable at room temperature and can be topically applicable.

3

4 Bone marrow stem cells are good candidate for skin rejuvenation!!

5 secretary factors are as potent as Stem cells

6 Limitations of Stem cell Bone marrow collection is required Only autologous transplantation possible Subcutaneous injection is mandatory Short life-span out of body Long time for manufacturing Save time Low price Mass production Quality controlled celleon but not stable at room temperature So, We made Cell EON encapsulated with liposome As cosmeceuticals

7 What is in celleon? Definition of celleon (Human bone marrow stem cell conditioned media ) celleon is a mixture of proteins extracted from conditioned medium of Bone marrow stem cell. Key ingredients of celleon Collagen Fibronectin TGF beta1 (transforming growth factor) PDGF (platelet derived growth factor) KGF (keratinocyte growth factor) Basic FGF (fibroblast growth factor) HGF (hepatocyte growth factor) VEGF (vascular endothelial growth factor) SOD (superoxide dismutase) Main component of dermis Promotes wound healing Stimulates collagen synthesis/secretion Regulates cell growth and division Promotes epithelial cell growth Promotes formation of new blood vessels Stimulates formation of new blood vessels Stimulates formation of new blood vessels Protects skin from oxidative damage

8 Advantages of celleon are Human proteins Active proteins are derived from human source and do not have allergic reactions no skin irritation Natural composition Natural composition of the various growth factors derived from BMSC can provide the best biological activity. Synergistic effect Each growth factor has pharmacological effect but combination of growth factors may enhance the pharmacological action of single protein. Multi-function celleon exhibits antiwrinkle, antioxidant and skin-whitening effect and hair regrowth effect.

9 Fibroblast proliferation by celleon control + celleon Cell proliferative activity of celleon was tested in human dermal fibroblast. Conditioned medium was replaced by celleon, which increased fibroblasts proliferation Sourced by : &

10 Wound healing effect by celleon control Inreased migration + celleon Cell migration effect was tested in human dermal fibroblast. Cells were wounded and the culture medium was replaced by celleon, which increased fibroblast migration Sourced by : &

11 celleon induced increasing of Collagen density Collagen Density <Stem cell> <Control> Mason-Trichrome stain celleon induced collgen expression, so it increased collagen density and dermal thickness. Sourced by : &

12 Collagen synthesis increased Proteins of type 1 procollagen and MMP-13 expression rate by western-blot Fig 1 mrna of type 1 procollagen expression rate by real time RT-PCR Fig 2 celleon increased collagen secretion and up-regulated mrna expression of ECM proteins in HDFs. Sourced by : &

13 Dermal thickness increased Dermal Thickness <Stem cell> <Control> H&E stain celleon induced increasing of dermal thickness by collagen synthesis Sourced by : &

14 Increased Angiogenesis Increased Angiogenesis in Stem cell injected mice (CD31) Fig 1 Increased Angiogenesis in Stem cell injected mice (NG2) Fig 2 <Fig 1> <Fig 2> <Stem cell injection> <Control> <Stem cell injection> <Control> Sourced by : &

15 Melanin (fold induction) celleon inhibits melanin synthesis celleon (%) 0% 10% 50% 100% celleon inhibited melanin synthesis in B16 melanoma cells as a concentration dependent manner Sourced by : &

16 Antioxidant capacity (nm) Antioxidant effect by celleon N/C Vit.C 100uM celleon 50% celleon 100% celleon had antioxidant effect more potent than vitamin C (100 mm) Sourced by : &

17 Encapsulated celleon How to use - Simply apply the encapsulated Cell EON serum topically, - Topically apply with air-spray gun - Topically apply after skin exfoliation post luxeu, a portable microdermabrasion device - Topically apply and do facial massaging with multiplefunctional, portable RUMI device electrophoresis, RF, EMS, vibrastion and LED lighting

18 celleon therapy Homecare Skin treatment Cleansing CellEon (With brush) CellEon + Air spray gun Luxe U RUMI CellEon (With brush)

19 Enhanced neck Wrinkle/and pigmentation in eye rim Before Before After After

20 Before After Before After

21 Before After Before After Before After

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