SFSPM Novembre Valeur prédictive et pronostique de l infiltrat immunitaire dans les cancers du sein traités par chimiothérapie néoadjuvante
|
|
- Darrell Robinson
- 6 years ago
- Views:
Transcription
1 SFSPM Novembre 217 Valeur prédictive et pronostique de l infiltrat immunitaire dans les cancers du sein traités par chimiothérapie néoadjuvante Dr Fabien REYAL Service de Chirurgie INSERM U932 Immunity and Cancer Institut Curie
2 Tumor infiltration in the neoadjuvant setting Role of tumor-infiltrating lymphocytes (TILs) High levels of TILs at diagnosis : better response to NAC Better prognosis (triple negative breast cancers (TNBC) and HER2-positive BC) TILs following neoadjuvant chemotherapy (NAC)? Myashita Dieci Loi Hamy BC subtype TNBC TNBC TNBC HER2-pos Numbers n=131 n=278 n=111 n=175 Pairs pre & post n=78 n=19 n=39 n=175 Analysis in pcr patients No No No Yes 2
3 Tumor infiltration and response to treatment in breast cancer NEOREP cohort Institut Curie n=718 Microbiopsy BEFORE Neoadjuvant chemotherapy DURING Surgery AFTER TIL baseline TILs dynamics TIL residual Identify patterns of immune infiltration related to response to treatment and prognosis
4 Patients characteristics NEOREP cohort n=718 Mean age : 48 y.o TNBC 44% Luminal 31% HER2 24% Median tumor size: 45mm Anthra taxanes (8.4%) N=718 BMI class BMI<19 41 (5.7) BMI: 19 to (57.7) BMI: 25 to (23.2) BMI>3 96 (13.4) Tumor size 45. (2.5) Tumor size T1 47 (6.5) T2 482 (67.1) T3 189 (26.3) Clinical node status N 282 (39.3) N1-N2-N3 435 (6.7) BC subtype Luminal 223 (31.1) TNBC 32 (44.6) HER2 175 (24.4) Histology Ductal carcinoma NST 661 (92.6) Other 53 (7.4) Grade Grade I-II 211 (3.1) Grade III 491 (69.9) NAC regimen Anthracyclines based regimens 61 (8.5) Anthracyclines-taxanes regimens 577 (8.4) Others 8 (11.1)
5 Microbiopsy before NAC TIL=2% Microbiopsy before NAC TIL>6% 5
6 Surgical Specimen after NAC TIL=2% Surgical Specimen after NAC TIL>6%6
7 Lymphocyte PBC before neoadjuvant chemotherapy is a rare entity Lymphocyte predominant breast cancer Cut-off stromal TILs : 5 or 6% luminal TNBC HER BC subtype luminal TNBC HER Baseline TIL levels (%) Luminal 2% TN 18% HER2-positive 1%
8 Baseline TILs vary by BC subtype Baseline TILs are associated with agressive tumor characteristics A * B C * D * E * BC subtype 5 25 Clinical tumor size 5 25 Grade 5 25 Pre NAC mitotic index 5 25 Invasive tumor cellularity 5 25 luminal TNBC HER2 T1 T2 T3 Grade I II Grade III < >22 <=6% > 6%
9 Response to treatment
10 luminal TNBC HER2 luminal TNBC HER2 Baseline TIL levels* are associated with pcr Pre NAC str TILs (%) Pre NAC str TILs (%) c Post NAC str TILs (%) Pre NAC str TILs (%) d Post NAC str TILs (%) a b a b Pre NAC str TILs (%) ** pcr No pcr 6 6 pcr No pc Luminal and TNBC and NOT in HER2+ BC Significant interaction by BC subtype (p=.4) pcr No pcr
11 luminal TNBC HER2 luminal TNBC HER2 Baseline TIL levels* are associated with RCB a b c 6 6 a b Pre NAC str TILs (%) Pre NAC str TILs (%) Pre NAC str TILs (%) Pre NAC str TILs (%) pcr RCB I RCB II RCB III 4 4 c d In luminal and TNBC, NOT in HER2+ BC 6 11 pcr RCB I RCB II RCB III ) )
12 2 2nd tert 3rd tert % p 2 2 Baseline TILs levels are associated with pcr in luminal and TNBC not in HER2-positive BC luminal TNBC HER2 <6% =>6% % p luminal TNBC HER % =>5% B 1 t rt t t % pcr Str TILs (,1] (1,2] (2,3] (3,4] (4,5] (5,6] (6,7] (7,8] (8,9] luminal TNBC HER2 12
13 TILs dynamic
14 TILs levels decrease after neoadjuvant chemotherapy A Stromal TIL levels (%) Pre All Post B Luminal Pre Post C TNBC Pre Post D HER2 Pre Post
15 TILs dynamics is strongly correlated with baseline TILs levels TILs changes before and after NAC TILs changes before and after NAC, by baseline TILs (1% classes) 1 (,1] (1,2] (2,3] (3,4] (4,5] (5,6] (6,7] (7,8] (8,9] Baseline TIL levels (by 1% increment) 15
16 irrespective of response to treatment No pcr pcr TILs variation (abs. val.) 5 5 (,1] (1,2] (2,3] (3,4] (4,5] (5,6] (6,7] (7,8] (8,9] Baseline TILs 16
17 A high decrease in stromal TIL levels is associated with pcr 5 Change in str TIL levels (abs val) 5 pcr pcr No pcr
18 High baseline TILs and high decrease of lymphocytes after NAC are associated with pcr Median Ly density Change Ly density 1 75 cancer value stromal lymphocytes 18
19 Post-NAC stromal TILs
20 Lymphocyte-predominant breast Cancer is even rarer after NAC than before 1 luminal TNBC HER % cases 5 TILs levels (9,1] (8,9] (6,7] (5,6] (4,5] (3,4] (2,3] (1,2] (,1] TNBC luminal HER Post NAC TILs (%) Luminal 1% TN 4% HER2-positive 1%
21 Post-NAC TILs are higher in tumors with residual disease than in pcr specimens perc_stromal_lymphocyte2 Post NAC TILs (%) A perc_stromal_lymphocyte2 Post NAC TILs (%) luminal TNBC HER2 B pcr No pcr Post NAC TILs (%) C luminal TNBC HER2 pcr No pcr pcr No pcr pcr No pcr Post NAC TILs (%) D
22 luminal TNBC HER2 luminal TNBC HER2 Pre 2 Pre 2 Higher post-nac TIL levels are associated with increasing RCB only in HER2-positive BC pcr RCB I RCB II RCB III a b c c d Post NAC str TILs (%) Post NAC str TILs (%) luminal TNBC Post NAC str TILs (%) Post NAC str TILs (%) pcr RCB I RCB II RCB III NS HER2 4 2 (P interaction =.4) pcr RCB I RCB II RCB III
