Innovation in Science and Care June, Milan, Italy Auditorium GRUPPO 24 ORE Chair: Umberto Veronesi - Aron Goldhirsch.

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1 Innovation in Science and Care June, 2017 Milan, Italy Auditorium GRUPPO 24 ORE Chair: Umberto Veronesi - Aron Goldhirsch

2 WELCOME The Milan Breast Cancer Conference has been developed more than 15 years ago to specifically provide the audience of breast cancer professionals and scientists with education and discussion on progress in the field. The faculty of international experts was selected to present the most exciting areas of innovation related to breast cancer and to discuss issues of significant controversy. For the next edition of the Conference in 2017 we decided to maintain the very same spirit of innovation in science and care, changing to a biennial pace, to follow conferences on the subject, which provide concentrated information and debate, to maximize the yield of what is being presented at the Milan Breast Cancer Biennial Conference. Increasing the opportunity of discussing innovation in breast cancer has been defined as a major priority for the Conferece. Umberto Veronesi Aron Goldhirsch Scientific Committee: Bernardo Bonanni - Marco Colleoni - Giuseppe Curigliano - Viviana Galimberti - Mattia Intra - Roberto Orecchia - Virgilio Sacchini - Paolo Veronesi - Giuseppe Viale Barberis Massimo Bardelli Alberto Bernier Jacques Biganzoli Laura Bonanni Bernardo Burstein Harold Cassano Enrico Colleoni Marco Curigliano Giuseppe De Censi Andrea Denkert Carsten Di Leo Angelo Dubsky Peter Galimberti Viviana Garber Judy Garusi Cristina Gentilini Oreste Gianni Luca Goldhirsch Aron Harris Jay Intra Mattia Jereczek-Fossa Barbara Alicja King Tari Leonardi Maria Cristina Munzone Elisabetta Orecchia Roberto Partridge Ann Petit Jean Yves Pruneri Giancarlo Rietjens Mario Sacchini Virgilio Sapino Anna Serrano Davide Toesca Antonio Veronesi Paolo Viale Giuseppe Winer Eric Paul INTERNATIONAL INVITED FACULTY University of Turin Genolier - Switzerland Azienda USL 4 E.O. Ospedali Galliera Charité University Azienda USL 4 Klinik St. Anna San Raffaele Hospital San Raffaele Hospital,,, University of Turin,, Turin - Italy Genolier - Switzerland Prato - Italy Genova - Italy Berlin - Germany Prato - Italy Luzern - Switzerland Turin - Italy

3 GENERAL INFORMATION Abstract deadline: 15th February 2017 PRELIMINARY PROGRAMME Thursday 22 June Welcome remarks - Aron Goldhirsch News from St.Gallen: Panel recommendations Marco Colleoni Abstract submission Participants with new data relevant to the subjects of the conference may submit one abstract to be considered for e-poster presentation. Only papers whose abstracts have been reviewed and approved by the Scientific Committee will be presented as e-posters. Abstracts must be written in English and the text should not exceed 2000 characters (title included). The title should appear in capital letters. For each author, type surname first followed by given name and initials (presenting author in capital letters). List the affiliations after the authors list. The full address with telephone number, fax number, and of the corresponding author must be provided. The latter will receive all the subsequent communications concerning the abstract. Once accepted, the full paper can be presented in 6 slides, containing the following sections: background, material methods, results, conclusions. All the slides must be sent to the Organising Secretariat (mbcc@ieo.it) within 30th March 2017, to be uploaded in the e-poster player. Please indicate your approval for publication in case the abstracts will be issued in a journal. Registration fees Delegates Associated members Residents in training (ID document and declaration from the hospital needed) Developing countries residents Online registration available in the website CME accreditation The will apply for CME credits to the accreditation Council of Oncology in Europe and to the Italian Ministry of Health. Official language: english Early rate 400,00 200,00 200,00 Late rate 550,00 400, High Risk of developing breast cancer Chair: Bernardo Bonanni - Judy Garber Clinical and metabolic risk assessment - Andrea De Censi Germline mutations: genetic predisposition - Judy Garber Pathological findings of high risk - Carsten Denkert Discussants: Massimo Barberis, Bernardo Bonanni, Andrea De Censi, Carsten Denkert, Judy Garber In situ disease Chair: Giancarlo Pruneri - Virgilio Sacchini Pathology of Lobular and Ductal intraepthelial neoplasia - Giancarlo Pruneri Radiologic hurdles for DIN and LIN - Enrico Cassano State of the art surgery for intraepithelial lesions - Virgilio Sacchini How and when to irradiate an operated intraepithelial lesions - M. Cristina Leonardi Plastic surgery and lipofilling in case of intraepithelial Lesions - Jean Yves Petit Systemic Therapy of Intraepithelial ase management discussion Discussants: Bernardo Bonanni, Enrico Cassano, M. Cristina Leonardi, Jean Yves Petit, Giancarlo Pruneri, Virgilio Sacchini, Davide Serrano Lunch Global approach to breast surgery Chair: Oreste Gentilini - Paolo Veronesi What do you need to know before facing breast operation for breast cancer - Anna Sapino

