Ms. Y. Outline. Updates of SERMs and Estrogen
|
|
- Jodie Powell
- 5 years ago
- Views:
Transcription
1 Ms. Y Updates of SERMs and Estrogen Steven R. Cummings, MD, FACP San Francisco Coordinating Center CPMC Research Institute and UCSF Support from Lilly, Pfizer, Berlex 55 y.o. woman with mild hypertension treated with HCTZ Had a hysterectomy for fibroids No hot flushes Mother: breast cancer and kyphosis BMD FN T-score = -.3; spine -.9 Low bone mass / osteopenia GI upset with alendronate Gynecologist recommended Premarin.65 mg daily for osteopenia Outline SERMS Bone Breast cancer New SERMs Postmenopausal estrogen therapy Bone Recent findings about other risks and benefits 4 years of raloxifene decreases the risk of vertebral fracture % with fracture 36% 43% Placebo RLX 6 RLX
2 In women with low BMD, nonvertebral fractures are the most important 4 years of raloxifene did not decrease the risk of non-spine fractures % of days of disability due to fractures 5 RR =.93 (.8,.6) Nonvertebral fractures 9% 8% % with fractures 5 Placebo Raloxifene Clinical vertebral fractures Cummings, JAMA 6;96:6 Months Reduction in Risk of Breast Cancer Summary of 3 Raloxifene Trials Incidence of Invasive Breast Cancer per Woman-Years Placebo Raloxifene 44% 7% RUTH MORE CORE 56% FDA approved indications for prevention of breast cancer Raloxifene is indicated for reducing the risk of invasive breast cancer in postmenopausal women with osteoporosis for postmenopausal women at high risk for invasive breast cancer
3 5- year risk of invasive breast cancer Breast density and risk of breast cancer Age Family history No family history Odds Ratio for Breast Cancer BI-RADS Grade Cummings, et al. JNCI 9;:384 Bazedoxifene and raloxifene had similar effects on spine BMD 6,847 women, years old, with osteoporosis 3 years Bazedoxifene Silverman et al, JBMR 8 3
4 Bazedoxifene and raloxifene reduced vertebral fracture ~4% Bazedoxifene was not effective for nonvertebral fracture 6,847 women, years old, with osteoporosis 3 years Silverman JBMR 8;3:93 Combining a SERM with estrogen Bazedoxifene plus Conjugated Estrogen TSEC Might have more potent estrogenic effects on bone than the SERM alone However, the SERM may inhibit the effect of estrogen on bone Tested in the SMART Trial 3,397 postmenopausal women with spine or hip T-scores above -.5 4
5 Annualized Improvement in Spine BMD Versus Placebo Premarin + Bazedoxifene Bazedoxifene appears to blunt the improvement in BMD At low doses, stronger than raloxifene at ~4 mg of bazedoxifene, effects are similar Will the combination decrease fracture risk any more than the SERM alone? Safety? (Stroke? Breast cancer?) Plus Premarin.65 mg Lindsay et al. Fertil Steril 9;9:45 Lasofoxifene SERMs you won t see Reduced the risks of Vertebral and nonvertebral fracture Breast cancer Stroke Coronary heart disease Increased Venous thromboembolism Hot flushes, leg cramps Rarely lung cancers?? 5
6 Arzoxifene Summary More potent than raloxifene on bone resorption and BMD mice Large fracture trial showed Decreased risk of vertebral fracture Decreased risk of breast cancer No decrease in risk of nonvertebral fracture Numerical increase in risk of endometrial cancer Will not apply to FDA for approval Raloxifene reduces the risk of vertebral fractures Consider raloxifene (or tamoxifen) for women with high risk of breast cancer Over 6, family history, high breast density HRT and All Fractures ET/HT 5 HR.76 (.69,.85) Placebo E+P Time (years) 6
7 Effect of HRT on Hip Fracture Risk Women s Health Initiative overall risk and benefit 3 E+P Placebo Only ~/6 had osteoporosis HR.66 (.45,.98) Time (years) HT (E+P) Harm CHD.3 Stroke.4 P.E.. Breast Ca.3 Benefit Hip fracture.7 Colon cancer.6 ET (E only) Harm Stroke.4 Benefit Hip fracture.6 No significant effect CHD.9 P.E..3 Breast Ca.8 Colon Ca. Global Index net harm Who should receive estrogen for fracture prevention? Net harmful events per, ET and HT reduce risk of fracture Valuable for short-term use for hot flushes Is there a group of asymptomatic women for whom the benefits outweigh the risks? 7
8 The Young at Heart Theory The debate: is estrogen beneficial for early menopausal women? Estrogen prevents / slows atherosclerosis In atherosclerotic arteries, estrogen precipitates clots Therefore, estrogen therapy may protect against CVD in younger but increase risk in older women. NAMS Position The benefit-risk ratio is favorable for women who initiate HT close to menopause Analysis from WHI provide little support for the hypothesis of favorable effects among women who initiate HT soon after menopause for CHD or benefits vs. risks Menopause ;7:4 Prentice, et al. Am J Epidemiol 9;7: Does HT reduce CHD in 5-59 year olds? HT increased risk of lung cancer WHI analyses: No significant reduction in risk of CHD in women who started < years of menopause Increased risk in older women < years < years Toh, et al, Ann Intern Med ;5: ET did not increase risk of lung cancer Chlebowski Lancet 9;Sept :-9 8