23 Impact on prognosis 23
24 E TNBC F E TNBC Luminal F E Luminal HER2 F. < 2% => 2% TILS (cut off: 2%) + < 2% + => 2% p = Time number at risk %) TILS + TILS (cut off: 3%) + < 3% < 2% p =.17 p = => => 3% 2% Time Time number at at risk risk < 3% < 2% => => 3% 2% %) TILS + (cut off: TILS (cut off: 3%) < 3% + < 2% p =.79p =.39 + => 3% + => 2% Time Time number number at risk at risk < 3% < 2% => 3% => 2% C TNBC D C TNBC Luminal D C Luminal HER2 D Disease free survival < 4% => 4% TILS (cut off: 4%) + < 4% + => 4% p = Time number at risk Disease free survival Disease free survival TILS TILS (cut off: 5%) 4%) + + < 5% < 4% + + => => 5% 4% p = 4e Time Time number at at risk risk p =.4 < 5% < 4% => => 5% 4% Disease free survival Disease free survival TILS (cut off: TILS (cut off: 5%) 4%) + < 5% + < 4% + => 5% + => 4% p =.23p = Time Time number number at risk at risk < 5% < 4% => 5% => 4%
25 Log relative Hazard < 2% Baseline stromal TIL levels are associated with DFS in TNBC => 2% number at risk < 3% => 3% n C TNBC D Disease free survival Disease free survival.5.25 TILS (cut off: 4%) + < 4% + => 4% p =.1.. Baseline str TILs Time number at risk n < 4% => 4% < 5% => 5%
26 HER2 luminal TNBC Log relative Hazard Baseline stromal TIL levels are associated with DFS in TNBC HER2 luminal B 1 Str TILs 1st quart 2nd quart 3rd quart 4th quart % pcr Baseline str TILs luminal TNBC 26
27 Post-NAC TILs are NOT associated with DFS, but this effect differs by BC subtype - Significant interaction with BC subtype - Effect of post-nac TILs on DFS different in TNBC / HER2-positive (P interaction =.4) - Effect linear : cut-off unknown? Adverse impact of high post-nac TILs in RD in HER2-positive BC, but trend to protective effect in TNBC 27
28 Take home messages Confirmation association pre-nac TILs pcr Dynamics : The highest baseline TILs are, the highest their level decrease High TILs decrease correlates with pcr Different prognostic value pre and post-nac = > Complex interactions BC subtype and TILs TILs subsetting is pivotal to understand mechanisms of resistance to treatment Assessment pre NAC & post NAC should become routine practice 28
29 U932 Immunity and Cancer Anne-sophie Hamy-Petit Hélène Bonsang Kitzis Department of tumour biology Marick Laé Lucian Topiu Diane Decroze 29
30 Univariate Multivariate name levels OR 95%CI pval OR 95%CI p Age <45 y.o y.o.97 [ ].877 >55 y.o 1.4 [ ].11 Menopausal status postmenopausal 1 premenopausal.8 [ ].193 BMI class BMI: 19 to 25 1 BMI<19.56 [ ].156 BMI: 25 to 3.76 [ ].186 BMI>3.9 [ ].69 Tumor size (2 cl) T1-T2 1 T3.8 [ ].245 Clinical nodal status N 1 N1-N2-N3.9 [ ].546 ER status ER negative 1 ER positive.2 [ ] <.1 PR status PR negative 1 PR positive.13 [ ] <.1 HER2 status HER2 negative 1 HER2 positive 1.94 [ ] <.1 BC subtype TNBC 1 1 luminal.8 [ ] <.1.9 [ ] <.1 HER2 1.2 [ ] [ ].958 Histology ductal 1 other.82 [ ].543 Grade Grade I-II 1 Grade III 2.71 [ ] <.1 ki67 ki67<2 1 ki67>= [ ].51 NAC regimen Anthracyclines based regimens 1 Anthracyclines-taxanes regimens.98 [ ].936 Others 1.32 [ ].456 Pre-NAC mitotic index 3 Mitotic index <= 1 1 Mitotic index [ ].187 Mitotic index > [ ].1 Pre-NAC tumor cellularity (inv.) <= Pre-NAC tumor cellularity 6% 1 Pre-NAC tumor cellularity (inv.) > 6%.94 [ ].733 IS component (pre NAC) No pre-nac in situ component 1 Pre-NAC in situ component.83 [ ].417 Str TIL levels (continuous) 1.3 [ ] < [ ] <.1 Multivariate analysis pcr Whole population Baseline TILs (continuous or cutoff 4%) BC subtype 3
31 TNBC Univariate Multiivariate TNBC Class HR CI p p HR CI p Pre-NAC parameters Age, years < [ ].93 >55.84 [ ].55 Menopause status Post 1.47 Pre 1.18 [ ].47 BMI class BMI < BMI>= [ ].26 Tumor size T1-T2 1 <.1 T [ ] <.1 Clinical node status N 1.15 N1-N2-N [ ].15 Histology Ductal carcinoma NST 1.44 Other 1.34 [ ].44 Grade Grade I-II 1.6 Grade III 1.19 [ ].6 Ki 67 <2% % 1.32 [ ].52 Pre-NAC mitotic index < [ ].27 > [ ].17 Pre-NAC inv. tumor cellularity 6% 1.19 > 6%.74 [ ].19 Pre-NAC str TILs (cut-off 4%) < 4% 1 < %.35 [ ] <.1.39 [ ].2 Post-NAC parameters pcr No pcr 1 <.1 pcr.22 [ ] <.1 RCB index pcr 1 <.1 RCB-I 1.39 [ ] RCB-II 3.52 [ ] < [ ].626 RCB-III [ ] < [ ].82 Post-NAC Str TILS (cut-off 25%) str TILs 25% str TILs > 25% Post-NAC Mitotic index 1 1 < [ ] [ ].27 Multivariate analysis DFS TNBC Baseline TILs RCB Post-NAC mitotic index > [ ] < [ ] <.1 Post-NAC inv. tumor cellularity 3% 1.7 > 3% 1.61 [ ].7 Post-NAC Str TILS (continuous).99 [ ].79
32 HER2 Univariate Multiivariate TNBC Class HR CI p p HR CI p Pre-NAC parameters Age, years < [ ].62 >55.42 [ ].27 Menopause status Post 1.38 Pre 1.58 [ ].38 BMI class BMI < 25 1 < BMI>= [ ] [ ].2 Tumor size T1-T T [ ].15 Clinical node status N 1.57 N1-N2-N [ ].57 ER status Negative 1.81 Positive 1.12 [ ].81 PR status Negative 1.74 Positive.84 [ ].74 Grade Grade I-II Grade III.32 [ ].2.18 [ ].2 Pre-NAC mitotic index < [ ].54 >22.56 [ ].36 Pre-NAC inv. tumor cellularity 6% 1.7 > 6%.83 [ ].7 Pre-NAC str TILs (continuous).61 Pre-NAC str TILs (cut-off 4%) < 4% 1.8 4% 1.14 [ ].8 Post-NAC parameters pcr No pcr 1 <.1 pcr.9 [.1 -.7].2 RCB index pcr 1 <.1 RCB-I 3.29 [ ].4 RCB-II 11.1 [ ].2 RCB-III [ ] <.1 Post-NAC Str TILS (cut-off 25%) str TILs 25% 1 < Multivariate analysis DFS HER2 Post-NAC TILs Grade BMI str TILs > 25% 5.5 [ ] < [ ].1 Post-NAC Mitotic index [ ].66 > [ ].1 Post-NAC inv. tumor cellularity 3% 1.13 > 3% 2.7 [ ].13 Post-NAC Str TILS (continuous) 1 <.1 32
