Hematopoiesis Simplified: Part 1 Erythropoiesis

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1 Hematopoiesis Simplified: Part 1 Erythropoiesis Larry Johnson Texas A&M University

2 Hematopoiesis Simplified: Part 1 Erythropoiesis Objectives are to: Identify the developmental cells of erythropoiesis Characterize developmental changes in the cytoplasm and nucleus of these cells Bone marrow Blood vessel

3 19761 Bone marrow Blood in vessel

4 Peripheral blood 21 Erythrocytes Reticulocytes

5 Erythropoiesis Erythrocytes Reticulocytes No nucleus and red cytoplasm No nucleus and blue - grey cytoplasm Orthochromatophilic erythroblasts Polychromatophilic erythroblasts Dark, small, spherical nucleus blue grey cytoplasm Darkening, fractured,spherical nucleus and mixed pools of grey and blue cytoplasm Basophilic erythroblasts Proerythroblasts Fractured, spherical nucleus and thin rim of dark blue cytoplasm Uniformly light, spherical nucleus with thin rim of medium to dark blue cytoplasm

6 McGraw-Hill Companies

7 Erythropoiesis Erythrocytes Proerythroblasts Reticulocytes Orthochromatophilic erythroblasts Basophilic erythroblasts Polychromatophilic erythroblasts Erythropoiesis

8 Orthochromatophilic erythroblasts Erythrocytes

9 Erythrocyte Proerythroblast Reticulocytes Orthochromatophilic erythroblast Basophilic erythroblast Polychromatophilic erythroblast Erythropoiesis

10 Polychromatophilic erythroblasts

11 Erythrocyte Proerythroblast Reticulocytes Orthochromatophilic erythroblast Basophilic erythroblast Polychromatophilic erythroblast Erythropoiesis

12 Basophilic erythroblast

13 Erythrocyte Proerythroblast Reticulocytes Orthochromatophilic erythroblast Basophilic erythroblast Polychromatophilic erythroblast Erythropoiesis

14 Proerythroblasts

15 Erythropoiesis Erythrocytes Orthochromatophilic erythroblasts Reticulocytes

16 Early orthochromatophilic erythroblasts Late polychromatophilic erythroblasts

17 Polychromatophilic erythroblasts Early polychromatophilic erythroblasts

18 Basophilic erythroblasts Proerythroblasts

19 Orthochromatophilic erythroblasts ut 112 RBCs Late polychromatophilic erythroblast Basophilic erythroblast platelets Reticulocyte Polychromatophilic erythroblast Eosinophil or basophil Erythrocytes Proerythroblast

20 Bone marrow Reticulocyte entering blood vessel Blood vessel

21 The End of Hematopoiesis Simplified: Part 1 Erythropoiesis

22 Granulopoiesis is next

23 Hematopoiesis Simplified: Part 2 Granulopoiesis Larry Johnson Texas A&M University

24 Hematopoiesis Simplified: Objectives are to: Part 2 Granulopoiesis Identify the developmental cells of granulopoiesis Characterize developmental changes in the cytoplasm and nucleus of these cells Bone marrow

25 19761 Bone marrow Blood Blood

26 32583 ` Bone marrow Developing granulocytes

27 21 Peripheral blood

28 Granulopoiesis Neutrophils Lobulated, dark nucleus, mature grey cytoplasm with small granules Neutrophilic band or stab cells Horse-shoe shaped, darkening nucleus, grey mature cytoplasm Neutrophilic metamyelocytes Neutrophilic myelocytes Promyelocytes Oval to kidney bean-shaped, indented nucleus, grey mature cytoplasm with a weak blue tent Large, oval, non-indented nucleus, large amount of cytoplasm with specific and non-specific granules Large, oval, non-indented nucleus, large amount of sky blue cytoplasm with non-specific granules

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30 Granulopoiesis Neutrophils Promyelocytes Neutrophilic band cells Neutrophilic myelocytes Neutrophilic metamyelocytes

31 ut 112 Neutrophil Neutrophilic metamyelocytes Neutrophilic metamyelocyte Platelets Eosinophil or basophil Neutrophilic myelocytes

32 Neutrophils Promyelocytes Neutrophilic band cells Neutrophilic myelocytes Neutrophilic metamyelocytes Granulopoiesis

33 Neutrophilic metamyelocytes Lymphocytes Unknown nuclei Neutrophilic myelocytes Promyelocyte Neutrophilic myelocytes Lymphocytes Neutrophilic band cells Neutrophilic band cells Neutrophilic metamyelocytes Neutrophilic band cell

34 Neutrophils Neutrophilic band cells Granulopoiesis

35 Neutrophilic metamyelocytes Early neutrophilic metamyelocytes

36 Neutrophilic myelocytes

37 Late promyelocytes Promyelocyte

38 Neutrophilic metamyelocytes Unknown nuclei Neutrophilic myelocytes Neutrophilic band cells Neutrophilic metamyelocytes Orthochromatophilic erythroblasts Proerythroblast Eosinophils or basophils Orthochromatophilic erythroblasts

39 32583 Bone marrow White blood cell entering a blood vessel Blood vessel Blood vessel

40 he End of Hematopoiesis Simplified: Part 2 Granulopoiesis