9 Estrogen and the brain of women over age 65.8-fold increased risk of dementia HT decreased verbal memory; ET decreased spatial-rotational ability HT and ET shrunk the frontal cortex and hippocampus by ~ % Estrogen and skin Collagen production is stimulated by estrogen and this is necessary for skin to remain firm and wrinkle free Coker, et al. J Steroid Biochem Mol Biol ;8:34 From: Estrogen and skin: randomized blinded trial 485 women, ~ 5 years postmenopausal 5 or µg ethinyl estradiol/d for 48 weeks (plus norethindrone acetate) vs. placebo No significant differences in subjective or objective ratings of: wrinkling laxity / sagging dryness / texture Estrogen Update Don t prescribe hormone therapy for older women Valuable for bothersome hot flushes If an asymptomatic woman under age 6 has a high risk of fracture, consider bisphosphonates first Phillips, J Am Acad Dermatol 8;59:397 9
10 Ms. Y Ms. Y 55 y.o. woman with mild hypertension treated with HCTZ Had a hysterectomy for fibroids No hot flushes Mother: breast cancer and kyphosis BMD FN T-score = -.3; spine -.9 Low bone mass / osteopenia GI upset with alendronate Gynecologist recommended Premarin.65 mg daily for osteopenia 55 y.o. woman with mild hypertension treated with HCTZ Low risk of fracture; does not need treatment ~.4% 5 year risk of breast cancer Breast density? Consider raloxifene? The PEARL Trial Thank you 8556 women age 59 to 8 with osteoporosis Two daily doses (.5 mg or.5 mg) of lasofoxifene vs. placebo 5 years
11 In women with low BMD, nonvertebral fractures are the most important % of days of disability due to fractures Nonvertebral fractures 6% 38% Five years of lasofoxifene improved BMD by 3% Lasofoxifene, mg/d.5.5 Spine BMD +3.% +3.% Femoral neck MD B +.9% +3.% Clinical vertebral fractures p. for all Cummings, JAMA 6;96:6 Cummings, NEJM (in press) Lasofoxifene reduced the risk of vertebral fractures The.5 mg dose also reduced the risk of nonvertebral fractures Cumulative % % (p <.) 4% (p <.) Cumulative % % (P =.9) 9.4 4% (p <.) 8. Pbo.5 mg.5 mg Lasofoxifene Cummings, NEJM (in press) Pbo.5 mg.5 mg Lasofoxifene Cummings, NEJM (in press)
12 Lasofoxifene.5 mg reduced the risk of major coronary heart disease HR (95% C.I.) Laso.5 mg.76 (.56,.3) Laso.5 mg.68 (.5,.93) Lasofoxifene HR (95% C.I.) Laso.5 mg.6 (.39,.96) Laso.5 mg.64 (.4,.99) Extension of the STAR trial Tamoxifen vs. Raloxifene Raloxifene or tamoxifen? Vogel, et al., Cancer Prev Res ;3:696
13 Extension of the STAR trial Tamoxifen vs. Raloxifene Effects of tamoxifen after stopping Reduction in risk of breast cancer continues for at least years Adverse effects stop when treatment stops year perspective: twice the benefit for the same 5-year risk Vogel, et al., Cancer Prev Res ;3:696 Benefits Persist 5 years of tamoxifen continues to reduce breast cancer risk and mortality for at least more years after stopping treatment Adverse effects (& costs) last 5 years* Thus, long-term benefit with short-term costs EBCT Group. Lancet 5;365:687 SF *IBIS- Coordinating Trial: J Cuzick, CenterJNCI 7;99:7 Breast cancer mortality Treat Off Cumulative Hazard Estrogen alone: Total Breast Cancer Total Breast Cancer CEE Placebo HR =.8 (95% CI,.65-.4) P-value =. HR =.8 (95% CI ) P-value =. Time (years) CEE Placebo Stefanick et al: JAMA 6; 95:
14 Women s Health Initiative overall risk and benefit Harm CHD.3 Stroke.4 P.E.. Breast Ca.3 Benefit Hip fracture.7 Colon cancer.6 HT (E+P) Relative Risk Estrogen alone seemed safer for women age 5 to CHD.56.8 Global index to 59 6 to 69 7 to 79 Age Group Rossouw et al. JAMA. 7;97:465 Estrogen therapy seemed beneficial for younger women (early after menopause) ET seemed safer early after menopause, until you consider stroke.5 CHD.5. CHD Stroke +7 Relative Risk P=.5 Relative Risk < to 9 ³ Years Since Menopause Rossouw et al. JAMA. 7;97:465 < to 9 ³ Years Since Menopause Rossouw et al. JAMA. 7;97:465 4
15 Coronary Calcification Estrogen and Coronary Calcification WHI: Estrogen only; 5-59 y.o. Coronary CT with calcification scores (CACS) 7.4 years after randomization.3 years after the end of the trial Estrogen and Coronary Calcification Estrogen and Coronary Calcification Mean CACS Estrogen 83 Placebo 3 CACS < Estrogen 65% Placebo 57% P =.4 At least 8% adherence CACS < Estrogen 68% Placebo 54% P <. 5
16 HT and ET increased risk of cognitive impairment in women 65 Symptomatic benefits of estrogen therapy Hot flushes Improved sleep and mood Decreased arthralgias and myalgias No effect on depression in women without hot flushes Shumaker JAMA 4;9:947 Half Dose Esterified Estrogen Improves BMD in Older Women What about low dose? Mean % Change +/- SEM Placebo 6 8 Month 4 HK Genant et al, Arch Intern Med 57:69-65, 65, 997 6
17 3.5 3 Even lower Menostar patch also reduces hot flushes Spine p<. Mean % change from baseline.5.5 p<..%.%.6%.5.5%.6% Months 4 Months Placebo Estradiol.4mg 7