Prognostic significance of stroma tumorinfiltrating lymphocytes according to molecular subtypes of breast cancer
Prognostic significance of stroma tumorinfiltrating lymphocytes according to molecular subtypes of breast cancer Hee Jung Kwon, Nuri Jang, Min Hui Park, Young Kyung Bae Department of Pathology, Yeungnam
More informationWhat to do after pcr in different subtypes?
What to do after pcr in different subtypes? Luca Moscetti Breast Unit Università degli Studi di Modena e Reggio Emilia Policlinico di Modena, Italy Aims of neoadjuvant therapy in breast cancer Primary
More informationImpact of BMI on pathologic complete response (pcr) following neo adjuvant chemotherapy (NAC) for locally advanced breast cancer
Impact of BMI on pathologic complete response (pcr) following neo adjuvant chemotherapy (NAC) for locally advanced breast cancer Rachna Raman, MD, MS Fellow physician University of Iowa hospitals and clinics
More informationLocoregional treatment Session Oral Abstract Presentation Saulo Brito Silva
Locoregional treatment Session Oral Abstract Presentation Saulo Brito Silva Background Post-operative radiotherapy (PORT) improves disease free and overall suvivallin selected patients with breast cancer
More informationUK Interdisciplinary Breast Cancer Symposium. Should lobular phenotype be considered when deciding treatment? Michael J Kerin
UK Interdisciplinary Breast Cancer Symposium Should lobular phenotype be considered when deciding treatment? Michael J Kerin Professor of Surgery National University of Ireland, Galway and Galway University
More informationTriple Negative Breast Cancer
Triple Negative Breast Cancer Prof. Dr. Pornchai O-charoenrat Division of Head-Neck & Breast Surgery Department of Surgery Faculty of Medicine Siriraj Hospital Breast Cancer Classification Traditional
More informationHow to Use MRI Following Neoadjuvant Chemotherapy (NAC) in Locally Advanced Breast Cancer
Global Breast Cancer Conference 2016 & 5 th International Breast Cancer Symposium April 29 th 2016, 09:40-10:50 How to Use MRI Following Neoadjuvant Chemotherapy (NAC) in Locally Advanced Breast Cancer
More informationControversies in Breast Pathology ELENA PROVENZANO ADDENBROOKES HOSPITAL, CAMBRIDGE
Controversies in Breast Pathology ELENA PROVENZANO ADDENBROOKES HOSPITAL, CAMBRIDGE Neoadjuvant Chemotherapy Indications: Management of locally advanced invasive breast cancers including inflammatory breast
More informationEvaluation of Pathologic Response in Breast Cancer Treated with Primary Systemic Therapy
Evaluation of Pathologic Response in Breast Cancer Treated with Primary Systemic Therapy Eun Yoon Cho, MD, PhD Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University
More informationTNBC: What s new Déjà vu All Over Again? Lucy R. Langer, MD MSHS Compass Oncology - SABCS 2016 Review February 21, 2017
TNBC: What s new Déjà vu All Over Again? Lucy R. Langer, MD MSHS Compass Oncology - SABCS 2016 Review February 21, 2017 The problem with TNBC 1. Generally more aggressive 2. ONLY chemotherapy 3. No other
More informationClaudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression
Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression Mona A. Abd-Elazeem, Marwa A. Abd- Elazeem Pathology department, Faculty of Medicine, Tanta
More informationTriple-Negative Breast Cancer Time to Slice and Dice? Carsten Denkert, MD Charité University Hospital Berlin, Germany
Triple-Negative Breast Cancer Time to Slice and Dice? Carsten Denkert, MD Charité University Hospital Berlin, Germany Triple-Negative Breast Cancer (TNBC) 2018 Presentation Outline The molecular heterogeneity
More informationTumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer
García-Martínez et al. Breast Cancer Research 2014, 16:488 RESEARCH ARTICLE Open Access Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis
More informationAssessment of Risk Recurrence: Adjuvant Online, OncotypeDx & Mammaprint
Assessment of Risk Recurrence: Adjuvant Online, OncotypeDx & Mammaprint William J. Gradishar, MD Professor of Medicine Robert H. Lurie Comprehensive Cancer Center of Northwestern University Classical
More informationSesiones interhospitalarias de cáncer de mama. Revisión bibliográfica 4º trimestre 2015
Sesiones interhospitalarias de cáncer de mama Revisión bibliográfica 4º trimestre 2015 Selected papers Prospective Validation of a 21-Gene Expression Assay in Breast Cancer TAILORx. NEJM 2015 OS for fulvestrant
More informationThe Role of Pathologic Complete Response (pcr) as a Surrogate Marker for Outcomes in Breast Cancer: Where Are We Now?
