MM:Mammography, US:Ultrasonography, M I B I : 99 m Tc-MIBI scintimammography

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2 B A Fig. 1. Invasive ductal carcinoma involving the upper inner quadrant of the left breast in a 46-year-old woman. A. Craniocaudal mammogram shows an irregular-shaped dense mass which has radiating spicules with surrounding parenchymal distortion and infiltrations. This mass is highly suggestive of malignancy(category 5). B. On ultrasonography, an irregular-marginated and ill-defined hypoechoic mass with posterior shadowing is noted and consider as definitely malignant(group 5). C C.Planar lateral(left) and transverse(right) SPECT 99 m T c - M I B I Scintimammogram shows focal areas of increased uptake in the left breast that correspond to the mammographic and sonographic abnormality(arrow). The arithmetic mean of the semiquantitative indices was 3.87, suggesting malignancy

3 Table 1. Statistical Results of Mammography, Ultrasonography and 99 m Tc-MIBI Scintimammography in the Diagnosis of Breast L e s i o n s M M U S M I B I T P 25 ( %) 29 ( 46 %) 26 ( %) F N 0 4 ( 6. 8 %)0 0 4 ( 6. 4 %) 07 ( %) F P 11 ( %) 00 7 ( %) 08 ( %) T N 19 ( %) 0 23 ( %) 23 ( %) T o t a l TP:True positive, FN:False negative, FP:False positive, TN:True negative M I B I : 99 m Tc-MIBI scintimammography MM:Mammography, US:Ultrasonography,

4 Table 2. Comparison Between Mammographic, Ultrasonog r a p h i c and Scintigraphic Results in Breast Lesions M M U S M I B I Sensitivity (%) Specificity (%) PPV (%) NPV (%) FPR (%) FNR (%) Accuracy (%) PPV:positive predictive value, NPV:negative predictive value, FPR:false positive rate, FNR:false negative rate. MM:Mammography, US:Ultrasonography, M I B I : 99 m Tc-MIBI scintimammography B A Fig. 2. Fibroadenoma interpreted as malignancy on 99 m T c - M I B I Scintimammogram in a 36-year-old woman. A. Mammogram reveals lobulated well-circumscribed isodense mass in upper outer quadrant of the right breast. This lesion was interpreted as probably benign finding(category 3). B. Ultrasonogram shows a lobulated, well-defined homogeneous isoechoic mass without posterior shadowing that is suggestive of benign finding(group 2). C.On planar lateral 99 m Tc-MIBI Scintimammogram(left), probably malignant diffuse tracer uptake was noted in the right C breast(arrow). Transverse SPECT scan(right) also shows increased tracer uptake in right breast(arrow). The arithmetic mean of the semiquantitative indices was 2.64, suggesting malignancy

