Medical Facts of Aronia. Steven Saulsbury M.D. February

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1 Medical Facts of Aronia Steven Saulsbury M.D. February

2 Medical Facts Facts and medical advice change with time

3 Medical Facts Information increasingly media and market driven Confusing and often contradictory Take Vitamins we believe that the case is closed supplementing the diet of well-nourished adults with (most) mineral or vitamin supplements has no clear benefit and might even be harmful. These vitamins should not be used for chronic disease prevention. Enough is enough. Take an aspirin daily "This shows that if you are healthy, with no symptoms of cardiovascular disease, then it's not sensible to take regular aspirin. It won't improve your health,"

4 Supplements

5 What is the role for Aronia?

6 Fundamentals

7 Utility of Aronia Clinical Trials Epidemiological Studies

8 Epidemiology of Polyphenol Rich Diet How do we measure health empirically? Longevity Cancer Cardiovascular disease Chronic disease/infection

9 Blue Zone

10 Costa Rica

11 Sardinia

12 Ikaria

13 Okinawa

14 Epidemiology Numerous epidemiological studies have associated a plant based diet rich in polyphenols with protective effect against chronic disease Ghosh and Scheepens 2009 Kuriyama et al Mink et al Szmitko and Verma, 2005 Auclair et al Schroeter et al Chong and Terao, 2010

15 Clinical Trials Aronia Bacteriostatic, Antiviral Cardio, Chemo, Radiation, Neuro, Oxidative, UV protective Anti-mutagenic, Anti-carcinogenic, Anti-inflammatory Mitigates Obesity, Diabetes II, Arthritis, Autoimmune ds

16 Clinical Utility of Aronia Chronic Inflammation Epigenetics

17 Inflammation is the driving force behind most if not all chronic disease.

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19 Atherosclerosis

20 NF-kB

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24 Activation of NF-kB is the central event in the inflammatory response Aronia attenuates the activation of NF-kB Aronia reduces the gene expression of inflammatory cytokines such as TNFα and Interleukin Inhibits intracellular ROS and CAM expression Prednisone, Ibuprofen, Dexamethasone

25 Epigenetics

26 Epigenetics in Cancer Vast majority of cancers (90-95%) are due to cumulative epigenetic changes on multiple genes Diet, tobacco, obesity, sedentary lifestyle, infection Abnormal methylation (primarily hypermethylation) inhibits reparative processes, tumor suppressor genes

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28 The polyphenolic-rich Aronia melanocarpa juice kills teratocarcinomal cancer stem-like cells, but not their differentiated counterparts Tanveer Sharif, Mouni Stambouli, Benjamin Burrus, Fathi Emhemmed, Israa Dandache, Cyril Auger, Nelly Etienne-Selloum, Valérie B Schini-Kerth, Guy Fuhrmann ABSTRACT A diet rich in plant-derived products is expected to have anticancer chemopreventive effects by acting on the appearance and growth of cancer stem cells (CSCs). Thus the effects of Aronia melanocarpa juice (AMJ) on the mouse embryonal carcinoma (EC) stem cell line P19 were investigated. AMJ inhibited cell proliferation, induced cell cycle arrest in S phase and triggered apoptosis. A pronounced upregulation of tumour suppressors p53 and p73 was observed in association with caspase-3 activation and a downregulation of the anti-apoptotic protein UHRF1 and the stemness factor Oct-4. Overall the results strongly suggest that AMJ is functionally able to counteract the carcinogenesis process by targeting CSCs. Interestingly AMJ selectively kills undifferentiated EC cells, without significant effects on normal restricted pluripotent cells (i.e. NIH/3T3 fibroblasts) or even differentiated EC cells. This argues that a differentiation therapy might normalize the pathological phenotype of a CSC which becomes insensitive to further plant-derived pharmacological treatment.

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30 Aronia down regulates UHRF1 UHRF1 is an epigenetic integrator over expressed in many cancers breast, bladder, cervical, colorectal, prostate, pancreas, gliomas, sarcomas Binds to specific DNA sequences and recruits DNA methyltransferase Essential protein required to maintain abnormal methylation Overexpression is associated with progression and a poor prognosis

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32 Oncol Rep Oct;28 Induction of apoptosis and reduction of MMP gene expression in the U373 cell line by polyphenolics in Aronia melanocarpa and by curcumin. Abdullah Thani NA1, Sallis B, Nuttall R, Schubert FR, Ahsan M, Davies D, Purewal S, Cooper A, Rooprai HK. Malignant brain tumours are rare but are the most challenging types of cancers to treat. Despite conventional multimodality approaches available for their management, the outlook for most patients remains dismal due to the ability of the tumour cells to invade the normal brain. Our results also suggest that curcumin induces apoptosis but chokeberry extract is necrotic to this cell line. It is possible that chokeberry extract kills the cells by other non-apoptotic pathways. Taken together, the comparative data suggest that both curcumin and chokeberry extract may exhibit their anticancer potential by inducing apoptosis and inhibiting invasion by reducing MMP gene expression.

33 Aronia and Epigenetics

34 Fundamentals o Your DNA is not necessarily your destiny o It s all about inflammation

35 Fundamentals Let thy food be thy medicine Time is the coin of your life. Carl Sandburg People that eat a low inflammatory diet rich in polyphenols are some of the healthiest and longest living in the world

36 Aronia There are many sources for beneficial polyphenols Aronia is certainly at the head of the class The potential to moderate inflammation and chronic disease at a genetic level is enormous

37 If you are not already eating Aronia It s time to get on board