1 The Role of Pathologic Complete Response (pcr) as a Surrogate Marker for Outcomes in Breast Cancer: Where Are We Now? Terry Mamounas, M.D., M.P.H., F.A.C.S. Medical Director, Comprehensive Breast Program
More informationPost Neoadjuvant therapy: issues in interpretation
Post Neoadjuvant therapy: issues in interpretation Disclosure: Overview D Prognostic features in assessment of post treatment specimens: Tumor size Cellularity Grade Receptors LN Neoadjuvant chemotherapy:
More informationResidual cancer burden in locally advanced breast cancer: a superior tool
ABSTRACT Objectives Locally advanced breast cancer (LABC) poses a difficult clinical challenge with an overall poor long-term prognosis. The strength of the association between tumour characteristics,
More informationEditorial Process: Submission:05/09/2017 Acceptance:08/23/2018
RESEARCH ARTICLE Editorial Process: Submission:05/09/2017 Acceptance:08/23/2018 Predictors of Pathological Complete Response to Neoadjuvant Chemotherapy in Iranian Breast Cancer Patients Pegah Sasanpour
More informationBreast : ASCO Abstracts for Review
Breast : ASCO 2011 Susana Campos, MD, MPH Dana Farber Cancer Institute Abstracts for Review Prevention Neoadjuvant Metastatic Brain mets LBA 504: Exemestane for primary prevention of breast cancer in postmenopausal
More informationOnly Estrogen receptor positive is not enough to predict the prognosis of breast cancer
Young Investigator Award, Global Breast Cancer Conference 2018 Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer ㅑ Running head: Revisiting estrogen positive tumors
More informationPMRT for N1 breast cancer :CONS. Won Park, M.D., Ph.D Department of Radiation Oncology Samsung Medical Center
PMRT for N1 breast cancer :CONS Won Park, M.D., Ph.D Department of Radiation Oncology Samsung Medical Center DBCG 82 b & c Overgaard et al Radiot Oncol 2007 1152 pln(+), 8 or more nodes removed Systemic
More informationClinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05
Abstract No.: ABS-0075 Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer 2018/04/05 Cheol Min Kang Department of surgery, University of Ulsan
More informationAdjuvant endocrine therapy (essentials in ER positive early breast cancer)
Adjuvant endocrine therapy (essentials in ER positive early breast cancer) Giuseppe Curigliano MD, PhD Breast Cancer Program Division of Experimental Therapeutics Outline Picking optimal adjuvant endocrine
More informationClinical significance and prognostic value of receptor conversion in hormone receptor positive breast cancers after neoadjuvant chemotherapy
Yang et al. World Journal of Surgical Oncology (2018) 16:51 https://doi.org/10.1186/s12957-018-1332-7 RESEARCH Open Access Clinical significance and prognostic value of receptor conversion in hormone receptor
More information2017 San Antonio Breast Cancer Symposium: Local Therapy Highlights
2017 San Antonio Breast Cancer Symposium: Local Therapy Highlights Mylin A. Torres, M.D. Director, Glenn Family Breast Center Associate Professor Department of Radiation Oncology Winship Cancer Institute
More informationNeoadjuvant Treatment of. of Radiotherapy
Neoadjuvant Treatment of Breast Cancer: Role of Radiotherapy Neoadjuvant Chemotherapy Many new questions for radiation oncology? lack of path stage to guide indications should treatment response affect
More informationPoint of View on Early Triple Negative
Point of View on Early Triple Negative Valentina Rossi, MD UOSD Oncologia dei Tumori della Mammella Azienda Ospedaliera S.Camillo-Forlanini VRossi@scamilloforlanini.rm.it Outline Neoadjuvant Setting IPSY-2
More informationRadiotherapy Management of Breast Cancer Treated with Neoadjuvant Chemotherapy. Julia White MD Professor, Radiation Oncology
Radiotherapy Management of Breast Cancer Treated with Neoadjuvant Chemotherapy Julia White MD Professor, Radiation Oncology Agenda Efficacy of radiotherapy in the management of breast cancer in the Adjuvant
More informationDO YOUNG AGE AND TRIPLE NEGATIVE MOLECULAR SUBTYPE HAVE A NEGATIVE EFFECT ON SURVIVAL IN PATIENTS WITH EARLY STAGE BREAST CANCER?