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6 Kopans DB. The positive predictive value of mamography. R a d i o l Clin North Am 1992 ; 158 : Sickles EA, Filly RA, Callen PW. Breast cancer detection with sonography and mammography;comparison using state-of-the-art equipment. AJR 1983 ; 140 : ( ) Andersson I. Mammographic screening and mortality from breast cancer:mammographic screening trial. Br J Med 1988 ; 297 : Ciatto S, Cataliotti L, Distante V. Nonpalpable lesions detected 15.,, with mammography: review of 512 consecutive cases. R a d i o l o g y 1987 ; 165 : Hermann G, Janus C, Schwartz IS et al. Nonpalpable breast lesions:accuracy of prebiopsy mammographic diagnosis. R a d i o l o g y 1987 ; 165 : Robertson CL. A private breast imaging practice:medical audit of 25,788 screening and 1,077 diagnostic examinaiton. R a d i o l o g y 1993 ; 187 : Kopans DB. Positive predictive value of mammography. A J R 1992 ; 158 : Joensuu H, Asola R,Holli K, Kumpulainen E, Nikkanen V, Parvinen LM. Delayed diagnosis and large size of breast cancer after a false negative mammogram. Eur J Cancer 1994 ; 30 : Kopans DB. What is a useful adjunct to mammography? R a d i o l o g y 1986 ; 161 : Feig SA. Breast masses. Mammographic and sonographic Evaluation. In Bassett LW, editor. Breast Imaging: Current Status and Future Directions. Radiol Clin of North Am 1992 ; 30 ( 1 ): Fornage BD, Lorigan JG, Andry E. Fibroadenoma of breast:sonographic appearance. Radiology 1989 ; 172 : Wei Tse Yang, MBBS, FRCR et al. Role of high frequency ultrasonography in the evaluation of palpable breast masses in Chinese women:alternative to Mammography? J Ultrasound Med ; 1 5 : ; 32 ( 4 ): Williams SM, Kaplan PA, Petersen JC, Leiberman RP. Mammography in women under age 30:Is there clinical benefit? R a d i o l o g y 1986 ; 161 : Sergio Piccolo, Secondo Lastoria, Ciro Mainolfi et al. Technetium- 99m-Methylene Diphosphonate scintimammography to image primary breast cancer. J Nucl Med 1995 ; 36 : H.Palmedo, F.Grunwald, H.Bender et al. Scintimammography with technetium-99m methoxyisobutylisonitrile: comparison with mammography and magnetic resonance imaging. Eur J Nucl Med ; 23 : Kao CH, Yong MD, Wang SJ et al. The Tc-99m MIBI scintigraphy in the evaluation of mass abnormalities of the breast. Eur J Nucl Med 1993 ; 20 : 979 ( a b s ). 20. A Ozdemir, I I. Oznur, G Vural et al. Tl-201 scintigraphy, mammography and ultrasonography in the evaluation of palpable and nonpalpable breast lesions:a correlative study. Eur J Rad 1997 ; 24 : Z. Burak, M. Argon, A. Memis et al. Evaluation of palpable breast masses with 99mTc-MIBI:a comparative study with mammography and ultrasonography. Nucl Med Commun 1994 ; 15 : ; ,,. : 1 9 6

7 Comparison between Mammogra p hy, Ultra s o n o g ra p hy and 9 9 m Tc-MIBI Scintimammogra p hy in the Diagnosis of Breast Cancer 1 Eun-Joo Lee, M.D., Han-Kyung Lee, M.D., Mi-Sun Chang, M.D., Kyung-Ah Jang, M.D., Kyung-Ho Cha, M.D., Jong-Ho Kim, M.D. 1 Department of Diagnostic Radiology, Gacheon Medical College, Chung-Ang Gil Hospital 2 Department of General Surgery, Gacheon Medical College, Chung-Ang Gil Hospital 3 Department of Nuclear Medicine, Gacheon Medical College, Chung-Ang Gil Hospital Purpose: To compare the feasibility of 9 9 m Tc-MIBI scintimammography as a tumor localizing agent in breast lesions in comparison with that of mammography and ultrasonography, and to evaluate the efficacy of these three modalities. Materials and Methods: Sixty-four breast lesions were classified as benign or malignant on the basis of sonographic and mammographic criteria and were further analyzed by means of 9 9 m Tc-MIBI scintimammography. The classifications thus obtained were compared with the biopsy findings, and in order to compare the three techniques, the sensitivity, specificity, accuracy, and negative and positive predictive values were calculated for each individual modality. Results: Of 64 histologically proven lesions, 33 were malignant and 31 were benign. Sensitivities and specificities for malignancy were 86.2% and 64.5% for mammography, 87.9% and 76.7% for sonography, and 78.8% and 74.2% for 9 9 m Tc-MIBI scintimammography. Conclusion: Mammography and ultrasonogrphy are reliable diagnostic modalities for the detection of breast cancer. 9 9 m Tc-MIBI scintimammography has a higher specificity than mammography and it may help to reduce unnecessary biopsies. Index words : Breast, neoplasm Breast, radiography Breast, radionuclide studies Breast, US Address reprint requests to : Eun-Joo Lee, M.D., Department of Diagnostic Radiology, Gacheon Medical College, Chung-Ang Gil Hospital, #1198, Kuwol-dong, Namdong-ku, Incheon, Korea. Tel Fax ej_toya@yahoo.co.kr 1 9 7