SERMS, Hormone Therapy and Calcitonin
SERMS, Hormone Therapy and Calcitonin Tiffany Kim, MD Clinical Fellow VA Advanced Women s Health UCSF Endocrinology and Metabolism I have nothing to disclose Thanks to Clifford Rosen and Steven Cummings
More informationDINE AND LEARN ENDOCRINOLOGY PEARLS. Dr. Priya Manjoo, MD, FRCPC Endocrinology, Victoria, BC
DINE AND LEARN ENDOCRINOLOGY PEARLS Dr. Priya Manjoo, MD, FRCPC Endocrinology, Victoria, BC OUTLINE HRT and CVD HRT and Breast Cancer Osteoporosis When to treat How long to treat for Bisphosphonates BMD
More informationLearning Objectives. Peri menopause. Menopause Overview. Recommendation grading categories
Learning Objectives Identify common symptoms of the menopause transition Understand the risks and benefits of hormone replacement therapy (HRT) Be able to choose an appropriate hormone replacement regimen
More informationOutline. Estrogens and SERMS The forgotten few! How Does Estrogen Work in Bone? Its Complex!!! 6/14/2013
Outline Estrogens and SERMS The forgotten few! Clifford J Rosen MD rosenc@mmc.org Physiology of Estrogen and estrogen receptors Actions of estrogen on bone BMD, fracture, other off target effects Cohort
More informationKathryn M. Rexrode, MD, MPH. Assistant Professor. Division of Preventive Medicine Brigham and Women s s Hospital Harvard Medical School
Update: Hormones and Cardiovascular Disease in Women Kathryn M. Rexrode, MD, MPH Assistant Professor Division of Preventive Medicine Brigham and Women s s Hospital Harvard Medical School Overview Review
More informationHORMONE THERAPY A BALANCED VIEW?? Prof Greta Dreyer
HORMONE THERAPY A BALANCED VIEW?? Prof Greta Dreyer -- PART 1 -- Definitions HRT hormone replacement therapy HT genome therapy ERT estrogen replacement therapy ET estrogen EPT estrogen progesterone therapy
More informationBenton Franklin County Medical Society 31st Annual CME Seminar
Management of Current HT/ET and SERM Recommendations Benton Franklin County Medical Society 31st Annual CME Seminar February 21, 2015 Kennewick, Washington Spokane steoporosis Dr. Lynn Kohlmeier Lynn Kohlmeier,
More informationNew Developments in Osteoporosis: Screening, Prevention and Treatment
Osteoporosis: Overview New Developments in Osteoporosis: Screening, Prevention and Treatment Judith Walsh, MD, MPH Departments of Medicine and Epidemiology and Biostatistics UCSF Definitions Risk factors
More informationHORMONE REPLACEMENT THERAPY
TRIALS OF HR RUTH (Barrett- Connor et al 29 ) JULY 2006 (Country) mean ± sd, range International trial 67.5 an Placebo component in 67.5 ± 6.7 women with Raloxifene or multiple 67.5 ± 6.6 risk factors
More informationSelective estrogen receptor modulators in the treatment of osteoporosis: a review of the clinical evidence
Review: Clinical Trial Outcomes Selective estrogen receptor modulators in the treatment of osteoporosis: a review of the clinical evidence Clin. Invest. (2011) 1(5), 719 724 The ideal selective estrogen
More informationLessons from the WHI HT Trials: Evolving Data that Changed Clinical Practice
Lessons from the WHI HT Trials: Evolving Data that Changed Clinical Practice JoAnn E. Manson, MD, DrPH, FACP Chief, Division of Preventive Medicine Interim Executive Director, Connors Center Brigham and
More informationLearning Objectives. Controversies in Osteoporosis Prevention and Management. Etiology. Presenter Disclosure Information. Epidemiology.
12:45 1:30pm Controversies in Osteoporosis Prevention and Management SPEAKER Carolyn Crandall, MD, MS Presenter Disclosure Information The following relationships exist related to this presentation: Carolyn
More informationOSTEOPOROSIS: PREVENTION AND MANAGEMENT
OSTEOPOROSIS: OVERVIEW OSTEOPOROSIS: PREVENTION AND MANAGEMENT Judith Walsh, MD, MPH Departments of Medicine and Epidemiology and Biostatistics UCSF Definitions Key Risk factors Screening and Monitoring
More informationA KL/R / AN A K/O / P O G G
Outline and New Treatments on the Horizon Steven R. Cummings, MD CPMC and UCSF San Francisco Coordinating Center Support from Lilly and Amgen New treatments, new mechanisms of action Cathepsin K inhibition
More informationHormones and Healthy Bones Joint Project of National Osteoporosis Foundation and Association of Reproductive Health Professionals
Hormones and Healthy Bones Joint Project of National Osteoporosis Foundation and Association of Reproductive Health Professionals Literature Review (January 2009) Hormone Therapy for Women Women's Health
More informationPrior disclosures past 3 years Consultant for Pfizer University of Virginia received Grants/research support from TherapeuticsMD
Prior disclosures past 3 years Consultant for Pfizer University of Virginia received Grants/research support from TherapeuticsMD JoAnn V. Pinkerton, MD Professor of Obstetrics and Gynecology Director,
More informationMENOPAUSE. I have no disclosures 10/11/18 OBJECTIVES WHAT S NEW? WHAT S SAFE?