DO YOUNG AGE AND TRIPLE NEGATIVE MOLECULAR SUBTYPE HAVE A NEGATIVE EFFECT ON SURVIVAL IN PATIENTS WITH EARLY STAGE BREAST CANCER? Çetin Ordu, Atilla Bozdoğan, Gül Alço, Kezban N. Pilancı, Derya Selamoğlu,
More informationA Study to Evaluate the Effect of Neoadjuvant Chemotherapy on Hormonal and Her-2 Receptor Status in Carcinoma Breast
Original Research Article A Study to Evaluate the Effect of Neoadjuvant Chemotherapy on Hormonal and Her-2 Receptor Status in Carcinoma Breast E. Rajesh Goud 1, M. Muralidhar 2*, M. Srinivasulu 3 1Senior
More informationNeoadjuvant (Primary) Systemic Therapy
Diagnosis and Treatment of Patients with Primary and Metastatic reast Cancer Neoadjuvant (Primary) Systemic Therapy Neoadjuvant Systemic Therapy Versions 2002 2017: auerfeind / lohmer / Costa / Dall /
More informationThe Oncotype DX Assay in the Contemporary Management of Invasive Early-stage Breast Cancer
The Oncotype DX Assay in the Contemporary Management of Invasive Early-stage Breast Cancer Cancer The Biology Century Understanding and treating the underlying tumor biology Cancer genetic studies demonstrate
More informationInternational Society of Breast Pathology. Immune Targeting in Breast Cancer. USCAP 2017 Annual Meeting
International Society of Breast Pathology USCAP 2017 Annual Meeting Immune Targeting in Breast Cancer Ashley Cimino-Mathews, MD Assistant Professor of Pathology and Oncology The Johns Hopkins Hospital
More informationTriple-Negative Breast Cancer
June 2017 Triple-Negative Breast Cancer Amir Sonnenblick, MD, PhD Sharett institute of oncology Hadassah-Hebrew university medical center, Jerusalem, Israel This presentation is the intellectual property
More informationIn Honour of Dr. Neera Patel
In Honour of Dr. Neera Patel Residual Cancer Burden (RCB) vs Pathologic Complete Response (pcr) as an End-point W. Fraser Symmans, M.D. Professor of Pathology UT M.D. Anderson Cancer Center Pathologic
More informationGábor CSERNI. 1. Bács-Kiskun County Teaching Hospital, Kecskemét 2. University of Szeged, Szeged
Lymphocytes infiltrant la tumeur (TIL) sur micro-biopsies et pièces opératoires Quel impact clinique? Quels moyens de mise en évidence? Comment restituer les résultats? TILs - Clinical impact / Evaluation
More informationBreast Imaging: Multidisciplinary Approach. Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina
Breast Imaging: Multidisciplinary Approach Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina No Disclosures Objectives Discuss a multidisciplinary breast
More informationPregnancy and Breast Cancer. Elena Provenzano Addenbrookes Hospital Cambridge
Pregnancy and Breast Cancer Elena Provenzano Addenbrookes Hospital Cambridge Pregnancy and Breast Cancer Pregnancy and Breast Cancer 1. Pregnancy associated breast cancer: Histology, management, clinical
More informationLong term survival study of de-novo metastatic breast cancers with or without primary tumor resection
Long term survival study of de-novo metastatic breast cancers with or without primary tumor resection Dr. Michael Co Division of Breast Surgery Queen Mary Hospital The University of Hong Kong Conflicts
More informationImplications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers
日大医誌 75 (1): 10 15 (2016) 10 Original Article Implications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers Naotaka Uchida 1), Yasuki Matsui 1), Takeshi Notsu 1) and Manabu
More information10/15/2012. Biologic Subtypes of TNBC. Topics. Topics. Histopathology Molecular pathology Clinical relevance
Biologic Subtypes of TNBC Andrea L. Richardson M.D. Ph.D. Brigham and Women s Hospital Dana-Farber Cancer Institute Harvard Medical School Boston, MA Topics Histopathology Molecular pathology Clinical
More informationCirculating Tumor Cells in non- Metastatic Triple Negative Breast Cancer
Circulating Tumor Cells in non- Metastatic Triple Negative Breast Cancer Carolyn Hall, Ph.D. Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Triple Negative Breast Cancer
More informationBreast cancer in elderly patients (70 years and older): The University of Tennessee Medical Center at Knoxville 10 year experience
Breast cancer in elderly patients (70 years and older): The University of Tennessee Medical Center at Knoxville 10 year experience Curzon M, Curzon C, Heidel RE, Desai P, McLoughlin J, Panella T, Bell
More informationEvaluación de la respuesta patológica completa tras tratamiento neoadyuvante en cáncer de mama. José Palacios Calvo Servicio de Anatomía Patológica
Evaluación de la respuesta patológica completa tras tratamiento neoadyuvante en cáncer de mama José Palacios Calvo Servicio de Anatomía Patológica E-Cadherin HER2 HER2 p63 Pathological Response Pathological
More informationTriple negative breast cancer -neoadjuvant and adjuvant systemic therapy
Triple negative breast cancer -neoadjuvant and adjuvant systemic therapy Sung-Bae Kim, MD, PhD Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul, Korea DISCLOSURE
More informationPresent Role of Immunohistochemistry in the. Subtypes. Beppe Viale European Institute of Oncology University of Milan Milan-Italy
Present Role of Immunohistochemistry in the Classification of Molecular Subtypes Beppe Viale European Institute of Oncology University of Milan Milan-Italy We know it is many diseases Breast cancer is
More informationEnterprise Interest Speaker and consultant for Astrazeneca, MSD, BMS, Roche, Pfizer, Novartis, Sanofi Resarch grants from BMS, Roche, MSD, Novartis
Enterprise Interest Speaker and consultant for Astrazeneca, MSD, BMS, Roche, Pfizer, Novartis, Sanofi Resarch grants from BMS, Roche, MSD, Novartis Centre Jean Perrin Centre de Lutte contre le Cancer d'auvergne
More informationEARLY STAGE BREAST CANCER ADJUVANT CHEMOTHERAPY. Dr. Carlos Garbino
EARLY STAGE BREAST CANCER ADJUVANT CHEMOTHERAPY Dr. Carlos Garbino EARLY BREAST CANCER ADJUVANT CHEMOTHERAPY SUSTANTIVE DIFFICULTIES FOR A WORLDWIDE APPLICABILITY DUE TO IMPORTANT INEQUALITIES + IN DIFFERENT
More informationSupplementary Online Content
Supplementary Online Content Giannakeas V, Sopik V, Narod SA. Association of Radiotherapy With Survival in Women Treated for Ductal Carcinoma In Situ With Lumpectomy or Mastectomy. JAMA Netw Open. 2018;1(4):e181100.