4 Axilla Dethroned? - Viviana Galimberti Long-term consequences of breast conservation vs. breast removal and reconstruction - Peter Dubsky All you want to know about intraoperative radiotherapy - Roberto Orecchia Breast surgery and beyond for the special Patient - Mattia Intra Surgery for advanced disease: why and when? - Tari King Discussants: Peter Dubsky, Viviana Galimberti, Oreste Gentilini, Mattia Intra, Tari King, Roberto Orecchia, Anna Sapino, Paolo Veronesi Breast Surgery live theater (author-commented videos) Chair: Viviana Galimberti - Mattia Intra Oncoplastic Surgery - Mario Rietjens The axilla - Viviana Galimberti Contralateral mastectomy for high risk - Antonio Toesca Surgery for lymphedema - Cristina Garusi Discussants: Viviana Galimberti, Cristina Garusi, Mattia Intra, Mario Rietjens, Antonio Toesca Adjourn Type of disease and risk assessment in the choice of adjuvant systemic therapies (including choice of chemotherapy for lobular breast cancer) - Giuseppe Viale Innovation in adjuvant endocrine therapies for pre and postmeno pausal patients - Marco Colleoni The special case of younger patients with breast cancer - Ann Partridge Chemotherapy for patients with HER2- positive and triple negative disease - Angelo Di Leo The evolving role of neoadjuvant treatments - Eric Winer Support and avoiding alopecia during adjuvant chemotherapy - Elisabetta Munzone Discussants: Marco Colleoni, Angelo Di Leo, Elisabetta Munzone, Ann Partridge, Giuseppe Viale, Eric Winer Lunch Spotlight Liquid biopsy: clinical implications - Alberto Bardelli EIO Award Keynote lecture - Judy Garber New targets and new drugs Chair: Harold Burstein - Giuseppe Curigliano Friday 23 June Panel EUSOMA accreditation for Breast Units: debate on process, details and relevance - Chair: Laura Biganzoli Radiation therapy: standards and beyond Chair: Jacques Bernier - Roberto Orecchia Standard of radiotherapy for breast cancer - Jay Harris Irradiation of the reconstructed breast - Barbara Alicja Jereczek-Fossa Re irradiation for cancer re-appearance - Maria Cristina Leonardi Radiotherapy in patient with autoimmune disorder - Giuseppe Curigliano Discussants: Jacques Bernier, Sandra Demaria, Jay Harris, Barbara A. Jereczek Fossa, M. Cristina Leonardi, Roberto Orecchia Improving endocrine responsiveness - Harold Burstein Improving antiher2 responsiveness - Luca Gianni Enhancing immunogenicity and improving immune response - Giuseppe Curigliano The chapter of metronomic chemotherapies: from advanced breast cancer to the adjuvant setting - Marco Colleoni Targeting DNA repair - to be defined Panel Discussants: Harold Burstein, Marco Colleoni, Giuseppe Curigliano, Luca Gianni Conclusions Adjuvant and neoadjuvant systemic therapies: standards and beyond Chair: Marco Colleoni - Eric Winer

5 Conference venue Auditorium GRUPPO 24 ORE Via Monte Rosa, Milano (area Fiera Milanocity) Organising Secretariat MZ Congressi srl Via Carlo Farini Milano Tel Fax mbcc@ieo.it