MENOPAUSE WHAT S NEW? WHAT S SAFE? I have no disclosures Sara Whetstone, MD, MHS OBJECTIVES To describe risks of HT by age and menopause onset To recommend specific HT regimen for women who undergo early
More informationWHI Estrogen--Progestin vs. Placebo (Women with intact uterus)
HORMONE REPLACEMENT THERAPY In the historical period it was commonly held that estrogen had two principal benefits to postmenopausal women: 1) To alleviate the constitutional symptoms related to the climacteric
More informationHRT and bone health. Management of osteoporosis and controversial issues. Delfin A. Tan, MD
Strong Bone Asia V. Osteoporosis in ASEAN (+), Danang, Vietnam, 3 August 2013 Management of osteoporosis and controversial issues HRT and bone health Delfin A. Tan, MD Section of Reproductive Endocrinology
More informationBreast Cancer Prevention for the Population at Large
Breast Cancer Prevention for the Population at Large Jack Cuzick Centre for Cancer Prevention Wolfson Institute of Preventive Medicine St Bartholomew s Medical School Queen Mary University of London London,
More informationUpdates in Osteoporosis. I have no conflicts of interest. What Would You Do? Mrs. C. What s New in Osteoporosis. Page 1
Updates in Osteoporosis Jeffrey A. Tice, MD Associate Professor of Medicine Division of General Internal Medicine, University of California, San Francisco I have no conflicts of interest What s New in
More informationChemo-endocrine prevention of breast cancer
Chemo-endocrine prevention of breast cancer Andrea DeCensi, MD Division of Medical Oncology Ospedali Galliera, Genova; Division of Cancer Prevention and Genetics, European Institute of Oncology, Milano;
More informationNEW DEVELOPMENTS IN OSTEOPOROSIS: SCREENING, PREVENTION AND TREATMENT
NEW DEVELOPMENTS IN OSTEOPOROSIS: SCREENING, PREVENTION AND TREATMENT Judith Walsh, MD, MPH Departments of Medicine and Epidemiology and Biostatistics UCSF OSTEOPOROSIS: OVERVIEW Definitions Risk factors
More informationWomen s Health: Managing Menopause. Jane S. Sillman, MD Assistant Professor of Medicine Harvard Medical School
Women s Health: Managing Menopause Jane S. Sillman, MD Assistant Professor of Medicine Harvard Medical School Disclosures I have no conflicts of interest. Learning Objectives 1. Apply strategies to help
More informationOsteoporosis Screening and Treatment in Type 2 Diabetes
Osteoporosis Screening and Treatment in Type 2 Diabetes Ann Schwartz, PhD! Dept. of Epidemiology and Biostatistics! University of California San Francisco! October 2011! Presenter Disclosure Information
More informationJames H. Liu, M.D. Arthur H. Bill Professor Chair of Reproductive Biology Dept of Obstetrics and Gynecology
Disclosure Estrogen Therapy After Postmenopausal Hysterectomy: Issues, Challenges, Risks/Benefits James H. Liu, M.D. Arthur H. Bill Professor Chair of Reproductive Biology Dept of Obstetrics and Gynecology
More informationOB/GYN Update: Menopausal Management What Does The Evidence Show? Rebecca Levy-Gantt D.O. PremierObGyn Napa Inc.
OB/GYN Update: Menopausal Management What Does The Evidence Show? Rebecca Levy-Gantt D.O. PremierObGyn Napa Inc. Napa, California IMPORTANT SAFETY INFORMATION ABOUT EVAMIST: WARNING: ENDOMETRIAL CANCER,
More informationHRT: Neue Kombinationen
HRT: Neue Kombinationen 4. Februar 2015 Gyndolomiti Cumulative Hazards of Invasive Breast Cancer WHI Conj. Estrogen + MPA Cumulative Hazards of Invasive Breast Cancer WHI Estrogen only CE+MPA Time, y WHI
More informationSomething has changed? The literature from 2008 to present?
Something has changed? The literature from 2008 to present? Elina Hemminki National Institute for Health and Welfare, Helsinki, Finland Rome Oct 7, 2011: Post-menopausal hormone therapy and women's information
More informationThe preferred treatment for osteoporosis
Alternate Options to Hormone Replacement Therapy for Osteoporosis James R. Shoemaker, DO Andrea B. Klemes, DO This presentation, developed from a symposium lecture at the 40th Annual Convention of the
More informationMarco Gambacciani President Italian Menopause Society Department of Obstetrics and Gynecology Pisa University Hospital Italy
La Terapia Ormonale Sostitutiva in Menopausa: Rivalutazione dei rischi e benefici nell ultimo decennio Marco Gambacciani President Italian Menopause Society Department of Obstetrics and Gynecology Pisa
More informationRALOXIFENE Generic Brand HICL GCN Exception/Other RALOXIFENE EVISTA Is the request for the prevention (risk reduction) of breast cancer?