More informationESMO Breast Cancer Preceptorship Singapore November Special Issues in Treatment of Young Women with Breast Cancer
ESMO Breast Cancer Preceptorship Singapore November 2017 Special Issues in Treatment of Young Women with Breast Cancer Prudence Francis MD Peter MacCallum Cancer Centre Melbourne, Australia Conflict of
More informationOncotype DX testing in node-positive disease
Should gene array assays be routinely used in node positive disease? Yes Christy A. Russell, MD University of Southern California Oncotype DX testing in node-positive disease 1 Validity of the Oncotype
More informationKathy Albain, MD. Chemotherapy in Luminal Breast Cancer: Who Benefits? Loyola University Chicago Stritch School of Medicine
Chemotherapy in Luminal Breast Cancer: Who Benefits? Kathy Albain, MD Loyola University Chicago Stritch School of Medicine, Director, Breast Clinical Research Program, Cardinal Bernardin Cancer Center,
More informationTable S2. Expression of PRMT7 in clinical breast carcinoma samples
Table S2. Expression of PRMT7 in clinical breast carcinoma samples (All data were obtained from cancer microarray database Oncomine.) Analysis type* Analysis Class(number sampels) 1 2 3 4 Correlation (up/down)#
More information2014 San Antonio Breast Cancer Symposium Review
2014 San Antonio Breast Cancer Symposium Review HER2 Positive Disease 01-10-2015 Elisavet Paplomata, MD Assistant Professor Hematology & Medical Oncology Emory University Winship Cancer Institute S6-01
More informationSCIENCE CHINA Life Sciences
SCIENCE CHINA Life Sciences RESEARCH PAPER April 2013 Vol.56 No.4: 335 340 doi: 10.1007/s11427-013-4435-y Risk factors of recurrence in small-sized, node negative breast cancer in young women: a retrospective
More informationPrognostic and Predictive Factors
Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer Prognostic and Predictive Factors Prognostic and Predictive Factors Version 2002: Thomssen / Harbeck Version 2003 2009: Costa
More informationMorphological and Molecular Typing of breast Cancer
Morphological and Molecular Typing of breast Cancer Ian Ellis Molecular Medical Sciences, University of Nottingham Department of Histopathology, Nottingham University Hospitals NHS Trust Histological
More informationADAPT. Adjuvant Dynamic marker- Adjusted Personalized Therapy trial optimizing risk assessment and therapy response prediction in early breast cancer
ADAPT Adjuvant Dynamic marker- Adjusted Personalized Therapy trial optimizing risk assessment and therapy response prediction in early breast cancer Therapieindikation gesteuert durch prognostische Information
More informationOverview of peculiarities and therapeutic options for patients with breast cancer and a BRCA germline mutation
Overview of peculiarities and therapeutic options for patients with breast cancer and a BRCA germline mutation Dr Niklas Loman PhD MD Consultant oncologist Skåne University Hospital Lund, Suecia Prognosis
More informationThe effect of delayed adjuvant chemotherapy on relapse of triplenegative
Original Article The effect of delayed adjuvant chemotherapy on relapse of triplenegative breast cancer Shuang Li 1#, Ding Ma 2#, Hao-Hong Shi 3#, Ke-Da Yu 2, Qiang Zhang 1 1 Department of Breast Surgery,
More informationPage 1. AHN-JHU Breast Cancer Symposium. Novel Local Regional Clinical Trials. Background. Neoadjuvant Chemotherapy Benefit.
AHN-JHU Breast Cancer Symposium Novel Local Regional Clinical Trials March 22, 2019 Thomas B. Julian, MD, FACS Associate Medical Director, Cancer Program Development, ANH Cancer Institute Background In
More informationA Study on Importance of Molecular Subtyping As a Prognostic Indicator of Breast Carcinoma
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 79-8, p-issn: 79-86.Volume 8, Issue Ser. (January. 9), PP - www.iosrjournals.org A Study on Importance of Molecular Subtyping As a Prognostic
More informationCover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/55957 holds various files of this Leiden University dissertation Author: Dekker T.J.A. Title: Optimizing breast cancer survival models based on conventional
More informationIdeal neo-adjuvant Chemotherapy in breast ca. Dr Khanyile Department of Medical Oncology, University of Pretoria
Ideal neo-adjuvant Chemotherapy in breast ca Dr Khanyile Department of Medical Oncology, University of Pretoria When is neo-adjuvant Chemo required? Locally advanced breast ca: - Breast conservative surgery
More informationBreast Cancer: ASCO Poster Review
Breast Cancer: ASCO Poster Review Carmen Criscitiello, MD, PhD Istituto Europeo di Oncologia Milano HER2+ SUBTYPE Research questions in early HER2+ BC De-escalation of toxicity without compromising efficacy
More informationEarly Stage Disease. Hope S. Rugo, MD Professor of Medicine Director Breast Oncology and Clinical Trials Education UCSF Comprehensive Cancer Center
SABCS 2014: Early Stage Disease Hope S. Rugo, MD Professor of Medicine Director Breast Oncology and Clinical Trials Education UCSF Comprehensive Cancer Center Topics for Discussion Chemotherapy plus 10
More informationBasement membrane in lobule.
Bahram Memar, MD Basement membrane in lobule. Normal lobule-luteal phase Normal lobule-follicular phase Lactating breast Greater than 95% are adenocarcinomas in situ carcinomas and invasive carcinomas.
More informationLessons Learnt from Neoadjuvant Hormone Therapy. 10 Lessons Learnt from Neoadjuvant Endocrine Therapy. Lesson 1
Lessons Learnt from Neoadjuvant Hormone Therapy Mike Dixon Clinical Director Breakthrough Research Unit Edinburgh 10 Lessons Learnt from Neoadjuvant Endocrine Therapy 10 Lessons Learnt from Neoadjuvant
More informationResponse of Triple Negative Breast Cancer to Neoadjuvant Chemotherapy: Correlation between Ki-67 Expression and Pathological Response
RESEARCH ARTICLE Response of Triple Negative Breast Cancer to Neoadjuvant Chemotherapy: Correlation between Ki-67 Expression and Pathological Response Gamal M Elnemr 1,2 *, Ahmed H El-Rashidy 3,4, Ahmed
More informationLessons Learnt from Neoadjuvant Hormone Therapy. Mike Dixon Clinical Director Breakthrough Research Unit Edinburgh
Lessons Learnt from Neoadjuvant Hormone Therapy Mike Dixon Clinical Director Breakthrough Research Unit Edinburgh 10 Lessons Learnt from Neoadjuvant Endocrine Therapy 10 Lessons Learnt from Neoadjuvant
More informationNeoadjuvantTreatment In BC When, How, Who?
NeoadjuvantTreatment In BC When, How, Who? Clifford Hudis, M.D. Chief, Breast Cancer Medicine Service, MSKCC Professor of Medicine, Weill Cornell Medical College President, ASCO 15 Potential Benefits Of
More informationTriple negative breast cancer Biology and targeted therapy
Triple negative breast cancer Biology and targeted therapy MR SCI MED DR I BOŽOVIĆ -SPASOJEVIĆ INSTITUT ZA ONKOLOGIJU I RADIOLOGIJU SRBIJE I VA N A B O Z O V I C @ O U T L O O K. C O M Current challanges
More information8/8/2011. PONDERing the Need to TAILOR Adjuvant Chemotherapy in ER+ Node Positive Breast Cancer. Overview
Overview PONDERing the Need to TAILOR Adjuvant in ER+ Node Positive Breast Cancer Jennifer K. Litton, M.D. Assistant Professor The University of Texas M. D. Anderson Cancer Center Using multigene assay
More informationConsiderations in Adjuvant Chemotherapy. Joyce O Shaughnessy, MD Baylor Sammons Cancer Center Texas Oncology US Oncology
Considerations in Adjuvant Chemotherapy Joyce O Shaughnessy, MD Baylor Sammons Cancer Center Texas Oncology US Oncology 80 70 60 50 40 30 20 10 0 EBCTCG 2005/6 Overview Control Arms with No Systemic Treatment
More informationNeoadjuvant chemotherapy (NACT) in young women with breast cancer. Hanne Melgaard Nielsen, MD Ph.D Department of Oncology, Aarhus University Hospital
Neoadjuvant chemotherapy (NACT) in young women with breast cancer Hanne Melgaard Nielsen, MD Ph.D Department of Oncology, Aarhus University Hospital Young women according to EUSOMA guidelines Is under
More informationTime to Start Adjuvant Systemic Treatment in Breast Cancer; a Retrospective Cohort Study
Cancer and Clinical Oncology; Vol. 6, No. 2; 2017 ISSN 1927-4858 E-ISSN 1927-4866 Published by Canadian Center of Science and Education Time to Start Adjuvant Systemic Treatment in Breast Cancer; a Retrospective
More informationAdjuvant chemotherapy in older breast cancer patients: how to decide?
Adjuvant chemotherapy in older breast cancer patients: how to decide? H. Wildiers University Hospitals Leuven Belgium Wildiers H, Kunkler I, Lancet Oncol 2007 Biganzoli L, Wildiers H, Lancet Oncol. 2012
More informationEditorial Process: Submission:11/30/2017 Acceptance:01/04/2019
RESEARCH ARTICLE Editorial Process: Submission:11/30/2017 Acceptance:01/04/2019 in Non-Metastatic Triple-Negative Breast Cancer O Al jarroudi*, A Zaimi, S A Brahmi, S Afqir Abstract Introduction: Triple-negative
More informationThe Neoadjuvant Model as a Translational Tool for Drug and Biomarker Development in Breast Cancer
The Neoadjuvant Model as a Translational Tool for Drug and Biomarker Development in Breast Cancer Laura Spring, MD Breast Medical Oncology Massachusetts General Hospital Primary Mentor: Dr. Aditya Bardia
More informatione-session 381 BCY3 - Highlights of the 3rd ESO-ESMO Breast Cancer in Young Women International Conference
Expert: Dr Olivia Pagani, Oncology Institute of Southern Switzerland, Lugano, Switzerland Discussant: Dr Fedro Alessandro Peccatori, European Institute of Oncology, Milan, Italy e-session 381 BCY3 - Highlights
More informationRace is not a factor in overall survival in patients with triple negative breast cancer: a retrospective review
Starlard-Davenport et al. SpringerPlus 2013, 2:516 a SpringerOpen Journal RESEARCH Open Access Race is not a factor in overall survival in patients with triple negative breast cancer: a retrospective review
More informationExtended Hormonal Therapy
Extended Hormonal Therapy Dr. Caroline Lohrisch, Medical Oncologist, BC Cancer Agency Vancouver Centre November 1, 2014 www.fpon.ca Optimal Endocrine Therapy for Women with Hormone Receptor Positive Early
More informationGene Signatures in Breast Cancer: Moving Beyond ER, PR, and HER2? Lisa A. Carey, M.D. University of North Carolina USA