Generic Brand HICL GCN Exception/Other RALOXIFENE EVISTA 16917 GUIDELINES FOR USE 1. Is the request for the prevention (risk reduction) of breast cancer? If yes, continue to #2. If no, approve by HICL
More informationEstrogen and progestogen therapy in postmenopausal women
Estrogen and progestogen therapy in postmenopausal women The Practice Committee of the American Society for Reproductive Medicine American Society for Reproductive Medicine, Birmingham, Alabama Hormone
More informationAusPharm CE Hormone therapy 23/09/10. Hormone therapy
Hormone therapy Learning objectives: Assess options to address quality of life and health concerns of menopausal women Outline indications for hormone therapy Counsel women on the risks and benefits of
More informationHormone therapy. Dr. med. Frank Luzuy
Hormone therapy Dr. med. Frank Luzuy Reasons for Initiating/Continuing HT* Menopause-Related Symptoms Osteoporosis, Bone Loss, Fracture Prevention Doctor Prescribed It, Told Me to Take It Cardiovascular
More informationHealth Risks and Benefits 3 Years After Stopping Randomized Treatment With Estrogen and Progestin. The WHI Investigators
Health Risks and Benefits 3 Years After Stopping Randomized Treatment With Estrogen and Progestin The WHI Investigators 1 Background: WHI Hormone Program Design YES N= 10,739 Conjugated equine estrogen
More informationCLINICIAN INTERVIEW CARDIOVASCULAR DISEASE IN POSTMENOPAUSAL WOMEN
CARDIOVASCULAR DISEASE IN POSTMENOPAUSAL WOMEN Nanette K. Wenger, MD, is a recognized authority on women and coronary heart disease. She chaired the US National Heart, Lung, and Blood Institute conference
More informationOsteoporosis. Current Trend in Osteoporosis Management for Elderly in HK- Medical Perspective. Old Definition of Osteoporosis
Current Trend in Osteoporosis Management for Elderly in HK- Medical Perspective Dr Dicky T.K. Choy Physician Jockey Club Centre for Osteoporosis Care and Control, CUHK Osteoporosis Global public health
More informationVirtual Mentor Ethics Journal of the American Medical Association November 2005, Volume 7, Number 11
Virtual Mentor Ethics Journal of the American Medical Association November 2005, Volume 7, Number 11 Clinical Pearl Post Women's Health Initiative Menopausal Women and Hormone Therapy by JoAnn V. Pinkerton,
More informationMenopausal Symptoms. Hormone Therapy Products Available in Canada for the Treatment of. Physician Desk Reference - 3rd Edition
Hormone Therapy Products Available in Canada for the Treatment of Menopausal Symptoms Physician Desk Reference - 3rd Edition A clinical resource provided to you by: The Society of Obstetricians and Gynaecologists
More informationGynecologists are first-line providers for
Update OSTEOPOROSIS A new agent, and new understandings of old drugs, top the year s developments in bone health Steven R. Goldstein, MD Dr. Goldstein is Professor, Department of Obstetrics and Gynecology,
More information2017 Position Statement of Hormone Therapy of NAMS: overview SHELAGH LARSON, MS, RNC WHNP, NCMP ACCLAIM, JPS HEALTH NETWORK
2017 Position Statement of Hormone Therapy of NAMS: overview SHELAGH LARSON, MS, RNC WHNP, NCMP ACCLAIM, JPS HEALTH NETWORK WHI the only large, long-term RCT of HT in women aged 50 to 79 years, Drug trail
More informationPostmenopausal osteoporosis is a systemic
OSTEOPOROSIS: HARD FACTS ABOUT BONES Steven T. Harris, MD, FACP* ABSTRACT As a consequence of the aging process, osteoporosis affects all men and women. Agerelated loss of bone mass leads to skeletal fragility
More informationMenopausal Management: What Has Changed?
Menopausal Management: What Has Changed? Julia V. Johnson, M.D. Professor and Chair, OB/GYN University of Massachusetts Medical School UMass Memorial Medical Center Conflicts of Interest None Learning
More informationMenopausal Hormone Therapy
V FORUM on WOMEN, HEALTH, and GENDER Madrid, October 14-15, 2008 Menopausal Hormone Therapy The Women s Health Initiative (WHI) randomized, placebo-controlled trials Marcia L. Stefanick, Ph.D. Professor
More informationCOMMENTARY: DATA ANALYSIS METHODS AND THE RELIABILITY OF ANALYTIC EPIDEMIOLOGIC RESEARCH. Ross L. Prentice. Fred Hutchinson Cancer Research Center
COMMENTARY: DATA ANALYSIS METHODS AND THE RELIABILITY OF ANALYTIC EPIDEMIOLOGIC RESEARCH Ross L. Prentice Fred Hutchinson Cancer Research Center 1100 Fairview Avenue North, M3-A410, POB 19024, Seattle,
More informationPage 1. New Developments in Osteoporosis. What s New in Osteoporosis
New Developments in Osteoporosis Eliseo J. Pérez-Stable MD Professor of Medicine Division of General Internal Medicine Department of Medicine July 4, 2013 Declaration of full disclosure: No conflict of
More informationOutline. Switching treatment. Evidence from randomized trials. The effects of switching 7/8/2016. When and for whom? Steven Cummings, MD
Outline Switching treatment When and for whom? Steven Cummings, MD Focus on switching from alendronate or risedronate Evidence about the effects of switching on BMD Purposes of switching Symptoms Poor
More informationNorth American Menopause Society (NAMS)
North American Menopause Society (NAMS) 2012 Hormone Therapy Position Statement Cynthia B. Evans, MD Assistant Professor-Clinical Department of Obstetrics and Gynecology The Ohio State University College
More informationDoes raloxifene (Evista) prevent fractures in postmenopausal women with osteoporosis?