Gene Signatures in Breast Cancer: Moving Beyond ER, PR, and HER2? Lisa A. Carey, M.D. University of North Carolina USA When Are Biomarkers Ready To Use? Same Rules for Gene Expression Panels Key elements
More informationSubtype-directed therapy of TNBC Global Breast Cancer Conference 2015 & 4th International Breast Cancer Symposium Jeju Island, Korea, April 2015
Subtype-directed therapy of TNBC Global Breast Cancer Conference 2015 & 4th International Breast Cancer Symposium Jeju Island, Korea, April 2015 Ruth M. O Regan, MD Visiting Professor and Division Chief
More informationBreast Cancer. Dr. Andres Wiernik 2017
Breast Cancer Dr. Andres Wiernik 2017 Agenda: The Facts! (Epidemiology/Risk Factors) Biological Classification/Phenotypes of Breast Cancer Treatment approach Local Systemic Agenda: The Facts! (Epidemiology/Risk
More informationDuctal Carcinoma in Situ (DCIS)
Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer Ductal Carcinoma in Situ (DCIS) Ductal Carcinoma in Situ DCIS Versions 2002 2017: Audretsch / Blohmer / Brunnert / Budach /
More informationImplications of ACOSOG Z11 for Clinical Practice: Surgical Perspective
:$;7)#*8'-87*4BCD'E7)F'31$4.$&'G$H'E7)F&'GE'>??ID >?,"'@4,$)4*,#74*8'!74/)$++'74',"$'A.,.)$'7%'()$*+,'!*42$)!7)74*67&'!3 6 August 2011 Implications of ACOSOG Z11 for Clinical
More informationNew approaches in the neoadjuvant systemic therapy of breast cancer
New approaches in the neoadjuvant systemic therapy of breast cancer Ph.D. Thesis Orsolya Rusz, Pharm.D. Supervisor: Prof. Zsuzsanna Kahán, M.D., D.Sc. Department of Oncotherapy University of Szeged Doctoral
More informationAssociation of microrna-7 and its binding partner CDR1-AS with the prognosis and prediction of 1 st -line tamoxifen therapy in breast cancer
www.nature.com/scientificreports Received: 1 March 2018 Accepted: 12 June 2018 Published: xx xx xxxx OPEN Association of microrna-7 and its binding partner CDR1-AS with the prognosis and prediction of
More informationTriple Negative Breast cancer New treatment options arenowhere?
Triple Negative Breast cancer New treatment options arenowhere? Ofer Rotem, M.D., B.Sc. Breast Unit, Davidoff center Rabin Medical center October 2017 Case 6/2013 - M.D., 38 years old woman, healthy, no
More informationBreast cancer treatment
Report from the San Antonio Breast Cancer Symposium Breast cancer treatment Determining the best options for select patient groups Sara Soldera, MD, Resident; Nathaniel Bouganim, MD, FRCPC, Medical Oncologist;
More informationSt Gallen 2017 controversies & consensus
St Gallen 2017 controversies & consensus Shani Paluch-Shimon, MBBS, MSc Head, Breast Cancer Service for Young Women Breast Unit, Division of Oncology Sheba Medical Centre June 2017 St Gallen 2017 De-escalation
More informationMolecular in vitro diagnostic test for the quantitative detection of the mrna expression of ERBB2, ESR1, PGR and MKI67 in breast cancer tissue.
Innovation for your breast cancer diagnostics Now valid ated on: -Roche cob as z 480 A nalyzer -Roche L ightcycle r 480 II - ABI 750 0 Fast -Versant kpcr Cyc ler PGR ESR1 MKI67 Molecular in vitro diagnostic
More informationAdvances in Breast Cancer Therapeutics in the Adjuvant and Metastatic Settings. Eve Rodler, MD University of California at Davis October 2016
Advances in Breast Cancer Therapeutics in the Adjuvant and Metastatic Settings Eve Rodler, MD University of California at Davis October 2016 17th Annual Advances in Oncology September 30-October 1, 2016
More informationMolecular in vitro diagnostic test for the quantitative detection of the mrna expression of ERBB2, ESR1, PGR and MKI67 in breast cancer tissue.
Innovation for your breast cancer diagnostics PGR G ATA G C G A C G AT C G A A A G A A G T TA G ATA G C G A C G AT C G A A A G A A G T TA G ATA G C G A C G AT C G A A A G A A G T TA G ATA G C G A C ERBB2
More informationJosé Palacios Calvo Servicio de Anatomía Patológica
Criterios de respuesta patológica con los distintos subtipos de cáncer de mama. Qué cambios se dan en el tejido postquimioterapia y qué dificultades se plantean para evaluar la respuesta? José Palacios
More informationImmunotherapy in breast cancer. Carmen Criscitiello, MD, PhD European Institute of Oncology Milan, Italy
Immunotherapy in breast cancer Carmen Criscitiello, MD, PhD European Institute of Oncology Milan, Italy Outline Rational for immune-based therapy in breast cancer Immunogenic chemotherapy Targeting immune
More information* * * * Supplementary Figure 1. DS Lv CK HSA CK HSA. CK Col-3. CK Col-3. See overleaf for figure legend. Cancer cells
Supplementary Figure 1 Cancer cells Desmoplastic stroma Hepatocytes Pre-existing sinusoidal blood vessel New blood vessel a Normal liver b Desmoplastic HGP c Pushing HGP d Replacement HGP e f g h i DS
More informationBreast Cancer Statistics
1 in 8 Breast Cancer Statistics Incidence Mortality Prevalence 2 Breast Cancer Incidence Breast Cancer Mortality Breast Cancer Prevalence ~$100,000 Female Breast Anatomy Breasts consist mainly of fatty
More information