FPIN's Clinical Inquiries Raloxifene for Prevention of Osteoporotic Fractures Clinical Inquiries provides answers to questions submitted by practicing family physicians to the Family Physicians Inquiries
More informationHRT in Perimenopausal Women. Dr. Rubina Yasmin Asst. Prof. Medicine Dhaka Dental College
HRT in Perimenopausal Women Dr. Rubina Yasmin Asst. Prof. Medicine Dhaka Dental College 1 This is the Change But the CHANGE is not a disease 2 Introduction With a marked increase in longevity, women now
More informationMenopausal hormone therapy currently has no evidence-based role for
IN PERSPECTIVE HT and CVD Prevention: From Myth to Reality Nanette K. Wenger, M.D. What the studies show, in a nutshell The impact on coronary prevention Alternative solutions Professor of Medicine (Cardiology),
More informationBisphosphonates. Making intelligent drug choices
Making intelligent drug choices Bisphosphonates are a first choice for treating osteoporosis, according to Kedrin E. Van Steenwyk, DO, an obstetrician/gynecologist at Sycamore Women s Center, Miamisburg,
More informationPotential dangers of hormone replacement therapy in women at high risk
ESC meeting, Stockholm, August 30, 16.30-18.00, 2010 Potential dangers of hormone replacement therapy in women at high risk Karin Schenck-Gustafsson MD, PhD, FESC Professor, Chief consultant Department
More informationBSO, HRT, and ERT. No relevant financial disclosures
BSO, HRT, and ERT Jubilee Brown, MD Professor & Associate Director, Gynecologic Oncology Levine Cancer Institute at the Carolinas HealthCare System Charlotte, North Carolina No relevant financial disclosures
More informationEveryone knows 1/15/2018. Does Osteopenia Warrant Treatment? Osteoporosis Prevention: Is it Ever Warranted?
/5/8 Wednesday, October, 7 : AM :5 AM Osteoporosis Prevention: Is it Ever Warranted? James A. Simon, MD, CCD, NCMP, IF, FACOG Clinical Professor Department of Ob/Gyn George Washington University Washington,
More informationMenopausal Symptoms The Who: Hot flashes are reported by as many as 75% of perimenopausal women in the U.S.
Menopausal Hormone Therapy: The Who, What, Where, When and Why Laurie Birkholz, MD, NCMP Knowledge of Clinical Trials Regarding Hormone Therapy and Likelihood of Prescribing Hormone Objective: The aim
More informationBAZEDOXIFENO. NUEVO SERM EN EL MANEJO DE LA OSTEOPOROSIS
BAZEDOXIFENO. NUEVO SERM EN EL MANEJO DE LA OSTEOPOROSIS Dr. Santiago Palacios Palacios Institute of Woman s Health Chairman of CAMS (Council of Affiliated Menopause Societies) President of SIBOMM (Ibero
More informationFinancial Conflicts of Interest
Hormone Treatment of Menopausal Women: What Are the Data Telling Us (and Not Telling Us)? S. Mitchell Harman, M.D., Ph.D. Chief, Endocrine Division Phoenix VA Health Care System Clinical Professor, Medicine
More informationEffective Health Care Program
Comparative Effectiveness Review Number 17 Effective Health Care Program Comparative Effectiveness of Medications To Reduce Risk of Primary Breast Cancer in Women Executive Summary Background Breast cancer
More informationPage 1. Current and Emerging Strategies What s New in Osteoporosis. Osteoporosis. What is Osteoporosis? Traditional Risk Factors for Fracture
Current and Emerging Strategies for Osteoporosis What s New in Osteoporosis Risk stratification Douglas C. Bauer, MD University of California, San Francisco Under recognition and poor compliance New potential
More informationIncreased Risk of Breast Cancer: Screening and Prevention. Elizabeth Pritchard, MD 4/5/2017
Increased Risk of Breast Cancer: Screening and Prevention Elizabeth Pritchard, MD 4/5/2017 No disclosures Defining Risk Risk Factors Modifiable Lifestyle obesity physical activity alcohol consumption breast
More informationOVERVIEW WOMEN S HEALTH: YEAR IN REVIEW
OVERVIEW WOMEN S HEALTH: YEAR IN REVIEW Judith Walsh, MD, MPH Professor of Medicine UCSF Update in Women s Health for SGIM Drs. Mary Beattie and Pam Charney Review of literature from March, 2008 through
More informationOsteoporosis: An Overview. Carolyn J. Crandall, MD, MS
Osteoporosis: An Overview Carolyn J. Crandall, MD, MS Osteoporosis: An Overview Carolyn J. Crandall, MD, MS Professor of Medicine David Geffen School of Medicine at UCLA Objectives Review osteoporosis
More informationUpdates in Osteoporosis
Updates in Osteoporosis Jeffrey A. Tice, MD Associate Professor of Medicine Division of General Internal Medicine, University of California, San Francisco I have no conflicts of interest What s New in
More informationTissue-selective estrogen complexes for postmenopausal women. BMS Satellite Symposium 14 nov 2015 A Pintiaux ULg
Tissue-selective estrogen complexes for postmenopausal women BMS Satellite Symposium 14 nov 2015 A Pintiaux ULg Effects of CEE in Post Menopausal Women with Hysterectomy CHD 0.91 ( 0.75-1.12 ) BC 0.77
More informationCalcium, Vitamin D and Bisphosphonates: Disclosures. Benefits, Risks and Drug Holiday. Calcium YES or NO? Calcium Bad News!!
Calcium, Vitamin D and Bisphosphonates: Benefits, Risks and Drug Holiday Disclosures I am disclosing financial relationships as follows: Global Advisory Boards: Amgen, Lilly, Merck, Novartis Research grants:
More informationMenopause management NICE Implementation
Menopause management NICE Implementation Dr Paula Briggs Consultant in Sexual & Reproductive Health Southport and Ormskirk NHS Hospital Trust Why a NICE guideline (NG 23) Media reports about HRT have not
More informationDisclosures. Learning Objectives. Effects of Hormone Therapy on the Metabolic Syndrome and Cardiovascular Disease. None
Effects of Hormone Therapy on the Metabolic Syndrome and Cardiovascular Disease Micol S. Rothman, MD Associate Professor of Medicine Endocrinology, Diabetes and Metabolism Clinical Director Metabolic Bone
More informationUPDATE: Women s Health Issues
UPDATE: Women s Health Issues Renee B. Alexis, MD, MBA, MPH, FACOG Associate Professor Department of OBGYN Kiran C. Patel College of Osteopathic Medicine Disclosure of Conflicts of Interest I have no financial
More informationSupplementary Online Content
Supplementary Online Content Gartlehner G, Patel SV, Feltner C, et al. Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: Evidence Report and Systematic Review for
More informationOVERVIEW OF MENOPAUSE
OVERVIEW OF MENOPAUSE Nicole Budrys, MD, MPH Reproductive Endocrinology Michigan Center for Fertility and Women s Health Presented at SEMCME March 13,2019 Objectives Define menopause Etiology of menopause
More informationMeta-analysis: analysis:
1 Diabetes and TZDs: Risk Factors for Fracture Ann Schwartz, PhD Dept. of Epidemiology and Biostatistics University of California San Francisco July 2010 Osteoporosis CME Presenter Disclosure Information
More informationLearning Objectives. Controversies in Osteoporosis Prevention and Management. Definition. Presenter Disclosure Information.
4 4:45 pm Controversies in Osteoporosis Prevention and Management SPEAKER Carolyn Crandall, MD, MS Presenter Disclosure Information The following relationships exist related to this presentation: Carolyn
More informationWhat is Osteoporosis?
What is Osteoporosis? 2000 NIH Definition A skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture. Bone strength reflects the integration of
More informationHormone therapy in Breast Cancer patients with comorbidities
Hormone therapy in Breast Cancer patients with comorbidities Diana Crivellari Centro di Riferimento Oncologico Aviano- ITALY Madrid November 9th, 2007 Main issues Comorbidities in elderly women Hormonal
More informationHT: Where do we stand after WHI?
HT: Where do we stand after WHI? Hormone therapy and cardiovascular disease risk Experimental and clinical evidence indicate that hormone therapy (HT) reduces the risk of cardiovascular disease (CVD) Women
More informationThe Bare Bones of Osteoporosis. Wendy Rosenthal, PharmD
The Bare Bones of Osteoporosis Wendy Rosenthal, PharmD Definition A systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase
More informationBREAST CANCER RISK REDUCTION
BREAST CANCER RISK REDUCTION Clinical Practice Guideline Update Introduction ASCO published its first breast cancer risk reduction (BCRR) guideline in 1999 ASCO Guidelines are updated at intervals by an
More informationAppendix: Reference Table of HT Brand Names
Appendix: Reference Table of HT Brand Names This is a full reference table in alphabetical order, of Brand Name drugs used in HT. It is the basis for prescription advice throughout this handbook. Drug
More informationAN OVERVIEW of TREATMENT: WHO and WHEN to TREAT
AN OVERVIEW of TREATMENT: WHO and WHEN to TREAT Dolores Shoback, MD Professor of Medicine, UCSF San Francisco VA Medical Center July 16, 21 ~ QUESTIONS ~ Who should receive therapy to prevent fractures?
More informationModeling the annual costs of postmenopausal prevention therapy: raloxifene, alendronate, or estrogen-progestin therapy Mullins C D, Ohsfeldt R L
Modeling the annual costs of postmenopausal prevention therapy: raloxifene, alendronate, or estrogen-progestin therapy Mullins C D, Ohsfeldt R L Record Status This is a critical abstract of an economic
More informationCoronary Heart Disease in Women Go Red for Women
Coronary Heart Disease in Women Go Red for Women Dr Fiona Stewart Green Lane Cardiovascular Service and National Women s Health Auckland City Hospital Auckland Heart Group Women are Different from Men
More informationPage 1. Updates in Osteoporosis. I have no conflicts of interest. What is osteoporosis? What s New in Osteoporosis
Updates in Osteoporosis Jeffrey A. Tice, MD Professor of Medicine Division of General Internal Medicine, University of California, San Francisco I have no conflicts of interest What s New in Osteoporosis
More informationCurrent and Emerging Strategies for Osteoporosis
Current and Emerging Strategies for Osteoporosis I have nothing to disclose. Anne Schafer, MD Assistant Professor of Medicine Division of Endocrinology & Metabolism December 12, 2014 Outline Osteoporosis
More informationOutline Vertebroplasty and Kyphoplasty: Who, What, and When
Outline Vertebroplasty and Kyphoplasty: Who, What, and When Douglas C. Bauer, MD University of California San Francisco, USA Vertebral fracture epidemiology, consequences and diagnosis Kyphoplasty and
More informationAssessment and Treatment of Osteoporosis Professor T.Masud
Assessment and Treatment of Osteoporosis Professor T.Masud Nottingham University Hospitals NHS Trust University of Nottingham University of Derby University of Southern Denmark What is Osteoporosis? Osteoporosis
More informationWHI, HERS y otros estudios: Su significado en la clinica diária. Manuel Neves-e-Castro
WHI, HERS y otros estudios: Su significado en la clinica diária III Congreso Ecuatoriano de Climaterio Menopausia y Osteoporosis por Manuel Neves-e-Castro (Lisboa-Portugal) Julho, 2003 Machala The published
More informationPost-menopausal hormone replacement therapy. Evan Klass, MD May 17, 2018
Post-menopausal hormone replacement therapy Evan Klass, MD May 17, 2018 Are we really still talking about this? Are we really still talking about this? 1960-1975- estrogen prescriptions doubled. Pharma
More informationCurrent Issues in Osteoporosis
Current Issues in Osteoporosis California AACE 18TH Annual Meeting & Symposium Marina del Rey, CA September 15, 2018 Michael R. McClung, MD, FACP,FACE Director, Oregon Osteoporosis Center Portland, Oregon,
More informationAll medications are a double-edged sword with risks
Menopause: The Journal of The North American Menopause Society Vol. 14, No. 5, pp. 1/14 DOI: 10.1097/gme.0b013e31802e8508 * 2007 by The North American Menopause Society REVIEW ARTICLE Postmenopausal hormone
More informationMenopause and HRT. John Smiddy and Alistair Ledsam
Menopause and HRT John Smiddy and Alistair Ledsam Menopause The cessation of menstruation Diagnosed retrospectively after 1 year of amenorrhoea Average age 51 in the UK Normal physiology - Menstruation
More informationThe Practice Committee of the American Society for Reproductive Medicine,
FERTILITY AND STERILITY VOL. 81, NO. 1, JANUARY 2004 Copyright 2004 American Society for Reproductive Medicine Published by Elsevier Inc. Printed on acid-free paper in U.S.A. PRACTICE COMMITTEE Estrogen
More informationDr Anna Fenton. Gynaecological Endocrinologist Christchurch
Dr Anna Fenton Gynaecological Endocrinologist Christchurch 16:30-17:25 WS #46: Management Options for Osteoporosis 17:35-18:30 WS #56: Management Options for Osteoporosis (Repeated) Osteoporosis Update
More informationASJ. Selective Estrogen Receptor Modulators. Asian Spine Journal. Introduction. Ki-Chan An. are acceptable and safety
Asian Spine Journal Asian Spine Review Journal Article Asian Spine J 2016;10(4):787-791 SERMs http://dx.doi.org/10.4184/asj.2016.10.4.787 are acceptable and safety Selective Estrogen Receptor Modulators
More informationLong-term Osteoporosis Therapy What To Do After 5 Years?
Long-term Osteoporosis Therapy What To Do After 5 Years? Developing a Long-term Management Plan North American Menopause Society Philadelphia, PA October 11, 2017 Michael R. McClung, MD, FACP Institute
More informationIntegrated care: guidance on fracture prevention in cancer-associated bone disease; treatment options
Paris, November 1st 2016 Integrated care: guidance on fracture prevention in cancer-associated bone disease; treatment options René Rizzoli MD International Osteoporosis Foundation and Division of Bone
More informationJ Clin Oncol 29: by American Society of Clinical Oncology INTRODUCTION
VOLUME 29 NUMBER 17 JUNE 10 2011 JOURNAL OF CLINICAL ONCOLOGY O R I G I N A L R E P O R T Benefit/Risk Assessment for Breast Cancer Chemoprevention With Raloxifene or Tamoxifen for Women Age 50 Years or
More informationDiagnosis and Treatment of Osteoporosis: What s New and Controversial in ? What s New in Osteoporosis
Diagnosis and Treatment of Osteoporosis: What s New and Controversial in 2018-19? What s New in Osteoporosis The crisis in treatment and compliance Douglas C. Bauer, MD Professor of Medicine and Epidemiology
More informationCurrent and Emerging Approaches for Osteoporosis
Current and Emerging Approaches for Osteoporosis Douglas C. Bauer, MD Professor of Medicine and Epidemiology & Biostatistics University of California, San Francisco No Disclosures What s New in Osteoporosis
More information